Chapter 77: References - Roadmap for 'Food and Drugs' in Cancer Nutrition: Specific Nutritional Pathways During Chemotherapy for Cancer Patients (2023)


1) Aalinkeel, R., Bindukumar, B., Reynolds, J. L., Sykes, DE, Mahajan, SD, Chadha, K. C., & Schwartz, S. A. 2008. The dietary bioflavonoid quercetin selectively induces apoptosis of prostate cancer cells by regulating down the expression of heat shock protein 90 .prostate. 68(16): 1773-89

2) Abdalah, R., Wei, L., Francis, K. and Yu, S. P. 2006. Volinomycin-induced apoptosis in Chinese hamster ovary cells. Neuroscience letters. 405(1-2): 68-7

3) Abdel Malek, M.A., Jagannathan, S., Malek, E., Sayed, D.M., Elgammal, S.A., Abd El-Azeem, H.G., Thabet, N.M. and Driscoll, J.J. 2015. Molecular chaperone GRP78 Enhances Aggresome Delivery to Autophagosomes to Promotion of Drug Resistance in Multiple Myeloma. oncotarget 6(5): 3098-110

4) Abdel-Aal EM, Akhtar H, Zaheer K, and Ali R 2013. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutritious. 5(4): 1169-1185

5) Abdelalim, E. M. and Tooyama, I. 2014. Deletion of p53 represses Nanog expression in embryonic stem cells. Communications on biochemical and biophysical research. 443(2): 652-657

6) Abdi, J., Garssen, J., Faber, J. and Redegeld, F.A. 2014. Omega-3 fatty acids EPA and DHA induce apoptosis and increase drug sensitivity in multiple myeloma cells, but not in normal peripheral mononuclear cells. The Journal of Nutritional Biochemistry. 25(12): 1254-1261

7) Abdin, A. A. 2013. Targeting of sphingosine kinase 1 (SphK1) and apoptose by colon-specific resveratrol delivery formula in the treatment of experimental ulcerative colitis bei Ratten. Eur J Pharmacol. 718 (1-3): 145-53

8) Achcar, F., Kerkhoven, E.J., Silico Tryp Consortium Bakker, BM, Barrett, M.P. and Breitling, R. 2012. Dynamic modeling under uncertainty: the origin of energy metabolism in Trypanosoma brucei. Pls ComputBiol. 8(1): e1002352, doi: 10.1371/journal.pcbi.1002352

9) Adachi, K., Suemori, H., Yasuda, S., Nakatsuji, N., and Kawase, E. 2010. Role of SOXO2 in the maintenance of human embryonic stem cell pluripotency. genes to cells. 15(5): 455-469

10) Adachi, S., Shimizu, M., Shirakami, Y., Yamauchi, J., Natsume, H., Matsushima-Nishiwaki, R., To, S., Weinstein, IB, Moriwaki, H., and Kozawa, O. 2009. (-)-Epigallocatechin gallate downregulates the EGF receptor through phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells. carcinogenesis. 30(9): 1544-1552

11) Adams, C., Totpal, K., Lawrence, D., Marsters, S., Pitti, R., Yee, S., Ross, S., Deforge, L., Koeppen, H., Sagolla, M. ., Compaan, D., Lowman, H., Hymowitz, S., and Ashkenazi, A. 2008. Structural and functional analysis of the interaction between the agonist monoclonal antibody apomab and the pro-apoptotic receptor DR5. distinguish cell death. 15(4):751-61

12) Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, and Heber D 2006. Pomegranate juice, pomegranate total ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agricultural food chemistry. 54(3):980-5

13) Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, and Holmes MD 2005. Dietary intake of flavonols and flavonol-rich foods and risk of breast cancer. International Journal of Cancer. 114(4): 628-633

14) Adebisi, A.J., Oyewo, BE and Jibodu, S.I. 2014. Vitamins A, C and lycopene content of some tomato and pepper cultivars in the southwestern region of Nigeria. Advances in science and technology of life. 23: 63-67, ISSN 2224-7181

15) Adler-Wailes, D.C., Liu, H., Ahmad, F., Feng, N., Londos, C., Manganiello, V., and Yanovski, J.A. on basal and catecholamine stimulators Lipolysis. J Clin Endocrinol Metab. 90(6):3251–3261

16) Adrogue, H.J. and Madias, N.E. 2007. Sodium and potassium in the pathogenesis of hypertension. The New England Journal of Medicine., 356(19): 1966-1978.

17) Aggarwal, B.B. 2004. Core Factor kB: The Enemy Within. célula cancerosa. 6(3): 203-208

18) Aggarwal, B.B., Bhardwaj, A., Aggarwal, R.S., Seeram, N.P., Shishodia, S., & Takada, Y. 2004. Role of resveratrol in cancer prevention and therapy: preclinical and clinical studies. Cancer research. 24(5A): 2783-2840

19) Aggarwal BB, Sundaram C, Prasad S and Kannappan R 2010. Tocotrienols, the vitamin E of the century: their potential against cancer and other chronic diseases. Biochemical Pharmacology. 80(11): 1613-1631

20) Agostinis, P., Berg, K., Cengel, K.A. et al. 2011. Photodynamic therapy of cancer: an update. A cancer journal for physicians. 61(4):250-281

21) Agundez, J. A. G. 2004. Cytochrome P450 Gene Polymorphism and Cancer. Curr Metab de drogas. 5(3): 211-24

22) Ahamad, MN, Saleemullah, M., Shah, HU, Khalil, IA & Saljoqi, AUR 2007. Determination of beta-carotene content in fresh vegetables by high performance liquid chromatography. Sarhad J Agric. 23(3):767-770

23) Ahmad, R., Rasheed, Z. and Ali, R. 2009. Hydroxyl radical damaged thymidine 5-monophosphate presents unique apitopes for cancer antibodies. The open journal of cancer immunology. 2(1): 10-17

24) Ahmed, S., Wang, N., Lalonde, M., Goldberg, VM & Haggi, TM 2004. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1-induced matrix expression beta - Metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol de Exp Ther. 308(2):767-73

25) Ahn, H.J., Kim, K.I., Hoan, N.N., Kim, CH, Moon, E., Choi, KS, Yang, S.S. and Lee, J. 2014. Targeting of cancer cells with reactive oxygen and nitrogen species induced by atmospheric pressure generates air plasma. Plus one. 9(1): e86173, 12 pages, doi: 10. 1371/ Journal. cornbread 0086173

26) Ahn, H., Nam, J. W., Seo, E. K. and Mar, W. 2008. Induction of NAD(P)H:quinine reductase by rutaecarpin isolated from Evodia rutaecarpa fruits in the mouse liver Hepa 1c1c7 cell line. Plant Med. 74(11):1387–90

27) Ahn, K. S., Sethi, G., Krishnan, K. & Aggarwal, B. B. 2007. Gamma-tocotrienol inhibits the nuclear factor kappaB signaling pathway by inhibiting the receptor-interacting protein and TAK1, leading to suppression of antiapoptotic action. gene products and enhancement of apoptosis. JBiolChem. 282(1):809-20

28) Ahsan H., Ali, A. and Ali, R. 2003. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 131(3):398-404

29) Akada, H., Akada, S., Gajra, A., Bair, A., Graziano, S., Hutchison, R. E. and Mohi, G. 2012. Efficacy of vorinostat in a murine model of polycythaemia vera. Blut. 119(16): 3779–3789

30) Akama, T., Shida, Y., Sugaya, T., Ishida, H., Gomi, K., and Kasai, M. 1996. New 5-aminoflavone derivatives as specific antitumor agents in breast cancer. J MedChem. 39(18):3461-9

31) Ala-aho, R. and Kahari, VM 2005. Collagenase in cancer. Install biochemistry. 87(3-4): 273-86

32) Alaejos., M. S., Romero, F. J. D. and Romero, CD Selenium and cancer: some nutritional aspects. Nutrition. 16(5):376-383

33) Alaoui-Jamali, M.A., Bismar, T.A., Gupta, A., Szarek, WA, Su, J., Song, W., Xu, Y., Yu, B., Liu, G., Vlahakis, J.Z., Roman, G., Jiao, J., and Schipper, H. M. 2009. A new experimental therapy directed against heme oxygenase-1 for hormone-resistant prostate cancer. cancer res 69(20): 8017-24

34) Albert, B. and Hahn, H. 2014. Interplay of vitamin D and hedgehog signaling pathways in basal cell carcinoma. Adv Exp Med Biol. 810: 329-41, doi:

35) Alcaraz, M.J., Fernandez, P. and Guillén, M.I. 2003. Anti-inflammatory effects of the heme oxygenase-1 signaling pathway. Curr Pharm Des. 9(30):2541-51

36) Alda, M. L., Gogoasa, I., Alda, S., Moigradean, D., Bordean, D. M., Maria, R., Cristea, T. and Gergen, I. 2014. Monitoring of lycopene content in some fruits and vegetables . Journal of Horticulture, Forestry and Biotechnology. 18(4):33-36

37) Aldea, M.D., Petrushev, B., Soritau, O., Tomuleasa, C.I., Berindan-Neagoe, I., Philip, A.G., Chereches, G., Cenariu, M., Craciun, L., Tatamir, C. . , Florian, I., Crivii, C.B. and Kacso, G. 2014. Metformin plus sorafenib acts strongly on glioblastoma stem cells resistant to temozolomide. JBUON. 19(2):502-511

38) Aleksunes, L. M. and Manautou, J. E. 2007. Novel role of Nrf2 in protection against liver and gastrointestinal diseases. ToxicolPatol. 35(4): 459-473

39) Alfonso, S.H., Fritschi, L., de Klerk, H.N., Ambrosini, G., Beilby, J., Olsen, N., and Musk, W.A. 2005. Plasma retinol, carotene and vitamin E concentrations and lung function in a crocidolite-exposed cohort from Wittenoom, Western Australia: a cohort study. Nutrition Magazine. 4:16, doi: 10.1186/1475-2891-4-16, 8 pages

40) Al-Ghnaniem R, Peters J, Foresti R, Heaton N, and Pufulete M 2007. Methylation of the estrogen receptor alpha and mutL 1 homologue in normal colonic mucosa: Association with folate and vitamin B -12 status in subjects with and no colorectal neoplasia. Bin J Clin Nutr. 86(4): 1064-72

41) Ali, S. and Coombes, R.C. 2000. Estrogen receptor alpha in human breast cancer: occurrence and significance. J Biol Mammary Gland Neoplasm. 5(3): 271-81

42) Ali, Z. A. 2009. The inhibitory effect of some benzoic acid derivatives on the catalase activity of human erythrocytes. Ibn Al-Haitham Journal for Pure and Appl. Science. 22(3):140-147

43) Aljada, A., Ghanim, H., Mohanty, P., Hofmeyer, D., Tripathy, D. y Dondona, P. 2001 Cells and plasma matrix metalloproteinasa 2 and 9 (MMP-2 and MMP-9). J Clin Endocrinol Metab. 86(12):5988-91

44) Al-Katib, MA, Sun, Y, Goustin, SA, Azmi, SA, Chen, B, Aboukameel, A, and Mohammad, MR 2009. Bcl-2 TW-37 SMI is active in a spectrum of B-tumors cells regardless of their state of proliferation and differentiation. Journal of Hematology and Oncology. 2:8, doi: 10.1186/1756-8722-8, 13 pages

45) Allen LF, Lenehan PF, Eiseman IA, Elliott WL and Fry DW 2002. Potential benefits of the irreversible pan-erbB inhibitor canertinib (CI-1033) in the treatment of breast cancer. Semin Oncol. 29(3): 11-21

46) Allfrey, V.G., Boffa, L.C. and Vidali, G. 1977. Selective inhibition of protein synthesis in colon cancer cells with sodium cyanate. Cancer. 40(5 supplement): 2692-8

47) Almeida, M., Iyer, S., Martin-Millan, M., Bartell, S.M., Han, L., Ambrogoni, E., Onal, M., Xiong, J., Weinstein, R.S., Jilka, R.L. , O'Brien, CA and Manolagas, S.C. 2015. Estrogen receptor α signaling in osteoblast progenitors stimulates corticol bone formation. The Journal of Clinical Investigation. 123(1):394-404

48) Alrawaiq, N. S. and Abdullah, A. 2014. A review of the flavonoid quercetin: metabolism, bioactivity, and antioxidant properties. International journal of pharmaceutical technology research. 6(3): 933-941

49) Al-Sherbini, EM, El Noury, AH, El Rouby, MN, and Tarek, I. 2009. Vitamin E (α-tocopherol) potentiates the PDT effect of hematoporphyrin derivatives in breast cancer cells. cervix. Medical laser application. 24(1):65-73

50) Altomare, D. and Testa, J.R. 2005. Disorders of AKT signaling in human cancer. oncogene 24(50): 7455-7464

51) Aman, R., Carle, R., Conrad, J., Beifuss, U., & Schieber, A. 2005. Isolation of carotenoids from plant materials and dietary supplements by high-speed countercurrent chromatography. chromatography J.A. 1074(1-12): 99-105

52) Ambati, R.S., Lopes, CE, Kosugi, K., Mony, U., Zehir, A., Shah, K.S., Taldone, T., Moreira, L.A., Meyers, A.P., Chiosis, G., and Moore, SAM 2014. Preclinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing's sarcoma. Molecular Oncology. 8(2):323-336

53) Ambolet camoite, A., Bui, L. C., Pierre, S., Chevallier, A., Marchand, A., Coumoul, X., Garlatti, M., Andreau, K., Barouki, R. and Aggerbeck, M. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin antagonizes the p53 response to a genotoxic agent by increasing the expression of the metastatic marker agr2 in the hepatocellular carcinoma cell, such as HepG2. Toxicol Sci. 115(2): 501-512

54) Ames, B. N. 2001. DNA damage from micronutrient deficiencies is probably one of the main causes of cancer. mutation research. 475(1-2): 7-20

55) Ames, B. N., Shigenaga, M. K., and Gold, L: S. 1993. DNA damage, inducible DCNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. environmental health perspective. 101 (Supplement 5): 35-44

56) Ameyar, M., Wisniewska, M. und Weitzman, J. B. 2003. A role for AP-1 in apoptosis: the case for and contra. Bioquímica. 85(8): 747-52

57) Amin, P.J. and Shankar, B.S. 2015. Sulforaphane induces ROS-mediated induction of NKG2D ligands in human cancer cell lines and increases susceptibility to NK cell-mediated lysis. Life sciences. 126: 19-27, doi: 10.1016/j.lfs. 2015.01.026

58) Amin, R.M.R.A., Wang, D., Zhang, H., Peng, S., Shin, C.J.H., Brandes, C.J., Tighiouart, M., Khuri, R.F., Chen, G.Z. and Shin, M.D. (1999). 2010. Enhanced anti- Tumor activity by the combination of the natural products (-)-apigallocatechin-3-gallate and luteolin. The Journal of Biological Chemistry. 285(45): 34557–3

59) Amini, A., Masoumi-Moghaddam, S., Ehteda, A., & Morris, D.L. 2014. Bromelain and N-acetylcysteine ​​inhibit gastrointestinal cancer cell proliferation and survival in vitro: importance of combination therapy. Journal of Experimental Research and Cancer Clinic. 33:92, doi:10.1186/s13046-014-0092-7

60) Amoroso, F., S. Falzoni, E. Adinolfi, D. Ferrai and F. Virgilio, 2012. The P2X7 receptor is a key modulator of aerobic glycolysis. cell death Dis. 3(8):e370, doi:10.1038/cddis.2012.105, 18 pages

61) Amoroso, F., Falzoni, S., Adinolfi, E., Ferrari, D., & Virgilio, Di, F. 2012. The P2X7 receptor is a key modulator of aerobic glycolysis. cell death and disease. 3: e370, doi: 10.1038/cddis.2012.105

62) An, B. S., Tavera-Mendoza, L. E., Dimitrov, V., Wang, X., Calderon, M. R., Wang, H. J. y White, J. H. 2010. Stimulation of Sirt1-regulated Foxo protein function by the ligand-bound vitamin D Rezeptor. Mol Cell Biol. 30(20): 4890-900

63) An, J., Tzagarakis-Foster, C., Scharschmidt, TC, Lomri, N., and Leitman, D.C. 2001. Selective transcriptional activity of estrogen receptor β and recruitment of coregulators by phytoestrogens. JBC (Journal of Biological Chemistry). 276(21):17808-17814

64) Anand, P., Sundaram, C., Jhurani, S., Kunnumakkara, AB & Aggarwal, BB 2008. Curcumin and cancer: a 'disease of aging' with an 'old' solution. cancer letters 267(1): 133-164

65) Anastas, N.J. and Moon, T.R. 2013. Wnt signaling pathways as therapeutic targets in cancer. Nature informs about cancer. 13:11-26, doi.1038/nrc3419

66) Andersson, S. C., Rumpunen, K., Johansson, E. and Olsson, M. E. 2011. Carotenoid content and composition in rose hips (Rosa spp.) during ripening, determination of suitable ripening markers and implications for food products that promote health. Food Chemistry. 128(3): 689-696

67) Andreani, A., M. Granaiola, A. Locatelli, R. Morigi, M. Rambaldi, L. Varoli, N. Calonghi, C. Cappadone, G. Farruggia, C. Stefanelli . ., Masotti , L. , Nguyen , L.T. , Hamel , E. and Shoemaker , H.R. . 2012. Substituted 3-(5-imidazol[2,1-b]thiazolylmethylene)-2-indolinones and analogues. Synthesis, cytotoxic activity and mechanism of action investigation. J MedChem. 55(5): 2078–2088

68) Andreeva, O.A., Ivashev, M.N., Ozimina, II and Maslikova, G.V. 1998. Diosmetin glycosides from snow peas: isolation and study of biological activity. Journal of Pharmaceutical Chemistry. 32(11): 595-597

69) Androutsopoulos, V. P., Papakyriakou, A., Vourloumis, D. & Spandidos, DA 2011. Comparative profile of CYP1A1 and CYP1B1 substrate and inhibitor of dietary flavonoids. Bioorg Med Chem. 19(9):2842-9

70) Androutsopoulos VP, Tsatsakis AM, and Spandidos DA 2009. Cytochrome p450 CYP1A1: broader roles in cancer progression and prevention. BMC cancer. 9: 187-203, doi: 10.1186/1471-2407-9-187

71) Anedda, A., Rial, E. and Gonzales-Barroso, M.M. 2008. Metformin induces oxidative stress in white adipocytes and increases levels of uncoupling protein-2. Endocrinology Journal. 199(1):33-40

72) Anetor JI, Ajose F, Anetor GO, Iyanda AA, Babalola OO and Adeniyi FA 2008. High cadmium/zinc ratio in cigarette smokers: potential implications as a biomarker of prostate cancer risk. Nigerian Journal of Physiological Sciences. 23(1-2):41-49

73) Anglesio, MS, George, J, Kulbe, H, Friedlander, M, Rischin, D, Lemech, C, Power, J, Coward, J, Cowin, PA, House, CM, Chakravarty, P., Gorringe, K. L. , Campbell, I.G., Australian Ovarian Cancer Study Group, Okamoto, A., Birrer, M.J., Huntsman, D.G., de Fazio, A., Kalloger, S.E., Balkwill, F., Gilks, C.B. et al Bowtell , D. D. 2011 IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Chronic Ovarian Cancer. Cancer Clinic Res. 17(8): 2538-48

74) Anita, S., Modiano, M., Lee, J.J., Peng, Y., Xu, M., Vallar, H., Dalton, W., and Lippman, S. 2003. Accumulation of renitamides in breast tissue in short randomized trials -Time -Fenretinide study. Clinical cancer research. 9(7): 2400-2405

75) Prophet, B., Lachambre, M., Bousquet-Gagnon, N., Page, M., Gingras, D. & Beliveau, R. 2002. The polyphenol (-)-epigallocatechin-3-gallate from green tea inhibits MMP-2 Secretion and Migration Driven by MT1-MMP in Glioblastoma Cells. Biochemical and Biophysical Act (BBA)-Molecular Cell Research. 1542(1-3): 209-2

76) Ansari, N.A. and Rasheed, Z. 2010. Nonenzymatic glycation of proteins: from diabetes to cancer. Biomedical Chem. 56(2): 168-78

77) Antalis, C.J., Stevens, L.J., Campbell, M., Pazdro, R., Ericson, K., and Burgess, J.R. 2006. Omega-3 fatty acid status in attention deficit/hyperactivity disorder. prostaglandins leukotrienes and essential fatty acids. 75(4-5): 299-308.

78) Anto, R. J., Mukhopadhyay, A., Denning, K. and Aggarwal, B. B. 2002. Curcumin (diferuloylmethane) induces apoptosis through caspase-8 activation, BID cleavage and cytochrome c release: its repression by ectopic expression of Bcl-2 and Bcl-xl. carcinogenesis. 23(1): 143-150

79) Antonsson, A. and Persson, L.J. 2009. Induction of apoptosis by staurosporine involves inhibition of the expression of key cell cycle proteins at the G2/M checkpoint accompanied by changes in Erk and Akt kinase activities. Cancer research. 29(8): 2893-2898

80) Antonsson, B., Montessuit, S., Sanchez, B. and Martinou, J. 2001. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. JBiolChem. 276(15):11615-23

81) Antoon WI, Bratton RM, Guillot ML, Wadsworth S, Salvo AV, and Burow EM 2012. Inhibition of p38 MAPK alters SRC coactivation and estrogen receptor phosphorylation. Cancer Biology and Therapy. 13(11): 1026-1033

82) Antunes-Ricardo , M. , Moreno-Garcia , B.E. , Gutierrez-Uribe , J.A. , Araiz-Hernandez , D. , Alvarez , M.M. and Serna-Saldivar, S.O. of Opuntia ficus – evident Pads an. Pflanzliche Food product Hum Nutr. 69(4): 331-6

83) Anwar-Mohamed, A., Elbekai, R. H., and El-Kadi, A. O. 2008. MG-132 inhibits TCDD-mediated Cyp1a1 induction at catalytic activity but not mRNA at the protein level in Hepa 1c1c7 cells. 182(1-3): 121-6

84) Aparna, R., Subhashini, J., Roy, R. K., Reddy, S. G., Robinson, M., Uskokovic, R. M., Reddy, V. G., and Reddanna, P. 2008. Selective inhibition of cyclooxygenase-2 (COX-2 ) by 1α,25-dihydroxy-16-ene-23-yne vitamin D3, a less calcemic vitamin D analogue. Cellular Biochemistry Journal. 104:1832-1842, doi:10.1002/jcb.21749

85) Apte RN, Dotan S, Elkabets M, White MR, Reich E, Carmi Y, Song X, Dvozkin T, Krelin Y, and Voronov E 2006 The role of IL-1 in tumorigenesis, tumor invasiveness, metastasis, and tumor-host interactions. Cancer metastasis Rev. 25(3): 387-408

86) Ara, T. and Declerck, YA 2010. Interleukin-6 in bone metastases and cancer progression. Eur J Cancer. 46(7):1223-31

87) Arab, L. and Steck, S. 2007. Lycopene and cardiovascular disease. Bin J Clin Nutr. 71(6): 1691-1695

88) Arab, L., Steck-Scott, S. and Fleishauer, A. T. 2002. Lycopene and the lung. Ex. Biol. Medicine. 227(10): 894-9

89) Arafa, H. F. 2009. Possible contribution of beta-glucosidase and caspases to glufosfamide cytotoxicity in colon cancer cells. European Journal of Pharmacology. 616(1-3): 58-63

90) Arai K, Lee S, van Leyen K, Kurose H and Lo EH 2004. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. Neurochemistry Journal. 89(1): 232-239

91) Arany, I., Clark, J. S., Reed, D., Szabo, I., Ember, I. und Juncos, L. A. 2013. The role of p66Shc in dichloroacetic acid and taxol-dependent renal toxicity. Anti-Krebs-Res. 33(8): 3119-22

92) Aratanechemuge, Y., Hibasami, K., Sanpin, K., Katsuzaki, H., Imai, K., Komiya, T. 2004. Induction of apoptosis by lupeol isolated from mokumen (Gossampinus malabarica L. Merr) in humans Promyelical leukemia HL-60-Zellen. Well. Reps. 11, 289-2


94) Arese, P., Gallo, V., Pantaleo, A. and Turrini, F. 2012. Life and death of glucose-6-phosphate dehydrogenase (G6PD) deficient erythrocytes: role of redox stress and volume 3 modifications . Transfus Med Hemadre. 39(5):328-334

95) Arivalagan, M., Gangopadhyay, K. K. and Kumar, G. 2013. Determination of steroid saponin and fixed oil content in fenugreek (Trigonella foenum-graecum) genotypes. Indian J. Pharm. Sci. 75(1): 110-113

96) Arkhipenko, Y.V. and Sazontova, T.G. (nineteen ninety five). Mechanisms of the cardioprotective effect of a diet enriched with w-3 polyunsaturated fatty acids. pathophysiology 2(3): 131-140.

97) Armstrong, GA und Hearst, J. E. 1996. Carotenoid 2: Genetics and molecular biology of carotenoid pigment biosynthesis. PHASEB J. 10(2)=228-37

98) Arnold, C., Schwarzenbolz, U., & Böhm, V. 2014. Carotenoids and chlorophylls in xanthophyll-rich processed foods. LWT-FoodSciandTech.57: 442-445,

99) RA-specific coactivator ARA70, a ligand-dependent RA-associated protein (ARA70) that acts as an activator to increase AR transcriptional activity in the presence of 10(−10) M dihydrotestosterone or 10(−9) M testosterone for the 10 times (Yeh and Chang 1996).

100) Artaza, J.N. and Norris, K.C. 2009. Vitamin D reduces the expression of collagen and important profibrotic factors by inducing an antifibrotic phenotype in multipotent mesenchymal cells. Endocrinology Journal. 200(2):207-221

101) Artinyan, A., Essani, R., Lake, J., Kaiser, AM, Vukasin, P., Danenberg, P., Danenberg, K., Haile, R., and Beart, RW Jr. 2005. Molecular Predictors of lymph node metastases in colon cancer: increased risk with reduced expression of thymidylate synthase. J Gastrointestinal. Surgeon. 9(9):1216-21

102) Asghar, U., Witkiewicz, K. A., Turner, C. N. und Knudsen, S. E. 2015. The history and future of targeting cyclin-dependent kinase in cancer therapy. Nature Reviews Drug Discovery. 14: 130-146, Doi: 10.1038/nrd4504

103) Asiri, AY 2010. Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signaling expression in rat heart tissues. Oxid Med Cell Longev. 3(5): 308-316

104) Aster, J.C. and Blacklow, S.C. 2012. Pointing to the Notch Path: Twists and Turns on the Road to Rational Therapeutics. J Clin Oncol. 30(19): 2418-20

105) Astle, M.V., Hanna, KM., Ng, P.Y., Lee, R.S., George, A.J., Hsu, AK, Haupt, Y., Hannan, RD, and Pearson, R.B. 2012. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for mTOR targeting during malignancy. Oncogene 31(15): 1949-62

106) Athar, H.U.R., Khan, A. and Ashraf, M. 2009. Induction of salt tolerance in wheat by openly applied ascorbic acid by different modes. Plant Nutrition Magazine. 32(11):1799-1817

107) Atkinson, J., Epand, R.F. and Epand, R.M. 2008. Review of tocopherols and tocotrienols in membranes: a critical review. Free Radical Biol Med. 44(5): 739-64

108) Atta-Aly, M.A. (1999). 1999. Effect of nickel addition on yield and quality of parsley leaves. Scientia Horticulture. 82(1-2): 9-2

109) Attard, G., Reid, A.H.M., A'Hern, R., Parker, C., Oomnen, N.B., Folkerd, E., Messiou, C., Molife, L.R., Maier, G., Thompson, E. , Olmos, D., Sinha, R., Lee, G., Dowsett, M., Kaye, S.B., Dearnley, D., Kheoh, T., Molina, A., and de Bono, J.S. 2009. Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. Journal of Clinical Oncology. 27(23): 3742-3748

110) Atwood, S. X., Chang, A. L. S. und Oro, A. E. 2012. Inhibition of the Hedgehog pathway and the race against tumor evolution. J Cell Biol. 199(2) 193-197

111) Auborn, J.K., Fan, S., Rosen, ME, Goodwin, L., Chandraskaren, A., Williams, ED, Chen, D., and Carter, HT 2003. Indole-3-carbinol is a negative estrogen regulator . The Journal of Nutrition. 133 (7 amendments): 2470S-2475S

112) Auclair, M., Afonso, P., Capel, E., Caron-Debarle, M., and Capeau, J. 2014. Ritonavir-enhanced effect of darunavir, atazanavir, and lopinavir on cultured human endothelial cells: positive effect of pravastatin . Antivir Ther. 19(8):773-82

113) Audo, I., Darjatmoko, SR, Schlamp, CL, Lokken, JM, Lindstrom, MJ, Albert, DM, & Nickells, RW 2003. Vitamin D analogues increase p53, p21, and apoptosis in a retinoblastoma xengraft model human . Reverse Ophthalmol Vis Sci. 44(10): 4192-9

114) Auger, C., Mullen, W., Hara, Y. und Crozier, A. 2008. Bioavailability of polyphenon E flavan-3-ols in humans with ileostomy. J Nutr. 138(8): 1535S-1542S

115) Avisetti, R.D., Babu, S.K. and Kalivendi, V.S. 2014. Activation of the p38/JNK signaling pathway is responsible for Embelin-induced apoptosis in lung cancer cells: role of reactive oxygen species transition. Plus one. 9:1 ​​Doi: 10.1371/journal.pone.0087050, 10 pages.

116) Ayoub, N. M., Akl, M. R., and Sylvester, P. W. 2013. Combination treatment with β-tocotrienol and Met inhibitor suppresses breast cancer cell proliferation, epithelial to mesenchymal transition, and migration. cell proliferator. 46(5):538-553

117) Azevedo, C. H. and Rodriguez-Amaya, D. B. 2005. Carotenoid composition of kale influenced by maturity, season, and minimal processing. J Sci Food Agric. 85(4):591-597

118) Azevedo-Meleiro, CH and Rodriguez-Amaya, DP 2007. Quantitative and qualitative differences in the composition of carotenoids between Cucurbita moschata, Cucurbita maxima and Cucurbita pepo. Journal of agricultural and food chemistry. 55(10): 4027-4033

119) Azmi, A.S., Bhat, SH, Hanif, S., & Hadi, SM 2006. Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes, leading to oxidative DNA breakage: a putative mechanism for anticancer properties . letters FEBS. 580(2): 533-538

120) Azorín-Ortuño, M., Yáñez-Gascón, M.J., Pallares, F.J., Rivera, J., González-Sarrias, A., Larrosa, M., Vallejo, F., García-Conesa, M.T., Tomas-Barberan , F. and Espin, J.C. 2012. A grape extract rich in dietary resveratrol prevents the development of atherosclerotic lesions in the aorta of pigs fed an atherogenic diet. Journal of agricultural and food chemistry. 60: 5609-5620,

121) Baardseth, P. and Slinde, E. 1983. Peroxidase, catalase and palmitoyl-CoA hydrolase activities in blanched carrot tubes after storage at -20 °C. 34(11):1257-1262

122) Bachawal, S.V., Wali, V.B. and Sylvester, P.W. 2010. Combination treatment with β-tocotrienol and erlotinib/gefitinib suppresses Stat and Akt signaling in murine breast tumor cells. Cancer research. 30(2): 429-437

123) Badal, S. and Delgoda, R. 2013. CYP1B1: Friend or foe?. A critical review. Biochemistry AO. 1(1): 8-15

124) Bae, E., Han, M.J., Kim, E. and Kim, D. 2003. Transformation of ginseng saponins to Rh2 ginsenoside by human intestinal bacteria and acids and biological activities of their transformants. Archives of Pharmaceutical Research. 27(1): 61-67

125) Bae, K.M., Su, Z., Frye, C., McClellan, S., Allan, R.W., Andrejewski, J.T., Kelley, V., Jorgensen, M., Steindler, D.A., Vieweg, J., and Siemann, D. W. 2010. Expression of pluripotent stem cell reprogramming factors by prostate tumor-initiating cells. J Urol. 183(5): 2045-53

126) Bagnardi, V., Blangiardo, M., La Vechia, C. and Corrao, G. 2001. Alcohol consumption and cancer risk. A meta-analysis. Alcohol Research and Health. 25(4): 263-270

127) Bahadoor, A., Castro, A. C., Chan, L. K., Keaney, G. F., Nevalainen, M., Nevalainen, V., Peluso, S. y Tibbitts, T. T. 2011. Triazoles as inhibitors of fat acid synthase. Patentanmeldungsnummer: US201102744654

128) Bahadoor, A., Castro, A. C., Chan, L. K., Keaney, G. F., Nevalainen, M., Nevalainen, V., Peluso, S., Synder, D. A. y Tibbitts, T. T. 2011. Tetrazolones as inhibitors of fat acid synthase . Patentanmeldung Nr.: US20110274655

129) Bahnassy, ​​A. A., Zekri, A.N., El-Houssini, S., El-Shehaby, A.MR., Mahmoud, MR., Abdallah, S., and El-Serafi, M. 2004. Cyclin A and cyclin D1 as markers significant prognoses in patients with colorectal cancer. BMC Gastroenterol. 4:22, doi: 10.1186/1471-230X-4-22

130) Bai, F., Qi, N., Wu, C., & Nie, Y. 2013. A new insight into the action of heme oxygenase-1 in malignancies. Research Journal in Gastroenterology and Hepatology. 2(1): 353-358

131) Bai, H., Jin, H., Yang, F., Zhu, H., and Cai, J. 2014. Reactive oxygen species associated with apigenin-induced MCF-7 cell apoptosis. To Scan 36(6): 622-31

132) Bai L, Weng J, Chiu C, Wu C, Yeh S, Sargeant AM, Lin P, and Liao Y 2013. OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia via reactive oxygen species. mediated apoptosis. Biochemical Pharmacology. 86(10): 1430-1440

133) Bai L, Weng J, Chiu C, Wu C, Yeh S, Sargeant AM, Lin P, and Liao Y 2013. OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia via reactive oxygen species. mediated apoptosis. Biochemical Pharmacology. 86(10): 1430-1440

134) Bai, S., Lee, S., Na, H., Ha, K., Han, J., Lee, H., Kwon, Y., Chung, C., and Kim, Y. 2005. Β- Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by repressing redox-based NF-kβ activation. Experimental and Molecular Medicine. 37(4):323-334

135) Bai X, Cerimele F, Ushio-Fukai M, Wagas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K., Murad, E., Dubiel, W., Soff, G., and Arbiser, J. L. 2003. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Journal of Biological Chemistry. 278(37): 35501-7

136) Bai, Y., Lu, H., Wu, C., Liang, Y., Wang, S., Lin, C., Chen, B., & Xia, P. 2014. Resveratrol inhibits epithelial transition- mesenchymal and renal fibrosis by antagonizing hedgehog signaling. Biochem Pharmacol. 92(3): 484-93

137) Bailer, J., Aichinger, T., Hackl, G., de Heuber, K. & Dachler, M. 2001. Essential oil content and composition in commercially available types of dill compared to caraway. Industrial plants and products. 14(3): 229-239

138) Bajpai, P. and Bajpai, P.K. 1993. Production of eicosapentaenoic acid (EPA) from microorganisms: a review. Journal of Applied Biotechnology. 30(2): 161-183.

139) Baker, D. G., Krakauer, K. A., Tate, G., Laposata, M. and Zurier, R. B. 2005. Suppression of human synovial cell proliferation by dihomolinolenic acid. Arthritis Rheumatism. 32(10): 1273–1281.

140) Balakrishnan, K., Peluso, M., Fu, M., Rosin, N.Y., Burger, J.A., Wierda, W.G., Keating, M.J., Faia, K., O'Brien, S., Kutok, J.L. and Gandhi, V. 2015. The phosphoinositide-3-kinase (PI3K) delta and gamma inhibitor IPI-145 (duvelisib) overcomes PI3K/AKT/S6 signaling and promotes apoptosis in CLL. Leukemia. 29(9): 1811-22

141) Balendiran, G.K., Dabur, R. & Fraser, D. 2004. The role of glutathione in cancer. cellular biochemistry function 22(6):343-52

142) Ballin, N.Z. and Sorensen, A.T. 2014. Coumarin content in cinnamon-containing products on the Danish market. Food inspection. 38: 198-203,

143) Ballin, N.Z. and Sorensen, A.T. 2014. Coumarin content in foods containing cinnamon on the Danish market. Food inspection. 38: 198-203,

144) Bandi, N. and Kompella, U.B. 2001. Budesonide reduces secretion and expression of vascular endothelial growth factor in airway (Calu-1) and alveolar (A549) epithelial cells. Eur J Pharmacol. 425(2):109-16

145) Banerjee, A., Baksi, K. & Banerjee, D. 2008. Tunicamycin inhibits VEGF-induced vascular sprouting in Matrigel. Cancer research. AACR Annuls Meeting - April 12-16, 2008, San Diego, CA., USA.

146) Banerjee, A., Lang, J.Y., Hung, MC, Sengupta, K., Banerjee, SK, Baksi, K. & Banerjee, DK 2011. In microvessels of nu/nu mice for the treatment of mammary tumors there is a protein displayed response required with tunicamycin. JBiolChem. 286(33): 29127-38

147) Banerjee, P., Basu, A., Wegiel, B., Otterbein, LE, Mizumura, K., Gasser, M., Waaga-Gasser, AM, Choi, AM, & Pal, S. 2012. Heme oxygenase- 1 promotes the survival of renal cancer cells by modulating apoptosis and autophagy regulatory molecules. The Journal of Biological Chemistry. 287(38): 32113-32123

148) Bang, H.O., Dyerberg, J., and Nielsen, A. 1971. Plasma lipid and lipoprotein patterns in Eskimos from the west coast of Greenland. Lancet. 1 (7710): 1143-1145.

149) Bang, Y., Kang, Y., Alsina, M., Wainberg, ZA, Chau, I., Zhu, J., Chan, W.Y., Patel, PH, Meng, RD, and Ajani, J.A. 2014. JAGUAR: A Phase II Randomized Trial of the Akt Inhibitor Ipatasertib (GDC-0068) Versus Placebo in Combination with mFOLFOX6 Chemotherapy in Patients (PT) with Locally Advanced or Metastatic HER2-Negative Gastric (G) or Gastroesophageal Junction (GEJ) . (ASCO Annual Meeting 2014. Session Type and Title: General Poster Session, Gastrointestinal (Non-Colorectal) Cancer. Abstract Number: TPS4147.) J Clin Oncol. 32:5s, 2014 (Supplement, Abstract TPS4147)

150) Bao, Y., Ng, K., Wolpin, BM, Michaud, DS, Giovannucci, E, & Fuchs, CS 2010. Predicted vitamin D status and risk of pancreatic cancer in two prospective cohort studies. British journal of cancer. 102(9): 1422-1427

151) Baranska, M., Schütze, W. and Schulz, H. 2006. Determination of lycopene and beta-carotene content in tomato fruits and related products: comparison of FT-Raman, ATR-IR and NIR spectroscopy. Anal Chem. 78(24):8456-61

152) Barbeau, M.L., Klemp, KF, Guyton, J.R. and Rogers, KA 1997. Dietary fish oil. Influence on the regression of lesions in the porcine model of atherosclerosis. Arteriosclerosis, thrombosis and vascular biology. 17(4): 688-694.

153) Barber, M.D., Ross, J.A., Voss, A.C., Tisdale, M.J. and Fearon, K.C.H. 1999. The effect of a fish oil-fortified oral dietary supplement on weight loss in patients with pancreatic cancer. British journal of cancer. 81(1): 80-86.

154) Barkhem, T., Carlsson, B., Nilsson, Y., Enmark, E., Gustafsson, J., & Nilsson, S. 1998. Differential response of estrogen receptor alpha and estrogen receptor beta to agonists/ partial estrogen antagonists. Mol Pharmacol. 54(1): 105-12

155) Barnhart, B. C., Alappat, E. C. und Peter, M. E. 2003. The CD95 type I/type II model. Seminar in Immunology. 15(3): 185-193

156) Barrera, G. 2012. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncology. 2012: 137289, doi: 10.S402/2012/137289

157) Bartke, A. 2005. Abstract: Role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology. 146(9): 3718-3723

158) Bartkiene, E., Juodeikiene, G. and Basinkiene, L. 2012. In vitro fermentative production of plant lignans from cereal products in relation to non-starch polysaccharide components. Getreide, Lebensmitteltechn. Biotechnology. 50(2): 237-245

159) Bartoli, GM, Palozza, P, Luberto, C, Franceschelli, P and Piccioni, E. 1995. Dietary fish oil inhibits Mg,NaK-ATPase of human erythrocytes. Communications on biochemical and biophysical research. 213(3):881-887.

160) Basak, S., Pookot, D., Noonan, E.J. and Dahiya, R. 2008. Genistein downregulates the androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol Cancer Ther. 7(10): 3195-202

161) Baselga, J. 2011. Targeting of the phosphoinositide-3 (PI3) kinase pathway in breast cancer. The oncologist. 16 (Supplement 1): 12-9

162) Bates, D., Cartlidge, N.E., French, J.M. et al. 1989. A double-blind controlled study of n-3 long-chain polyunsaturated fatty acids in the treatment of multiple sclerosis. Neurology, Neurosurgery and Psychiatry with Practical Neurology. 52(1): 18-22.

163) Bauchart-Thevret, C., Stoll, B. and Burrin, D. G. 2009. Intestinal metabolism of sulfur-containing amino acids. Reviews of nutritional research. 22(2): 175-187

164) Baud, V. and Karin, M. 2009. Is NF-kβ a good target for cancer therapy? hopes and traps Nat Rev Drug Discovery. 8(1): 33-40

165) Bavaresco, L., Fregoni, M., Trevisan, M., Mattivi, F., Vrhovsek, U. und Falchetti, R. 2002. Das Vorkommen des Stilbens Piceatannol in Garpes. Rebbe. 41(3): 133-136

166) Beauvaris, M.D., Burbach, J.B. and Rapraeger, CA 2004. The syndecan-1 ectodomain regulates αbβ3 integrin activity in human mammary carcinoma cells. The Journal of Cell Biology. 167(1): 171-181

167) Becerra, J. A. H., Flores, A. A. O., Valerio-Alfaro, G., Soto-Rodriguez, I., Rodriguez-Estrada, M. T. and Garcia, H. S. 2014. Cholesterol oxidation and astaxanthin degradation in shrimp during sun-drying and storage. Lebensmittelchemie. 145: 832-839, doi: 10.1016/j.foodchem.2013.08.098

168) Bedard, K. and Krause, K. 2007. The Nox family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiological summaries. 87(1): 245-313

169) Beer, TM and Myrthue, A. 2004. Calcitriol in the treatment of cancer: from the laboratory to the clinic. Mol Cancer Ther March. 3(3):373-381

170) Begley, M., Gahan, CGM and Hill, C. 2005. The interaction between bacteria and bile. Reviews on microbiology. 29(4):625-651

171) Beier, R. C. 1990. Natural pesticides and bioactive components in foods. Rev Environ Contam Toxicol. 113:47-137

172) Belalcazar, A.D., Ball, J.G., Frost, LM, Valentovic, MA, & Wilkinson, J. 2013. Transsulfurization is an important source of sulfur for glutathione production in human mammary epithelial cells. ISRN Biochemistry. Article ID: 637897, 7 pages. DOI: 10.1155/2013/637897

173) Belguise, K., Guo, S. and Sonenshein, G. E. 2007. Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression and reverses the invasive phenotype of cancer cells of breast. res of cancer 67(12): 5763-70

(174) Bell , H.S. , Dufes , C. , O'Prey , J. , Crighton , D. , Bergamaschi , D. , Lu , X. , Schatzlein , A.G. , Vousden , K.H. and Ryan , KM . 2007. A p53- the derived apoptotic peptide derepresses p73 to induce tumor regression in vivo. J Clin Invest. 117(4): 1008–1018

(175) Bell , M.C. , Crowley-Nowick , P. , Bradlow , H.L. , Sapkovic , D.W. , Schimdt-Grimminger , D. , Howell , P. , Mayeaux , E.J. , Tucker , A. , Turbat-Herrera , E.A. and Mathis , J.M. 2000. Placebo-controlled study of indole-3-carbinol in the treatment of CIN. Gynecologic oncology. 78(2):123-9

176) Bellosta, S., Baetta, R., Canavesi, M., Comporato, C., Granata, A., Monetti, M., Cairoli, F., Puglisi, L. and Corsini, A. 2007. The raloxifene inhibits Expression and activity of matrix metalloproteinases in macrophages and smooth muscle cells. pharmaceutical. Res. 56(2): 160-7

177) Belluzzi, A. 2001. N-3 and n-6 ​​Fatty Acids in the Treatment of Autoimmune Diseases. European journal of lipid science and technology. 103(6): 399-407.

178) Bendrik, C. and Dabrosin, C. 2009. Estradiol increases IL-8 secretion from normal human breast tissue and breast cancer in vivo. J Immunol. 128(1):371-8

179) Bennett , B. L. , Sasaki , D. T. , Murray , B. W. , O'Leary , E. C. , Sakata , S. T. , Xu , W. , Leisten , J. C. , Motiwala , A. , Pierce , S. , Satoh , Y. , Bhagwat , 2005 . 179) 179. SS, Manning, AM and Anderson, DW 2001. SP600125, an Anthrapyrazolone Inhibitor of Jun-N-terminal Kinase. Proc Natl Acad Sci. HIRSCH. 98(24): 13681–6

180) Benson, Al. B. 1993. Oltipraz: a clinical and laboratory review. J Cell Biochem. Zuschlag 53 (Erganzung 17F): 278-291

181) Benthsath, A., Rusznyak, S.T., Szent-Györgyi, A. 1937. Vitamin P. Nature. 139 (46): 326-327

182) Berger, M., Küchler, T., Maaßen, A., Busch-Stockfisch, M. and Steinhart, H. 2008. Correlations of carotene with sensory properties in carrots under different storage conditions. Food Chemistry. 106(1):235-240

183) Berger, S.P., Hünger, M., Yard, B.A., Schnuelle, P. and Der Woude, V.FJ. 2000. Dopamine induces heme oxygenase-1 expression by human endothelial cells in vitro. inner kidney 58(6):2314-9

184) Berman, D.M., Karhadkar, S.S., Maitra, A., Montes De Oca, R., Gerstenblith, M.R., Briggs, K., Parker, A.R., Shimada, Y., Eshleman, J.R., Watkins, D.N. and Beachy, PA 2003. Widespread requirement for hedgehog ligand stimulation in the growth of digestive tract tumors Nature. 425(6960):846-51

185) Berndt, SI, Carter, HB, Landis, PK, Hallfrisch, J, Rohrman, S, Metter, J, & Platz, EA 2005. Prediagnosis plasma vitamin C levels and subsequent risk of prostate cancer. Nutrition. 21(6):686-90

186) Berndtsson, M., Hagg, M., Panaretakis, T., Havelka, AM, Shoshan, MC, & Linder, S. 2007. Acute apoptosis by cisplatin requires the induction of reactive oxygen species, but is not associated with damage to the ligated DNA nucleus. Int J Cancer. 120(1): 175-80

187) Berneis, K., Bollag, W., Kofler, M. and Luthy, H. 1966. The enhancement of the after-effect of ionizing radiation by a cytotoxic methyhydrazine derivative. Eur J Cancer. 2(1):43-49

188) Bernstein, H., Bernstein, C., Payne, CM, Dvorakova, K. y Garewal, H. 2005. Bile acids as carcinogens in human gastrointestinal cancer. mutar res. 58(1): 47-65

189) Bertea, C., Schalk, M., Mau, C. J. D., Karp, F., Wildung, M. R. and Croteau, R. 2003. Molecular evaluation of a green mint verändert mutant in the expression of limonene hydroxylases targeting the essential oil monterpene biosynthesis . Phytochemistry. 64(7): 1203–1211

190) Bertoia, M., Albanes, D., Mayne, TS, Mannisto, S., Virtamo, J., & Wright, EM 2010. There is no association between fruits, vegetables, antioxidant nutrients, and the risk of renal cell carcinoma. Int J Cancer. 126(6): 1504-1512

191) Bertrand, F., Rochotte, J., Colacios, C., Montfort, A., Tilkin-Mariame, AF, Touriol, C., Rochaix, P., Lajoie-Mazenc, J., Andrieu-Abadie, N. 191., Levade, T., Benoist, H., and Sequi, B. 2015. Tumor necrosis factor α blockade enhances CD8 T-cell dependent immunity in experimental melanoma. cancer res 75(13):2619-2

192) Bhabak, K. P. and Mugesh, G. 2010. Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants. Acc.Chem.Res. 43(11):1408-1419

193) Bhagwat, S., Haytowitz, D., and Holden, J. 2008. USDA Database for Isoflavone Content of Selected Foods (Version 2.0ed). Beltsville, Maryland: United States Department of Agriculture. Consulted on March 10, 2015.

194) Bharate, B.S., Manda, S., Mupparapu, N., Battini, N., and Vishwakarma. 2012. Chemistry and biology of fescaplisine, a potent inhibitor of CDK-4 of marine origin. Mini-reviews in medicinal chemistry. 12(7): 650-664

195) Bhardwaj, A., Sethi, G., Vadhan-Raj, S., Bueso-Ramos, C., Takada, Y., Gaur, U., Nair, A.S., Shishodia, S., and Aggarwal, B.B. 2007. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance by downregulating STAT3 and nuclear factor kB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. 109(6): 2293-2302

196) Bhatnagar, D. and Durrington, P.N. 2003. Omega-3 fatty acids, their role in the prevention and management of risk factors and complications associated with atherosclerosis. International Journal of Clinical Practice. 57(4):305-314.

197) Bhatt PA, Bhende MP, Sin S, Roy D, Dittmer PD and Damania B 2015. Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-dependent lymphomas. Blood. 115(22): 4455-4463

198) Bhattacharyya, R.S., Krishnan, AV, Swami, S., & Feldman, D. 2006. Fulvestrant (ICI 182,780) downregulates androgen receptor expression and decreases the androgen response in LNCaP human prostate cancer cells. Cancer Ther. 5(6): 1539-49

199) Bhui, K., Tyagi, S., Srivastava, AK, Singh, M., Roy, P., Singh, R., & Shukla, Y. 2012. Bromelain inhibits nuclear factor kappa-B translocation and drives Human squamous cell carcinoma precedes A431 cells and A375 melanoma by G(2)/M arrest until apoptosis. carcinogenic mole 51(3): 231-43

200) Biaglow, J. E. and Durand, R. E. 1978. The enhanced radiation response of an in vitro tumor model by cyanide released from hydrolyzed tonsillar. Int J Radiant Biol Relat Stud Phys. Chem. Med. 33(4): 397-401

( 201 ) Biehler , E. , Alkerwi , A. , Hoffmann , L. , Krause , E. , Guillaume , M. , Lair , M. and Bohn , T. 2011 Recording: Assessment in Luxembourg. Journal of food composition and analysis. 25(1): 56-65

202) Bikle, D. D., Ng, D., Oda, Y., Hanley, K., Feingold, K., and Xie, Z. 2002. The vitamin D response element of the involucrin gene mediates its regulation by 1 , 25-dihydroxyvitamin D3. Journal of Investigative Dermatology. 119(5): 1109-1113

203) Billottet, C., Grandage, L.V., Gale, E.R., Quattropani, A., Rommel, C., Vanhaesebroeck, B., & Khwaja, A. 2006. A selective inhibitor of the p110 isoform of PI3 kinase inhibits AML - Cell proliferation and survival and enhances the cytotoxic effects of VP16. Oncogene 25(69): 6648-59

204) Bimakr, M., Rahman, R.A., Taip, F.S., Chuan, L.T., Ganjloo, A., Salleh, L. Md., Selamat, J. and Hamid, A. 2008. Supercritical carbon dioxide (SC-CO2). ) extraction of catechin, apicatechin, rutin and luteolin from leaves of mint (Mentha spicata L.). World Journal of Applied Science. 5(4): 410-4

205) Birt, D. F., Hendrich, S., & Wang, W. 2001. Dietary supplements in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Thermal 90(2-3): 157-77

206) Bishayee, A. 2009. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Previous Res. 2(5): 409-418

207) Black, S. H. und Rhodes, E. L. 2016. Potential benefits of omega-3 fatty acids in non-melanoma skin cancer. J.Clin. Medicine. 5:23, 10 seconds, doi:10.3390/jcm5020023

208) Blagden, S., Omlin, A., Josephs, D., Stavraka, C., Zivi, A., Pinato, D.J., Anthoney, A., Decorlova, S., Swales, K., Riisnaes, R. , L. Pope, K. Noguchi, R. Shiokawa, M. Inatani, J. Prince, K. Jones, C. Twelves, J. Spicer, and U. Banerji. 2014. First human study of CH5132799, a class I oral PI3K inhibitor, to investigate toxicity, pharmacokinetics, and pharmacodynamics in patients with metastatic cancer. Cancer Clinic Res. 20(23): 5908-17

209) Blake , JF , Xu , R , Bencsik , JR , Xiao , D , Kallan , NC , Schlachter , S , Mitchell , JS , Spencer , KL , Bank , AL , Wallace , EM , Gloor , SL , Martinson , M. , Woessner , R. D. , Vigers , G. P. , Brandhuber , B. J. , Liang , J. , Safina , B. S. , Li , J. , Zhang , B. , Chabot , C. , Do , S. , Lee , L. , . Oeh, J., Sampath, D., Lee, B. B., Lin, K., Liederer, B. M. und Skelton, N. J. 2012. Discovery and preclinical pharmacology of an ATP-selected competitive Akt inhibitor (GDC-0068) for the treatment of humans Tumor. J MedChem. 55(18):8110–27

210) Blanarova , V.O. , Jelinkova , I. , Szoor , A. , Skender , B. , Soucek , K. , Horvath , V. , Vaculova , A. , Andera , L. , Sova , P. , Szollosi , J . , Hofmanova, J., Vereb, G. and Kozubik, A. 2011. Cisplatin and a potent platinum (IV) complex-mediated enhancement of TRAIL-induced cancer cell destruction is associated with modulation of upstream events in the extrinsic apoptotic pathway. carcinogenesis. 32(1): 42-5

211) Bland, J.S. 1998. The pro-oxidant and antioxidant effects of vitamin C. Alternative Medicine Review. 3(3): 170-173

212) Block, G. 1991. Epidemiological evidence on vitamin C and cancer. American journal of clinical nutrition. 54 (6 supplements): 1310S-1314S

213) Block, G. 1991. Vitamin C and cancer prevention: epidemiological evidence. American journal of clinical nutrition. 53 (1 supplement): 2705-825

214) Blot, W.J., Li, J.Y., Taylor, P.R., Guo, W., Dawsey, S., Wang, G.Q., Yang, C.S., Zheng, S.F., Gail, M., and Li, G.Y. 1993. Nutritional intervention studies in Lixian, China: Supplementation with specific vitamin and mineral combinations, cancer incidence, and disease-specific mortality in the general population. J National Cancer Institute 85(18):1483-1492

215) Blunt , MD , Carter , MJ , Larrayoz , M , Smith , LD , Aguilar-Hernandez , M , Cox , KL , Tipton , T , Reynolds , M , Murphy , S , Lemon , E , . Dias , S. , Duncombe , A. , Strefford , J. C. , Johnson , P. W. , Forconi , F. , Stevenson , F. K. , Packham , G. , Cragg , M. S. and Steele , A. J. 2015. The PI3K/mTOR inhibitor PF-04691502 induces Apoptosis and inhibits microenvironmental signaling in CLL and the Eμ-TCL1 mouse model. Blood. 125(26): 4032-41

216) Bobe G, Weinstein JS, Albanes D, Hirvonen T, Ashby J, Taylor RP, Virtamo J, and Stolzenberg-Solomon ZR 2008. Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Epidemiology, biomarkers and cancer prevention. 17(3):553-62

217) Boddupalli, S., Mein, J.R., Lakkanna, S., and James, D.R. 2012. Induction of phase 2 antioxidant enzymes by sulforaphane from broccoli: prospects for maintaining the antioxidant activity of vitamins A, C, and E. Front Genet. 3:7, doi:10.3389/fgene.2012.00007.eCollection2012.

218) Bohlke, K., Spiegelman, D., Trichopoulou, A., Katsouyanni, K., and Trichopoulos. 1999. Vitamins A, C, and E and the risk of breast cancer: results of a case-control study in Greece. British journal of cancer. 79(1): 23-29

219) Bohn, T., Davidsson, L., Walczyk, T., & Hurrell, F. R. 2004. Phytic acid added to white wheat bread inhibits the apparent fractional absorption of magnesium in humans. American journal of clinical nutrition. 79(3): 418-423

220) Bokun, R., Bakotin, J., and Milasinovic, D.D. 1987. Semiquantitative cytochemical evaluation of glucose-6-phosphate dehydrogenase activity in benign diseases and breast cancer. Cytol Act. 31(3): 249-252

221) Boland, GM and Donnelly, DMX 1998. Isoflavonoids and related compounds. Natural product reviews. 15(3):241-260

222) Bolarinwa, F.I., Orfila, C. and Morgan, ARM 2014. Amygdalin content of commercially available seeds, grains and food products in the UK. Food Chemistry. 152: 133-139, doi: 10.1016/J.foodchem.2013.11.002

223) Bombardier, C., Laine, L., Reicin, A., Shapiro, D., Burgos-Vargas, R., Davis, B., Day, R., Ferraz, M.B., Hawkey, C.J., Hochberg, M.C. , Kvien, TK, Schinitzer, TJ, and Weaver, A. 2000. Comparison of the upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. New England Journal of Medicine. 343(21): 1520-1528

224) Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., & Nelson, P. S. 2005. Characterization of chemical constituents in Scutellaria bacicalensis with antiandrogenic and antiproliferative activities against prostate carcinoma. Cancer Clinic Res. 11(10): 3905-14

225) Booth, N.L., Overk, C.R., Yao, P., Burdette, J.E., Nikolic, D., Chen, S., Bolton, J.L., van Breemen, R.B., Pauli, G.F. and Farnsworth, N.R. 2006. The Chemical and Biological Profile of a Phase II Clinical Extract of Red Clover (Trifolium pretense). J Alternative Complement Med. 12(2): 133-139

226) Borek, C. 2004. Dietary antioxidants and human cancer. Comprehensive cancer therapies. 3(4): 333-341.

227) Borges CC, Salles FA, Bringhenti I, Souza-Mello V, Mandarim-de-Lacerda AC and Aguila BM 2016. Adverse effects of vitamin D deficiency on the PI3K/Akt pathway and pancreatic islet morphology in relation to obesity diet. Molecular nutrition and food research. 60(2): 346-357

228) Bosetti, C., Filomeno, M., Riso, P., Polesel, J., Levi, F., Talarnini, R., Montella, M., Negri, E., Franceschi, S., and Vecchia, La C. 2012. Cruciferous vegetables and cancer risk in a network of case-control studies. Ana Oncól. 23(8): 2198-2203

229) Bostick RM, Potter JD, Sellers TA, Mckenzie DR, Kushi LH, and Folsom AR 1993. Relationship of calcium, vitamin D, and dairy food intake to colon cancer incidence in elderly women. American Journal of Epidemiology. 137(12):1302-1317

230) Bostrick RM, Potter JD, McKenzie DR, Sellers TA, Kushi LH, Steinmetz KA, and Folsom AR 1993. Colon cancer risk reduction from high vitamin E intake: Iowa Women's Health Study. Research on cancer. 53(18): 4230-4237

231) Botterweck AM, van den Brandt PA and Goldbohm RA 2000. Vitamins, carotenoids, dietary fiber and risk of gastric carcinoma. Results of a prospective study after 6.3 years of follow-up. Cancer. 88(4):737-748

232) Bours, V., Bentires-Alj, M., Hellin, A. C., Viatour, P., Robe, P., Delhalle, S., Benoit, V. and Merville, M. P. 2000. Factor nuclear-kappa B, cancer and apoptosis. Biochem Pharmacol. 60(8):1085-9

233) A. Boutis, K. Papazisis, K. Pistevou, K. Gompaki, A. Lambropoulos, I. Sofraniadis, A. Papageorgiou, E. Destouni and A. Kortsaris (2006). induced apoptosis and cell cycle arrest in Raji-Zellen. Anti-Krebs-Res. 26(5A): 3493-8

234) Boutron, M. C., Faivre, J., Marteau, P., Couillault, C., Senesse, P. y Quipourt, V. 1996. Calcium, phosphorus, vitamin D, milk products and colorrectal carcinogenesis: a French case-control lernen Revista británica de cancer. 74(1):145-151

235) Bowers, J.L., Tyulmenkov, V.V., Jernigan, SC & Klinge, CM 2013. Resveratrol acts as a mixed agonist/antagonist of the α and β estrogen receptors. Endocrinology. 141(10): 3657-3667

236) Bowie, A.G. and O'Neill, L.A. 2000. Vitamin C inhibits the activation of NF-kappa-beta by TNF through activation of p38 mitogen-activated protein kinase. J Immunol. 165(12):7180-8

237) Brachwitz, K., Voigt, B., Meijer, L., Lozach, O., Schachtele, C., Molnar, J., and Hilgeroth, A. 2003. Evaluation of the first active 1-aza-9-cytostatic Los Oxafluorenes as new selective CDK1 inhibitors with glycoprotein-modulating properties P. J MedChem. 46(5):876-9

238) Bradford, PG and Awad, AB 2007. Phytosterols as anticancer compounds. Mol Nutr Food Res. 51, 161-170.

239) Bradham, C. and McClay, D.R. 2006. p38 MAPK development and cancer. cellular cycle. 5(8):824-8

240) Bradley, J.R. 2008. TNF-mediated inflammatory disease. J. Pathol. 214(2):149-60

241) Braga , M. , Gianotti , L. , Vignali , A. and Carlo , D.V. 1998. Immunonutrition in gastric cancer surgery patients. Nutrition. 14(11-12): 831-8

242) Bragado, P., Armesilla, A., Silva, A. and Porras, A. 2007. Cisplatin apoptosis requires p53-mediated activation of p38alpha MAPK through ROS generation. apoptosis. 12(9): 1733-42

243) T., L. M., E. D., & E. 2014. Associations of long-chain ω-3 fatty acids and fish consumption with endometrial cancer risk in the VITamine and lifestyle cohort. Bin J Clin Nutr. 99(3):599-608

244) Bray, G. A. and Popkin, B. M. 1998. Dietary fat intake affects obesity. American journal of clinical nutrition. 68(6): 1157-1173.

245) Bremer, E. 2013. Targeting the tumor necrosis factor receptor superfamily for cancer immunotherapy. ISRN Oncology. Volume 2013, article ID371854, 25 pages,

246) Brennan, K. and Clarke, R.B. 2013. Combining Notch inhibition with current therapies for the treatment of breast cancer. Ther Adv Med Oncol. 5(1): 17-24

247) Brennan, M., Bhatti, H., Nerusu, K.C., Bhagavathula, N., Kang, S., Fisher, G.J., Varani, J., and Voorhees, J.J. 2003. Matrix metalloproteinase-1 is the major collagenolytic enzyme, which is responsible for collagen damage in UV-irradiated human skin. Photobiol photochemistry. 78(1):43-8

248) Brenner, A.K., Reikvam, H., Lavecchia, A. and Bruserud, Ø. 2014. Therapeutic targeting of cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia: the possibility of targeting multiple kinases by inhibiting the different CDC25 isoforms. molecules. 19(11): 18414-18447

249) Brezak , M.C. , Quaranta , M. , Mondesert , O. , Galcera , M.O. , Lavergne , O. , Alby , F. , Cazales , M. , Baldin , V. , Thurieau , C. , Harnett , J. , . Lanco, C., Kasprzyk, PG, Prevost, GP and Ducommun, B. 2004. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer res 64(9):3320-5

250) Brignall, M. S. 2001. Prevention and treatment of cancer with indole-3-carbinol. Alternative medicine review. 6(6): 580-589

251) Brizuela, L., Dayon, A., Doumerc, N., Ader, I., Golzio, M., Izard, J., Hara, Y., Malavaud, B., and Cuvillier, O. 2010. Sphingosine La Survival pathway kinase 1 is a molecular target for tumor-suppressing tea and wine polyphenols in prostate cancer. The FASEB Journal. 24(10):3882-3894

252) Bromberg, J. and Wang, TC 2009. Inflammation and cancer: IL-6 and STAT3 complete the link. cancer cell. 15(2): 79-80

253) Brooks, E.E., Gray, N.S., Joly, A., Kerwar, S.S., Lum, R., Mackman, R.L., Norman, TC, Rosete, J., Rowe, M., Schow, S.R., Schultz, P.G., Wang, X., Wick, M.M. and Shiffman, D. 1997. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. JBiolChem. 272(46): 29207-11

254) Brooks, J.D., Paton, VG and Vidanes, G. 2001. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Biomarkers of the cancer epidemic Prev. 10(9): 949-54

255) Brooks, P.J., Enoch, M-A., Goldman, D., & Yokoyama, A. 2009. The alcohol flush reaction: an unrecognized risk factor for esophageal cancer from alcohol use. Plos Med. 6(3): e1000050, doi: 10.1371/journal.pmed.1000050

256) Broome CS, McArdle F, Kyle JAM, Andrews F, Lowe NM, Hart CA, Arthur JR, and Jackson MJ 2004. Increasing selenium intake improves immune function and poliovirus management in adults with marginal selenium status . Bin J Clin Nutr. 80(1):154-162

257) Brown, E., Hurd, N.S., McCall, S., & Ceremuga, TE 2007. Evaluation of the anxiolytic effect of chrysin, a developed Passiflora extract, in laboratory rats. AANAJ. 75(5):333-7

258) Brown, J. M. 2007. Tumor hypoxia in cancer therapy. Enzymol methods. 435:297-321, doi=10.1016/50076-6879(07) 35015-5

259) Brude, L.R., Drevon, C.A., Hjerman, I. et al. 1997. Low-density lipoprotein peroxidation in hyperlipidemic male co-smokers supplemented with omega-3 fatty acids and antioxidants. Arteriosclerosis, thrombosis and vascular biology. 17(11): 2576-2588.

260) Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., and Hannon, G. J. 1995. Radiation-induced cell cycle caused by p21 deficiencies. Nature 377 (6549): 552-7

261) Brumatti, G. and Ekert, G.P. 2013. Searching for an MCL-1 inhibitor. cell death and differentiation. 20:1440–1441, doi:10.1038/cdd.2013.114

262) Bruno , RD , Gover , TD , Burger , AM , Brodie , AM and Njar , VCO 2008 Stress Worms of the Endoplasmic Reticulum . Mol Cancer Ther. 7(9): 2828–2

263) Bruno, RD and Njar, VCO 2007. Targeting of cytochrome P450 enzymes: a new approach in cancer drug development. BioorgMed Chem. 15(15): 5047-5060

264) Brusselmans, K., Vrolix, R., Verhoeven, G., and Swinnen, J.V. 2005. The induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. The Journal of Biological Chemistry. 280(7): 5636-5645

265) Bryant, H. U., Glasebrook, A. L., Yang, N. N. und Sato, M. 1999. An estrogen receptor basis for raloxifene action on bone. J Steroid Biochem Mol Biol. 69(1-6): 37-44

266) Bu, H., Schweiger, M.R., Manke, T., Wunderlich, A., Timmermann, B., Kerick, M., Pasqualini, L., Shehu, E., Fuchsberger, C., Cato, AC, and Klocker, H. 2013. Anterior gradient 2 and 3: two prototype androgen-responsive genes that are transcriptionally upregulated by androgens and estrogens in prostate cancer cells. FEBRUARY J. 280(5): 1249-66

267) Bubici, C. and Papa, S. 2014. JNK signaling in cancer: need for new, smarter therapeutic targets. Br J Pharmacol. 171(1):24-37

268) Bubols, G. B., Vianna, D. Da., Medina-Remon, A., von Poser, G., Lamuela-Raventos, R. M., Eifler-Lima, V. L. and Garcia, S, C. 2013. The antioxidant activity of Coumarine and Flavonoid. Mini-Reviews in Medizinischer Chemie. 13(3): 318-34

269) Buerkle , A. M. , Pahernik , A. S. , Sutter , A. , Jonczyk , A. , Messmer , K. and Dellian , M. 2002 solid Tumor in vivo . Hno. J Krebs. 86(5): 788-795

270) Buglio, D., Georgakis, VG, Hanabuchi, S., Arima, K., Khaskhely, N. and Liu, Y. 2008. Vorinostat inhibits STAT6-mediated TARC and TH2 cytokine production and induces cell death on Hodgkin lymphoma cell lines. Blood. 112(4):1424-3

271) Bulavin, D. V. und Fornace Jr., A. J. 2004. The emerging role of P38 MAP kinase as a tumor suppressor. Adv Cancer Res. 92: 95-118, doi: 10.1016/SOO65-230X(04)92005-2

272) Bulbulyan, M.A., Figgs, L.W., Zahm, S.H., Savitskaya, T., Goldfarb, A., Astashevsky, S., and Zaridze, D. 1995. Cancer incidence and mortality among beta-naphthylamine dye workers and benzidine in Moscow. Int J Epidemiol. 24(2): 266-75

273) Bullock P, Pearce R, Draper A, Podval J, Bracken W, Veltman J, Thomas P and Parkinson A 1995. Induction of liver microsomal cytochrome P450 in Cynomolgus monkeys. Metabolism and disposition of drugs. 23(7):736-748

274) Bumke-Vogt, C., Osterhoff, AM, Borchert, A., Guzman-Perez, V., Sarem, Z., Birkenfeld, L.A., Bahr, V., and Pfeiffer, HFA 2014. The flavones apigenin and luteolin induce FOXO1 translocation, but inhibits the expression of gluconeogenic and lipogenic genes in human cells. Plus one. 9(8): e104321, doi: 10.1371/journal.pone.0104321, 16 pages

275) Bundock, EA, Drummond, GS & Kappas, A. 1996. Tissue distribution of synthetic heme analogues: studies with tin, chromium and zinc mesoporphyrins. Pharmacology. 52(3):187-98

276) Bunz, F., Hwang, P.M., Torrance, C., Waldman, T., Zhang, Y., Dillehay, L., Williams, J., Lengauer, C., Kinzler, KW, and Vogelstein, B. 1999 Disruption of p53 in human cancer cells alters responses to therapeutic agents. J Clin Invest. 104(3): 263-269

277) Burrows, N., Babur, M., Resch, J., Ridsdale, S., Mejin, M., Rowling, E.J., Brabant, G., and Williams, K.J. 2011. GDC-0941 inhibits the metastatic properties of thyroid carcinoma via the phosphoinositide-3-kinase (PI3K) and hypoxia-inducible factor 1α (HIF-1α) pathway. The Journal of Clinical Endocrinology and Metabolism. 96(12): E1934-E1943

278) Burstein , H.J. , Sun , Y. , Dirix , L.Y. , Jiang , Z. , Paridaens , R. , Tan , AR , Awada , A. , Ranade , A. , Jiao , S. , Schwartz , G. , Abbas , R., Powell, C., Turnbull, K., Vermette, J., Zacharchuk, C. and Badwe, R. 2010. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in positive breast cancer patients for ErbB2 advanced . J Clin Oncol. 28(8):1301-7

279) Burton, G.W. and Ingold, K.U., 1984. Beta-carotene: an unusual type of lipid antioxidant. Science. 224(4649):569-73

280) Busam, J.K., Roberts, BA and Sporn, BM 1992. Inhibition of mitogen-induced c-fos expression in melanoma cells by retinoic acid affects serum response element. The Journal of Biological Chemistry. 267(28): 1997-1-19977

281) Bussolati B, Ahmed A, Pemberton H, Landis RC, Di Carlo F, Haskard DO, and Mason JC 2004. Bifunctional function of VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocyte infiltration. Blood. 103(3): 761-766

282) Bustin, SA and Jenkins, PJ 2001. The insulin-like growth factor-1 axis of growth hormone and colorectal cancer. Trends in Molecular Medicine. 7(10): 447-454

283) by degree of maturity, season and minimum processing. J Sci Food Agric. 85(4):591-597

(284) Bykov VJ, Issaeva N, Zache N, Shilov A, Hultcrantz M, Bergman J, Selivanova G and Wiman KG 2005 human tumor cells by maleimide analogues. JBiolChem. 280(34):30384-9

285) Byun, E. H., Fujimura, Y., Yamada, K., and Tachibana, H. 2010. Inhibitory pathway of TLR4 signaling induced by the green tea polyphenol epigallocatechin-3-gallate through the 67 kDa laminin receptor . The Journal of Immunology. 185(1):33-45

286) Cadoo, K. A., Gucalp, A. and Traina, T. 2014. Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. breast cancer. 6:123-133, doi:10.2147/BCTT.S46725

287) Cai, D., Latham, VM Jr., Zhang, X., and Shapiro, GI 2006. Combined cell cycle depletion and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. cancer res 66(18): 9270-80

288) Cai, W., Kerner, Z. J. Hong, H. und Sun, J. 2008. Tumor necrolsis factor alpha-targeted cancer therapy. Einblicke en die Biochemie. 1:5-21

289) Cailleux, A., Subra, J.F., Riberi, P., Tuchais, E., Premel-Cabic, A. and Allain, P. 1988. Blood cyanide and thiocyanate levels in patients with renal failure or respiratory diseases. J Med. 19(5-6): 345-51

290) Cain, K., Bratton, S. B. and Cohen, G. M. 2002. The Apaf-1 apoptosome: a large caspase-activating complex. Biochemistry. 84(2-3): 203-14

291) Calder, PC. 2003a. Long-chain n-3 fatty acids and potential use in inflammation in surgical and trauma patients. Brazilian journal of medical and biological research. 36(4): 433-446.

292) Calderon-Montano, J. M., Burgos-Moron, E., Perez-Guerrero, C. and Lopez-Lazaro, M. 2011. A review of the dietary flavonoid kaempferol. Mini-Rev. Medicine. Chemistry 11(4): 298-344

293) Caligiuri, M., Becker, F., Murthi, K., Kaplan, F., Dedier, S., Kaufmann, C., Machl, A., Zybarth, G., Richard, J., Bockovich, N. ., Kluge, A. and Kley, N. 2005. A proteome-specific CDK/CRK kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem. Biol. 12(10): 1103-15

294) Callens, C., Moura, CI, Lepelletier, Y., Coulon, S., Renand, A., Dussiot, M., Ghez, D., Benhamou, M., Monteiro, CR, Bazarbachi, A. and Hermine, O. 2008. Recent advances in therapy for adult T-cell leukemia: focus on a novel anti-transferrin receptor monoclonal antibody. Leukemia. 22(1): 42-48

295) Callero MA, Suarez GV, Luzzani G, Itkin B, Nguyen B and Loaiza-Perez AI 2012. Activation of the aryl hydrocarbon receptor by aminoflavone: a new molecular target for the treatment of renal cancer. International Journal of Oncology. 41(1): 125-134

296) Calviello , G. , Di Nicuolo , F. , Piccioni , E. , Marcocci , ME , Serini , S. , Maggiano , N. , Jones , HK , Cornwell , DG and Palozza , P. 2003. ϒ-tocopherolquinone Apoptosis induced in cancer cells through caspase-9 activation and cytochrome c release. carcinogenesis. 24(3): 427-433

297) Calvo, M.S., Whiting, S.J. and Barton, C.N. 2004. Vitamin D fortification in the United States and Canada: current status and data needs. Bin J Clin Nutr. 80 (6 supplements): 1710S-1716S

298) Cameron, E. and Pauling, L. 1976. Adjunctive ascorbate in cancer supportive care: prolonging survival in end-stage cancer. Proceedings of the National Academy of Sciences of the United States of America. 73(10):3685-9

299) Cameron, E. and Pauling, L. 1978. Adjuvant ascorbate in cancer supportive care: reappraisal of prolongation of survival in end-stage cancer. Proceedings of the National Academy of Sciences of the United States of America. 75(9):4538-42

300) Camitato, R., Nesaretnam., Leoni, G., Ambra, R., Canali, R., Bolli, A., Marino, M., and Virgili, F. 2009. A Novel Mechanism of Natural Vitamin E Tocotrienol Activity : Description of Erbeta signal transduction. I'm J Physiol Endocrinol Metab. 297(2): E427–37

301) Campa, V. M., Iglesias, J. M., Carcedo, M. T., Rodriguez, R., Riera, J., Ramos, S. and Lazo, P. S. 2005. Polyinosic acid induces the production of TNF and NO, as well as NF-kappaB and AP-1 Transcriptional activation in the RAW 264.7 monocyte-macrophage cell line. Inflammatory Resistance 54(8): 328-37

302) Campeau, P.M., Foulkes, W.D. and Tischkowitz, M.D. 2008. Hereditary Breast Cancer: New Genetic Developments, New Therapeutic Pathways. human genetics. 124(1):31-42

303) Campos, MG, Webby, R.F. and Markham, K.R. 2002. The unique occurrence of the flavone aglycon tricetin at the poles of Myrtaceae. Natural Research Journal C. 57 (9-10): 944-946

304) Canada, A. T., Giannella, E., Nguyen, T. D., & Mason, R. P. 1990. The production of reactive oxygen species by dietary flavonols. Free Radical Biol Med. 9(5): 441-9

305) Canavese, M., Santo, L., & Raje, N. 2012. Cyclin-dependent kinases in cancer: potential for therapeutic intervention. Cancer Biol. Ther. 13(7) 451-7

306) Candelario-Jalil, E., Akundi, R. S., Bhatia, H. S., Lieb, K., Appel, K., Muñoz, E., Hüll, M. and Fiebich, BL 2006. Ascorbic acid enhances the inhibitory effect of neuronal aspirin cyclooxygenase-2 mediated by prostaglandin E2 production. J Neuroimmunol. 174(1-2): 39-5

307) Cao H H, Tse AK, Kwan H Y, Yu H, Cheng C Y, Su T, Fong WF, and Yu Z L 2014. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 87(3): 424-34

308) Cao, Y., Wang, D., Wang, X., Zhang, J., Shan, Z., & Teng, W. 2013. (-)-Epigallocatechin gallate inhibits PAI-1 production induced by TNF-α in vascular endothelial cells. J Cardiovasc Pharmacol. 62(5): 452-6

309) Capel, E., Auclair, M., Caron-Debarle, M. und Capeau, J. 2012. Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes . . . . Antiviral Therapy. 17:549–556, doi:10.3851/IMP1988

310) Carbajo-Pescador, S., Steinmetz, C., Kashyap, A., Lorenz, S., Mauriz, J.L., Heise, M., Galle, P.R., Gonzalez-Gallego, J. and Strand, S. 2013. Melatonin induces the transcriptional regulation of Bim by Fox03a in HepG2 cells. British journal of cancer. 108:442-449, doi=10.1038/bjc.2012.563

311) Cardenas, E. and Ghosh, R. 2013. Vitamin E: a dark horse at the crossroads of cancer treatment. Farmacología Bioquímica. 86(7):845-852.

312) Cardus, A., Panizo, S., Encinas, M., Dolcet, X., Gallego, C., Aldea, M., Fernandez, E., and Valdivielso, J. M. 2009. 1,25-Dihydroxyvitamin D3 regulates VEGF production by a vitamin D response element in the VEGF tomometer. atherosclerosis 204(1):85-9

313) Carew, J. S., Espitia, C. M., Zhao, W., Kelly, KR, Coffey, M., Freman, J. W., & Nawrocki, S. T. 2013. Rheolysin is a new reovirus-based drug that induces reticular stress-mediated apoptosis endoplasmic cancer of the pancreas. cell death and disease. 4: e728, doi: 1038/cddis.2013.259

314) Cargnello, M. and Roux, P. P. 2011. Activation and function of MAPKs and their substrates, MAPK-activated protein kinases. Microbial Mole Biol Rev. 75(1):50-83

315) Carlson EM, Chichumroonchokchai C, Vodovotz Y, Schwartz SJ, Gunn JS, Bhatiya A, Kerem Z, Berhow M, Bomser JA and Failla ML 2009. Gastrointestinal activity of soybean and tomato saponins. Journal of the Federation of American Societies for Experimental Biology. 23 (Meeting Summary Supplement 717.15)

316) Carmichael, SL, Gonzales-Feliciano, AG, Ma, C, Shaw, GM & Cogswell, ME 2011. Estimated dietary intake of phytoestrogens and major dietary sources in women in the year before pregnancy. Nutrition Magazine. 10:105 Doi: 10.1186/1475-2891-10-105

317) Carr, A. and Frei, B. 1999. Does vitamin C act as a pro-oxidant under physiological conditions?. The FASEB Journal. 13(9): 1007-1024

318) Carreón, T., Hein, M.J., Hanley, KW, Viet, SM and Ruder, AM 2014. Incidence of bladder cancer in workers exposed to o-toluidine, aniline and nitrobenzene in a rubber chemical factory. Occupy Environment Med. 71(3): 175-82

319) Carreras, A., Moteos-Martin, M. L., Velazquez-Palenzuela, A., Brillas, E., Cascante, M., Julia, L. and Torres, J. L. 2012. Punicalagin and catechins contain polyphenolic substructures that affect affect cell viability and can be monitored by radical chemosensors sensitive to electron transfer. Journal of agricultural and food chemistry. 60(7): 1659-1665

320) Carter, L.G., D'Orazio, J.A. and Pearson, K.J. 2014. Resveratrol and cancer focus on in vivo evidence. Endocrinology connection cancer. 21(3): R209-R225

321) Cassidy, E. C. and Setzer, W. N. 2011. Lonchocarpus polyphenols and their biological activity. The natural products magazine. 1(2): 75-104

322) Catalan, J., Moriguchi, T., Slotnick, B., Murthy, M., Greiner, R.S. and Salem, N. Jr. 2002. Cognitive deficits in rats deficient in docosahexaenoic acid. behavioral neuroscience. 116(6): 1022-1031.

323) Center MM, Jemal A, Lortet-Tieulent J, Ward E, Ferlay J, Brawley O, and Bray F 2012. International variation in prostate cancer incidence and mortality rates. european urology. 61(6): 1079-1092

324) Cerioni, L., Palomba, L. and Cantoni, O. 2003. The Raf/MEK inhibitor PD98059 enhances peroxynitrite-mediated ERK 1/2 phosphorylation through forced mitochondrial generation of reactive oxygen species. letters FEBS. 547(1-3): 92-96

325) Cervello, M., Bachvarov, D., Lampiasi, N., Cusimano, A. and Azzolina, A. 2013. The novel combination of sorafenib and celecoxib provides synergistic antiproliferative and proapoptotic effects in human liver cancer cells. More one. 8(6): e65569, doi:10.1371/journal.pone.0065569, 16 pages.

326) Chadli, A., Felts, S.J., Wang, Q., Sullivan, WP, Botuyan, M.V., Faug, A., Ramirez-Alvarado, M., and Mer, G. 2010. Celastrol inhibits Hsp90 accompanying of steroid receptors by inducing p23 cochaperone fibrillation. JBiolChem. 285(6): 4224-31

327) Chakraborti, K.C. 2011. Vitamin D as a Promising Anticancer Agent. Indian J Pharmacol. 43(2):113-120

328) Chakraborty, D.S. 2015. Antimetastatic Mechanism and Efficacy of Bromelain. International Journal of Ayurveda and Pharmaceutical Research. 3(1):10-13

329) Chakraborty, K., Ramsauer, V., Kang, S.S., Lightner, J., Campbell, S., Stone, WL, and Krishnan, K. 2011. Poster Preventions-PI3K/Akt/mTOR Pathway Inhibitors, Abstract 4490: Tocotrienols inhibit the PI3/Akt and ERK pathways to induce growth arrest in pancreatic cancer cell lines through Her-2/Erbβ2 receptors. res of cancer 71 (8 supplement): 4490

330) Chalhoub, N. and Baker, S.J. 2009. PTEN and the PI3 kinase pathway in cancer. Annu Rev. Pathol. 4:127-150, doi:10.1146/annurev.pathol.4.110807.092311

331) Challita, M.P., Morrison, K., Etessami, S., An, Z., Morrison, J.K., Perez-Villar, J.J., Raitano, B.A., Jia, X., Gudas, M.J., Kanner, B.S. and Jakobovits, A. 2007. Monoclonal antibodies against prostate six-transmembrane epithelial antigen-1 inhibit intercellular communication in vitro and the growth of human tumor xenografts in vivo. res of cancer 67(12): 5798-805

332) Chammugam, P., Feng, L., Liou, S., Jang, B.C., Boudreau, M., Yu, G., Lee, J.H., Kwon, H.J., Beppu, T., Yoshida, M., Xia , Y., Wilson, CB and Hwang, D. 1995. Radicicol, a protein tyrosine kinase inhibitor, suppresses mitogen-inducible cyclooxygenase expression in lipopolysaccharide-stimulated macrophages and in experimental glomerulonephritis. The Journal of Biological Chemistry. 270(10): 5418-5426

333) Chan, C. M., Fang, J. Y., Lin, H. H., Yang, C. Y., & Hung, C. F. 2009. Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppressing PI3K/Akt and MAPK signaling pathways . Biochem Biophys Communal Res. 388(1):172-6

334) Chan, J.M., Stampfer, M.J., Ma, J., Rimm, EB, Willett, W.C. and Giovannucci, EL. 1999. Supplemental vitamin E intake and risk of prostate cancer in a large cohort of men in the United States. Biomarkers of the cancer epidemic Prev. 8(10):893-899

335) Chan KT, Li K, Liu SL, Chu KH, Toh M and Xie WD 2010. Cucurbitacin B inhibits STAT3 and Raf/MEK/ERK signaling in the K562 leukemia cell line. cancer letters 289(1): 46-52

336) Chan, MJ, Stampfer, JM, Ma, J, Rimm, BE, Willett, CW & Giovannucci, LE 1999. Supplemental vitamin E intake and risk of prostate cancer in a large cohort of men in the United States. Biomarkers of the cancer epidemic Prev. 8(10):893-9

337) Chan, M. M., Fong, D., Soprano, K. J., Holmes, W. F. und Heverling, H. 2003. Growth inhibition and sensitization to cisplatin-mediated ovarian cancer cell killing by polyphenolic chemopreventive agents. J-Zellfisiol. 194(1): 63-70

338) Chandrasekar, N., Jasti, S., Alfred-Yung, W.K., Ali-Osman, F., Dinh, D.H., Olivero, W.C., Gujrati, M., Kyritsis, A.P., Nicolson, GL, Rao, J.S. and Mohanam, S. 2000. Modulation of endothelial cell morphogenesis in vitro by MMP-9 during endothelial cell-glial interactions. Clinical and experimental metastasis. 18(4):337-342

339) Chang, HK, Shin, M.S., Yang, HY, Lee, J.W., Kim, Y.S., Lee, M.H., Kim, J., Kim, K.H. and Kim, C.J. 2006. The Amygdala Induces Apoptosis Through Regulation of Bax and Bcl-2 Expressions in DU145 and LNCaP Human Prostate Cancer Cells. BiolPharmBull. 29(8): 1597-602

340) Chang, P., Walker, MC, & Williams, RSB 2014. Seizure-induced reduction in PIP3 levels contributes to seizure activity and is rescued by valproic acid. Neurobiol Dis. 62(100):296-306

341) Chang, T.E., Canchola, J.A., Lee, S.V., Clarke, A.C., Purdie, M.D., Reynolds, P., Bernstein, L., Stram, O.D., Anton-Culver, H., Deapen, D., Mohrenweiser, H., Peel, D., Pinder, R., Ross, KR, West, W.D., Wright, W., Ziogas, A., and Horn-Ross, L.P. 2007. Wine and Other Alcohol Consumption and Ovarian Cancer Risk Study California Teachers Cohort. Causes and control of cancer. 18(1): 91-103

342) Chang, T.E., Lee, S.V., Canchola, J.A., Clarke, A.C., Purdie, M.D., Reynolds, P., Anton-Culver, H., Bernstein, L., Deapen, D., Peel, D., Pinder , R., Ross, KR, Stram, O.D., West, W.D., Wright, W., Ziogas, A., and Horn-Ross, L.P. 2007. Diet and ovarian cancer risk in the California teacher study cohort. Am J Epidemiol. 165(7):802-813

343) Chang, Y., Chi, C. & Wang, J. 2006. Production of reactive oxygen species is involved in quercetin-induced apoptosis in human hepatoma cells. Diet and cancer. 55(2):201-209

344) Chang, Y., Huang, C., Hung, C., Chen, W., & Wei, P. 2015. GRP78 mediates the therapeutic efficacy of curcumin in colon cancer. tumor biol 36: 633-641, doi: 10.1007/s13277-014-2640-3

345) Chang, Y., Huang, Y., Li, Z., and Chen, C. 2012. Knockdown of GRP78 enhances apoptosis through downregulation of oxidative stress and the Akt pathway after epirubicin treatment in cells DLD-1 of colorectal cancer. Plus one. 7:4, e.35123, 11 pages, doi: 10.1371/journal.pone.0035123

346) Chanmugam, P., Feng, L., Liou, S., Jang, B.C., Boudreau, M., Yu, G., Lee, J.H., Kwon, H.J., Beppu, T., Yoshida, M., Xia , Y., Wilson, B.C. and Hwang, D. 1995. Radicicol, a protein tyrosine kinase inhibitor, suppresses mitogen-inducible cyclooxygenase proliferation in lipopolysaccharide-stimulated macrophages and in experimental glomerulonephritis. The Journal of Biological Chemistry. 270:5418-5426, doi:10.1074/jbc.270.10.5418

347) Chapman, J.R., Tazaki, H., Mallouh, C., and Konno, S. 1999. Brefeldin A-induced apoptosis in prostate cancer DU-145 cells: a potential p53-independent pathway of death. BJU International. 83(6):703-708

348) Charalapopoulos, K., Kotsalos, A., Batistatou, A. et al. 2006. Selenium in serum and neoplastic tissues in correlation of breast cancer with CEA. British journal of cancer. 95(6): 674-676.

349) Charoensiri, R., Kongkachuichai, R. and Sungpuag, S,S,P. 2009. Beta-carotene, lycopene and alpha-tocopherol content in selected Thai fruits. Food Chemistry. 113(1):202-207

350) Chaturvedi, P.K., Bhui, K. and Shukla, Y. 2008. Lupeol: Connotations for chemoprevention. Cancer Lett. 263(1):1-1

351) Chaudhary, P.M., Eby, M., Jasmin, A., Bookwalter, A., Murray, J. and Hood, L. 1997. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB signaling pathway. Immunity. 7(6):821-830

352) Chaudhary, SC, Siddiqui, MS, Athar, M., & Alam, MS 2012. D-limonene modulates inflammatory oxidative stress and the Ras-ERK pathway to inhibit skin tumorigenesis in mice. Hum Exp Tox. 31(8):798-811

353) Chaudhuri, D., Orsulic, S. und Ashok, B. 2007. Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells. Mol Cancer Ther. 6(1):334-345

354) Chavez, I.O., Apan, T.R. and Martinez-Vazquez, M. 2005. Cytotoxic activity and effect on nitric oxide production of tirucallan-type triterpenes. J. Pharm. Pharmacol. 57(9):1087-91

355) Che, H.Y., Guo, H.Y., Si, X.W., You, Q.Y. and Lou, W.Y. 2014. PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, inhibits the proliferation and migration of anaplastic thyroid carcinoma cells. tumor biol 35(9): 8659-64

356) Chen, AY and Chen, YC 2013. A review of the dietary flavonoid kaempferol for human health and cancer chemoprevention. Food Chemistry. 138(4): 2099-2107

357) Chen, C. H. and Chen, R. J. 2011. Prevalence of telomerase activity in human cancer. J Formos Med Assoc. 110(5):275-89

358) Chen, C., Yu, R., Owuor, E. D. und Kong, A. N. 2000. Activation of antioxidant response element (ARE), mitogen-activated protein kinase (MAPK) and caspases by major polyphenolic components of green tea during cell survival and Tod. Arch Pharm. Res. 23(6): 605-12

359) Chen, D., Wan, S. B., Yang, H., Yuan, J., Chan, T. H., & Dou, Q. P. 2011. EGCG, green tea polyphenols and their synthetic analogs and prodrugs for cancer prevention and treatment human. Av. Clin. Chemistry 53: 155-177, doi: 10.1016/B978-0-12-385855-9.00007-2

360) Chen G, Xu X, Zhang L, Fu Y, Wang M, Gu H, and Xie X 2014. Blockade of autocrine VEGF signaling by sunitinib, an anticancer drug, promotes self-renewal of embryonic stem cells and somatic cell reprogramming. . cell research. 24(9):1121-1136

361) Chen, H. Y., Ren, X. Y., Wang, W. H., Zhang, Y. X., Chen, S. F., Zhang, B., and Wang, L. X. 2014. Upregulated ROS production induced by proteasome inhibitor MG-132 on expression of the XBP1 gene and cell apoptosis in Tca-8113 cells. Biomedical Pharmacist. 68(6):709-13

362) Chen, H., Li, D., Saldeen, T., Romeo, F., & Mehta, J. L. 2002. Mixed-tocopherol preparation is superior to alpha-tocopherol alone against hypoxia and reoxygenation injury. Biochem Biophys Communal Res. 291(2):349-53

363) Chen H, Lin C, Lee C, Shih N, Peng S, Tsuzuki M, Amagaya S, Huang W, and Yang J 2013. Kaempferol suppresses cell metastasis by inhibiting ERK-p38-JNK and AP signaling pathways -1 in humans U-2-OS osteosarcoma cells. Oncol Rep. 30(2):925-932

364) Chen, J. 2012. Targeted therapy of obesity-associated colon cancer. Gastrointestinal Cancer Transl. 1(1): 44-57

365) Chen JC, Hwang JM, Chen GW, Tsou MF, Hsia TC, and Chung JG 2003. Curcumin decreases DNA adduct formation, arylamine N-acetyltransferase activity, and expression in human colon tumor cells (colo205) . Live. 17(3):301-309

366) Chen, J., Chou, C., Chang, Y., and Chen, C. 2008. Proteasome inhibitors enhance TRAIL-induced apoptosis through intronic regulation of DR5: NF-kB and p53-mediated involvement by Reactive Oxygen Species - Activation The Journal of Immunology. 180(12): 8030-8039

367) Chen, J., Freeman, A., Liu, J., Dai, Q., and Lee, RM 2002. Apoptotic action of HA14-1, a small molecule that interacts with Bcl-2, requires Bax translocation and is extended by PK11195. Mol Cancer Ther. 1(12):961-7

368) Chen, J., Huang, W., and Chen, C. 2005. Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling and CCAAT/proteasome protein recruitment. δ enhancer binding and CREB binding protein. Mol Biol. Cell. 16(12): 5579-5591

369) Chen, J., Zeng, Y., Dai, T. and Tang, Q. 2015. Intrathecal L-arginine reduces sevoflurane antinociception in formalin-induced pain in rats. Neuroscience letters. 590: 156-160, doi:10.16/j.neulet.2015.02.006

370) Chen KB, Lin AM and Chiu TH 2003. Systemic vitamin attenuated oxidative damage in rat brain locus coeruleus. Ann NY Acad. science 993(1):313-324

371) Chen ML, Lin YH, Yang CM, and Hu ML 2012. Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting the MMP-2/UPA system through the PI3K-Akt and ERK/p38-mediated signaling pathways. by VEGFR2. Mol Nutr Food Res. 56(6):889-99

372) Chen M, Tang W, Hsu C, Tsai Y, Wu J, Lin C, Cheng Y, and Hsu Y 2012. Induction of apoptosis in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane. Alternative and complementary medicine based on evidence. Vol. 2012, Article ID: 415231, doi: 10.1155/2012/415231, 13 pages

373) Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, and Levine M 2005. Concentrated pharmacological ascorbic acid selectively kills cancer cells: acts as a prodrug to deliver hydrogen peroxide to tissues . Proceedings of the National Academy of Sciences of the United States of America (PNAS). 102(38):13604-13609

374) Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, and Levine M 2008. Pharmacological doses of ascorbate act as pro-oxidants and reduce the growth of aggressive tumor xenografts in mice. Proceedings of the National Academy of Sciences of the United States of America. 105(32):11105-11109

375) Chen, Q., Ganapathy, S., Singh, KP, Shankar, S., & Srivastava, R. K. 2010. Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells . Plus one. 5(12): e15288, doi: 10.1371/journal.pone.0015288

376) Chen, Qi., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, CP, Buettner, G. R., Shacter, E., & Levine, M. 2005. Pharmacological concentrations of ascorbic acid selectively kill cancer cells: acting as a prodrug for the delivery of hydrogen peroxide to tissues. PNAS (Proceedings of the National Academy of Sciences of the United States of America). 102(38):13604-13609

377) Chen, S., Cho, M., Karlsberg, K., Zhou, D., and Yuan, Y. 2004. Biochemical and biological characterization of a novel anti-aromatase coumarin derivative. Journal of Biological Chemistry. 279(46): 48071-8

378) Chen, S., Dai, Y., Pei, X., and Grant, S. 2009. Upregulation of Bim by histone deactylase inhibitors mediated by interactions with the Bcl-2 antagonist ABT-737: Evidence for distinct functions for Bcl-2, Bcl-xl and Mcl-1. Molekular- und Zellbiologie. 29(23): 6149-6169

379) Chen TW, Liang YN, Feng D, Tao LK, Qi K, Zhang HY, Wang HK, Lin QS, and Kong H 2013. Metformin inhibits proliferation and promotes apoptosis of HER2-positive breast cancer cells by downregulation of HSP90. J Buon. 18(1):51-6

380) Chen, W., Balakrishnan, K., Kuang, Y., Han, Y., Fu, M., Gandhi, V., and Peng, X. 2014. Inducible reactive oxygen species (ROS) DNA crosslinkers and its effect on cancer cells and normal lymphocytes. 57(11): 4498-4510

(- )-epigallocatechin gallate in a human keratinocyte cell line. carcinogenic mol 24(2): 79-84

382) Chen, WJ and Yeh, SL 2003. Effects of fish oil on parenteral nutrition. Nutrition. 19(3):275-279.

383) Chen, X., Dodd, G. & Kunsch, C. 2009. Sulforaphane inhibits TNF-α-induced activation of p38 MAP kinase and the expression of VCAM-1 and MCP-1 in endothelial cells. inflammation research. 58(8):513-521

384) Chen, X., Ren, K., He, H. and Shao, R. 2008. Involvement of the PI3K/AKT/GSK3β signaling pathway in tetrandrine-induced G1 arrest and apoptosis. Cancer Biology and Therapy. 7(7): 1073-1078

385) Chen X, Zhao M, Hao M, Sun X, Wang J, Mao Y, Zu L, Liu J, Shen Y, Wang J, and Shen, K. 2013. Dual PI3K and mTOR inhibition mitigates compensatory activation of AKT and improved response to tamoxifen in breast cancer. Mol Cancer Res. 11 (10): 1269-78

386) Chen, Y.C., Pradhu, KS, & Mastro, AM 2013. Is selenium a potential treatment for cancer metastasis? Nutritious. 5(4):1149-1168

387) Chen Y, Ma J, Wang F, Hu J, Cui A, Chengguo W, Yang Q, and Li F 2013. Amygdala induces apoptosis in HeLa cells of the human cervical cancer cell line. Immunopharmacology and Immunotoxicology. 35(1): 43-51

388) Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W, Sun L, Yang X, Wang Y, Zhang Y, and Shang, Y. 2008. The molecular mechanism determining the oncogenic potential of SOX2 in breast cancer. JBiolChem. 283(26): 17969-78

389) Chen Z, Huang C, Yang YL, Ding Y, Ou-Yang HQ, Zhang YY, and Xu M 2012. Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthin in SaOS2 cells. Acta Pharmacol Sin. 33(1):101-8

390) Cheng, C.K., Gustafson, W.C., Charron, E., Houseman, B.T., Zunder, E., Goga, A., Gray, N.S., Pollok, B., Oakes, S.A., James, C.D., Shokat, K.M., Weiss, W. A. ​​and Fan, Q. W. 2012. Dual lipid- and cyclin-dependent kinase blockade induces lethality in malignant glioma. Proc Natl Acad Sci USA. 109(31): 12722-7

391) Cheng, J. Q., Lindsley, C. W., Cheng, G. Z., Yang, H. und Nicosia, S. V. 2005. The Akt/PKB pathway: molecular target for cancer drug discovery. Onkogen. 24(50):7482-7492

392) Cheng, K.C., Gustafson, C.W., Charron, E., Houseman, T.B., Zunder, E., Goga, A., Gray, S.N., Pollok, B., Oakes, A.S., James, D.C., Shokat, M.K., Weiss, A. W. and Fan, Q. 2012. Double blockade of lipid- and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci. 109(31): 12722-12727

393) Cheng, L., Xia, T.S., Wang, Y.F., Zhou, Y.F., Zhou, W., Liang, X.Q., Xue, J.Q., Shi, L., Wang, Y., Ding, Q., and Wang, M 2014. The anticancer effect and mechanism of α-hederin in breast cancer cells. international J Oncol. 45(2):757-63

394) Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke Z, Son YO, Wang X, Luo J, and Shi X. 2010. Quercetin induces selective tumor apoptosis by downregulating Mcl-1 and Bax activation. Cancer Clinic Res. 16(23): 5679-91

395) Cheng, T. D., Barnett, J. M., Kristal, R. A., Ambrosone, B. C., King, B. I., Thornquist, D. M., Goodman, E. G., and Neuhouser, L. M. 2011. Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer in current smokers. J Nutr. 141(9): 1731-1737

396) Cheong, E., Ivory, K., Doleman, J., Parker, ML, Rhodes, M., & Johnson, TI 2004. Synthetic and natural COX-2 inhibitors suppress proliferation in a human esophageal adenocarcinoma cell line (OE33) by induction of apoptosis and cell cycle arrest. carcinogenesis. 25(10): 1945-1952

(397) Cherubini, A., Andrés-Lacueva, C., Martín, A. et al. 2007. Low plasma n-3 fatty acids and dementia in the elderly. The InCHIANTI study. The Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 62(10): 1120-1126.

398) Chiang, I.T., Liu, Y.C., Wang, WH, Hsu, FT, Chen, HW, Lin, WJ, Chang, WY, and Hwang, JJ 2012. Sorafenib inhibits TPA-induced MMP-9 and VEGF expression by suppression of the ERK/NF-kB pathway in hepatocellular carcinoma cells. Live. 26(4): 671-81

399) Chiang K.C., Tsui, K.H., Chung, LC, Yeh, C.N., Feng, T.H., Chen, W.T., Chang, P.L., Chiang, H.Y. and Juang, H.H. 2014. Cisplatin modulates B-cell translocation gene 2 to attenuate cell proliferation of prostate carcinoma cells in both p53-dependent and independent signaling pathways. Scientific reports. 4:5511, doi:10.1038/srep05511, 10 pages

400) Chin, LS, Murray, SF, Doherty, PF and Singh, SK 1999. K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c. reverse cancer. 17(6):391-5

401) Chinta, J. S., Poksay, S. K., Kaundinya, G., Hart, M., Bredesen, E. D., Andersen, K. J., and Rao, V. R. 2009. Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci. 39(1-2): 157-168

402) Chio, JF, Tai, CJ, Huang, MT, Wei, PL, Wang, YH, An, J, Wu, CH, Liu, TZ, and Chang, YJ 2010. Glucose-regulated protein 78 is a new contributor to the acquisition of resistance to sorafenib in hepatocellular carcinoma. Ann Sung Oncol. 17(2): 603-12

403) Chitnis, M. M., Yuen, J. S., Protheroe, A. S., Pollak, M., & Macaulay, V. M. 2008. The insulin-like growth factor receptor type 1 pathway. Clinical Cancer Res. 14(20):6364- 70

404) Chitnis, P. M., Adwankar, K. M. & Amonkar, J. A. 1985. Studies of high-dose amygdalin chemotherapy in P388 murine lymphocytic leukemia and P815 mast cell leukemia. J Cancer Res Clin Oncol. 109(3):208-9

405) Chiu, C.J., Klein, R., Milton, R.C., Gensler, G., & Taylor, A. 2009. Does eating certain diets modify the risk of age-related macular degeneration in wearers of age-related eye diseases? British journal of ophthalmology. 93(1):1-6.

406) Cho, E., Hung, S., Willett, W.C. et al. 2001. Prospective study on dietary fat and risk of age-related macular degeneration. American journal of clinical nutrition. 73(2): 209-218.

407) Cho N, Han H, Leem D, Choi I, Jung I, Kim H, Moon K, Choi K, Soh Y, Kong G., Cho, S., and Choi, S. H. 2009. Sulforaphane enhances cell-dependent apoptosis. caspase al by inhibiting cyclooxygenase-2 expression in human oral squamous cell carcinoma cells and nude mouse xenograft models. Oral oncology. 45(8): 654-660

408) Cho, Y., Jeong, H., Kim, J., and Lee, H. 2014. Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes. Drugs Des Devel Ther. 8: 2137-2145, doi:

409) Chobotava, K., Vernallis, AB, & Majid, FAA 2010. Activity and potential of bromelain as an anticancer agent: current evidence and perspectives. Cancer Letters 290(2): 148-156

410) Choi, A. M. and Alam, J. 1996. Heme oxygenase-1: function, regulation, and involvement of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol. 15(1): 9-19

411) Choi, EJ and Ahn, WS 2008. Kaempferol induced apoptosis through cell cycle arrest in MDA-MB-453 human breast cancer cells. Nutr Practice Res. 2(4): 322-325

412) Choi, H.Y., Chong, S.A. and Nam, M.J. 2009. Resveratrol induces apoptosis in SK-HEP-1 human liver cancer cells. Cancer genomics and proteomics. 6(5): 263-268

413) Choi HS, Cho MC, Lee HG and Yoon DY 2010. Indole-3-carbinol induces apoptosis via p53 and activation of caspase-8 signaling in A549 lung cancer cells. Food Chem Toxicol. 48(3):883-90

414) Choi, J.W., Schroeder, MA, Sarkaria, J.N. and Bram, R.J. 2013. Cyclophilin B supports Myc-dependent and p53 mutant survival of glioblastoma multiforme cells. Molecular and cellular pathobiology. 74:2, doi: 10.1158/0008-5472.CAN-13-0771, 12 pages

415) Choi, S., Son, Y., Yun, J., & Kim, H. S. 2012. Fisetin inhibits osteoclast differentiation by downregulating the p38 and c-Fos-NFATc1 signaling pathways. Alternative and complementary medicine based on evidence. Volume 2012. Entry ID 810563, doi:

416) Choi, W. Y., Choi, B. T., Lee, W. H., & Choi, Y. H. 2008. Sulforaphane generates reactive oxygen species leading to mitochondrial disruption by apoptosis in U937 human leukemia cells. biomedicine and pharmacotherapy. 62(9): 637-644

417) Choi, Y.J., Lee, W.S., Lee, E.G., Sung, M.S. and Yoo, W.H. 2014. Sulforaphane inhibits IL-1β-induced synovial fibroblast proliferation in rheumatoid arthritis and the production of MMP, COX-2, and PGE2. Inflammation. 37(5): 1496-503

418) Choi, YJ, Lee, YH, and Lee, S. 2015. Galangin and kaempferol repress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase 9 expression in HT-1080 human fibrosarcoma cells. molecules and cells. 38(2): 151-155

419) Choi, Y., Park, GB, Kim, J.Y., Kim, H.J., Kim, S., Kim, Y., Lee, H., Cho, D., Lee, W.J., Bae, KW, and Hur, D.Y. 2013. Sorafenib induces apoptosis through production of reactive oxygen species, activation of JNK/p38 MAPK, and suppression of Akt/NF-kB signaling in EBV-transformed B cells (P2088). The Journal of Immunology. Lecture Summary Supplement 190:132.34

420) Chong, E.W.-T., Kreis, A.J., Wong, TY, Simpson, J.A. and Guymer, R. H. 2008. Dietary intake of w-3 fatty acids and fish for the primary prevention of age-related macular degeneration. A systematic review and meta-analysis. Ophthalmology Archive. 126(6):826-833.

421) Chong L, Zhang W, Nie Y, Yu G, Liu L, Lin L, Wen S, Zhu L, and Li C 2014. Protective effect of curcumin on acute airway inflammation in allergic asthma in mice a via the Notch1-GATA3 signaling pathway. Inflammation. 37(5): 1476-85

422) Chou, L.C., Yang, J.S., Huang, L.J., Wu, H.C., Lu, CC, Chiang, J.H., Chen, KT, Kuo, S.C. and Chung, J.G. 2009. Synthesized 2-(2-fluorophenyl)-6 ,7-methylenedioxyquinoline-4-one (CHM-1) promoted G2/M arrest by inhibiting CDK1 and induced apoptosis via the mitochondria-dependent pathway in CT-26 mouse colorectal adenocarcinoma cells. J Gastroenterol. 44(10): 1055-63

423) Choudhari, KS, Chaudhary, M, Bagde, S, Gadbail, RA and Joshi, V. 2013. Nitric oxide and cancer: a review. World Oncology Surg J. 11:118, doi:10.1186/1477-7819-11-118, 11 pages

424) Christakos, S., Barletta, F., Huening, M., Dhawan, P., Liu, Y., Porta, A., and Peng, X. 2003. Vitamin D target proteins: function and regulation. J Cell Biochem. 88(2): 238-44

425) Christen, S., Jiang, Q., Shigenaga, M. K. und Ames, B. N. 2002. Analysis of plasma alpha, gamma, and 5-nitro-gamma tocopherols in inflammatory rats by coulometric HPLC detection. J Lipidres. 43(11): 1978-85

426) Christen, S., Woodall, A. A., Shigenaga, N. K., Southwell-Keely, P. T., Duncan, M. W., & Ames, B. N. 1997. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci USA. 94(7):3217-22

427) Christman, J. K., Sheikhnejad, G., Dizik, M., Abileah, S., & Wainfan, E. 1993. Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe deficiency of methyl in the diet. carcinogenesis. 14(4):551-7

428) Chrzan, B. G. and Bradford, P. G. 2007. Phytoestrogens activate estrogen receptor β1 and estrogen responses in human bone and breast cancer cell lines. Mol Nutr Food Re. 51(2):171-177

429) Chu, I., Blackwell, K., Chen, S., & Slingerland, J. 2005. The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation and inhibition of cell proliferation. estrogen-dependent gene expression. in antiestrogen-resistant breast cancer. Cancer Res 65(1): 18-25

430) Chuang, J., Huang, Y., Lu, H., Ho, H., Yang, J., Li, T., Chang, N., & Chung, J. 2007. Coumarin induces cycle arrest cellular and apoptosis in human cervical cancer HeLa cells through a mitochondrial mechanism and dependent on caspase-3 and downregulation of NF-kB. Live. 21(6): 1003-1010

431) Chun, KS, Keum, YS, Han, SS, Song, YS, Kim, SH & Surh, YJ 2003. Curcumin inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin by suppressing activity regulated by extracellular signals and NF-kappaB activation. carcinogenesis. 24(9): 1515-24

432) Chung, F. L. 1995. Inhibition of lung tumorigenesis by administration of a polyphenol. Patent publication number: US5391568

433) Chung, K., Wong, T., Wei, C., Hunag, Y., and Lin, Y. 1998. Tannins and human health: a review. Critical Reviews in Food Science and Nutrition. 38(6): 421-464

434) Chung, M.H., Kim, D.H., Na, HK, Kim, J.H., Kim, HN, Haegeman, G., and Surh, YJ 2014. Genistein inhibits phorbol ester-induced NF-kB transcriptional activity and expression of COX-2 by blocking p65/ReIA phosphorylation in human mammary epithelial cells. mutate res. 768: 74-83, doi: 10.1016/j.mrfmmm.2014.04.003

435) Cianchi, F., Cortesini, C., Fantappie, O., Messerini, L., Schiavone, N., Vannacci, A., Nistri, S., Sardi, I., Baroni, G., Marzocca, C ., Perna, F., Mazzanti, R., Bechi, P. und Masini, E. 2003. Inducible stickoxidsynthase expression in human colorectal cancer. Bin J. Pathol. 162(3): 793-801

436) Ciara, O., Maureen, B., Abbas, D., Yashodharan, K., Lutfun, N., Fiona, S. and Satyajit, D. S. 2005. Hirsutannobnonol, oregonine and genkwanin from Alnus glutinosa (Betulaceae) seeds ). ). Systematic biochemistry and ecology. 33(7):749-752

437) Ciarcia , R. , Vitiello , M.T. , Galdiero , M. , Pacilio , C. , Iovano , V. , d'Angelo , D. , Pagnini , D. , Caparrotti , G. , Conti , D. , Tomei , V., Florio, S. and Giordano, A. 2012. Imatinib treatment inhibits IL-8, NF-kB and AP-1 production and modulates intracellular calcium in patients with CML. Cell Physiol J. 227(6): 2798-803

438) Cipollone, R., Ascenzi, P., Tomao, P., Imperi, F., and Visca, P. 2008. Enzymatic cyanide detoxification: evidence from Pseudomonas aeruginosa rhodanese. J Mol Microbial Biotechnol. 15(2-3): 199-211

439) Clark, L.C., Alberts, D.S. 1995. Selenium and cancer: risk or protection?. J National Cancer Institute 87(7): 473-475

440) Clark, L.C., Combs, G.F., Turnbull, B.W. et al. 1996. Effects of selenium supplementation for cancer prevention in patients with skin carcinoma. A randomized controlled trial. Cancer nutritional prevention study group. Journal of the American Medical Association. 276(24): 1957-1963.

441) Clarke, L.H., Clarke, C.R. and Lippman, M. 1999. The influence of maternal diet on the risk of breast cancer in female offspring. Nutrition. 15(5):392-401.

442) Clayton, EH, Hanstock, TL, Garg, ML, and Hazell, PL. 2007. Omega-3 long-chain polyunsaturated fatty acids in the treatment of psychiatric disorders in children and adolescents. Act of neuropsychiatry. 19(2):92-103.

443) Cleland, LG, James, MJ, & Proudman, SM 2003. The role of fish oils in the treatment of rheumatoid arthritis. Drugs 63(9):845-853.

444) Cochrane , DR , Bernales , S , Jacobsen , BM , Cittelly , DM , Howe , EN , D'Amato , NC , Spoelstra , NS , Edgerton , SM , Jean A , Guerrero , J , Gomez , F , Medicherla , . S. , Alfaro , IE , McCullagh , E , Jedlicka , P , Torkko , K , Thor , AD , Elias , AD , Protter , AA and Richer , JK 2014 Cancer and preclinical analysis of enzalutamide. Carcinoma research. 16:R7, doi:10.1186/bcr3599

445) Cohen-Lahav, M., Shany, S., Tobvin, D., Chaimovitz, C., & Douvdevani, A. 2006. Vitamin D decreases NFkappa B activity by increasing IkappaBalpha levels. Nephrol Dial transplant. 21(4):889-97

446) Cole, A. L. 2009. New discoveries in the biology and detection of human chorionic gonadotropin. Reprod Biol Endocrinol. 7:8, doi: 1186/1477-7827-7-8, 37 pages

447) Cole, B.F., Baron, J.A., Sandler, R.S., Haile, R.W. et al. 2007 Folic acid for the prevention of colorectal adenomas. NEVER. 297(21):2351-2359 (more than 20 authors)

448) Cole, B.J.W., Bentley, M.D. and Hua, Y. 1991. Triterpenoid extracts in the outer bark of Betula lenta (black birch). wood research. 45(4): 265-268

449) Cole, G.M., Ma, Q.L. and Frautschy, S.A. 2009. Omega-3 fatty acids and dementia. Prostaglandins, Leukotrenes, and Essential Fatty Acids, 81(10):213-221.

450) Colin, A., Reggers, J., Castronova, V., & Ansseau, M. 2003. Lipids, depression, and suicide. encephalon 29(1): 49-58.

451) Colin, E.M., Uitterlinden, A.G., Meurs, J.B., Bergink, A.P., van de Klift, M., Fang, Y., Arp, PP, Hofman, A., van Leeuwen, J.P. and Pols, H.A. 2003. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype affects vertebral fracture risk. J Clin Endocrinol Metab. 88(8):3777-84

452) Conaway, C. C., Getahun, S. M., Liebes, L. L., Pusateri, D. J., Topham, D. K., Botero-Omary, M. und Chung, F. L. 2000. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed broccoli and fresh. Nutr Krebs. 38(2): 168-178

453) Confield, S.E., Zhiu, K., Williams, S.A. and McConkey, D.J. 2006. Bortezomib inhibits docetaxel-induced apoptosis through a p21-dependent mechanism in human prostate cancer cells. Mol Cancer Ther. 5(8): 2043-50

454) Connelly-Frost, A., Poole, C., Satia, J.A., Kupper, L.L., Millikan, R.C. and Sandler, R.S. 2006. Selenium, apoptosis, and colorectal adenomas. Epidemiology, biomarkers and cancer prevention. 15(3): 486-493

455) Connor, W.E., Neuringer, M., and Lin, D.S. 1990. Dietary effects on brain fatty acid composition, reversibility of n-3 fatty acid deficiency, and brain docosahexaenoic acid turnover and brain, erythrocyte, and plasma docosahexaenoic acid turnover in rhesus monkeys. Lipid Research Journal. 31(2): 237-247.

456) Conray, SM, Koga, K, Woolcott, CG, Dahl, T, Byrne, C, Nagata, C, Ursin, G, Yaffe, MJ, Vachon, CM, & Maskarinec, G. 2012. Higher alcohol consumption can altering the association between mammographic density and breast cancer: analysis of three case-control studies. cancer epidemiology. 36(5): 458-460

457) Cooney RV, Franke AA, Harwood PJ, Hatch-Pigott V, Cuter LJ and Mordan LJ 1993. Nitrogen dioxide detoxification with gamma-tocopherol: superiority over alpha-tocopherol. Proc Natl Acad Sci USA. 90(5):1771-5

458) Cordero-Herrera, I., Martin, M.A., Bravo, L., Goya, L., Ramos, S. 2013. Epicatechin gallate induces cell death through p53 activation and p38 stimulation and JNK in human colon cancer SW480 cells. Walnut cancer. 65(5):718-28

459) Coriat, R., Nicco, C., Chereau, C., Mir, O., Alexandre, J., Ropert, S., Weill, B., Chaussade, S., Goldwasser, F., and Batteux, F. 2012. Sorafenib-induced cell death in hepatocellular carcinoma is dependent on the production of reactive oxygen species in vitro and in vivo. Mol Cancer Ther. 11(10):2284-93

460) Corral, L.G., Haslett, P.A., Muller, GW, Chen, R., Wong, LM, Ocampo, CJ, Patterson, RT, Stirling, D.I. and Kaplan, G. 1999. Differential cytokine modulation and T-cell activation by two different classes of thalidomide analogs that are potent inhibitors of TNF-alpha. J Immunol. 163(1):380-6

461) Correa-Betanzo, J., Jacob, J. K., Perez-Perez, C. & Paliyath, G. 2011. Effect of an edible sodium caseinate coating on phytochemicals of berry cactus (Myrtillocactus geometrizans) fruits. Food Res Int. 44(7): 1897-1904

462) Corriveau, C. C., Madara, P. J., Van Dervort, A. L., Tropea, M. M., Wesley, R. A. y Danner, R. L. 1998. Effects of stickoxide on chemotaxis and endotoxin-pressed interleukin-8 production in human neutrophils. J Infektionsdis. 177(1): 116-26

463) Cortes, M., Liu, Y. S., Kwan, W., Alexa, K., Goessling, W., & North, ET 2015. Accumulation of the vitamin D precursor cholecalciferaol antagonizes hedgehog signaling to promote the formation of the hemogenic endothelium. Stem Cell Reports. 5(4): 471-479

464) Costa, D., Campos, N., Rangel, L., Zanphorlin, L., Ramos, C., & Silva, J. 2014. Resveratrol prevents p53 core domain aggregations (754.1). The FASEB Journal. 28 (1 supplement), poster. 754.1

465) Coulibaly, A., Kouakou, B., and Chen, J. 2011. Phytic acid in cereal grains: structure, healthy or harmful ways to reduce phytic acid in cereal grains, and its impact on nutritional quality. American Journal of Plant Nutrition and Fertilization Technology. 1(1): 1-22

466) Crane C, Panner A, Pieper RO, Arbiser J, and Parsa AT 2009. Honokiol-mediated inhibition of the PI3K/mTOR pathway: a potential strategy for excessive immunoresistance in glioma, breast and prostate carcinoma without affecting the function of the T cells. J Immunotro. 32(6):585-92

467) Cravo, M., Fidalgo, P., Pereira, AD, Gouveia-Oliveira, A., Chaves, P., Selhub, J., Mason, J.B., Mira, F.C. and Leito, C.N. 1994. DNA methylations an intermedia Biomarkers in colorectal cancer: modulation by folic acid supplements. Eur J Cancer Before. 3(6): 473-9

468) Crawford, S., Belajic, D., Wei, J., Riley, P.J., Dunford, J.P., Bembenek, S., Fourie, A., Edwards, P.J., Karlsson, L., Brunmark, A., Wolin , L. R. and Blevitt, M. J. 2008. A new inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing that IL-8 is a potential pharmacodynamic biomarker. Mol Cancer Ther. 7(3): 492-9

469) Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J and Frytak S 1979. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer . A controlled study. N Engl. J Med. 301(13):687-90

470) Cromie, M. M. and Gao, W. 2015. Epigallocatechin-3-gallate enhances the therapeutic effect of leptomycin B in human lung cancer A549 cells. Oxidative medicine and cellular longevity. Vol. 2015, Article ID 217304, doi: 10.1155/2015/217304, 10 pages

471) Cross, A.J. and Sinha, R. 2004. Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ mol mutagen. 44(1): 44-55

472) Cross, RK and Wilson, KT 2003. Nitric oxide in inflammatory bowel disease. Inflammatory Bowel Disease 9(3): 179-89

473) Crowell, A.J., Steele, E.V., Sigman, CC, and Fay, R.J. 2003. Is inducible nitric oxide synthase a target for chemoprevention? Mol Cancer Ther. 2(8):815-23

474) Crowston JG, Chang LH, Constable PH, Daniels JT, Akbar AN and Khaw PT 2002. Apoptosis gene expression and death receptor signaling in human cone capsular fibroblasts treated with mitomycin c. Reverse Ophthalmol Vis Sci. 43(3): 692-9

475) Croxtall, J.D., Emmas, C., White, J.O., Choudhary, Q., and Flower, R.J. 1994. Tamoxifen inhibits the growth of estrogen receptor-negative A549 cells. Biochem Pharmacol. 47(2): 197-202

476) Croxtall, J.D., van Hal, P.T., Choudhury, Q., Gilroy, D.W. and Flower, R.J. 2001. Several glucocorticoids differ in their genomic and non-genomic mechanism of action in A549 cells. Br J Pharmacol. 135(2):511-519

477) Cui, R., Liu, Z. and Xu, Q. 2014. Blood, α-tocopherol levels and risk of prostate cancer: a meta-analysis of prospective studies. More one. 9(3):e9304. Doi: 10.1371/journal.pone.0093044, 7 pages.

478) Cui, Y., Morgenstern, H., Greenland, S., Tashkin, P.D., Mao, T.J., Cai, L., Cozen, W., Mack, MT., Lu, Q. & Zhang, Z. 2008 Dietary intake of flavonoids and lung cancer: a population-based case-control study. Cancer. 112(10): 2241-2248

479) Cullen, S. P. and Martin, S. J. 2009. Activation pathways to capsizing: some recent developments. cell death and differentiation. 16:935-938, doi:10.1038/cdd.2009.59

480) Cuzick, J. und Baum, M. 1985. Tamoxifen and Controlateral Breast Cancer. Lanzette. 2(8449): 282, doi: 10.1016/S0140-6736(85)90338-1

481) Cuzzocrea, S., Bruscoli, S., Crisafulli, C., Mazzon, E., Agostini, M., Muia, C., Esposito, E., Di Virgilio, R., Meli, R., Vegeto, E., Maggi, A. and Riccardi, C. 2007. The estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effects of glucocorticoids. Molecular Pharmacology. 71(1): 132-144

482) D'Andrea, G. 2015. Quercetin: a flavonol with multiple therapeutic applications? physical therapy. 106: 256-271, doi: 10.1016/j.fitote.2015.09.018

483) D'Eliseo, D. & Velotti, F. 2016. Omega-3 fatty acids and cancer cell cytotoxicity: implications for targeted cancer therapy. J.Clin. 5(2): 15

484) D'mello, P., Gadhwal, M. K., Joshi, U., & Shetgiri, P. 2011. Modeling of the COX-2 inhibitory activity of flavonoids. Akademische Wissenschaften. 3(4): 33-40

485) D'Uscio, L.V., Milstien, S., Richardson, D., Smith, L., and Katusic, Z.S. 2003. Long-term treatment with vitamin C increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res. 92(1):88-95

486) Da Costa DCF, Casanova FA, Quarti J, Malheiros MS, Sanches D, dos Santos PS, Fialho E, and Silva JL 2012. Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells: PlosOne 7( 11): e48746, doi: 10.1371/journal.pone.0048746, 12 pages

487) Dai C, Tang S, Deng S, Zhang S, Zhou Y, Velkov T, Li J, and Xiao X, 2015 Mice on activation of the Nrf2/HO-1 signaling pathway. Antimicrobials and chemotherapy. 59(1): 579-585, doi: 1128/AACO3925-14

488) Dai, Y., Dent, P. and Grant, S. 2002. Induction of apoptosis in human leukemia cells by CDK1 inhibitor. Zellzyklus. 1(2): 143-152

489) Dall'Asta, C., Galaverna, G., Biancardi, A., Gasparini, M., Sforza, S., Dossena, A. and Marchelli, R. 2004. Simultaneous liquid chromatography-A-type fluorescence analysis and Type B trichothecenes as fluorescent derivatives by reaction with coumarin-3-carbonyl chloride. chromatography J. A. 1047(2): 241-7

490) Dallaglio, K., Bruno, A., Cantelmo, A.R., Esposito, A.I., Ruggiero, L., Orecchioni, S., Calleri, A., Bertolini, F, Pfeffer, U., Noonan, D.M. and Albini, A. 2014. Paradoxical effects of metformin on endothelial cells and angiogenesis. carcinogenesis. 35(5): 1055-66

491) Daly , T. , Ryan , E. , Aherne , SA , O'Grady , M.N. , Hayes , J. , Allen , P. , Kerry , J.P. . and O'Brien, N.M. 2010. Bioactivity of ellagic acid, lutein -o Sesamol-enriched meat pastries evaluated by in vitro digestion and a Caco-2 cell model system. International food research. 43(3):753-760

492) Dameron, K. M., Volpert, O. V., Tainsky, M. A. y Bouck, N. 1994. Control of angiogenese in fibroblasts by p53 Regulation of Thrombospondin-1. Wissenschaft. 265 (5178): 1582-4

493) Danaei, G., Ding, E.L., Mozaffarian, D. et al. 2009. Comparative risk assessment of diet, lifestyle, and metabolic risk factors. PLOS Medicine. 6:4. 23 pages

494) Dang, CV 2012. Links between metabolism and cancer. Gene Dev. 26(9):877-90

495) Daniel, C., Schröder, O., Zahn, N., Gasschott, T., & Stein, J. 2004. The P38-MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression. Communication. 324(4): 1220-1226

496) Daniels, R. T., Ortiz-Sanchez, E., Luria-Perez, R., Quintero, R., Helguera, G., Bonavida, B., Martinez-Maza, O., and Penichet, L. M. 2011. An antibody is based on a multifaceted approach targeting the human transfer receptor for the treatment of B-cell malignancies. J Immunotro. 34(6): 500-508

497) Daniels, T.R., Bernabeu, E., Rodriguez, J.A., Patel, S., Kozman, M., Chiappetta, DA, Holler, E., Ljubimova, J.Y., Hulguera, G. and Penichet, M.L. 2012. Receptor transmission and targeted delivery of cancer therapies. Biochim Biophys Act. 1820(3): 291-317

498) Darnell, J. E. 2002. Transcription factors as targets for cancer therapy. Naturberichte Krebs. 2(10): 740-749

499) Dartigues, J., Dabis, F., Gros, N., Moses, A., Bois, G., Salamon, R., Dilhuydy, J., and Courty, G. 1990 risk of squamous cell lung cancer in the South-West of France. Eur J Epidemiol. 6(3): 261-265

500) Das, A., Banik, NL and Ray, SK 2009. Flavonoids activated caspases for apoptosis in T98G and U87MG human glioblastoma cells, but not in normal human astrocytes. Cancer. 116(1): 164-176

501) Das, M., Das, S., Wang, P., Powell, S. R., Das, D. K. 2008. Caveolin and proteasome in tecotrienol-mediated myocardial protection. Zellphysiol. Biochemistry 22(1-4): 287-94

502) Das, S. K. and Hoefler, G. 2013. The role of triglyceride lipases in cancer-associated cachexia. Trends in Molecular Medicine. 19(5):292-301

503) Dasgupta, S. and Bhattacharyya, D.K. 2007. Nutritional effects of eicosapentaenoic acid (EPA)-containing soybean pholipid. Oleoscience Magazine. 56(11): 563-568.

504) Dasmahapatra, G., Yerram, N., Dai, Y., Dent, P., and Grant, S. 2007. Synergistic interactions between vorinostat and sorafenib in chronic myeloid leukemia cells involve downregulation of Mcl- 1 and p21C1P1. Cancer Clinic Res. 13(14): 4280-90

505) Datta, A., Loo, S.Y., Huang, B., Wong, L., Tan, S. SL, Tan, TZ, Lee, S, Thiery, JP, Lim, YC, Yong, WP, Lam, Y , Kumar, AP, & Yap, CT 2014. SPHK1 regulates survival and proliferative responses in triple-negative breast cancer. oncotarget 5(15): 5920-5933

506) Daughaday, W. H. 1989. A personal history of the origin of the somatomedin hypothesis and recent challenges to its validity. biological person Med. 32(2):194-211

507) David, O., Jett, J., LeBeau, H., Dy, G., Hughes, J., Friedman, M., and Brody, AR 2004. Overexpression of Phospho-Akt in lung cancer cells. non-small confers significantly more survival disadvantage independent of stage. Cancer Clinic Res. 10(20): 6865-6871

508) Davidson, M.H. and Geohas, C.T. 2003. Efficacy of over-the-counter dietary supplements. Current reports of atherosclerosis. 5(1): 15-21.

509) Davies, D. R., Bindschedler, L. V., Strickland, T. S. and Bolwell, G. P. 2006. Production of reactive oxygen species in suspension cultures of Arabidopsis thaliana cells in response to a Fusarium oxysporum trigger: implications for basal resistance. Journal of Experimental Botany. 57(8): 1817-1827

510) Daviglus, M.L., Dyer, AR, Persky, V., Chavez, N., Drum, M., Goldberg, J., Liu, K., Morris, D.K., Shekelle, R.B. and Stamler, J. 1996. Dietary Beta-carotene, vitamin C, and risk of prostate cancer: results of the Western Electric study. Dietary antioxidants and prostate cancer. 7(5):472-476

511) Davis, CD, Zeng, H & Finley, JW 2002. Selenium-enriched broccoli reduces tumorigenesis in mice with multiple intestinal neoplasms. J Nutr. 132(2):307-9

512) Davis, R., Singh, K.P., Kurzrock, R., & Shankar, S. 2009. Sulforaphane inhibits angiogenesis by activating FOXO transcription factors. Oncol Rep. 22(6):1473-8

513) Davis, S.R., Quinlivan, E.P., Shelnut, K.P., Ghandour, H., Capdevila, A., Coats, B.S., Wagner, C., Shane, B., Selhub, J., Bailey, L.B., Shuster, J.J. , Stacpoole, P.W. and Gregory, J.F. 2005. Homocysteine ​​synthesis is increased, but overall remethylation is not affected by the methylenetetrahydrofolate reductase 677C→T polymorphism or dietary folate restriction in young women. J Nutr. 135(5): 1045-1050

514) Day, Pg. 1999. Cancer, why are we still anxious to know the truth. Publisher: Credence Publications. Later edition (May 1999). ISBN-10: 095301248, 202 pages, USA

515) Dayan, G., Lupien, M., Auger, A., Anghel, SI, Rocha, W., Croisetiere, S., Katzenellenbogen, J. A., & Mader, S. 2006. Tamoxifen and raloxifene differ in their interactions functional with aspartate 351 estrogen receptor α. Molecular Pharmacology. 70(2): 579-588

516) De Haes, W., Frooninckx, L., Van Assche, R., Smolders, A., Depuydt, G., Billen, J., Braeckman, BP, Schoofs, L. y Temmerman, L. 2014. Metformina promueve la esperanza de vida a través de la mitohormesis a través de la peroxirredoxina PRDX-2. Proc Natl Acad Sci USA. 111(24): E2501-E2509

517) De Marchi, U., Biasutto, L., Garbisa, S., Toninello, A., & Zoratti, M. 2009. Quercetin may act as an inhibitor or inducer of mitochondrial permeability transition: a demonstration of the ambivalent redox character of polyphenols. Biochim Biophys Act. 1787(12): 1425-32

518) de Mattos, F.S., Villalonga, P., Clardy, J. and Lam, E.W. 2008. FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther. 7(10):3237-46

519) De Oliveira, J.M.P.F., Costa, M., Pedrosa, T., Pinto, P., Remedios, C., Oliveira, H., Pimentel, F., Almeida, L. and Santos, C. 2014. Sulforaphane induces Oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling. Plus one. 9(3): e92980, doi: 10.1371/journal.pone.0092980, 11 pages.

520) De Stefani, E., Boffetta, P., Ronco, A.L., Deneo-Pellegrini, H., Acosta, G., Gutierrez, L.P. and Mendilaharsu, M. 2008. Nutrient Patterns and Lung Cancer Risk: A Factor Analysis in Uruguayan Men. lung cancer. 61(3):283-291

521) De Wardener, H.E., He, F.J. and MacGregor, G.A. 2004. Plasma sodium and hypertension. International Kidney. 66(6): 2454-2466.

522) De, P., Dey, N., Terakedis, B., Bergsagel, P.L., Li, Z.H., Mahadevan, D., Garlich, J.R., Trudel, S., Makale, M.T. and Durden, D.L. 2013. Anintegrin- The pan-isoform phosphoinositide-3-kinase targeting inhibitor SF1126 has in vivo activity against multiple myeloma. Cancer Chemother Pharmacol. 71(4):867-81

523) Debeb, B.G., Cohen, E.N., Boley, K., Freiter, EM., Li, L., Robertson, F.M., Reuben, J.M., Cristofanilli, M., Buchholz, T.A. and Woodward, W.A. 2012. Preclinical studies of the Notch signaling pathway inhibitor RO4929097 in inflammatory breast cancer cells. breast cancer treatment. 134(2): 495-510

524) Degirolamo, C., Modica, S., Palasciano, G., & Moschetta, A. 2011. Bile acids and colon cancer: solving the puzzle with nuclear receptors. Trends in Molecular Medicine. 17(10):564-572

525) Degner, S. C., Papoutsis, A. J., Selmin, O. und Romagnolo, D. F. 2009. Targeting aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by indole-3-carbinol metabolizes 3,3 'diindolylmethane in breast cancer cells. J Nutr. 139(1): 26-32

526) Deladeriere , A. , Gambardella , L. , Pan , D. , Anderson , K. E. , Hawkins , P. T. and Stephens , L. R. 2015. Sci-Signal. 8(360):ra8, doi:10.1126/scisignal.2005564, September 6th

527) Delgado-Vargas, F., Juimenez, A.R. and Parades-Lopez, O. 2000. Natural pigments: carotenoids, anthocyanins and betalains - properties, biosynthesis, processing and stability. Critical Reviews in Food Science and Nutrition. 40(3)= 173-289

528) Delie, F., Petignat, P., & Cohen, M. 2012. GRP78 protein expression in ovarian cancer patients and prospects for a targeted approach. Oncology Journal. Article ID: 468615, 5 pages

529) Dell'Aica, I., Dona, M., Sartor, L., Pezzato, E. and Garbisa, S. 2002. (-) Epigallocatechin-3-gallate directly inhibits MT1-MMP activity, which leads to accumulation of leads MMP-2 at the cell surface. invest in lab 82(12): 1685-93

530) Demark-Wahnefried, W., Price, D.T., Polascik, T.J. et al. 2001. Pilot study of dietary fat reduction and flaxseed supplementation in men with prostate cancer before surgery. Exploring the effects on hormone levels, prostate specific antigen and histopathology. Urology. 58 (6 Suppl 1): 42–52.

531) DeMichele, A., Clark, A.S., Tan, KS, Heitjian, D.F., Gramlich, K., Gallagher, M., Lal, P., Feldman, M., Zhang, P., Colameco, C., Lewis , D, Langer, M, Goodman, N, Domchek, S, Gogineni, K, Rosen, M, Fox, K, and O'Dwyer, P. 2015. CDK 4/6 inhibitor palbociclib (PDO332991) in Rb+ breast cancer advanced: phase II activity, safety and evaluation of predictive biomarkers. Cancer Clinic Res. 21(5): 995-1001

532) Demma, M., Maxwell, E., Ramos, R., Liang, L., Li, C., Hesk, D., Rossman, R., Mallams, A., Doll, R., Liu, M. ., Seidel-Dugan, C., Bishop, W. R., and Dasmahapatra, B. 2010. SCH529074, a small molecule activator of mutant p53 that binds to the DNA-binding domain (DBD) of p53, restores the suppressive function of p53. growth of p53 mutant. p53 and disrupts HDM2-mediated ubiquitination of wild-type p53. JBiolChem. 285(14): 10198-212

533) Deng, C., Zhang, P., Harper, J.W., Elledge, S.J. and Leder, P. 1995. Mice lacking p21CIP1 undergo normal development but are defective in G1 checkpoint control. Cell. 82(4): 675-84

534) Deng, L., Ding, W., and Granstein, R.D. 2003. Thalidomide inhibits tumor necrosis factor alpha production and antigen presentation by Langerhans cells. J Invest Dermatol. 121(5): 1060-5

535) Deng, YT, Huang, HC & Lin, JK 2010. Rotenone induces ROS-mediated apoptosis in MCF-7 human breast cancer cells through JNK and p38 signalling. carcinogenic mole 49(2):141-51

536) Derr RL, Ye X, MU Islands, Desideri S, Saudek CD, and Grossman SA 2009. Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma. J Clin Oncol. 27(7): 1082-1086

537) Deryugina, E.I. and Quigley, J.P. 2006. Matrixmetalloproteinases and tumor metastasis. Cancer and metastasis reviews. 25(1):9-34

538) Desphande, A., Sicinski, P. und Hinds, P. W. 2005. Cycline and cdks in development and cancer: a perspectiva. Onkogen. 24(17): 2909-2915

539) Dessi, S., Batetta, B., Cherchi, R., Onnis, R., Pisano, M., and Pani, P. 1988. Hexomonophosphate shunting enzymes in normal glucose-6-phosphate dehydrogenase lung tumors and -Lack of Oncology topics. 45: 287-291, doi: 10.1159/000226624

540) Devin, A., Lin, Y., Yamaoka, S., Li, Z.W., Karin, M., and Liu, Z.G. 2001. Alpha and beta subunits of kinase I kappa B (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. molecular and cell biology. 21(12): 3986-3994

541) Devitt, L.C., Fanning, K., Dietzgen, R.G. and Holton, T.A. 2010. Isolation and functional characterization of a lycopene beta-cyclase gene that controls the color of papaya fruit (Carica papaya L.). J Exp Bot. 61(1):33-9

542) Devore, E.E., Grodstein, F., Van Rooij, F.J. et al. 2009. Dietary intake of fish and omega-3 fatty acids in relation to long-term risk of dementia. American journal of clinical nutrition. 90(1): 170-176.

543) Dewar, R., Chen, S., Yeckes-Rodin, H., Miller, K., & Khosravi-Far, R. 2011. Bortezomib treatment induces remission in a Ph+ALL patient displaying FoxO as markers theranostics. Cancer Biol. Ther. 11(6):552-558

544) Dhadayuthapani, S., Marimuthu, P., Hormann, V., Kumi-Diaka, J., and Rathinavelu, A. 2013. Induction of apoptosis in HeLa cells by caspase activation by resveratrol and genistein. Food J Med. 16(2): 139-4

545) Dhawan, P. and Richmond, A. 2002. A novel NF-kappa B-inducing MAPK-kinase signaling pathway positively regulates NF-kappa B activity in melanoma cells. JBiolChem. 277(19):7920-8

546) Dhir, A., Padi, S. S., Naidu, P. S. und Kulkarni, S. K. 2006. Protective effect of naproxen (non-selective COX inhibitor) or rofecoxib (selective COX-2 inhibitor) on biochemical and behavioral changes induced by immobilization stress in Mausen. Eur J Pharmacol. 535(1-3): 192-8

547) Di Maro G, Salerno P, Unger K, Orlandella FM, Monaco M, Chiappetta G, Thomas G, Oczko-Wojciechowska M, Masullo M, Jarzab, B., Santoro, M. and Salvatore, G. 2014. Anterior gradient protein 2 promotes survival, migration, and invasion of thyroid papillary carcinoma cells. molecular cancer. 13:160, doi:10.1186/1476-4598-13-160

548) Di Tomo, P., Canali, R., Ciavardelli, D.D., Di Silvestre, S., De Marco, A., Giardinelli, A., Pipino, C., Di Pietro, N., Virgili, F., and Pandolfi, A. 2012. B-carotene and lycopene affect the endothelial response to TNF-α, thereby reducing nitrooxidative stress and interaction with monocytes. Molecular nutrition and food research. 56(2):217-27

549) Diccianni, MB, Yu, J, Mepelink, G, de Vries, M, Shao, L, Gebauer, S, Shih, H, Roberts, W, Kilcoin, NP, Pullen, J., Carson, DA, and Yu, A. L. 2004. 3-Aminothioacridone inhibits DNA synthesis and induces DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. J Exp Ther Oncol. 4(3):223-3

550) Dickinson, SE, Melton, TF, Olson, ER, Zhang, J, Saboda, K, and Bowden, GT 2009. AP-1 inhibition by sulforaphane involves interaction with cysteine ​​in the DNA-binding domain of cFos; Implications for chemoprevention of UVB-induced skin cancer. Cancer research. 69(17): 7103-7110

551) Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE and Reedijk M 2007. High level JAG1 mRNA and protein predict poor outcome in breast cancer. pathol mode 20(6): 685-93

552) Dietrich, M., Traber, M.G., Jacques, PF, Cross, CE, Hu, Y. and Block, G. 2006. Review Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review. Jelly. cabbage. nutrition 25(4):292-9

553) Ding, X., Hiraku, Y., Ma, N., Kato, T., Saito, K., Nagahama, M., Semba, R., Kuribayashi, K. & Kawanishi, S. 2005. Nitric inducible Oxide synthase-dependent DNA damage in a mouse model of inflammatory bowel disease. Cancer Science 96(3):157-63

554) Ding Y, Yang M, She S, Min H, Xv X, Ran X, Wu Y, Wang W, Wang L, Yi L., Yang, Y. and Gao, Q. 2015. iTRAQ-based quantitative proteomic analysis of cervical cancer. International Journal of Oncology. 46(4): 1748,1758

555) Dinkova-Kostova, A. T., Fahey, J. W., Wade, K. L., Jenkins, S. N., Shapiro, T. A., Fuchs, E. J., Kerns, M. L., and Talalay, P. 2007. Induction of the phase 2 response in mouse skin and human by sulforafanohaltige Brokkolisprossenextrakte. Biomarker for Krebseepidemien Prev. 16(4):847-51

556) Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Hoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., and Talalay, P. 2002. Direct evidence that sulfhydryl groups of Keap 1 are the sensors that regulate the induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA. 99(18): 11908-13

557) Dip, R., Lenz, S., Gmuender, H., & Naegeli, H. 2009. Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 47(4): 787-95

558) Diwadkar-Navsariwaka, V. and Diamond, A.M. 2004. The link between selenium and chemoprevention: a case for selenoproteins. Nutrition Magazine. 134(11):2899-2902.

559) Dixit, D., Ghildiyal, R., Anto, N. P., Ghosh, S., Sharma, V., and Sen, E. 2013. Guggulsterone sensitizes glioblastoma cells to SANT-1-induced apoptosis of the sonic hedgehog inhibitor in a Ras/NFkB-dependent pathway. cancer letters 336(2): 347-358

560) Do, MH, Lee, SS, Jung, PJ, & Lee, MH 2003. Dietary intake of fat and vitamins in relation to breast cancer risk in Korean women: a case-control study. J Korean Med Sci. 18(4):534-540

561) Do MT, Kim HG, Khanal T, Choi JH, Kim DH, Jeong TC, and Jeong HG 2013. Metformin inhibits heme oxygenase-1 expression in cancer cells by inactivating Raf-ERK- signaling and pharmacology Nrf2. 271(2): 229-238

562) Do MT, Kim HG, Tran TT, Khanal T, Choi JH, Chung YC, Jeong TC, and Jeong HG 2014. Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by downregulating expression of the aryl hydrocarbon receptor. Toxicol Appl Pharmacol. 280(1): 138-48

563) Dolai, S., Pal, S., Yadav, R. K., & Adak, S. 2011. Stress-induced endoplasmic reticulum apoptosis in Leishmania by a caspase-independent mechanism. JBiolChem. 286(15):13638-46

564) Dolatabadian, A., Sanavy, SAMM, and Chashmi, N.A. 2008. Emphasizing the effects of foliar application of ascorbic acid (vitamin C) on antioxidant enzyme activities, lipid peroxidation, and proline accumulation of rapeseed (Brassica napus L.) under saline conditions. Magazine of Agronomy and Crop Sciences. 194(3):206-213

565) Doleckova, I., Rarova, L., Gruz, J., Vondrusova, M., Strnad, M. und Krystof, V. 2012. Antiproliferative and antiangiogenic effects of the flavones eupatorin, an active component of the chloroform extract of Orthosiphon stamineus Blatter. Phytotherapy. 83(6):1000-7

566) Domingues-Faria, C., Chanet, A., Salles, J., Berry, A., Giraudet, C., Patrac, V., Denis, P., Bouton, K., Goncalves-Mendres, N. , Vasson, M., Boirie, Y., and Walrand, S. 2014. Vitamin D deficiency downregulates the Notch pathway and contributes to skeletal muscle atrophy in aged Wistar rats. nutrition and metabolism. 11:47, doi: 10.1186/1743-7075-11-47, 13 pages

567) Don-Doncow, N., Escobar, Z., Johansson, M., Kielstrom, S., Garcia, V., Muñoz, E., Sterner, O., Biartell, A. & Hellsten, R. 2014. Galellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. JBiolChem. 289(23): 15969-78

568) Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, and Kiyama, R. 2013. Brefeldin A is an estrogenic activating Erk 1/2 component in the mycelium extract of Agaricus blazei. J Agricultural food chemistry. 61(1):128-36

569) Dong X, Wang G, Zhang G, Ni Z, Suo J, Cui J, Cui A, Yang Q, Xu Y, and Fan L 2013. Endothelial lipase protein is a promising urinary biomarker for the diagnosis of gastric cancer. Diagnostic pathology. 8(1): 45-54

570) Donnelly, A. and Blagg, B. S. 2008. Novobiocin and additional inhibitors of the C-terminal nucleotide binding pocket of Hsp90. Curr Med. Chem. 15(26): 2702-17

571) Donnely, E. T., McClure, N. and Lewis, S. E. 1999. The effect of in vitro ascorbate and alpha-tocopherol supplementation on DNA integrity and hydrogen peroxide-induced DNA damage in human sperm. mutagenesis. 14(5):505-12

572) Dörrie, J., Gerauer, H., Wachter, Y. and Zunino, S.J. 2001. Resveratrol induces extensive apoptosis through depolarization of mitochondrial membranes and activation of caspase-9 in acute lymphoblastic leukemia cells. res of cancer 61(12): 4731-9

573) Drasch, G., Schöpfer, J. und Schrauzer, G. N. 2005. Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and non-smokers, and relevant to the protective effects of selenium against cancer . Biol Spurenelementres. 103(2):103-7

574) Drobnjak, M., Osman, I., Scher, H.I., Fazzari, M., & Cordon-Cardo, C. 2000. Cyclin D1 overexpression is associated with prostate cancer metastatic to bone. Cancer Clinic Res. 6(5):1891-5

575) Du, J., Cullen, J.J. and Buettner, G.R. 2012. Ascorbic Acid: Chemistry, Biology, and Cancer Treatment. Biochemistry and Biophysics Act. 1826(2):443-457

576) Du, J., Daniels, D. H., Asbury, C., Venkataraman, S., Liu, J., Spitz, DR, Oberley, L. W., and Cullen, J. J. 2006. Mitochondrial production of reactive oxygen species mediates cytotoxicity induced by dicumarol in cancer cells. The Journal of Biological Chemistry. 281(49): 37416-37426

577) Duan, Z., Bradner, J., Greenberg, E., Mazitschek, R., Foster, R., Mahoney, J., and Seiden, M.V. 2007. 8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a new inhibitor of Janus kinase-2, increases the Chemotherapy sensitivity in human ovarian cancer cells. Mol Pharmacol. 72(5):1137-45

578) Dudzik P, Dulinska-Litewka J, Wyszko E, Jedrychowska P, Opalka M, Barciszewski J and Laidler P 2011. Effects of kinetin riboside on proliferation and proapoptotic activities in normal and cancerous human cell lines. J Cell Biochem. 112(8):2115-2

579) Duffy, SM, Lawley, WJ, Kaur, D, Yang, W, & Bradding, P. 2003. Inhibition of human mast cell proliferation and survival by tamoxifen associated with ion channel modulation. J Allegy Clin Immunol. 112(5):965-72

580) Dulinska , J. , Gil , D. , Zagajewski , J. , Hartwich , J. , Bodzioch , M. , Dembinska-Kiec , A. , Langmann , T. , Schmitz , G. and Laidler , P. 2005 . Differential effect of beta-carotene on prostate cancer cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular bases of diseases. 1740(2):189-201

581) Dulinska, J., Gil, D., Zagajewski, J., Hartwich, J., Bodzioch, M., Dembinska-Kiec, A., Langmann, T., Schmitz, G. & Laidler, P. 2005. Differential effect of beta-carotene on the proliferation of prostate cancer cells. Biochimica et Biophsica Acta (BBA) - Molecular bases of diseases. 1740(2): 189-201

582) Dumble , M. , Crouthamel , M. , Zhang , S. , Schaber , M. , Levy , D. , Robell , K. , Liu , Q. , Figueroa , D.J. , Minthorn , EA , Seefeld , MA , Rouse , M. B., Rabindran, S. K., Heerding, DA and Kumar, R. 2014. Discovery of novel AKT inhibitors with enhanced antitumor activity in combination with MEK inhibitor. More one. 9(6): e100880, doi:10.1371/journal.pone.0100880, 11 pages

583) Duthie, S. J. 2011. Folate and cancer: how DNA damage, repair, and methylation influence the development of colorectal cancer. Journal of hereditary metabolic diseases. 34(1): 101-9

584) Duthie, Arthur, J.R., James, W.P.T. und Vint, S.M. 1989. 'Antioxidant status of smokers and non-smokers: Effects of vitamin E supplementation', Annals of the New York Academy of Sciences. 570, 435-438

585) Dyall, SC and Michael-Titus, A. T. 2008. Neurological benefits of omega-3 fatty acids. Neuromolecular Medicine. 10(4): 219-235.

586) Easton, D.F. How many more genes of predisposition to breast cancer are there? breast cancer research. 1(1): 14-17

587) Eder, K. and Brandsch, C. 2002. The effects of the fatty acid composition of rapeseed oil on plasma lipids and the oxidative stability of low-density lipoproteins in cholesterol-fed hamsters. European journal of lipid science and technology. 104(1):3-13.

588) Edgar AK, Nannini M, Hong R, Eigenbrot C, Schmidt S, Young A, Sampath D, Wallin JJ, and Friedman SL 2015. Abstract 2672: Characterization of the enhanced potency of the PI3K inhibitor taselinib (GDC-0032) in PI3K models and mutant cell lines. cancer res 75:2672, doi:10.1158/1538-7445.AM2015-2672

589) Edgar, K. A., Wallin, J. J., Berry, M., Lee, L. B., Prior, W. W., Sampath, D., Friedman, L. S. y Belvin, M. 2010 solide Tumore. Krebsres. 70(3): 1164-72

590) Edwards, J.A., Vinyard, TB, Wiley, R.E., Brown, DE, Collins, KJ, Perkins-Veazie, P., Baker, A.R. and Clevidence, AB 2003. Consumption of watermelon juice increases plasma concentrations of lycopene and B-carotene Inhumans. J Nutr. 133(4): 1043-1050

591) Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, and Jalili T 2007. Quercetin lowers blood pressure in hypertensive patients. J Nutr. 137(11):2405-11

592) Edwards, R., Peet, M., Shay, J., & Horrobin, D. 1998. Omega-3 polyunsaturated fatty acids in the diet and in red blood cell membranes of depressed patients. Journal of Mood Disorders. 48, (2-3): 149-155.

(Video) Insights into Cancer: Nutrition and Cancer

593) Egger, T., Schuligoi, R., Wintersperger, A., Amann, R., Malle, E., & Sattler, W. 2003. Vitamin E (alpha-tocopherol) attenuates cyclooxygenase 2 transcription and synthesis in immortal murine BV-2 microglia. Biochemistry J. 370 (Pt2): 459-467

594) Ehrhardt, M., Craveiro, B. R., Holst, I. M., Pietsch, T., & Dilloo, D. 2015. The PI3K inhibitor GDC-0941 shows promising efficacy in vitro and in vivo for targeted medulloblastoma therapy. oncotarget 6(2):802-8

595) Ehrlich, M. 2009. DNA hypomethylation in cancer cells. epigenomics. 1(2): 239-259

596) Eichholzer, M., Stahelin, H. B., Gutzwiller, F., Lüdin, E., & Bernasconi, F. 2000. Association of low plasma cholesterol with cancer mortality at different sites in men: 17-year follow-up of the prospective study from Basel. Bin J Clin Nutr. 71(2):569-574

597) Eide, M. J., Johnson, D. A., Jacobsen, G. R., Krajenta, R. J. Rao, S., Lim, H. W., and Johnson, C. C. 2011. Vitamin D and non-melanoma skin cancer in a health maintenance organization cohort. Arch Dermatol. 147(12):1379-1384

598) Eil, C. 1992. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 24(8): 367-70

599) Eileen Tan MH, Jun L, Xu HE, Melcher K, and Yong E 2015. Androgen receptor: structure, function in prostate cancer, and drug discovery. Acta Pharmacologica Sinica. 36:3-23, doi:10.10381 aps.2014.18

600) Eisenberg-Lerner, A. and Kimchi, A. 2012. PKD is a Vps34 kinase that mediates ROS-induced autophagy downstream of DAPk. distinguish cell death. 19(5):788-97

601) Eitsuka, T., Nakagawa, K. and Miyazawa, T. 2006. Negative regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocothreinol. Communications on biochemical and biophysical research. 348(1):170-175

602) Ekoff, M., Kaufmann, T., Engstrom, M., Motoyama, N., Villunger, A., Jönsson, J., Strasser, A., and Nilsson, G. 2007. The BH3-only protein PUMA play an essential role in apoptosis induced by cytokine deprivation of mast cells. Blood. 110(9): 3209-3217

603) El Hajji, H., Nkhili, E., Tomao, V., & Dangles, O. 2006. Interactions of quercetin with iron and copper ions: complexation and autoxidation. Free Radical Res. 40(3): 303-20

604) Elamin, M. H., Shinwari, Z., Hendrayani, S. F., Al-Hindi, H., Al-Shail, E., Khafaga, Y., Al-Kofide, A., & Aboussekhra, A. 2010. Curcumin inhibits the sonic hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. carcinogenic mole 49(3):302-1

605) Elbarbry, F. and Elrody, N. 2011. Potential health benefits of sulforaphane: a review of the experimental, clinical, and epidemiological evidence and the underlying mechanisms. Research Journal of Medicinal Plants. 5(4): 473-484

606) El-Bayoumy, K., Sinha, R., Pinto, J. T., & Rivlin, R. S. 2006. Cancer chemoprevention by garlic and sulfur- and selenium-containing compounds in garlic. J. Nutr. 136(3): 864S-869S

607) Elbekai, R.H., Duke, J. and El-Kadi, A.O.2007. Ascorbic acid differentially modulates the induction of hemo oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+). Cancer Lett. 246(1-2): 54-6

608) Eldahshan, O.A. and Singapore, A.N. 2013. ISSN 2278-4136, number 2DB: 2668735-5, IC Journal No: 8192. Journal of Carotenoid Pharmacognosy and Phytochemistry. 2(1):225-234

609) Elferink, J. G. and de Koster, B. M. 2000. Inhibition of interleukin-8-activated human neutrophil chemotaxis by tapsigargin in a calcium- and AMP-cycle-dependent manner. Biochem Pharmacol. 59(4): 369-75

610) Eliassen, H. A., Liao, X., Rosner, B., Tamimi, M. R., Tworoger, S. S. y Hankinson, E. S. 2015. Plasma carotinoides and risk of breast cancer over 20 y of followup. Bin J Clin Nutr. doi: 10.3945/ ajcn.114.105080, 9 Seiten

611) Elis, S., Wu, Y., Courtland, H., Cannata, D., Sun, H., Beth-On, M., Liu, C., Jasper, H., Domene, H., Karabatas , L., Guida, C., Basta-Pljakic, J., Cardoso, L., Rosen, C.J., Frystyk, J., & Yakar, S. 2011. Unbound (bioavailable) IGF1 promotes somatic growth. Dis. Model. Mech. 4(5): 649-658

612) Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O. and Oren, M. 1989. Wild-type p53 can inhibit oncogene-mediated foci formation. Proc Natl Acad Sci. 86(22):8763-6

613) Ellison, L.F. 2000. Consumption of tea and other beverages and risk of prostate cancer: a Canadian retrospective cohort study. Eur J Cancer Before. 9(2): 125-30

614) El-Najjar, N., Chatila, M., Moukadem, H., Vuorela, H., Ocker, M., Gandesiri, M., Schneider-Stock, R. and Gali-Muhtasib, H. 2010. Las reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. apoptosis. 15(2):183-95

615) El-Sayed, W. M., Aboul-Fadl, T., Roberts, J. C., Lamb, J. G., and Franklin, M. R. 2007. Murine hepatoma cells (Hepa1c1c7): a sensitive in vitro system for the induction of chemoprotective enzymes by compounds of organoselenium. In vitro toxicology. 21(1):157-164

616) El-seweidy, MM, El-swyfy, S.E., Ameen, R.S. and Hashem, R. M. 2002. Effect of aging receptor blockers and/or co-administration of anti-inflammatories on glycation, oxidative stress, and cytokine production in stz (streptozotocin) diabetic rats. Pharmacological Research. 45(5):391-398.

617) Emde, A.M., Maslak, K., Liu, H., Reles, AE, Possinger, K. and Eucker, J. 2007. Combination of fulvestrant and lapatinib in adriamycin-resistant and non-adriamycin-resistant breast cancer cell lines overexpress HER2 . Journal of Clinical Oncology. Supplement to the 25th, 18th ASCO Meeting, Abstract: 14050

618) Emmanuel, C.O. and Hubbard, V. S. 1993. Role of essential fatty acids (EFAs) in pancreatic hormone release and concomitant metabolic effect. The Journal of Nutritional Biochemistry, 4(9): 498-509.

619) Emmick, J.T., Stuewe, SR, & Mitchell, M. 2002. Review of the cardiovascular effects of tadalafil. Supplements to the European Heart Journal. 4 (additional H): H32-H47, doi:

620) Endres, S., Ghorbani, R., Kelley, V.E. et al. 1989. The effect of dietary supplementation with polyunsaturated (n-3) fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine. 320(5):265-271.

621) Engelmann, D. and Putzer, B. M. 2012. The dark side of E2F1: in transit beyond apoptosis. cancer res 72(3):571-5

622) EPA and DHA not only modulate the genes involved in NFkB, Wnt, MAPK/ERK, Akt, but also in hedgehog signaling (Abdi et al. 2014).

623) Epstein, EH 2008. Basal cell carcinomas: hedgehog attack. Nat Nev Krebs. 8(10): 743-54

624) Erdogan, A., Most, AK, Wienecke, B., Fehsecke, A., Leckband, C., Voss, R., Grebe, MT, Tillmanns, H., Schaefer, CA & Kuhlmann, CR 2007. Apigenin Calcium-induced nitric oxide production affects calcium-gated potassium channels and is responsible for the antiangiogenic effects. J thrombus hemost. 5(8): 1774-81

625) Ericson, U., Sonestedt, E., Gullberg, B., Olsson, H., & Wirfalt, E. 2007. High folate intake is associated with lower incidence of postmenopausal breast cancer on the Malmö diet and the cancer cohort. Bin J Clin Nutr. 86(2):271-3

626) Eugster, H. P., Probst, M., Wurgler, FE & Sengstad, C. 1993. Caffeine, estradiol and progesterone interact with human CYP1A1 and CYP1A2. cDNA-directed expression detection in Saccharomyces cerevisiae. Elimination of drug metab. 21(1): 43-9

627) Eussen, S. JPM., Vollset, S.E., Hustad, S., Midttun, Ø., Meyer, K., Fredriksen, A. et al. 2010. Plasma vitamins B2, B6, B12 and related genetic variants as predictors of colorectal cancer risk. Biomarkers of the Cancer Epidemic Prev. 19(10):2549-2561 (author number is more than 10).

628) Evangelist, M., Tian, ​​H. and de Sauvage, F. J. 2006. The hedgehog signaling pathway in cancer. Cancer Clinic Res. 12 (20 points 1): 5924-8

629) Evangelisti, C., Ricci, F., Tazzari, P., Chiarini, F., Battistelli, M., Falcieri, E., Ognibene, A., Pagliaro, P., Cocco, L., McCubrey, J. A. und Martelli, A. M. 2011. Präklinische Prüfung des Akt-Inhibitors Triciribin bei akuter lymphoblastischer T-Zell-Leukämie. J- Cellfisiol. 226(3):822-31

630) Evans, C.E., Banso, A., and Samuel, O.A. 2002. Efficacy of some Nupe medicinal plants against Salmonella typhi: an in vitro study. J Ethnopharmaco. 80(1):21-4

631) Falk, R., Falk, A., Dyson, MR, Melidoni, AN, Parthiban, K., Young, J.L., Roake, W., and McCafferty, J. 2012. Anti-Notch antibody generation and its application in Blockade of Notch signaling in neural stem cells. methods. 58(1): 69-78

632) Fan P, Fan S, Wang H, Mao J, Shi Y, Ibrahim MM, Ma W, Yu X, Hou Z, Wang B, and Li, L. 2013. Genistein reduces the population of breast cancer stem cells by hedgehog signage. stem cell res thermal 4(6): 146, doi: 10.1186/scrt357, 10 pages

633) Fan, S., Li, X., Lin, J., Chen, S., Shan, J., & Qi, G. 2014. Honokiol inhibits factor-stimulated rat aortic smooth muscle cell proliferation of α tumor necrosis through caspase and mitochondria-dependent apoptosis. Inflammation. 37(1): 17-26

634) Fan, S., Meng, Q., Auborn, K., Carter, T., & Rosen, EM 2006. BRCA1 and BRCA2 as molecular targets for the phytochemicals indole-3-carbinol and genistein in breast cancer cells and prostate . Br J Cancer. 94(3): 407-26

635) Fan, S., Smith, M. L., Rivet, D. J. Duba, D., Zhan, Q., Kohn, K. W., Fornace, A. J. Jr. und O'Connor, P. M. 1995. Disruption of p53 function sensitizes cancer breast MCF- 7-Zellen zu Cisplatin und Pentoxifyllin. Krebsres. 55(8): 1649-54

636) Fang DD, Zhang CC, Gu Y, Jani JP, Cao J, Tsaparikos K, Yuan J, Thiel M, Jackson-Fisher A, Zong Q. , Lappin, P.B., Hayashi, T., Schwab, R.B., Wong, A., John-Baptiste, A., Bagrodia, S., Los, G., Bender, S., Christensen, J., and VanArsdale, T. 2013. Antitumor efficacy of the dual PI3K/mTOR inhibitor PF-04691502 in a model of human xenograft tumor derived from colon cancer stem cells harboring a PIK3CA mutation. Plus one. 8(6): e67258, doi: 10.1371/journal.pone.0067258, 12 pages

637) Fang J, Xia C, Cao Z, Zheng JZ, Reed E, and Jiang BH 2005. Apigenin inhibits VEGF and HIF-1 expression through the PI3K/AKT/p70S6K1 and HDM2/p53 signaling pathways. FASEB J. 19(3): 342-53

638) Fang, L., Hemion, C., Bento, A. C. P. F., Bippes, C. C., Flammer, J., & Neutzner, A. 2015. Mitochondrial function in neuronal cells depends on p97/VCP/Cdc48-mediated QC . Frontal cell neurosciences. 9:16, doi:10.3389/fancel. 2015. 00016

639) Fang, M. Z., Zhang, X., & Zarbl, H. 2010. Methylselenocysteine ​​restores rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo. 2010. Cancer Prev Res (Phila). 3(5): 640-652

640) Farag, MA and Motaal, AAA 2010. Sulforaphane composition, cytotoxic and antioxidant activity of cruciferous vegetables. Advanced Research Journal. 1(1): 65-70

641) Farkas, O., Palocz, O., Paszti-Gere, E., and Galfi, P. 2015. Polymethoxyflavone apigenin trimethylether suppresses the LPS-induced inflammatory response in the nontransformed porcine intestinal cell line IPEC-J2. Oxidative medicine and cellular longevity. Vol. 2015, Article ID: 673847, 10 pages

642) Farook, M.J., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, BS, Brann, D., Dhandapani, M.K. and Sen, N. 2013. GADD34 Induces Cell Death by Akt Inactivation After Traumatic Brain Injury. cell death and disease. 4: e754, doi: 10.1038/cddis.2013.280, 9 pages

643) Fasano, E., Serini, S., Piccioni, E., Toesca, A., Monego, G., Cittadini, RA, Ranelletti, O. F., and Calviello, G. 2012. DHA induces apoptosis by altering the expression and the localization of GRP78 in colon cancer cell lines. Biochemistry and Biophysics Act (BDA) - Molecular bases of diseases. 1822(11):1762-1

644) Faubert, B., Vincent, EE, Poffenberger, MC, & Jones, RG 2015. AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator. cancer metabolism. 356(2): 165-170

645) Favia, A., Desideri, M., Gambara, G., D'Alessio, A., Ruas, M., Esposito, B., Del Bufalo, D., Parrington, J., Ziparo, E., Palombi, F., Galione, A. and Filippini, A. 2014 VEGF-induced neoangiogenesis is mediated by NAADP and dual-channel channel 2-dependent Ca2+ signaling. Proc Natl Acad Sci USA. 111(44): E4706–E4715

646) Favoni, R.E., A. Pattarozzi, M. Lo Casto, F. Barbieri, M. Gatti, L. Paleari, A. Bajetto, C. Porcile, G. Gaudino, L. Mutti., Corte, G. and Florio , T. 2010. Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Curr targets for cancer drugs. 10(2): 176-91

647) Feber, A., Clark, J., Goodwin, G., Dodson, A.R., Smith, P.H., Fletcher, A., Edwards, S., Flohr, P., Falconer, A., Roe, T., Kovacs, G., Dennis, N., Fisher, C., Wooster, R., Huddart, R., Foster, C. S., and Cooper, C. S. 2004. E2F3 amplification and overexpression in human bubble cancer. Onco-open. 23: 1627-1630, doi: 10.1038/sj.onc.1207274

648) Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F. and Loguercio, C. 2007. Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer. 121(11):2381–2386

649) Feelisch, M. 1998. The use of nitric oxide donors in pharmacological studies. Arch Pharmacol by Naunyn Schmiedeberg. 358(1):113-122

650) Feldman, R. I., Wu, J. M., Polokoff, M. A., Kochanny, M. J., Dinter, H., Zhu, D., Biroc, S. L., Alicke, B., Bryant, J., Yuan, S., Buckman, B. O. , Lentz, D., Ferrer, M., Whitlow, M., Adler, M., Finster, S., Chang, Z. y Arnaiz, D. O. 2005. Novel smallmolecule inhibitors of 3-phosphoinositide-dependent kinase-1. JBiolChem. 280(20): 19867-74

651) Felts, J. S. and Toft, O. D. 2003. P23, a simple protein with complex activities. Cellular stress chaperones. 8(2): 108-113

652) Femenia, A., Rosselló, C., Mulet, A. and Canellas, J. 1995. Chemical composition of sweet and bitter apricot kernels. Journal of agricultural and food chemistry. 43(2):356-361

653) Feng, D., Ling, H.W. and Duan, DR. 2010. Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting ERK, p38MAPK, and NF-kβ activation in macrophages. inflammation research. 59(2):115-121

654) Feng, S., Cao, Z., & Wang, X. 2013. Role of the aryl hydrocarbon receptor in cancer. Biochem Biophys Act. 1836(2): 197-210

655) Fenton, MS, Marion, KM, Salem, AK, Hogen, R, Naeim, F, and Hershman, JM 2010. Sunitinib inhibits the MEK/ERK and SAPK/JNK pathways and increases sodium/iodide symporter expression in the papillary thyroid cancer. Thyroid. 20(9):965-74

656) Fenton, W.S., Dickerson, F., Boronow, J., Hibbeln, J.R. and Knable, M. 2001. A placebo-controlled study of omega-3 fatty acid (ethyleicosapentaenoic acid) supplementation for residual symptoms and cognitive decline in schizophrenia. American Journal of Psychiatry. 158(12): 2071-2074.

657) Fenwick, G.R., Heaney, R.K. y Mullin, W.J. 1983. Glucosinolates and their degradation products in food and food plants. Crit Rev Food Sci Nutr. 18(2):123-201

658) Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C., Forman, D., Mathers, C., and Parkin, DM 010. Estimates of the global burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer. 127(12):2893-2917

659) Fernández de Mattos, S., Essafi, A., Soeiro, I., Pietersen, A.M., Birkenkamp, ​​K. U., Edwards, CS, Martino, A., Nelson, BH, Francis, JM, Jones, MC, Brosens, JJ, Coffer, PJ, & Lam, EW 2004. FOXO3a and BCR-ABL regulate via cyclin transcription D2 a STAT5/BCL6 dependent mechanism. Mol-Cel-Biol. 24(22): 10058-71

660) Fernández, MA, Heras, B, García, MD, Sáenz, MT and Villar, A. 2001. New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. J. Pharm. Pharmacol. 53, 1533-1539

661) Fernandez-Martinez, A. B., Bajo, A. B., Bajo, A. M., Valdehita, A., Isabel, A. M., Sanchez-Chapado, M., Carmeno, M. J. und Prieto, J. C. 2009. Multifunctional role of VIP in cancer progression of prostate in ein Xenograft-Modell: Unterdrückung durch Curcumin und COX-2-Inhibitor NS-398. peptide. 30(12): 2357-64

662) Fernandez-Tome, P., Lizasoain, I., Leza, J. C., Lorenzo, P. und Moro, M. A. 1999. Neuroprotective effects of DETA-NONOate, a stickoxid-donor, on hydrogen peroxide-induced neurotoxicity in neurons cortical. Neuropharmacology. 38(9): 1307-1315

663) Ferrajoli, A., Keating, M.J., Manshouri, T., Giles, F.J., Dey, A., Estrov, Z., Koller, CA., Kurzrock, R., Thomas, DA., Faderl, S., Lerner, S., O'Brien, S., and Albitar, M. 2002. The clinical significance of plasma tumor necrosis factor alpha levels in patients with chronic lymphocytic leukemia. Blood. 100(4): 1215-1219

664) Ferrandez, A., Prescott, S. and Burt, RW 2003. COX-2 and colorrectal cancer. Curr Pharm Des. 9(27):2229-51

665) Ferraroni, M., Vecchia, C. La., D'Avanzo, B., Negri, E., Franceschi, S., & Decarli, A. 1994. Intake of selected micronutrients and risk of colorectal cancer. Br J Cancer. 70(6):1150-1155

666) Feskanich, D., Ziegler, G. R., Michaud, SD, Giovannucci, L. E., Speizer, EF, Willett, C. W., & Colditz, A. G. 2000. Prospective study on fruit and vegetable consumption and lung cancer risk in men and women. J National Cancer Institute 92(22): 1812-1823

667) Festuccia, N., Osorno, R., Halbritter, F., Karwacki-Neisius, V., Navarro, P., Colby, D., Wong, F., Yates, A., Tomlinson, S. R., and Chambers, I. 2012. Essrb is a direct Nanog target gene capable of displacing Nanog function in pluripotent cells. cellular stem cell. 11(4): 477-90

668) Fialkow, L., Wang, Y., & Downey, G. P. 2007. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radical Biol Med. 42 (2): 153-164

669) Fiedler, U., Cornelius, A., Akawardhani, S., Dawson, KM, Gilboy, P., Stumpp, MT, Dolado, I., and Molecular Partners, AG. 2014. Efficacy of Bortezomib in Combination with MPO250, a Bispecific Darpin Targeting VEGF and HGF, in a Preclinical Model of Multiple Myeloma. ASCO Annual Meeting 2014. J Clin Oncol. 32, complement; Summary: e19574

670) Field, A.E., Willett, W.C., Lissner, L., and Colditz, G.A. 2007. Dietary fat and weight gain in women in the Nurses' Health Study. Obesity. 15(4):967-976.

671) Filip, S., Vidovic, S., Adamovic, D., and Zekovic, Z. 2014. Fractionation of nonpolar compounds from basil (Ocimum basillicum L.) by supercritical fluid extraction (SFE). The journal of supercritical fluids.

672) Filipovic , A , Lombardo , Y , Fronato , M , Abrahams , J , Aboagye , E Nguyen , Q , d'Aqua , BB , Ridley , A , Green , A , Rahka , E ., ., ., Ellis , I. , Recchi , C. , Przulj , N. , Sarajlic , A. , Alattia , J. , Fraering , P. , Deonarain , M. and Coombes , R. C. 2014 Pleiotropic pharmacological antitumor effects in invasive breast cancer. Treatment of carcinoma. 148(2): 455-462

673) Filomeni, G., Desideri, E., Cardaci, S., Graziani, I., Piccirillo, S., Rotilio, G., & Ciriolo, M. R. 2010. Carcinoma cells activate autophagy dependent on activated protein kinase by AMP as a survival response in kaempferol-mediated energy impairment. autophagy. 6(2): 202-216

674) Finlay, CA, Hinds, P.W. and Levine, A.J. 1989. The p53 proto-oncogene may act as a suppressor of transformation. Cell. 57(7):1083-93

675) Finley, J.W., Davis, CD and Feng, Yi. 2000. Selenium from high-selenium broccoli protects rats from colon cancer. J Nutr. 130(9):2384-2389

676) Fisher, B., Costantino, J.P., Wickerham, D.L., Cecchini, R.S., Cronin, W.M., Robidoux, A., Bevers, T.B., Kavanah, M.T., Atkins, J.N., Margolese, R.G., Runowicz, C.D., James, J.M., Ford, L.G. and Wolmark, N. 2005. Tamoxifen for the prevention of breast cancer: update of the National Adjuvant Breast and Bowel Surgical Project p-1 study. J National Cancer Int. 97(22): 1652-62

677) Flavin, R., Zadra, G., & Loda, M. 2011. Metabolic changes and targeted therapies in prostate cancer. J. Pathol. 223(2): 283-294

678) Fleischhacker, W.W. (2003). New developments in the pharmacotherapy of schizophrenia. Journal of Neural Transmission Supplement, 64, 105-117. DOI:

679) Flores, O. and Burnstein, K. L. 2010. GADD45ϒ: a novel vitamin D-regulated gene that has antiproliferative effects in prostate cancer cells. Endocrinology. 151(10):4654-4664

680) Floris, G., Debiec-Rychter, M., Wozniak, A., Stefan, C., Normant, E., Faa, G., Machiels, K., Vanleeuw, U., Sciot, R., and Schoffski , P. 2011. Heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors. Mol Cancer Ther. 10(10): 1897-908

681) Fogerty, J. F., Akiyama, MS., Yamada, M. K., and Mosher, FD 1990. Inhibition of fibronectin binding to matrix assembly sites by anti-integrin (α5β1) antibodies. The Journal of Cell Biology. 111(2): 699-708

682) Folsom, A. R. und Demissie, Z. 2004. Fish consumption, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. American Journal of Epidemiology.160(10): 1005-1010

683) Fong, Y.M., Zhou, W., Liu, L., Alontaga, Y.A., Chandra, M., Ashby, J., Chow, A., O'Connor, F.T.S., Li, S., Chin, R.A., Somlo G, Palomares M, Li Z, Tremblay RJ, Tsuyada A, Sun G, Reid AM, Wu X, Swiderski P, Ren X, Shi, Y., Kong, M., Zhong, W., Chen, Y. and Wang, E. S. 2015. miR-122 secreted by breast cancer reprograms glucose metabolism in a premetastatic niche to promote metastasis. cell biology of nature. 17:183-194, doi:10.1038/ncb3094

684) Fontana, L., Klein, S., & Holloszy, JO 2006. Long-term low-protein, low-calorie diet and resistance exercise modulate metabolic factors associated with cancer risk. I'm J Clin Nutr. 84(6):1456-1462

685) Foster, CS, Falconer, A, Dodson, AR, Norman, AR, Dennis, N, Fletchner, A, Southgate, C, Dowe, A, Dearnaley, D, Jhavar, S, Eeles, R., Feber, A and Cooper, C. S. 2004. E2F3 transcription factor overexpressed in prostate cancer independently predicts clinical outcome. oncogene 23(35):5871-9

686) Foster , P. , Yamaguchi , K. , Hsu , PP , Qian , F. , Du , X. , Wu , J. , Won , KA , Yu , P. , Jaeger , CT , Zhang , W. , Marlowe , C.K. , Keast , P. , Abulafia , W. , Chen , J. , Young , J. , Plonowski , A. , Yakes , F.M. , Chu , F. , Engell , K. , Bentzien , F. , Lam , S.T. , Dale, S., Yturralde, O., Matthews, D.J., Lamb, P. and Laird, AD 2015. The selective PI3K inhibitor XL147 (SAR245408) inhibits tumor growth and survival and potentiates the activity of chemotherapeutic agents in preclinical tumors. models Mol Cancer Ther. 14(4):931-40

687) Fouad, MA, Agha, AM, Merzabani, MM Al. and Shouman, S.A. 2013. Resveratrol inhibits proliferation, angiogenesis, and induces apoptosis in colon cancer cells: caloric restriction is the power of cytotoxicity. Human and Experimental Toxicology. 32(10): 1067-1080

688) Fowke JH, Howard L, Andriole GL, and Freedland SJ 2014. Alcohol use increases risk of high-grade prostate cancer in men taking dutasteride in small study. european urology. 66(6): 1133-1138

689) Fox, E.M., Kuba, M.G., Miller, T.W., Davies, B.R. and Arteaga, C.L. 2013. The autocrine IGF/insulin receptor axis compensates for AKT inhibition in ER-positive breast cancer cells resistant to estrogen deprivation. breast cancer research. 15=R55, doi=10.1186/bcr3449, 14 pages

690) Franca, F., Clerici, M., Campa, T., Di Mauro, M.G., Magni, A., Mascotti, G., Moglia, D., De Palo, G., Costa, A. and Veronesi, U. 1993. Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations. Journal of Clinical Oncology. 11(10): 2036-2042

691) Francis , R. E. , Myatt , S. S. , Krol , J. , Hartman , J. , Peck , B. , McGovern , U. B. , Wang , J. , Guest , S. K. , Filipovic , A. , Gojis , O. , Palmieri , . C. , Peston , D. , Shousha , S. , Yu , Q. , Sicinski , P. , Coombes , R. C. and Lam , E. W. 2009. FoxM1 is a downstream target and marker of HER2 overexpression in carcinoma . In t. J. Oncol. 35(1): 57-6

692) Frangou, S., Lewis, M., & McCrone, P. 2006. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: a randomized, double-blind, place-controlled study. british journal of psychiatry. 188(1): 45-50.

693) Frank, J.E. 2005. Diagnosis and treatment of G6PD deficiency. I am a family doctor. 72(7):1277-82

694) Frank, J., Flaccus, A., Schwarz, C., Lambert, C., & Biesalski, HK 2006. Ascorbic acid suppresses cell death in rat SD sarcoma cancer cells treated with photodynamic therapy based on 5-aminolevulinic acid. induced. Biology and medicine of free radicals. 40(5):827-836

695) Fraser, G. E., Beeson, W. L. und Phillips, R. L. 1991. Diet and lung cancer in California Seventh-day Adventists. Am J Epidemiol. 133(7): 683-93

696) Frasure-Smith, N., Lesperance, F., & Julien, P. 2004. Major depression is associated with lower levels of omega-3 fatty acids in patients with recent acute coronary syndromes. Biological Psychiatry. 55(9):891-896.

697) Freedman, D. A. y Levine, A. J. 1999. Regulation of the p53 protein by the MDM2 oncoprotein 38 G. H. A. Clowes memorial Award Lecture. Krebsres. 59(1): 1-7

698) Freed-Pastor, AW and Prives, C. 2012. Mutant p53: one name, many proteins. Gene Dev. 26(12):1268-86

699) Freed-Pastor, A.W., Mizuno, H., Zhao, X., Langerod, A., Moon, S., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., Bissell, J. M., Osborne, F. T., Tian, ​​B., Lowe, W. S., Silva, M. J., Borresen-Dale, A., Levine, JA., Bargonetti, J., & Prives, C. 2012 p53 mutants disrupt the architecture of the mevalon pathway. Zelle. 148(1-2): 244-2

700) Freeman, MP 2000. Omega-3 fatty acids in psychiatry. A review. Clinical Psychology Annual Review, 12. 159-165.

701) Freeman, MP, Hibbeln, J.R., Wisner, K.L. et al. 2006. Omega-3 fatty acids: evidence base for treatment and future research in psychiatry. Journal of Clinical Psychiatry. 67(12): 1954-1967.

702) Frei, B. und Lawson, S. 2008. Review of vitamin C and cancer. PNAS. 105(32):11037-11038

703) Fresno Vara, J. A., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C. und Gonzales-Baron, M. 2004. PI3K/Akt-Signalweg und Krebs. Cancer Treat Rev. 30(2): 193-204

704) Freudenheim, JO. L., Graham, S., Marshall, J.R., Haughey, BP, Cholewinski, S. and Wilkinson, G. 1991. Folate intake and carcinogenesis of the colon and rectum. International Journal of Epidemiology. 20(2):368-373

705) Frew , J.A. , Lindemann , KR , Martin , P.B. , Clarke , P.J.C. , Sharkey , J. , Anthony , A.D. , Banks , K. , Haynes , M.N. , Gangatirkar , P. , Stanley , K. , Bolden , E.J. , . Takeda , K. , Yagita , H. , Secrist , P.J. , Smyth , J.M. . and Johnstone. 2008. Combination therapy of established cancer with a histone deacetylase inhibitor and a TRAIL receptor agonist. PNAS. 105(32): 11317–11322

706) Frey, R. S., Li, J. and Singletary, KW 2001. Effects of genistein on cell proliferation and cell cycle arrest in non-neoplastic human mammary epithelial cells: involvement of Cdc2, p21 (waf/cip1), p27 (kip1 ), and Cdc25C- Expression. Biochem Pharmacol. 61(8):979-89

707) Friedland JC, Smith DL, Sang J, Acquaviva J, He S, Zhang C, and Proia DA 2014. Targeted inhibition of Hsp90 by ganctespib is effective in a broad spectrum of breast cancer subtypes. Invest in new drugs. 32(1): 14-24

708) Friedman, A. und Moe, S. 2006. Review of the effects of omega-3 supplementation in dialysis patients. Klinisches Journal of the American Society of Nephrology. 1(2): 182–192.

709) Friedman, J.A., Wise, S.C., Hu, M., Gouveia, C., Broek, R.V., Freudlsperger, C., Kahnabiran, V.R., Arun, P., Mitchell, J.B., Chen, Z. and Waes, C.V. 2013. The HSP90 inhibitor SNX5422/2112 targets the dysregulated signaling and transcription factor network and the malignant phenotype of head and neck squamous cell carcinoma. transonc. 6(4): 429-441

710) Friso, S., Jacques, P.F., Wilson, P.W., Rosenberg, I.H., Selhub, J. 2001. Low circulation of vitamin B(6) is associated with an increase in the information marker C-reactive protein, independent of plasma homocysteine ​​levels Trafficking. 103(23):2788-91

711) Fritsch, C., Huang, A., Chatenay-Rivauday, C., Schbell, C., Reddy, A., Liu, M., Kauffmann, A., Guthy, D., Erdmann, D., De Pover , A. , Furet , P. , Gao , H. , Ferretti , S. , Wang , Y. , Trappe , J. , Brachmann , SM , Maira , SM , Wilson , C. , Boehm , M. , Garcia- Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hoffman F and Sellers WR 2014. Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of patient stratification strategy for trials clinicians. Mol Cancer Ther. 13(5):1117-29

712) Frodin, M. and Gammeltoft, S. 1999. Role and regulation of the 90 kDA ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol. 151(1-2): 65-77

713) Fruman, A.D. and Rommel, C. 2014. PI3K and Cancer: Lessons, Challenges and Opportunities. Nat Rev Descubrimiento de drogas. 13(2): 140-156

714) Fu, Z. and Tindall, DJ 2008. FOXO, cancer, and regulation of apoptosis. oncogene 27(16):2312-9

715) Fujihara, S., Kato, K., Morishita, A., Iwama, H., Nishioka, T., Chiyo, T., Nishiyama, N., Miyoshi, H., Kobayashi, M., Kobara, H. ., Mori, H., Okano, K., Suzuki, Y., & Masaki, T. 2015. The antidiabetic drug metformin inhibits the proliferation of esophageal adenocarcinoma cells in vitro and in vivo, Int J Oncol. 46(5): 2172-80

716) Fujioka, S, Sclabas, GM, Schmidt, C, Frederick, WA, Dong, QG, Abbruzzese, JL, Evans, DB, Baker, C & Chiao, PJ 2003. Role of nuclear factor kB in cancer metastasis pancreas. Cancer Clinic Res. 9(1): 346-354

717) Fujisawa, H., Misaki, K., Takabatake, Y., Hasegawa, M. and Yamashita, J. 2005. Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumors with hSNF5/1N11 gene inactivation. Journal of Neurooncology. 73(2):117-124

718) Fujiwara , T. , Kanazawa , S. , Ichibori , R. , Tanigawa , T. , Magome , T. , Shingaki , K. , Miyata , S. , Tohyama , M. and Hosokawa , K. 2014 . Arginine stimulates fibroblast proliferation through GPRCGA-ERK1/2 and PI3K/Akt pathway. More one. 9(3): e92168, doi:10.1371/journal.pone.0092168, 27 pages

719) Fukai, T., Marumo, A., Kaitou, K., Kanda, T., Tenada, S., and Nomura, T. 2002. Anti-Helicobacter pylori flavonoids from lakritzextrakt. Biowissenschaften. 71, 1449-1463.

720) Fukui, M., Kang, KS, Okada, K., and Zhu, BT 2013. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, activation of caspase-8 and induction of autophagy. J Cell Biochem. 114(1): 192-203

721) Fukumori, S., Murata, T., Taguchi, M., and Hashimoto, Y. 2007. Rapid and dramatic induction of CYP3A4 mRNA expression via the vitamin D receptor in human intestinal LS180 cells. Metab Pharmacokinet Drugs. 22(5):377-81

722) Fukushima N, Minami Y, Hayakawa F, Kiyoi H, Sadarangi A, Jamieson CHM. and Naoe, T. 2013. Treatment with hedgehog inhibitor, PF-04449913, attenuates the leukemia-initiating potential in acute myeloid leukemia cells. Blood. 122:21, 2 pages, accession number: 000331385003286

723) Fukuyo, Y., Inoue, M., Nakajima, T., Higashikuba, R., Horikoshi, N. T., Hunt, C., Usheva, A., Freeman, M. L., & Horikoshi, N. 2008. Oxidative stress plays a role a Role Crucial role in the inactivation of BRAF mutants by geldanamycin derivatives. res of cancer 68(15): 6324-30

724) Fumo, G., Akin, C., Metcalfe, D.D. and Neckers, L. 2004. 17-allylamino-17-demethoxygeldanamycin (17-AAG) is effective in downregulating constitutively activated and mutated KIT protein in human mast cells. 103(3): 1078-1084

725) Funk, CD and FitzGerald, GA 2007. COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol. 50(5): 470-9

726) Furuta, E., Okuda, H., Kobayashi, A., & Watabe, K. 2010. Metabolic genes in cancer: their role in tumor progression and clinical implications. Biochim Biophys Act. 1805(2): 141-152

727) Fustier P, Le Corre L, Chalabi N, Vissac-Sabatier C, Communal Y, Bignon YJ, and Bernard-Gallon DJ 2003. Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumor cell lines. Br J Cancer. 89(1):168-72

728) Gabitova, L., Gorin, A. und Astsaturov, I. 2013. Molecular Pathways.: Sterols and receptor signaling in cancer. Cancer Clinic Res. 19(23): 6344-6350

729) Gaggar, A., Hector, A., Bratcher, P. E., Mall, M. A., Griese, M. und Hartl, D. 2011. Serie „Matrix metalloproteinases in lung health and disease“. Eur Respir J. 38(2): 721-727

730) Gagliardi, A.R., Hennig, B., and Collins, D.C. 1996. Antiestrogens Inhibit Angiogenic Growth Factor-stimulated Endothelial Cell Growth. Res. against cancer. 16(3A): 1101-6

731) Gajjar , K. , Martin-Hirsch , PL and Martin , FL . 2012. CYP1B1 and hormone-induced cancer. Cancer Lett. 324(1):13-30

732) Galanis, J.D., Kolonel, N.L., Lee, J., & Nomura, A. 1998. Intake of selected foods and beverages and incidence of gastric cancer among Japanese residents of Hawaii: a prospective study. International Journal of Epidemiology. 27(2): 173-180

733) Galgon, T., Hoke, D. & Drager, B. 1999. Identification and quantification of betyl acid. Phytochemical analysis. 10(4): 187-190

734) Galimberti, S., Canestraro, M., Maffei, R., & Petrini, M. 2009. Vorinostat interferes with Wnt and NF-kB signaling pathways in the M-07e cell line. Leukemia. 23(10): 1935-1938

735) Galimov ER, Sidorenko AS, Tereshkova AV, Pletyushkina OY, Chemyak BV, and Chumakov PM 2012. The effect of the p66Shc protein on the resistance of the RKO colon cancer cell line to oxidative stress. Molecular biology. 46(1): 126-133

736) Gallaher, B. W., Hille, R., Raile, K. y Kiess, W. 2001. Apoptosis: Live or Die-hard work each way!. Horm Metab Res. 33(9): 511-519

737) Galli, F. 2007. Interactions of polyphenolic compounds with disposition and metabolism of drugs. Curr Drug Metab. 8(8):830-8

738) Galli, F. and Azzi, A. 2010. Summary of current trends in research on vitamin E. biofactors. 36(1): 33-42

739) Gallily, R., Breuer, A. and Mechoulam, R. 2000. 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor alpha production in murine macrophages and in mice. Eur J Pharmacol. 406(1): R5-7

740) Galloway, T.J., Wirth, L.J., Colevas, A.D., Gilbert, J., Bauman, J.E., Saba, N.F., Raben, D., Mehra, R., Ma, A.W., Atoyan, R., Wang, J. , Burtness, B. and Jimeno, A. 2015. A Phase 1 study of CUDC-101, a multitarget HDAC, EGFR, and HER2 inhibitor, in combination with chemoradiation in patients with head and neck squamous cell carcinoma. Cancer Clinic Res. 21(7):1566-73

741) Galluzzi L, De Santi M, Crinelli R, De Marco C, Zaffaroni N, Duranti A, Brandi G, and Magnani M 2012. Endoplasmic reticulum stress induction Response of cyclic tetrameric indole-3-carbinol derivative CTet in cancer human breast cell lines. Plus one. 7(8): e43249, doi: 10.1371/journal.pone.0043249, 14 pages.

742) Galluzzo, P., Martini, C., Bulzomi, P., Leone, S., Bolli, A., Pallottini, V., and Marino, M. 2009. Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen Mechanisms dependent on the -Alpha receptor. Mol Nutr Food Res. 53(6): 699-708

743) Galustian, C., Meyer, B., Labarthe, M.C., Dredge, K., Klaschka, D., Henry, J., Todryk, S., Chen, R., Muller, G., Stirling, D. , Schafer, P., Bartlett, J.B. and Dalgleish, A.G. 2009. The anticancer drugs lenalidomide and pomalidomide inhibit the proliferation and function of regulatory T cells. Cancer Immunol Immunotro. 58(7):1033-45

744) Gamet-Payrastre, L., Li, P., Lumeau, S., Cassar, G., Dupont, M., Chevolleau, S., Gasc, N., Tulliez, J. and Terce, F. 2000. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. cancer res 60(5): 1426-33

745) Gammon , M.D. , Santella , R.M. , Neugut , AI , Eng , S.M. , Teitelbaum , S.L. , Paykin , A. , Levin , B. , Terry , M.B. , Young , TL , Wang , LW , Wang , Q. , Britton , J.A. , Wolff , M.S. , Stellman , S.D. , Hatch , M. , Kabat , G.C. , Senie , R. , Garbowski , G. , Maffeo , C. , Montalvan , P. , Berkowitz , G. , Kemeny , M. , . Citron, M., Schnabel, F., Schuss, A., Hajdu, S. and Vinceguerra, V. 2002. Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic DNA-hydrocarbon adducts. Biomarkers of the cancer epidemic Prev. 11(8): 677-685

746) Gan, L., Chen, S., Wang, Y., Watahiki, A., Bohrer, L., Sun, Z., Wang, Y., and Huang, H. 2009. Androgen receptor inhibition as a novel Taxol chemotherapy mechanism in prostate cancer. res of cancer 69(21): 8386-94

747) Gangemi, R.M.R., Griffero, F., Marubbi, D., Perera, M., Capra, M.C., Malatesta, P., Ravetti, G.L., Zona, G.L., Daga, A. and Corte, G. 2009. SOX2 Silencing in glioblastoma tumor-initiating cells results in arrest of proliferation and loss of tumorigenicity. Mother cells. 27(1): 40-48

748) Gann, P. H., Ma, J., Giovannucci, E., Willett, W., Sacks, F. M., Hennekens, C. H., & Stampfer, M. J. 1999. Lower risk of prostate cancer in men with elevated plasma lycopene levels: results of a prospective study analysis. cancer res 59(6):1225-30

749) Gao, L. L., Li, F. R., Jiao, P., Yao, S. T., Sang, H., and Si, Y. H. 2011. Dioscin Paris chinensis-induced apoptosis of human ovarian cancer cells via the mitochondrial pathway mediated by Ca(2+) . . . . . . . . . . . . . . . . Asia-Pacific-J-Crab Previous. 12(5): 1361-6

750) Gao, Q., Yuan, Y., Gan, H., & Peng, Q. 2015. Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal junction and suppresses gastric cancer invasion and metastasis. Oncology Letters. 9(5): 2381-2387

751) Gao, S.S., Choi, B.M., Chen, X.Y., Zhu, R.Z., Kim, Y., So, H., Park, R., Sung, M., and Kim, B.R. 2010. Kaempferol Suppresses Cisplatin-Induced Apoptosis Through Inductions of Heme Oxygenase-1 and the Glutamate-Cysteine ​​Ligase Catalytic Subunit in the HEJ-OC1 Cell. Pharmaceutical Res. 27(2):235-45

752) Garcia, C., Bartsch, DU, Rivero, ME, Hagedorn, M, McDermott, CD, Bergeron-Lynn, G, Cheng, L, Appelt, K, and Freeman, WR 2002. Efficacy of prinomastat (AG3340), a Matrix metalloprotease inhibitor, for the treatment of retinal neurovascularization. Curr Eye Res. 24(1):33-8

753) García-Closas, R., Agudo, A., Gonzales, CA, & Riboli, E. 1998. Intake of certain carotenoids and flavonoids and risk of lung cancer in women from Barcelona, ​​Spain. Walnut cancer. 32(3):154-8

754) Garcia-Closas, R., Garcia-Closas, M., Kogevinas, M., Malats, N., Silverman, D., Serra, C., Tardon, A., Carrato, A., Castano-Vinyals, E., Dosemeci, M., Moore, L., Rothman, N. and Sinha, R. 2007. Food intake, nutrients and heterocyclic amines and the risk of bladder cancer. European Cancer Journal. 43(11):1731-1740

755) Garcia-Donas, J., Esteban, E., Leandro-Garcia, L.J., Castellano, D.E., del Alba, A.G., Climent, M.A., Arranz, J.A., Gallardo, E., Puente, J., Bellmunt, J. ., Mellado, B., Martinez, E., Moreno, F., Font, A., Robledo, M. und Rodriguez-Antona, C. 2011. Simngle Nucleotide Polymorphism Associations with Response and toxic Effects in Patients with Advanced Renal- Zellkarzinom behandelt mit First-Line-Sunitinib: eine multizentrische, beobachtende, prospektive Studie. Lancet Oncol. 12(12): 1143-50

756) Garlich, J.R., De, P., Dey, N., Su, J.D., Peng, X., Miller, A., Murali, R., Lu, Y., Mills, GB., Kundra, V., Miller, A., Murali, R., Lu, Y., Mills, GB, Kundra, V., Shu, HK, Peng, Q., and Durden, DL 2008. with antitumor and antiangiogenetic effects. Cancer Res 68(1): 206-15

757) Garon, E.B., Finn, R.S., Hamidi, H., Dering, J., Pitts, S., Kamranpour, N., Desai, A.J., Hosmer, W., Ide, S., Avsar, E., Jensen , MR, Quadt, C, Liu, M, Dubinett, SM, and Slamon, DJ 2913. The Hsp90 inhibitor NVP-AUY922 potently inhibits the growth of non-small cell lung cancer. Mol Cancer Ther. 12(6): 890-900

758) Gaspar, J., Rodrigues, A., Laires, A., Silva, F., Costa, S., Monteiro, M.J., Monteiro, C. and Rueff, J. 1994. About the mechanisms of genotoxicity and metabolism of quercetin mutagenesis. 9(5): 445-9

759) Gasper , A.V. , Al-Janobi , A. , Smith , J.A. , Bacon , J.R. , Fortun , P. , Atherton , C. , Taylor , M.A. , Hawkey , C.J. , Barrett , D.A. and Mithen, R.F. 2005. Glutathione S - Transferase M1 polymorphism and sulforaphane metabolism of broccoli standard and high in glucosinolates. Bin J Clin Nutr. 82(6):1283-91

760) Gatenby, AR and Gillies, JR 2005. Why do cancers have high aerobic glycolysis? Nature informs about cancer. 4:891-899, doi:10.1038/nrc1478

761) Gates, A.M., Tworoger, S.S., Hecht, L.J., De Vivo, I., Rosner, B., and Hankinson, S.E. 2007. A prospective study on dietary flavonoid intake and the incidence of epithelial ovarian cancer. Cancer International. 121(10): 2225-2232

762) Gates, A. M., Vitonis, F. A., Tworoger, S. S., Rosner, B., Titus-Ernstoff, L., Hankinson, E. S. und Cramer, W. D. 2009. Flavonoid intake and ovarian cancer risk in a case study and population-based controls. Int J Krebs. 124(8): 1918-1925

763) Gautam, S., Platel, K. and Srinivasan, K. 2010. Influence of beta-carotene-rich vegetables on the bioavailability of zinc and iron from cereals. Food Chemistry. 122(3):668-672

764) Gauthier, C., Legault, J., Girard-Lalancette, K., Mshvildadze, V., and Pichette, A. 2009. Hemolytic activity, cytotoxicity, and permeabilization of membrane cells of semisynthetic and natural lupan and oleanan-like saponins . Bioorg Med Chem. 17(5): 2002-8

765) Gavathiotis, E., Reyna, E.D., Bellairs, A.J., Lershchiner, S.E. and Walensky, DL 2012. Direct and selective small molecule activation of pro-apoptotic BAX. Nat Cherm Biol. 8(7): 639-645

766) Gavia, M.H., Couto, R.C., Oyama, L.M. et al. 2003. Diets rich in polyunsaturated fatty acids affect liver metabolism in rats. Nutrition. 19(2): 144-149.

767) Geelen, A., Schouten, J.M., Kamphuis, C. et al. 2007. Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. American Journal of Epidemiology. 116(10): 1116-1125.

768) Geiger, K., Hagenbuchner, J., Rupp, M., Fiegl, H., Sergi, C., Meister, B., Kiechl-Kohlendorfer, U., Müller, T., Ausserlechner, M.J. and Obexer, P. 2012. FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma. Mol.biol. Cell. 23(11):2226-2234

769) Genovese, M. C. 2009. p38 inhibition: Did the fat lady sing? arthritis and rheumatism. 60(2):317-320

770) Georgakis GV, Li Y, Rassidakis GZ, Medeiros LJ and Younes A 2006. HSP90 inhibitor 17-AAG interacts with doxorubicin and UO126 in anaplastic large cell lymphoma independently of ALK expression. Experimental hematology. 34(12):1670-1679

771) Geppert, J., Kraft, V., Demmelmair, H., & Koletzko, B. 2006. Docosahexaenoic acid from microalgae reduces plasma triacylglycerol in normolipidemic vegetarians: a randomized study. The British Journal of Nutrition. 95(4):779-786.

772) Germa-Lluch, J.R., Begent, H.R. and Bagshawe, D.K. 1980. Tumor marker levels and prognosis in malignant teratoma of the testis. Br J Cancer. 42(6):850-855

773) Gerstenmeyer, E., Reimer, S., Berghofer, E., Schwartz, H., & Sontag, G. 2013. Effect of thermal heating on some lignans in flax seed, sesame seed, and rye. Food Chemistry. 138(1-2): 1847-1855

774) Geuna, E., Milani, A., Martinello, R., Aversa, C., Valabrega, G., Scabtriti, M., and Montemurro, F. 2015. Buparlisib, an oral pan-PI3K inhibitor for the treatment of breast cancer. Opinion of experts in drug research. 24(3): 421-31

775) Ghosh, A.P., Klocke, B.J., Ballestas, M.E. and Roth, K.A. 2012. CHOP patently cooperates with FOXO3a in neuronal cells to regulate the expression of PUMA and BIM in response to ER stress. Plus one. 7(6):e39586, 11 pages, doi=10.1371/journal.pone.0039586

776) Giacinti, L., Claudio, P.P., Lopez, M. and Giordano, A. 2006. Epigenetic information and estrogen-alpha expression in breast cancer. Oncologist. 11(1): 1-8

777) Gialeli, C., Theocharis, A. D. & Karamanos, N. K. 2011. Roles of matrix metalloproteinases in cancer progression and its pharmacological targeting. FEB 278(1): 16-27

778) Gianotti, L., Nespoli, L., Sargenti, M. and Nespoli, A. 2003. Nutritional therapy in surgical patients: an update. Anesthesiological Minerva. 69(4): 275-280.

779) Gibson, RA, Neumann, MA & Makrides, M. 1997. Effect of increased docosahexaenoic acid in breast milk on plasma phospholipid fatty acids and erythrocytes and neural indices of exclusively breastfed infants. European Journal of Clinical Nutrition. 51(9): 578-584.

780) Gil, A. 2002. Polyunsaturated fatty acids and inflammatory diseases. Biomedical Pharmaceuticals, 56(8):388-396.

781) Gill, K.J., Franke, AA, Morris, S.J., Cooney, VR, Wilkens, RL, Le Marchand, L., Goodman, TM, Henderson, EB, and Kolonel, N.L. 2009. Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F2t in serum or urine with risk of prostate cancer. The multiethnic cohort. Cancer causes control. 20(7):1161-1171

782) Gillett, C., Smith, P., Gregory, W., Richards, M., Millis, R., Peters, G. und Barnes, D. 1996. Cyclin D1 and prognosis in human breast cancer. Int J Krebs. 69(2): 92-9

783) Gills, J. J. and Dennis, P. A. 2009. Perifosine: update on a new Akt inhibitor. Curr Oncol Rep. 11(2): 102-0

784) Giovannucci, E., Rimm, BE, Liu, Y., Stampfer, J. M., & Willett, C. W. 2002. A protective study on tomato products, lycopene, and prostate cancer risk. Journal of the National Cancer Institute. 94(5):391-398

785) Giovannucci, E., Rimm, E. B., Ascherio, A., Stampfer, M. J., Colditz, G. A., & Eillett, W. C. 1995. Alcohol, low-methionine and low-folate diets, and risk of colon cancer in men. JNCI. 87(4):265-273

786) Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, and Willett WC 1998. Multivitamin use, folate, and colon cancer in women in nursing for learning. Annals of Internal Medicine. 129(7):517-524

787) Giulianelli, S., Vague, J.P., Soldi, R., Wargon, V., Vanzulli, SI, Martins, R., Zeitlin, E., Molinolo, A., Helguero, L.A., Lamb, C.A., Gutkind, J. S. and Lanari, C. 2012. Estrogen receptor alpha mediates progestin-induced breast tumor growth through interaction with progesterone receptors on cyclin D1/MYC promoters. Cancer research. 72(9):2416-27

788) Glynn, S.A., Albanes, D., Pietinen, P., Brown, C.C., Rautalahti, M., Tangrea, J.A., Gunter, E.W., Barrett, M.J., Virtamo, J. and Taylor, P.R. 1996. Colorectal cancer and folate status: a nested case-control study in male smokers. Cancer Epidemiol Biomarkers. 5(7):487-494

789) Godbout, J.P., Berg, BM, Kelley, KW & Johnson, RW 2004. Alpha-tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and brain. J Neuroimmunol. 149(1-2): 101-9

790) Godugu, C., Patel, AR, Doddapaneni, R., Somagoni, J., & Singh, M. 2014. Approaches to improve the oral bioavailability and effects of new anticancer drugs berberine and betulinic acid. Plus one. 9(3): e89919, 15 pages

791) Goel, A., Boland, C.R., and Chauhan, D.P. 2001. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 172(2):111-8

792) Goel, A., Jhurani, S. & Aggarwal, BB 2008. Curcumin Multi-Target Therapy: How Spicy Is It? Mol Nutr Food Res. 52(9): 1010-1030

793) Goel, H. L. and Mercurio, A. M. 2013. VEGF targets the tumor cell. Nat Rew Cancer. 13(2):871-882

794) Gogada, R., Prabhu, V., Amadori, M., Scott, R., Hashmi, S., & Chandra, D. 2011. Resveratrol induces p53-independent x-linked inhibitor of protein apoptosis ( XIAP)- Bax protein-mediated oil gomerization in mitochondria to initiate cytochrome c release and caspase activation. J. Biol. Chem. 286(33): 28749-28760

795) Gogos, A.C., Ginopoulos, P., Salsa, B., Apostolidou, E., Zoumbos, C.N. and Kalfarentzos, F. 1998. Dietary supplementation of omega-3 polyunsaturated fatty acids plus vitamin E restores immunodeficiency and prolongs survival in patients with reversible disease with generalized malignancy. Cancer. 82(2): 395-402.

796) Gogus, U. and Smith, C. 2010. Omega N-3 fatty acids: a review of the current state of knowledge. International J. Food Science and Technology. 45(3): 417-436

797) Goh , K.C. , Novotny-Diermayr , V. , Hart , S. , Ong , CL , Loh , Y.K. , Cheong , A. , Tan , Y.C. , Hu , C. , Jayaraman , R. , William , A.D. , Sun , E. T. , Dymock, B. W. , Ong, K. H. , Ethirajulu, K. , Burrows, F. and Wood, J. M. 2012. TGO2, a novel oral multikinase inhibitor of CDK, JAK2 and FLT3 with potent antileukemic properties. Leukemia. 26(2): 236-2

798) Goldberg, R.J. and Katz, J. 2007. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation in inflammatory joint pain. efforts. 129(1-2): 210-223.

799) Golovko, O., Nazarova, N. and Tuohimao, P. 2005. Vitamin D-induced positive regulation of tumor necrosis factor alpha (TNF-alpha) in prostate cancer cells. Life sciences. 77(5): 562-577

800) Gomes, I.M., Maia, C.J. and Santos, CR. 2012. STEAP proteins: from structure to applications in cancer therapy. Mol Cancer Res. 10(5):573-87

801) Gomez-Toribio, V., Garcia-Martin, AB, Martinez, M.J., Martinez, AT & Guillén, F. 2015. Induction of extracellular hydroxyl radical production by white rot fungi by quinine redox cycling. Applied and environmental microbiology. 81(9):3944-3953

802) Gonçalves, L.C.P., Trassi, M.A. de Souza., Lopes, N.B., Dörr, A.F., dos Santos, T.M., Baader, J.W., Oiveira Jr., X.V. and Bastos, L.E. 2012. A comparative study on betamine purification. Food Chemistry. 131(1): 231-238

803) Gong, J., Robbins, L.A., Lugea, A., Waldron, R.T., Jeon, C.Y. und Pandol, S.J. 2014. Diabetes, pancreatic cancer and metformin therapy. Physiol Vorderseite. 5:426, doi:10.3389/fphys.2014.00426

804) Gong, K., Chen, C., Zhan, Y., Chen, Y., Huang, Z., & Li, W. 2012. Regulate autophagy-related gene (ATG7) and regulated/reactive oxygen species by extracellular signals Autophagy induced by tetrandrine kinase in human hepatocellular carcinoma. JBiolChem. 287(42): 35576-88

805) Gong L, Chen X, Wang H, Jiang Q, Pan S, Qiu J, Mei X, Xue Y, Qin W, Zheng F., Shi, Z. and Yan, X. 2014. Piperlongumine induces apoptosis and acts in synergy with cisplatin or paclitaxel in human ovarian cancer cells. Oxidative medicine and cellular longevity. Vol: 2014, Article ID: 906804, doi: 10.1155/2014/906804, 10 pages

806) Gong, Z., Holly, E. A. und Bracci, P. M. 2009. Intake of folate, vitamins B6, B12, and methionine and risk of pancreatic cancer in a large population-based case-control study. Krebs verursacht Kontrolle. 20(8):1317-1325

807) Gonzales-Sancho, J. M., Larriba, M. J., Ordonez-Moran, P., Palmer, H. G. and Muñoz, A. 2006. Effects of 1alpha, 25-dihydroxyvitamin D3 in human colon cancer cells. Anti-Krebs-Res. 26(4A): 2669-81

808) Goodman, G.E., Schaffer, S., Omenn, GS, Chen, C., & King, I. 2003. The association between lung and prostate cancer risk and serum micronutrients. Results and lessons from the B-carotene and retinol efficacy study. Biomarkers of the cancer epidemic Prev. 12(6):518-526

809) Gopiesh, KV and Krishnan, K. 2009. Anticancer cytotoxic activity of saponins isolated from HeLa cell-prostrate Gymnema sylvestre and Eclipta leaves. International Journal of Green Pharmacy. 3(3): 227-229

810) Gorjao, R., Azevedo-Martins, AK, Rodrigues, H.G. et al. 2009. Comparative effects of DHA and EPA on cell function. Drug therapy. 122(1):56-64.

811) Gorozhanskaya, E.G., Sviridova, S.P., Dobrovolskaya, M.M., Zubrikhina, G.N. and Kashiya, Sh. R. 2013. Selenium and oxidative stress in cancer patients. Biochemistry (Moscow) Supplement B: Biomedical Chemistry. 7(1): 32-39.

812) Gosselin, R., Hodge, H., Smith, R. und Gleason, M. 1976. Clinical toxicology of commercial products. Pour Edition. Baltimore: Williams and Wilkins, 1976

813) Gottlieb, N. 1999. Cancer treatment and vitamin C: the debate continues. J National Cancer Institute 91(24):2073-2075

814) Gouado, I., Schweigert, J.F., Ejeh, AR, Tchouanguep, F.M. and Camp, V.J. 2007. Systemic values ​​of mango and papaya carotenoids consumed in three forms (juice, fresh slice, and dried). European Journal of Clinical Nutrition. 61: 1180-1188, doi: 10.1038/sj.ejcn.1602841

815) Gourdier, I., Crabbe, L., Andreau, K., Pau, B., & Kroemer, G. 2004. The oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. Oncogene 23(45): 7449-57

816) Goy A, Hernandez-Ilzaliturri JF, Kahl B, Ford P, Protomastro E, and Berger M 2014. A phase I/II study of pan Bcl-2 inhibitor obatoclax mesylate cell lymphoma. leukemia and lymphoma. 55(12): 2761-2768

817) Gozdz, A., Vashishta, A., Kalita, K., Szatmari, E., Zheng, J.J., Tamiya, S., Delamere, N.A., and Hetman, M. 2008. Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK 1/2) by inhibition of ERK by inhibition of ERK ½ phosphatases. J Neurochem. 106(5): 2056-67

818) Granado, F., Olmedilla, B., Blanco, I. and Rojas-Hidalgo, E. 1996. Important contributions of fruits and vegetables to the main serum carotenoids in the Spanish diet. European Journal of Clinical Nutrition. 50(4):246-250

819) Granado-Serrano, A. B., Martin, M. A., Bravo, L., Goya, L. and Ramos, S. 2012. Quercetin modulates Nrf2 and glutathione-related defensins in hepG2 cells: Involvement of p38. Chemical-biological reactions. 195(2): 154-164

820) Granado-Serrano AB, Martin MA, Bravo L, Goya L and Ramos S 2006. Quercetin induces apoptosis via activated caspase, regulation of Bcl-2 and inhibitor of PI-3 kinase/ 2006. Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr. 136(11):2715–21

821) Granados-Principal, S., Liu, Y., Guevara, L.M., Blanco, E., Choi, S.D., Qian, W., Patel, T., Rodriguez, A.A., Cusimano, J., Weiss, L.H., Zhao H, Landis DM, Dave B, Gross SS, and Chang CJ 2015. Inhibition of iNOS as a new effective targeted therapy for triple negative breast cancer. breast cancer research. 17:25, doi:10.1186/s13058-015-0527-x, 16 pages

822) Granville, D.J., Cassidy, B.A., Ruehlmann, D.O., Choy, J.C., Brenner, C., Kroemer, G., van Breemen, C., Margaron, P., Hunt, DW, and McManus, B.M. 2001. Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis. I'm J Pathol. 159(1):305-11

823) Gray, N.S., Wodicka, L., Thunnissen, A.M., Norman, T.C., Kwon, S., Espinoza, F.H., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.H. , Lockhart, D. J. und Schultz, P. G. 1998. Exploitation of chemical libraries, structure and genomics in the search for kinase inhibitors. Wissenschaft. 281 (5376): 533-8

824) Greenberg, MD 1980. The case against Laetrile. The fraudulent cancer drug. Cancer. 45(4): 799-807

825) Greenhough, A., Smartt, H.J., Moore, AE, Roberts, H.R., Williams, AC, Paraskeva, C., and Kaidi, A. 2009. The COX-2/PGE2 pathway: key roles in cancer characteristics and Adaptation to the tumor microenvironment. carcinogenesis. 30(3): 377-86

826) Grethe, S., Ares, M.P., Andersson, T., and Pörn-Ares, MI 2004. P38 MAPK mediates TNF-induced apoptosis in endothelial cells through phosphorylation and downregulation of Bcl-x( L). Exp. cell res. 298(2): 632-42

827) Grieshop, C. M., Kadzere, C. T., Clapper, G. M., Flickinger, E. A., Bauer, L. L., Frazier, R. L. und Fahey Jr., G. C. 2003. Chemical and nutritional characteristics of U.S. soybeans and soybean meals. J. Agric. Life cycle chem. 51(26), S. 7684–7691

828) Griffin, EG 1997. World Without Cancer: The Story of Vitamin B17. Editor: Westlake Village, CA: American Media. ed. 580 páginas.

829) Griffiths, MA 1998. Inflammatory bowel disease. Nutrition. 14(10):788-791.

830) Grimble, RF 2006. The effects of sulfur amino acid ingestion on immune function in humans. J Nutr. 136(6): 1660S-1665S.

831) Grimley, CE, Holder, RL, Loft, DE, Morris, A and Nwokolo, CU 1999. Antibodies associated with Helicobacter pylori in patients with duodenal ulcer, adenocarcinoma of the stomach and esophagus. Eur J Gastroenterol Hepatol. 11(5):503-509

832) Grimm, S. W. und Dyroff, M. C. 1997. Inhibition of human drug-metabolizing cytochromes P450 by anastrozole, a potent and selected aromatase inhibitor. Drg Metab Dispos. 25(5): 598-602

833) Grimshaw, K.M., Hunter, L.J., Yap, T.A., Heaton, S.P., Walton, M.I., Woodhead, S.J., Fazal, L., Reule, M., Davies, T.G., Seavers, L.C., Lock, V., Lyons , J.F., Thompson, N.T., Workman, P., and Garrett, M.D. 2010. AT7867 is a potent oral inhibitor of AKT and p70S6 kinase that induces pharmacodynamic changes and inhibits the growth of human tumor xenografts. Mol Cancer Ther. 9(5): 1100-10

834) Grinter, R., Milner, J., and Walker, D. 2012. Ferrodoxin-containing bacteriocins point to a novel mechanism of iron uptake in Pectobacterium spp. Plus one. 7(3): e33033, doi: 10.1371/journal.pone.0033033, 9 pages.

835) Groeger , AL , Cipollina , C , Cole , MP , Woodcock , SR , Bonacci , G , Rudolph , TK , Rudolph , V , Freeman , BA and Schopfer , FJ . 2010. Cyclooxygenase-2 generates anti-inflammatory mediators of omega-3 fatty acids. national Chem. Biol. 6(6): 433-41

836) Groselj, B., Kerr, M., and Kiltie, A. 2013. The HDAC inhibitor panobinostat radiosensitizes TP53 mutant bladder cancer cells. 2013, NCRI Cancer Conference. Poster, B244

837) Gross-Steinmeyer, K., Stapleton, P. L., Tracy, J. H., Bammler, T. K., Strom, S. C., and Eaton, D. L. 2010. Sulforaphane and phenethyl isothiocyanate-induced inhibitor of aflatoxin B1-mediated genotoxicity in human hepatocytes. Rolle des GSTM1-Genotyps und der CYP3A4-Genexpression. Toxicol Sci. 116(2): 422-432

838) Gruber, C., Henkel, M., Budach, W., Belka, C. & Jendrossek, V. 2004. Participation of p56/Lck tyrosine kinase in the induction of apoptosis by anticancer drugs. Biochem Pharmacol. 67(10): 1859-72

839) Grunewald, P. G. T., Bach, H., Cossarizza, A., & Matsumoto, I. 2012. The STEAP family of proteins: versatile oxidoreductases and targets for cancer immunotherapy with distinct and overlapping cellular functions. biocell. 104(11): 641-657

840) Grünhagen, DJ, de Wilt, HW, ten Hagen, TLM, & Eggermont, AMM 2006. Technological insight: utility of TNF-α-based isolated limb perfusion to prevent amputation of unresectable limb tumors. Practical Nature Clinical Oncology. 3(2): 94-103

841) Grunz-Borgmann, E., Mossine, V., Fritsche, K. and Parrish, R. A. 2015. Ashwagandha attenuates TNF-α and LPS-induced NF-kB activation and CCL2 and CCL5 gene expression in NRK cells -52E. BMC Complementary and Alternative Medicine. 15:434, doi:10.1186/s12906-015-0958-z

842) Gruvberger-Saal, S.K., Bendahl, P., Saal, L.H., Laakso, M., Hegardt, C., Eden, P., Peterson, C., Malmstrom, P., Isola, J., Borg, A. and Fernö, M. 2007. Estrogen receptor beta expression is associated with response to tamoxifen in ER-alpha negative breast carcinoma. Cancer Clinic Res. 13(7): 1987-94

843) Gudkov, A. V. and Komarova, E. A. 2003. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer. 3(2): 117-129

844) Guelpen, B. Van., Hultdin, J., Johansson, I., Hallmans, G., Stenling, R., Riboli, E., Winkvist, A., & Palmqvist, R. 2006. Low folic acid levels May protect against colon cancer. Colon. 55(10):1461-1466

845) Guesmi, A., Hamadi, B.N., Ladhari, N. & Sakli, F. 2013. Sonicator dyeing of natural indicaxanthin dye modified acrylic fabrics. Industrial plants and products. 42: 63-69,

846) Guha, N., Kwan, L. M., Quesenberry, P. C., Weltzien, K. E., Castillo, L. A. und Caan, J. B. 2009. Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: life after cancer epidemiology (LACE) lernen Brustkrebsbehandlung. 118(2): 395-405

847) Guha, P., Dey, A., Sen, R., Chatterjee, M., Chattopadhay, S., & Bandyopadhyay, S. K. 2011. Intracellular GSH depletion triggered a mitochondrial to resveratrol-induced Bax translocation to achieve apoptosis in the U937 cell line. The Journal of Environmental Pharmacology and Therapeutics. 336(1): 206-214

848) Guha, P., Dey, A., Sen, R., Chatterjee, M., Chattopadhay, S., & Bandyopadhyay, S. K. 2011. Intracellular GSH depletion triggered a mitochondrial to resveratrol-induced Bax translocation to achieve apoptosis in the U937 cell line. The Journal of Environmental Pharmacology and Therapeutics. 336(1): 206-214

849) Guillen , F. , Munoz , C. , Gomez-Toribio , V. , Martinez , AT and Martinez , M.J. . 2000. Oxygen activation during oxidation of methoxyhydroquinones by Pleurotus eryngii laccase. Applied and environmental microbiology. 66(1): 170-175

850) Gulati, N., Laudet, B., Zahrabian, VM, Murali, R., & Jhanwar-Uniyal, M. 2006. The antiproliferative effect of quercetin on cancer cells is mediated through inhibition of the PI3K signaling pathway -Akt/PKB . Res. against cancer. 26(2A): 1177-81

851) Guo, M., Perez, C., Wei, Y., Rapoza, E., Su, G., Bou-Abdallah, F. and Chasteen, D. N. 2007. Iron-binding properties of plant phenolics and cranberry's bio- Auswirkungen. Dalton Transcript. 21(43): 4951-4961

852) Guo, Y., Nemeth, J.A., O'Brien, C., Susa, M., Liu, X., Zhang, Z., Choy, E., Mankin, H., Hornicek, F.J. and Duan, Z 2010. Effects of siltuximab on IL6-induced signaling in ovarian cancer. Clinical cancer research. 16(23): 5759-69

853) Guo, Y., Wang, X., Zhang, X., Sun, Z., & Chen, X. 2011. Ethanol promotes chemically induced oral cancer in mice by activating the 5-lipoxygenase signaling pathway of the arachidonic acid metabolism. Cancer Prev Res (Phila). 4(11): 1863-72

854) Guo, Y., Xu, F., Lu, T., Duan, Z., & Zhang, Z. 2012. Interleukin-6 Signaling Path in Targeted Therapy for Cancer. Cancer Treatment Rev. 38(7): 904-10

855) Gupta, M., Fan, S., Zhan, Q., Kohn, KW, O'Connor, PM, and Pommier, Y. 1997. Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF - 7 cancer cells. Cancer Clinic Res. 3(9): 1653-1660

856) Gupta, S., Hastak, K., Afaq, F., Ahmad, N. and Mukhtar, H. 2004. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa β and la induction of apoptosis . . . . . . . . . . . . . Oncogene 23:2507–2522, doi:10.1038/sj.onc.1207353

857) Gurchot, C. 1975. Revision of the trophoblastic theory of cancer (John Beard, 1857-1924). Oncology. 31(5-6): 310-33

858) Gurfinkel, D. M. and Rao, A. V. 2003. Soybean saponins: the relationship between chemical structure and anticancer activity in the colon. Walnut cancer. 47(1):24-33

859) Gussio, R., Zaharevitz, D.W., McGrath, C.F., Pattabiraman, N., Kellogg, G.E., Schultz, C., Link, A., Kunick, C., Leost, M., Meijer, L., and Sausville , E. A. 2000. Paullone scaffold structure-based design modifications for cyclin-dependent kinase inhibition. Anticancer drug Des. 15(1):53-66

860) Gutierrez, MC, Detre, S, Johnston, S, Mohsin, SK, Shou, J, Allred, DC, Schiff, R, Osborne, CC, and Dowsett, M. 2005. Molecular changes in tamoxifen-resistant breast cancer : relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J Clin Oncol. 23(11): 2469-76

861) Gyanchandani, R., Sano, D., Ortega Alves, M.V., Klein, J.D., Knapick, BA, Oh, S., Myers, J.N. and Kim, S. 2013. Interleukin-8 as a modulator of response to bevacizumab in preclinical models of head and neck squamous cell carcinoma. oral onc 49(8):761-70

862) Gysin, R., Azzi, A. & Visarius, T. 2002. Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by downregulating cyclins. FASEB J. 16(14):1952-4

863) Ha, S.K., Lee, P., Park, J.A., Oh, H.R., Lee, S.Y., Park, J.H., Lee, E.H., Ryu, J.H., Lee, KR, and Kim, S.Y. 2008. Apigenin inhibits NO and PGE2 production in microglia and inhibits neuronal cell death in a mouse model of focal ischemia caused by middle cerebral artery occlusion. NeurochemInt.52(4-5):878-86

Hahm ER, Karlsson AI, Bonner MY, Arbiser JL, and Singh SV 2014. Honokiol inhibits androgen receptor activity in prostate cancer cells. Prostate. 74(4): 408-20

864) Hahn, H., Wicking, C., Zaphiropoulous, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., Negus , K., Smyth, I., Pressman, C., Leffell, D. J., Gerrard, B., Goldstein, A. M., Dean, M., Toftgard, R., Chenevix-Trench, G., Wainwright, B. und Bale , A. E. 1996. Mutationen des humanen Homologs von Drosophila patched in the nevoid basocell carcinoma syndrome. Zelle. 85(6): 841-51

865) Hakkinen, S.H., Karenlampi, S.O., Heinonen, IM, Mykkanen, H.M. and Torronen, A.R. 1999. Content of the flavonols quercetin, myricetin and kaempferol in 25 edible berries. J Agricultural food chemistry. 47(6):2274-9

866) Halimah , E. , Diantini , A. , Destiani , D. P. , Pradipta , I. S. , Sastramihardja , H. S. , Lestari , K. , Subarnas , A. , Abdulah , R. and Koyama , H. 2015. Induction of caspase pathway in cascade by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Rep. Biomedical 3(1):115-117

867) Halimah , E. , Diantini , A. , Destiani , D. P. , Pradipta , I. S. , Sastramihardja , H. S. , Lestari , K. , Subarnas , A. , Abdulah , R. and Koyama , H. 2015. Induction of caspase pathway in cascade by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Rep. Biomedical 3(1):115-117

868) Hallahan, B., Hibbeln, J.R., Davis, J.M. and Garland, M. R. 2007. Omega-3 fatty acid supplementation in patients with recurrent self-harm. british journal of psychiatry. 190:118-122.

869) Hallberg, L., Rossander, L., and Skanberg, AB. 1987. Phytates and the inhibitory effect of bran on iron absorption in humans. Bin J Clin Nutr. 45(5):988-96

870) Halliwell, B. 2001. Vitamin C and genomic stability. mutation research. 474(1-2): 29-35

871) Halliwell, B. and Gutteridge, J.M. 1984. Oxygen toxicity, oxygen radicals, transition metals, and diseases. biochemistry J. 219(1): 1-14

872) Halpner, A. D., Handelman, G. J., Belmont, C. A., Harris, J. M., and Blumberg, J. B. 1998. Vitamin C protection from oxidant-induced vitamin E loss in rat hepatocytes. J. Nutr. Biochemistry 9(6): 335-359

873) Hamazaki, K., Homura, M., Huan, M. et al. (2005). Effect of phospholipids containing omega-3 fatty acids on blood catecholamine concentrations in healthy subjects; a randomized, placebo-controlled, double-blind study. Nutrition, 21 (6): 705-710.

874) Hamilton, N. M., Dawson, M., Fairweather, E. E., Hamilton, N. S., Hitchin, J. R., James, D. I., Jones, S. D., Jordan, A. M., Lyons, A. J., Small, H. F., Thompson, G. I., Waddell, I. D. und Ogilvie, D. J. 2012. Neuartige Steroidinhibitoren der Glucose-6-Phosphat-Dehydrogenase. J MedChem. 55(9): 4431-45

875) Hamner JB, Dickson PV, Sims TL, Zhou J, Spence Y, Ng CY, and Davidoff AM 2007. Bortezomib inhibits angiogenesis and reduces tumor burden in a murine neuroblastoma model. Surgery. 142(2):185-91

876) Hamre, K., Waagbo, R., Berge, R.K. and Lie, Ø. 1997. Vitamins C and E interact in juvenile Atlantic salmon. Biology and medicine of free radicals. 22(1-2):137-149

877) Han KS, Li N, Raven PA, Li E, Fazli L, Gleave ME and So AI 2013. ER stress protein GRP78 as a therapeutic target combined with antiangiogenic therapy in renal cell carcinoma. J Clin Oncol. Urogenital Cancer Symposium. Supplement 6; Abstract #: 428, Category: Urogenital cancer. Subcategory: Renal cell cancer

878) Han , M. , Serrano , CM , Lastra-Vicente , R. , Brinez , P. , Acharya , G. , Huhta , C.J. , Chen , R. and Linask , K.K. 2009. Folate rescues homocytic lithium and wnt3A - induced cardiac anomalies in vertebrates. This Model Mec. 2(9-10): 467-4

879) Han S, Meng Y, Tong Q, Li G, Zhang X, Chen Y, Hu S, Zheng L, Tan W, Li H., Chen, Y., Zhang, G., Li, B. and Guo, Y. 2014. The anti-ErbB2 antibody trastuzumab and the small molecule SRC inhibitor sacatinib synergistically inhibit ErbB2-overexpressing gastric cancer. MAb. 6(2): 403-8

880) Han, Y. H. and Park, W. H. 2010. Alterations of reactive oxygen species and glutathione by MG132, a proteasome inhibitor, affect the growth and death of As4.1 juxtaglomerular cells. Chem Biol Interact. 184(3):319-27

881) Han, Y., Shen, H., Carr, B. I., Wipf, P., Lazo, J. S., and Pan, S. S. 2004. NAD(P)H: quinone oxidoreductase-1-dependent and independent cytotoxicity of potent quinone Cdc25 Phosphatase inhibitor. J Pharmacol Exp Ther. 309(1): 64-70

882) Han, Z., Bhalla, K., Pantazis, P., Hendrickson, EA & Wyche, J. H. 1999. Cif (cytochrome efflux-inducing factor c) activity is regulated by Bcl-2 and caspases and correlates with Bid Activation. Mol Cell Biol. 19(2):1381-9

883) Hanausek M, Ganesh P, Walaszek Z, Arntzen CJ, Slaga TJ and Gutterman JU 2001. Avicins, a family of triterpenoid saponins from Acacia victoria (Bentham), suppress H-ras mutations and aneuploidy in a model of skin carcinogenesis murine. Proceedings of the US National Academy of Sciences 98(20): 11551-11556

884) Hankard, R.G., Haymond, M.W. and Darmaun, D. 1997. Role of glutamine as a glucose precursor in fasting humans. Diabetes. 46(10): 1535-41

885) Hanker, A., Healy, K., Nichols, J., and Der, C. 2009. Romidepsin inhibits Ras-dependent growth transformation of NIH-3T3 fibroblasts and RIE-I epithelial cells independently of inhibition of RAS signaling. Journal of Molecular Signaling. 4:5, doi: 10.1186/1750-2187-4-5, 13 pages

886) Hanker, A., Healy, K., Nichols, J., & Der, C. 2009. Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-I epithelial cells independently of signaling inhibition of RAS. Journal of Molecular Signaling. 4:5, doi: 10.1186/1750-2187-4-5, 13 pages

887) Hann, H. L., Stahlhut, M. W., & Blumberg, B. S. 1998. Iron nutrition and tumor growth: decreased tumor growth in iron-deficient mice. Cancer research. 48(15): 4168-4170

888) Haque, R. M. and Bradbury, H. J. 2002. Determination of total cyanide in plants and foods using the picrate and acid hydrolysis methods. Food Chemistry. 77(1): 107-114

889) Hara A, Sasazuki S, Inoue M, Shimazu T, Iwasaki M, Sawada N, Yamaji T, Ishihara J, Iso H, Tsugane S, and the Japan Public Health Center Prospective Study Group. 2011. Use of vitamin supplements and risk of cancer and cardiovascular disease from all causes in the Japanese general population: a population-based survey. BMC Public Health. 11(1):540-550

890) Hara, S. and Kudo, I. 2006. COX-2 inhibitors and the risk of cardiovascular events. JMAH. 49(7-9): 276-278

891) Harada, H. und Grant, S. 2012. Targeting the BIM regulatory machine for tharpy cancer. Crit Rev Eukaryoten-Genexpr. 22(2): 117-29

892) Harada, N., Murata, Y., Yamaji, R., Miura, T., Inui, H., & Nakano, Y. 2007. Resveratrol downregulates the androgen receptor at the post-translational level in cells of prostate cancer. J Nutr Sci Vitaminol. 53(6): 556-60

893) Harakeh, S., Diab-Assaf, M., Khalife, J.C., Abu-el-Ardat, K.A., Baydoun, E., Niedzwiecki, A., El-Sabban, M.E. and Rath, M. 2007. Assorbic acid Induced apoptosis in adults with T-Zell leukemia. Anti-Krebs-Res. 27(1A): 289–9

894) Hardman, W.E. 2004. (n-3) Fatty acids and cancer therapy. Nutrition Magazine. 134(12):3427-3430.

895) Haridas V, Nishimura G, Z, Connolly F, Hanausek M, Walaszek Z, Zoltaszek R, and Gutterman JU 2009. Avicin D: A Protein Reactive Plant Isoprenoid Dephosphorylates Stat 3 by regulating kinase and phosphatase activities. Plus one. 4, e5578

896) Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, AR, & Sadoshima, J. 2010. Foxo deacetylation by Sirt1 plays an essential role in mediating autophagy induced by starvation in cardiomyocytes. Circ Res. 107(12): 1470-1482

897) Harikumar, K. B. und Aggarwal, B. B. 2008. Resveratrol: a multitargeted agent for alters-associated Chronic Diseases. Zellzyklus. 7(8): 1020-35

898) Harnack , L. , Jacobs , D. R. Jr. , Nicodemus , K. , Lazovich , D. , Anderson , K. and Folsom , A. R. 2002 Contents of Darmkrebs . Cancer of nutrition. 43(2):152-8

899) Harris, DM, Besselink, E, Henning, SM, & Heber, D. 2005. Phytoestrogens induce differential estrogen receptor alpha or beta mediated responses in transfected breast cancer cells. Exp Biol Med (Maywood). 230(8):558-68

900) Harris, H.R., Bergkvist, K., & Wolk, A. 2012. Selenium intake and breast cancer mortality in a cohort of Swedish women. breast cancer research and treatment. 134(3):1269-1277

901) Harris, H.R., Orsini, N., & Walk, A. 2014. Vitamin C and survival in women with breast cancer: a meta-analysis. European Journal of Cancer. 50(7):1223-31

902) Harris, W. S., Park, Y. and Isley, W. L. 2003. Cardiovascular disease and long-chain omega-3 fatty acids. Current opinion in lipidology. 14(1): 9-14.

903) Hartman JT, Albanes D, Rautalahti M, Tangrea AJ, Virtamo J, Stolzenberg R and Taylor RP 1998. Physical activity and prostate cancer in the alpha-tocopherol, beta-carotene (ATBC) cancer prevention study (Finland ). Causes and control of cancer. 9(1):11-8

904) Hartman , S. , Gunther , N. , Biehl , M. ,katzer , A. , Kuger , S. , Worshech , E. , Sukhorukov , L.V. , Krohne , G. , Zimmermann , H. , Flentje , M . and Djuzenova, SC 2013. Inhibition of Hsp90 by NVP-AUY922 and NVP-BEP800 reduces migration and invasion of irradiated normoxic and hypoxic tumor cell lines. cancer letters 331(2): 200-210

905) Hau, M.F., Smelt, A.H.M., Bindels, A.J.G.H. et al. 1996. Effects of fish oil on the oxidative stability of VLDL in patients with hypertriglyceridemia. Arteriosclerosis, thrombosis and vascular biology. 16(9):1197-1202.

906) Hawkins LM, Jayanthan AA and Narendran A 2005 Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in pediatric acute lymphoblastic leukemia (ALL) in relation to Bc-Ab status and mesylate susceptibility imatinib. pediatrician Res. 57(3): 430-7

907) Hawthorne, AB, Daneshmend, TK, Hawkey, CJ et al. 1992. Treatment of ulcerative colitis with fish oil supplements, a 12-month prospective randomized controlled trial. Colon. 33(7):922-928.

908) Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Okada M, Ohta M, Tsukamoto S, Parker P, Workman P and Waterfield, M. 2006. Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel inhibitors of PI3-kinase p110α. Bioorganic and Medicinal Chemistry. 14(20): 6847–6

909) Hayashi, N., Tashiro, T., Yamamori, H. et al. 1999. Effect of intravenous W-6 and W-3 ​​fat emulsion on nitrogen retention and protein kinetics in burned rats. Nutrition. 15(2):135-139.

910) Hayashi, S., Eguchi, H., Tanimoto, K., Yoshida, T., Omoto, Y., Inoue, A., Yoshida, N., and Yamaguchi, Y. 2003. Estrogen receptor expression and function alpha and beta in human breast cancer and its clinical application. Endocrinology connection cancer. 10(2):193-202

911) Hayward, R. L., Macpherson, J. S., Cummings, J., Monia, B. P., Smyth, J. F. und Jodrell, D. I. 2004. Increased oxaliplatin-induced apoptosis after downregulation of Bcl-xl antisense is p53 and p53-dependent. Bax: genetic evidence from the Spezifität des Antisense-Effekts. Mol Cancer Ther. 3(2): 169-78

912) Hazgui , S. , A. Bonnomet , B. Nawrocki-Raby , M. Milliot , C. Terryn , J. Cutrona , M. Polette , Briembaut , P. and J. Zahm . Epigallocatechin-3-gallate (EGCG) inhibits migration behavior of tumor bronchial epithelial cells. investigation of breathing. 9:33, doi: 10.1186/1465-9921-9-33, 13 pages

913) He, B.C., Gao, J.L., Zhang, B.Q., Luo, Q., Shi, Q., Kim, S.H., Huang, E., Gao, Y., Yang, K., Wagner, E.R., Wang, L ., Tang N, Luo J, Liu X, Li M, Bi Y, Shen J, Luther G, Hu N, Zhou Q, Luu H H , Haydon, R.C., Zhao, Y. and He, TC 2011. Tetrandrine inhibits Wnt / B-catenin signaling and suppresses human colorectal cancer tumor growth. Mol Pharmacol. 79(2): 211-219

914) He FQ, Qui BY, Li TK, Xie Q, Cui de J, Huang XL, and Gan HT 2011. Tetrandrine suppresses amyloid B-induced inflammatory cytokines through inhibition of the NF-kB signaling pathway in BV2 murine microglial cells. Int. Immunopharmaceutical. 11(9):1220-5

915) He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen, K, Frazer, KA, Harismendy, O, Hadziapostolou, M, Liopoulos, D. 2015-2016 , Suetsugu , A , Hoffman , RM , Tateishi , R , Koike , K and Karin , M. 2013 Cancer precursors, their malignant progression depends on autocrine IL-6 signaling . Cell. 155(2):384-96

916) He, J., Ning, C., Wang, Y., Ma, T., Huang, H., Ge, Y., Liu, J., & Jiang, Y. 2015. Natural plant flavonoid apigenin directly interferes with the Hsp90/Cdc37 complex and inhibits the growth and migration of pancreatic cancer cells. Functional Food Magazine. 18 (Part A): 10-21, doi: 10.1016/j.jff.2015.06.052

917) He M, Li Y, Zhang L, Li L, Shen Y, Lin L, Zheng W, Chen L, Bian X, Ng H.K. and Tang, L. 2014. Curcumin suppresses cell proliferation by inhibiting Wnt/β-catenin signaling in medulloblastoma. Oncology Rep. 32(1): 173-80

918) Heber, D., Seeram, N.P., Wyatt, H., Henning, SM, Zhang, Y., Ogden, L.G., Dreher, M., and Hill, JO 2007. Safety and antioxidant activity of an ellagitannin-enriched polyphenol from pomegranate Food supplement for overweight people with increased waist circumference. J Agricultural food chemistry. 55(24): 10050-4

919) Heidemann, J., Ogawa, H., Dwinell, M.B., Rafiee, P., Maaser, C., Gockel, H.R., Otterson, M.F., Ota, D.M., Lugering, N., Domschke, W., and Binion, D. G. 2003. The angiogenic effects of interleukin 8 (CXCL8) on human intestinal microvascular endothelial cells are mediated by CXCR2. JBiolChem. 278(10):850-15

920) Heimburger, DC, Alexander, CB, Birch, R, Butterworth, Jr, CE, Bailey, WC, & Krumdieck, CL 1988. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a randomized, double-blind preliminary intervention study. NEVER. 259(10):1525-1530

921) Heine, J., Scheinichen, D., Jäger, K., Andre, M. and Leuwer, M. 1999. In vitro influence of parenteral lipid emulsions on the respiratory burst of neutrophils. Nutrition. 15(7-8): 540-545.

922) Heinecke, L. F., Grzanna, M. W., Au, A. Y., Mochal, C. A., Rashmir-Raven, A. and Frondoza, C. G. 2010. Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by unversifiable soybean avocado and epigallocatechingalate. Arthrosis and cartilage. 18(2): 220-2

923) Heinen MM, Verhage BA, Goldbohm RA, and van den Brandt PA 2012. Intake of vegetables, fruits, carotenoids, and vitamins C and E and risk of pancreatic cancer in the Dutch cohort study. IJC (International Journal of Cancer). 130(1):147-158

924) Heinicke, RM and Gortner, WA 1957. Stem bromelain: a new protease preparation from pineapple plants. Economic Botany. 11(3): 225-234

925) Heininger, K. A. 2000. A unifying hypothesis of Alzheimer's disease. third risk factors. Clinical and experimental human psychopharmacology. 15(1): 1-70.

926) Heinlein, CA and Chang, C. 2004. Androgen receptor in prostate cancer. Endocrine reviews. 25(2): 276-308

927) Heinonen , O.P. , Albanes , D. , Virtamo , J. , Taylor , P.R. , Huttunen , J.K. , Hartman , A.M. , Haapakoski , J. , Malila , N. , Rautalahti , M. , Ripatti , S. , Maenpaa , 2005 . H., Teerenhovi, L., Koss, L., Virolainen, M. and Edwards, BK 1998. Prostate cancer and dietary supplements containing α-tocopherol and B-carotene: incidence and mortality in controlled studies. J National Cancer Institute 90(6): 440-446

928) Heiss, E. H., Schilder, Y. D. C. & Dirsch, V. M. 2007. Chronic resveratrol treatment induces redox stress and mutant ataxia telangiectasia (ATM)-dependent senescence in p53-positive cancer cells. Journal of Biological Chemistry. 282:26759-26766, doi:10.1074/jbc.M7033229200

929) Helsen, C., Van den Broeck, T., Voet, A., Prekovic, S., Van Poppel, H., Joniau, S., & Claessens, F. 2014. Androgen receptor antagonists for therapy of prostate cancer. Endocrinology connection cancer. 21(4): T105-18, doi: 10.1530/ERC-13-0545

930) Heneman, K. und Zidenberg-Chherr, S. 2008. Nutrition and health fact sheet. Cooperative Extension Center for Research in Health and Nutrition UC. Department of Nutrition, University of California Davis, CA 95616-8669, 2 Seiten

931) Hennigan, S. and Kavanaugh, A. 2008. Interleukin-6 inhibitors in the treatment of rheumatoid arthritis. Ther Risk Management Clinic. 4(4):767-775

932) Hettmer , S. , Teot , L.A. , van Hummelen , P. , MacConaill , L. , Bronson , R.T. , Dall'Osso , C. , Mao , J. , McMahon , P. , Gruber , P.J. , Grier , H.E. , Rodriguez-Galindo , C. , Fletcher , C. D. and Wagers , A. J. 2013 . 231(1): 244-52

933) Hetz, C., Vitte, P., Bombrun, A., Rostovtseva, KT, Montessuit, S., Hiver, A., Schwarz, KM, Church, CD, Korsmeyer, J.S., Mortinou, J. and Antonsson, B. 2005. Bax channel inhibitors prevent mitochondrial-mediated apoptosis and protect neurons in a model of global brain ischemia. Journal of Biological Chemistry. 280(52): 42960-70

934) Heuberger RA, Mares-Perlman JA, Klein R, Klein BE, Millen AE, and Palta M 2001. Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Archives of Ophthalmology. 119(12): 1833-1838.

935) Hibbeln, J. R. 1998. Fish consumption and major depression. Lancet. 351 (9110): 1213.

936) Hibbeln, J.R. 2002. Seafood consumption, DHA content of breast milk, and prevalence rates of postpartum depression, a cross-national ecological analysis. Journal of Mood Disorders. 69(1-3): 15-29.

937) Hickinson, D.M., Klinowska, T., Speake, G., Vincent, J., Trigwell, C., Anderton, J., Beck, S., Marshall, G., Davenport, S., Callis, R. , Mills, E., Grosios, K., Smith, P., Barlaam, B., Wilkinson, RW, and Ogilvie, D. 2010. AZD8931, an equipotent factor receptor, ERBB2 (HER2) and ERBB3: a unique co-receptor ERBB receptor blocking agent in cancer. Clinic Res. 16(4): 1159-69

938) Hikita, T., Oneyama, C. & Okada, M. 2010. Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. genes to cells. 15(10): 1051-1062

939) Hill, G.J., Shine, TE, Hill, H.Z. and Miller, C. 1976. Amygdala failure to arrest B16 melanoma and BW5147-AKR leukemia. Cancer research. 36(6): 2102-2107

940) Hill, R., Li, Y., Tran, L.M., Dry, S., Calvopina, J.H., Garcia, A., Kim, C., Wang, Y., Donahue, T.R., Herschman, H.R. and Wu , H. 2012. Intrinsic cellular role of COX-2 in the development of pancreatic cancer. Mol Cancer Ther. 11(10):2127-37

941) Hirose E , Matsushima M , Takagi K , Ota Y , Ishigami K , Hirayama T , Hayashi Y , Nakamura T , Hashimoto N , Imaizumi K ... , Baba , K. , Hasegawa , Y. and Kawabe , T .Implication of hemoxygenase-1 in kaempferol-induced antiallergic effects in RBL-2H3 cells.

942) Hirvonen, T., Virtamo, J., Korhonen, P., Albanes, D. and Pietinen, P. 2001. Intake of flavonols and flavones and risk of cancer in male smokers (Finland). Causes and control of cancer. 12(9): 789-796

943) Hisamoto K, Ohmichi M, Kanda Y, Adachi K, Nishio Y, Hayakawa J, Mabuchi S, Takahashi K, Tasaka K, Miyamoto Y., Taniguchi, N. and Murata, Y. 2001. Induction of oxide synthase Endothelial nitric phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells. The Journal of Biological Chemistry. 276(5=): 47642-47649

944) Hnia, K., Gayraud, J., Hugon, G., Ramonatxo, M., De La Porte, S., Matecki, S., & Mornet, D. 2008. L-arginine reduces inflammation and modulates factor nuclear - kB cascade/matrix metalloproteinase in Mdx muscle fibers. The American Journal of Pathology. 172(6): 1509-1519

945) Ho, E., Clarke, J. D. y Dashwood, R. H. 2009. Dietary sulforaphane, a histone deactylase inhibitor for cancerprevention. J Nutr. 139(12):2393-2396

946) Ho, W. T., Exton, J. H., and Williger, B. T. 2003. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase 9 secretion induced by phorbol esters in HT 1080 fibrosarcoma cells. FEBS Lett. 537(1-3):91-5

947) Hobisch, A., Culig, Z., Radmayr, C., Bartsch, G., Klocker, H., & Hittmair, A. 1996. Androgen receptor status of lymph node metastases from prostate cancer. Prostate. 28(2): 129-135

948) Hoch, L., Faure, H., Roudaut, H., Schoenfelder, A., Mann, A., Girard, N., Bihannic, L., Ayrault, O., Petricci, E., Taddei, M. ., Rognan, D. and Ruat, M. 2015. MRT-92 inhibits hedgehog signaling by blocking overlapping binding sites in the smoothed receptor transmembrane domain. The FASEB Journal. 29(5): 1817-1829

949) Hodgson, J.M., Morton, L.W., Puddey, IB, Beilin, L.J. and Croft, K.D. 2000. Gallic acid metabolites are markers of black tea ingestion in humans. J Agricultural food chemistry. 48(6):2276-80

950) Hoellenriegel, J., Meadows, A.S., Sivina, M., Wierda, G.W., Kantarjian, H., Keating, M., Giese, N., O'Brien, S., Yu, A., Miller, L.L. , Lannutti, J. B. and Burger, A. J. 2015. The delta phosphoinositide 3-kinase inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 118(13): 3603-3612

951) Hoelzl, C., Glatt, H., Meinly, W., Sontaq, G., Haidinger, G., Kundi, M., Simic, T., Chakraborty, A., Bichler, J., Ferk, F. ., Angelis, K., Nersesyan, A. and Knasmüller, S. 2008. Consumption of Brussels sprouts protects human peripheral lymphocytes from 2-amino-1-methyl-6-phenylimidazole[4,5-6] Pyridine (PhlP) and Oxidative DNA Damage: Results of a Controlled Study of Human Intervention. Mol Nutr Food Res. 52(3):330-41

952) Hoensch, H., Groh, B., Edler, L., & Kirch, W. 2008. Prospective cohort comparison of flavonoid treatment in patients with colon cancer resected for prevention of recurrence. World J Gastroenterol. 14(14): 2187-2193

953) Hoermann, R., Spoettl, G., Moncayo, R. and Mann, K. 1990. Evidence for the presence of human chorionic gonadotropin (hCG) and hCG-free β subunit in the human pituitary gland. The Journal of Clinical Endocrinology and Metabolism. 71(1): 179-186

954) Hoffman, D.R., Birch, E.E., Birch, D.G. and Uauy, R. D. 1993. Effects of omega-3 long-chain polyunsaturated fatty acid supplementation on retinal and cortical development in premature infants. American journal of clinical nutrition. 57(5): 807-812.

955) Hoh, N., Semba, S., Ho, M., Takeda, H., Kawata, S., & Yamakawa, M. 2002. Akt/PKB phosphorylation is essential for suppression of cell apoptosis cancerous cells and tumor progression Human colorectal carcinoma required. Cancer. 94(12):3127-3133

956) Holden, J.M., Eldridge, AL., Beecher, GR., Buzzard, IM., Bhagwat, S., Davis, CS, Douglass, L.W., Gebhardt, S., Haytowitz, D. & Schakel, S. 1999. Carotenoid content of American foods: a database update. Journal of Food Composition and Analysis. 12:169-196, doi:10.1006/jfca.1999.0827

957) Holick, M. F. 2003. Vitamin D: A Millennium Perspective. J Cell Biochem. 88(2): 296-307

958) Holick, M. F. 2006. High prevalence of vitamin D deficiency and health implications. Mayo Clinic procedure. 81(3):353-373

959) Holick, N.C., Michaud, S.D., Stolzenberg-Solomon, R., Mayne, T.S., Pietinen, P., Taylor, R.P., Virtamo, J. and Albanes, D. 2002. Dietary carotenoids, serum β-carotene, and Risk of retinol and lung cancer in the alpha-tocopherol-beta-carotene cohort study. Am J Epidemiol. 156(6):536-547

960) Hollstein M, Sidransky D, Vogelstein B and Harris CC 1991. P53 mutations in human cancers. Science. 253(5015):49-53

961) Holm, T., Andreassen, A.K., Aukrust, P. et al. 2001. Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients. European magazine of the heart. 22(5): 428-436.

962) Holst, B. and Williamson, G. 2004. A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod. Rep. 21(3): 425-447

963) Hong, F., Freeman, M. L. und Liebler, D. C. 2005. Identification of sensorcysteines in humans Keap 1 modified by the cancer chemopreventive agent sulforaphane. Chemical Res. Toxicol. 18(12): 1917-26

964) Hong, M., Lin, M. Y., Huang, J. M., Baumeister, P., Roy, A. L. und Lee, A. S. 2005. Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation . JBiolChem. 280(17): 16821-8

965) Honn, K. V., Tang, D. G., Gao, X., Butovich, I. A., Liu, B., Timar, J., and Hagmann, W. 1994. 12-lipoxygenases and 12(S)-HETE: role in metastasis of cancer. Cancer metastasis Rev. 13(3-4): 365-96

966) Hope, C., Planutis, K., Planutiene, M., Moyer, M.P., Johal, KS, Woo, J., Santoso, C., Hanson, J.A. and Holcombe, R.F. 2008. Low Concentrations of Resveratrol Inhibit Wnt Signal Performance in Colon Cells: Implications for Colorectal Cancer Prevention. Mol Nutr Food Res. 52 (Supplement 1): S52-61, doi: 10.1002/mnfr.200700448

967) Horiguchi A, Asano T, Kuroda K, Sato A, Asakuma J, Ito K, Hayakawa M, Sumitomo M, and Asano T 2010. The STAT3 inhibitor WP1066 as a new therapy for renal cell carcinoma. Br J Cancer. 102(11):1592-9

968) Horikawa K, Oishi N, Nakagawa J, Kasai A, Hayakawa K, Hiramatsu N, Takana Y, Yokouchi M, Yao J and Kitamura M 2006. New potential of tunicamycin as an activator of dioxin-sensitive element signaling of the aryl hydrocarbon receptor. FEBS Lett. 580(15):3721-5

969) Horinaka, M., Yoshida, T., Shiraishi, T., Nakata, S., Wakada, M., & Sakai, T. 2006. The dietary flavonoid apigenin sensitizes malignant tumor cells to cancer-related induction of apoptosis. tumor necrosis factor ligand Mol Cancer Ther. 5(4):945-51

970) Horiuchi H, Kawamata H, Furihata T, Omotehara F, Hori H, Shinagawa Y, Ohkura Y, Tachibana M, Yamazaki T, Ajiki T ., Kuroda, Y. and Fujimori, T. 2004. MEK inhibitor (UO126) . markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. J Exp Clin Cancer Res. 23(4): 599-606

971) Horiuchi, T., Mitoma, H., Harashima, S., Tsukamoto, H., & Shimoda, T. 2010. TNF-α transmembrane: structure, function, and interaction with anti-TNF agents. Rheumatology. 49(7):1215-1228

972) Horrobin, D.F. 2001. Phospholipid metabolism and depression, the possible roles of phospholipase A2 and coenzyme A-independent transacylase. Human Psychopharmacology. 16(1): 45-52.

973) Horrobin, D.F., Jenkins, K., Bennett, C.N. and Christie, W. W. 2002. Eicosapentaenoic acid and arachidonic acid: cooperation, not antagonism, is the key to biological understanding. prostaglandins, leukotrienes and essential fatty acids. 66(1):83-90.

974) Horvitz, M.A., Simon, P.W. and Tanumihardjo, S.A. 2004. Lycopene and beta-carotene are bioavailable from lycopene "red" carrots in humans. Eur J Clin Nutr. 58(5):803-11

975) Hosokawa, Y. and Arnold, A. 1998. Mechanism of cyclin D1 (CCND1, PRAD1) overexpression in human cancer cells: allele-specific expression analysis. Krebs chromosome gene. 22(1): 66-71

976) Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H, and Inoue K 1997. Alpha-tocopherol transfer protein affinity as a determinant of the biological activities of vitamin E analogues .FEBS Lett. 409(1):105-8

977) Hossain, T., Rashid, A. & Alam, T. 2013. Detection of peroxidase in vegetables from Bangladesh. International Journal of Pharmaceutical Science and Research (IJPSR). 4(5):1934-1939

978) Hossein, G., Keshavarz, M., Ahmadi, S. and Naderi, N. 2013. Galectin-3 and paclitaxel in apoptosis of human ovarian cancer SKOV-3 cells. Asian Pacific Journal of Cancer Prevention. 14(12): 7561-8

979) Hotz, C. and Gibson, S. R. 2007. Traditional food processing and preparation practices to improve micronutrient bioavailability in plant-based diets. J Nutr. 137(4): 1097-1100

980) Hou, RCW, Chen, YS, Huang, JR, & Jeng, KCG 2006. Cross-linked bromelain inhibits lipopolysaccharide-induced cytokine production involving suppression of cell signaling in rats. Journal of agricultural and food chemistry. 54(6): 2193-2198

981) Howells, L.M., Gallacher-Horley, B., Houghton, C.E., Manson, M.M. and Hudson, E. A. 2002. Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human Breant tumor cell line MDA MB468 but not in the non-tumorigenic HBL 100 line. Mol Cancer Ther. 1(13):1161-72

982) Hrstka , R. , Nenutil , R. , Fourtouna , A. , Maslon , M.M. , Naughton , C. , Langdon , S. , Murray , E. , Larionov , A. , Petrakova , K. , Muller , P . , Dixon, MJ, Hupp, TR and Vojtesek, B. 2010. The anterior gradient 2 of prometastatic protein predicts poor prognosis in tamoxifen-treated breast cancer. Oncogene 29(34):4838–47

983) Hsia, TC, Yang, JH, Lin, HJ, Yu, CS, Yu, FS & Chung, JG 2004. Paclitaxel inhibits N-acetyltransferase activity and gene expression in human gastric tumor cells (SC-M1) . Res Commun Mol Pathol Pharmacol. 115-116:21-38, PMID: 17564303

984) Hsiao, G., Lee, T., Jan, J., Hsiao, C., & Cheng, Y. 2013. Heat shock protein inhibitor 90 radicicol attenuates matrix metalloproteinase expression in monocyte cells humans (P4153). The Journal of Immunology. Conference Abstract Supplement. 190, 112.10

985) Hsieh, B., Huang, L., Su, S., Cheng, H., Hu, Y., Hung, T., & Chang, K. 2011. Combination treatment with arginine and ascorbic acid induces apoptosis in the hepatoma cell lineage HA22T/VGH and changes in redox status affecting the pentose phosphate pathway and reactive oxygen and nitrogen species. The Journal of Nutritional Biochemistry. 22(3): 234-241

986) Hsieh, C., Santell, R.C., Haslam, S.Z. and Helferich, W.G. 1998. Estrogenic effects of genistein on the growth of estrogen receptor-positive (MCF-7) human breast cancer cells in vitro and in vivo. cancer res 58(17):3833-8

987) Hsieh, TC and Wu, JM 2008. Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol, and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells. international J Oncol. 33(4):851-9

988) Hsu, A.L., Ching, T.T., Wang, DS, Song, X., Rangnekar, VM, & Chen, CS 2000. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by inhibiting Akt activation in breast cancer cells. human prostate regardless of Bcl -2 blocked. JBiolChem. 275(15):11397-403

989) Hsu, Y., Wolter, G. K. and Youle, J. R. 1997. Cytosol-to-membrane redistribution of Bax and Bcl-xL during apoptosis. PNAS. 94(8): 3668–3672

990) Hu K, Berenjian S, Larsson R, Gulbo J, Nygren P, Lövgren T and Morein B 2010. Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index. Int J Nanomedicine. 5:51-62, doi:

991) Hu, T., Chung, Y.M., Guan, M., Ma, M., Ma, J., Berek, J.S. and C-T. Hu, M. 2014. Reprogramming of ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through activation of FOXO3. Scientific reports. 4:5810, doi:10.1038/srep05810, 13 pages.

992) Hu T, Zhnag C, Tang Q, Su Y, Chen L, Zhang Z, Cai T, and Zhu Y 2013. G6PD variant levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model. BMC cancer. 13: 251, doi: 10.1186/1471-2407-13-251, 11 pages

993) Huang, C.S., Liao, J.W. and Hu, ML. 2008. Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J Nutr. 138(3): 538-43

994) Huang CY, Chan CY, Chou IT, Lien CH, Hung HC, and Lee MF 2013. Quercetin induces growth arrest by activating the transcription factor FOXO1 in EGFR-overexpressing oral cancer cells. J Nutr Biochem. 24(9):1596-603

995) Huang, C., Ma, W., Goranson, A. and Dong, Z. 1999. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. carcinogenesis. 20(2): 237-242

996) Huang, D., Ding, Y., Zhou, M., Rini, I.B., Petillo, D., Qian, C., Kahnoski, R., Futreal, AP, Furge, AK and The, TB 2010. The interleukin-8 confers resistance to the antiangiogenic agent sunitinib in renal cell carcinoma. cancer res 70(3): 1063-1071

997) Huang, G., Han, S., Chen, Y., Guo, J., and Ping-ping, L. 2011. Mitochondrial reactive oxygen species in sunitinib-induced cardiomyocyte apoptosis. Chinese journal of pharmacology and toxicology. 25(2): 188-192

998) Huang, H., Alberg, J.A., Norkus, PE, Hoffman, CS, Comstock, WG, & Helzlsouer, JK 2003. Prospective study on blood antioxidant micronutrients and the risk of developing prostate cancer. Am J Epidemiol. 157(4):335-344

999) Huang, J. M., Sheard, MA, Sposto, R., & Keshelava, N. 2010. The combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant TP53 mutant neuroblastoma cell lines. Mol Cancer Ther. 9(12):3289-301

1000) Huang JR, Wu CC, Hou RCW and Jeng KC 2008. Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes through CD14 knockdown. immunological investigations. 37(4): 263-277

1001) Huang, L, Xu, J, Li, K, Zheng, MH and Kumta, SM 2004. Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumors of bone. Bone. 34(6):971-81

1002) Huang P, Chuang H, Chou C, Wang H, Lee S, Yang H, Chiu H, Kapuriya N, Wang D, Kulp SK and Chen, C. 2013. Vitamin E facilitates the inactivation of Akt kinase by PHLPP1 phosphatase. Science. Sign. 6(267):ra19 Doi:10.1126/scisignal.2003816

1003) Huang RF, Ho YH, Lin HL, Wei JS and Liu TZ 1999. Folate deficiency induces cell cycle specific apoptosis in HepG2 cells. J. Nutr. 129(1):25-31

1004) Huang, T., Chang, W., Wang, M., Yang, Y., and Hsu, Y. 2012. Effect of sulforaphane on the inhibition of the growth of GBM 8401 malignant glioma cells in the human brain by mitochondrial and MEK/ERK mediated apoptotic pathway. cell biochemistry biophys. 63(3):247-59

1005) Huang, W. and Zou, K. 2011. Cytotoxicity of a plant steroidal saponin in human lung cancer cells. Asia Pacific J Cancer Before. 12(2):513-517

1006) Huang, W. W., Chiu, Y. J., Fan, M. J., Lu, H. F., Yeh, H. F., Li, K. H., Chen, P. Y., Chung, J. G., and Yang, J. S. 2010. Signaling in human osteosarcoma OS U-2 cells. Molecular nutrition and food research. 54(11): 1585-1595

1007) Huang, W. Y., Cai, Y. Z., & Zhang, Y. 2010. Natural phenolic compounds from medicinal herbs and food plants: potential uses for cancer prevention. natural cancer. 62(1): 1-20

1008) Huang, X., Zhang, Z., Jia, L., Zhao, Y., Zhang, X., & Wu, K. 2010. Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in the SGC human gastric cancer in 7901 cells. cancer letters 296(1):123-131

1009) Huang Y, Chao KSC, Liao H, and Chen Y 2013. Targeting of Hedgehog sonic signaling by compounds and derivatives of natural products. Alternative and complementary medicine based on evidence. Vol.2013. Article ID: 748587, 5 pages

1010) Huang, Y., Huang, D., Guh, J., Chen, I., Tzeng, C. & Teng, C. 2005. CIL-102 interacts with microtubule polymerization and causes mitotic arrest after microtubule apoptosis in the human prostate cancer cell line PC-3. The Journal of Biological Chemistry. 280(4): 2771-2779

1011) Huang, Y., Lin, L., Shanker, A., Malhotra, A., Yang, L., Dikov, MM, and Carbone, D.P. 2011. Revitalizing Cancer Immune Surveillance: Selective Stimulation of DLL1-Notch Signaling in T Cells Rescues T Cell Function and Inhibits Tumor Growth. cancer res 71(19): 6122-6131

1012) Huber, R. J. and O'Day, D. H. 2012. The cyclin-dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and nuclear translocation of Cdk5 in Dictyostelium discoideum. J Cell Biochem. 113(3):868-76

1013) Hughes, P.J., Lee, J.S., Reiner, NE & Brown, G. 2008. Vitamin D receptor-mediated activation of phosphotidylinositol-3-kinase (PI3Kalpha) plays a role in 1alpha-stimulated increase, 25-Dihydroxyvitamin D3 on Steroid Sulfate Activity in Myeloid Leukemia Cell Lines. J Cell Biochem. 103(5):1551-72

1014) Hui KF, Lam BH, Ho DN, Tsao SW and Chiang AK 2013. Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block Epstein-Barr virus replication. Mol Cancer Ther. 12(5):747-58

1015) Hui, R.C., Francis, R.E., Guest, S.K., Costa, J.R., Gomes, AR, Myatt, S.S., Brosens, J.J. and Lam, E.W. 2008. Doxorubicin activates FOXO3a to induce expression of the multidrug resistance gene ABCB1(MDR1) to be induced in k562 leukemia cells. Mol Cancer Ther. 7(3): 670-8

1016) Hui, R.C., Francis, R.E., Guest, S.K., Costa, J.R., Gomes, A.R., Myatt, S.S., Brosens, J.J. and Lam, E. W. 2008. Doxorubicin activates FOXO3a to induce expression of the multidrug resistance gene ABCB1 (MDR1) in K562 leukemia cells. Mol Cancer Ther. 7(3):670-8

1017) Hultdin, J., Van Guelpen, B., Bergh, A., Hallmans, G. und Stattin, P. 2004. Plasma folate, vitamin B12 and homocyteine ​​and prostat cancer risk: A prospective study. Int J Krebs. 113(5): 819-824

1018) Hulten, K., van Kappel, L. A., Winkvist, A., Kaaks, R., Hallmans, G., Lenner, P., and Riboli, E. 2001. Carotenoids, alpha-tocopherols and retinol in plasma and breast cancer risk in northern Sweden. Causes and control of cancer. 12(6):529-537

1019) Hung, CF, Huang, TF, Chen, BH, Shieh, JM, Wu, PH & Wu, WB 2008. Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelium adhesion. Eur J Pharmacol. 586(1-3): 275-82

1020) Hung, H. 2004. Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol. Cell Physiol J. 198(2): 197-208

1021) Hung, J.H., Su, I.J., Lei, HY, Wang, HC, Lin, W.C., Chang, W.T., Huang, W., Chang, W.C., Chang, Y.S., Chen, CC, and Lai, M.D. 2004. Endoplasmic reticulum Stress stimulates cyclooxygenase-2 expression through activation of mitogen-activated protein kinase NF-kappaβ and pp38. JBiolChem. 279(45): 46384-92

1022) Hunter BT, Manima JN, Luddy AK, Catlin T, and Antonia JS 2011. Paclitaxel and TRAIL act together to kill paclitaxel-resistant small cell lung cancer cells through an AIF-mediated caspase-independent mechanism. Res. against cancer. 31(10): 3193-3204

1023) Hunter , DJ , Manson , JE , Colditz , GA , Stampfer , MJ , Rosner , B , Hennekens , CH , Speizer , FE and Willett , WC 1993 the Risk of breast cancer. N English. J Med. 329(4): 234-240

1024) Hunter, E.A. and Grimble, R.F. 1997. Dietary sulfur amino acid adequacy affects glutathione synthesis and glutathione-dependent enzymes during the inflammatory response to endotoxin and tumor necrosis factor alpha in rats. Clinic Sci. 92(3):297-305

1025) Huopalahti, R. and Linko, R. R. 1983. Composition and content of aromatic substances in dill, Anethum graveolens L at three different growth stages. Journal of agricultural and food chemistry. 31(2): 331-3

1026) Hur, J., Yoo, M., Shin, D., and Lee, S. 2013. Inhibition of nitric oxide production corresponds to sulforaphane content in Korean shepherd's bursa (Capsella bursa-pastoris) and species related in the BV-2 cell). Food Science and Biotechnology. 22(4): 1085-1089

1027) Husain, K., Francois, RA, Yamauchi, T., Perez, M., Sebti, SM, & Malafa, MP 2011. Vitamin E δ-tocotrienol increases the antitumor activity of gemcitabine and suppresses constitutive activation of NF -kB in Pancreatic Cancer. Mol Cancer Ther. 10(12): 2363-2372

1028) Husbeck, B., Bhattacharyya, R. S., Feldman, D., & Knox, S. J. 2006. Inhibition of androgen receptor signaling by selenite and methylselenic acid in prostate cancer cells: two distinct mechanisms of action. Mol Cancer Ther. 5(8): 2078-85

1029) Hussain, AR, Uddin, S, Bu, R, Khan, OS, Ahmed, SO, Ahmed, M, & Al-Kuraya, KS 2011. Resveratrol suppresses constitutive AKT activation through ROS formation and induces Diffuse apoptosis of large B-cell lymphoma cell lines. Plus one. 6(9): e24703, doi: 10.1371/journal.pone.0024703, 12 pages

1030) Hussain, SP, Hofseth, LJ and Harris, CC 2003. Radical causes of cancer. Nature informs about cancer. 3(4):276-285

1031) Hutchinson, J., Burley, V.J., Greenwood, D.C., Thomas, J.D. and Cade, J.E. 2010. Taking high-dose vitamin C supplements is associated with a self-reported history of breast cancer and other diseases in the Cohort Study of British Women. Nutrition in Public Health. 14(5):768-777

1032) Huycke, M. M. and Gaskins, H. R. 2004. Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models. Exp Biol Med (Maywood). 229(7):586-97

1033) Huynh, CK, Brodie, AMH and Njar, VCO 2006. Inhibitory effects of retinoic acid metabolites (RAMBA) on the growth of human prostate cancer cells and LNCaP prostate tumor xenografts in SCID mice. British journal of cancer. 94(4):513-523

1034) Hwang, H. J., Lee, H. J., Kim, C. J., Shim, I. und Hahm, D. H. 2008. Inhibitory effect of amygdala on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and induced rat arthritis for carrageenan. J Microbiol Biotechnol. 18(10): 1641-7

1035) Hwang, I. S., Lee, J., & Lee, D. G. 2011. Indole-3-carbinol generates reactive oxygen species and induces apoptosis. BiolPharmBull. 34(10): 1602-8

1036) Hwang, I. S., Lee, J., & Lee, D. G. 2011. Indole-3-carbinol generates reactive oxygen species and induces apoptosis. BiolPharmBull. 34(10): 1602-8

1037) Hwang, Y. P. and Jeong, H. G. 2008. Coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress. FEBB Lett. 582(17):2655-62

1038) Hwang, Y. P. and Jeong, H. G. 2010. Metformin blocks tumor cell migration and invasion by inhibiting matrix metalloproteinase 9 activation via a calcium-dependent signaling pathway and Calpha protein kinase: extracellular signal induced by phorbol-12-myristate-13-acetate-regulated kinase/activator protein-1. Bt J Pharmacol. 160(5):1195-211

1039) Ide, T., Kushiro, M., Takahashi, Y., Shinohara, K., Fukuda, N. y Sirato-Yasumoto, S. 2003. Sesamin, a sesame lignin, as a potent serum lipid-lowering diet componente JARQ.37(3):151-158.

1040) Ignarro, L. J., Napoli, C. & Loscalzo, J. 2002. Nitric oxide donors and cardiovascular agent that modulates nitric oxide bioactivity. circle research. 90(1):21-28

1041) Igual, M., García-Martínez, N. 2013. Effects of jam processing and storage on the content of β-carotene and flavonoids in grapefruit. Functional Food Magazine. 5(2): 736-744

1042) Ihle, N.T., Williams, R., Chow, S., Chew, W., Berggren, MI, Paine-Murrieta, G, Minion, D.J., Halter, R.J., Wipf, P., Abraham, R., Kirkpatrick , L. and Powis, G. 2004. Molecular pharmacology and antitumor activity of Px-866, a new inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther. 3(7):763-72

1043) Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M and Kiyohara, Y. 2009. Hyperglycemia increases the risk of gastric cancer due to Helicobacter infection pylori: a population-based cohort study. gastroenterology. 136(4): 1234-1241

[ PMC free article ] [ PubMed ] 1044) Ikeda H.O., Sasaoka N., Koike M., Nakano N., Muraoka Y., Toda Y., Fuchigami T., Shudo T., Iwata A., Hori S. , Yoshimura , N. and Kakizuka , A . 2014. Novel VCP modulators mitigate the main pathologies of rd10, a mouse model of pigment retinosis. Scientific reports. 4:5970, 9 pages, doi:10.1038/srep05970

1045) Ikemoto, A., Ohishi, M., Sato, Y. et al. 2001. Reversibility of n-3 fatty acid deficiency-induced changes in learning behavior in the rat: n-6 fatty acid content as another critical factor. Lipid Research Journal. 42(10):1655-1663.

1046) Ilic, D., Forbes, KM & Hassed, C. 2011. Lycopene in the prevention of prostate cancer. Cochrane Database Syst Rev. 11: CD008007, doi: 10.1002/14651858.CD008007.pub2

1047) National Academies Institute of Medicine, 20022005. Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Pages. 422–541. Washington DC: National Academies Press.

1048) Ip, C. and Hayes, C. 10989. Tissue selenium levels in selenium-supplemented rats and their relevance to protection against breast cancer. carcinogenesis. 10(5):921-925.

1049) Isbrucker, RA & Burdock, GA 2006. Safety and risk assessment of licorice root (Glycyrrhiza sp.), its extract and powder as a foot ingredient, focusing on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol 46, 167-192.

1050) Ishihara, J., Otani, T., Inoue, M., Iwasaki, M., Sasazuki, S., Tsugane, S. and for the Japan Public Health Center prospective study group. 2007. Low intake of vitamin B-6 is associated with increased risk of colon cancer in Japanese men. The Journal of Nutrition. 137(7):1808-1814

1051) Islam, MR, Jones, SJ, Macluskey, M. and Ellis, IR 2014. Is there a tradeoff between VEGF and oral cancer cell migration?. cell signal. 26(6):1294-302

1052) Isoda, K., Young, J.L., Zirlik, A., MacFarlane, L.A., Tsuboi, N., Gerdes, N., Schonbeck, U., & Libby, P. 2006. Metformin inhibits proinflammatory responses and factor nuclear kappaB in cells of the human vascular wall. Arterioscler Thromb Vasc Biol. 26(3): 611-7

1053) Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y and Kizaki M 2004. Induction of apoptosis in leukemia cells by the homovanillic acid derivative capsaicin under oxidative stress: implication of the phosphorylation of p53 at the Ser-15 residue by reactive oxygen species. Cancer Res 64(3): 1071-1078

1054) Iwasaki, M., Inoue, M., Otani, T., Sasazuki, S., Kurahashi, N., Miura, T., Yamamoto, S., and Tsugane, S. 2008 Breast cancer in Japanese women: A Nested case-control study from the Japan Public Health Center prospective study group. Journal of Clinical Oncology. 26(10): 1677-1683

1055) Izetti, P., Hautefeuille, A., Abujama, L.A., de Farias, B.C., Giacomazzi, J., Allemar, B., Lenz, G., Roesler, R., Schwartsmann, G., Osvaldt, BA, Haindut, P. and Ashton-Prolla, P. 2014. PRIMA-1, a p53 reactivator mutant, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines. Invest in new drugs. 32(5):783-794

1056) Izuta, S., Ueki, M., Ueno, M., Nishina, K., Shiozawa, S., and Maekawa, N. 2012. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver damage in mice. Biotechnology Lett. 34(12):2175-82

1057) Izzo, F., Marra, P., Beneduce, G., Castello, G., Vallone, P., De Rosa, V., Cremona, F., Ensor, M.C., Holtsberg, WF, Bomalaski, S.J., Clark, AM, Ng, C & Curley, AS 2004. Treatment of patients with inoperable hepatocellular carcinoma with pegylated arginine deiminase: results of phase I/II studies. Journal of Clinical Oncology. 22(10): 1815-1822

1058) Jaber BM, Gao T, Huang L, Karmakar S, and Smith CL 2006. The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the adenosine monophosphate response element-binding protein cyclic 3',5'-p300 Coactivators. moles of endocrinol. 20(11):2695-710

1059) Jacobs, E.J., Connell, C.J., McCullough, M.L., Chao, A., Jonas, CR., Rodriguez, C., Calle, E.E. and Thun, M.J. 2002. Use of vitamin C, vitamin E and multivitgamin supplements and mortality in gastric cancer in cohort II of the Cancer Prevention Study Biomarkers for Cancer Epidemics Prev. 11(1): 35-41

1060) Jacobs, E.J., Connell, C.J., Patel, A.V., Chao, A., Rodriguez, C., Seymour, J., McCullough, M.L., Calle, E.E. and Thun, M.J. 2001. Vitamin C and Vitamin E Supplement Use and Colorectal Cancer Mortality in a Large American Cancer Society Cohort. Epidemiology, biomarkers and cancer prevention. 10(1):17-23

1061) Jacobs, EJ, Henion, AK, Briggs, PJ, Connell, CJ, McCullough, ML, Jonas, CR, Rodriguez, C, Calle, EE, and Thun, MJ 2002. Use of vitamin C and vitamin E supplements and mortality by bubble cancer in a large cohort of American men and women. American Journal of Epidemiology. 156(11):1002-1010

1062) Jacobs, E. T., Alberts, D. S., Benuzillo, J., Hollis, B. W., Thompson, P. A., & Martinez, M. E. 2007. Serum 25(OH)D level, dietary vitamin D intake, and colorectal adenoma recurrence. The journal of steroid biochemistry and molecular biology. 103(3-5): 752-756

1063) Jacobs ET, Pelt CV, Forster RE, Zaidi W, Hibler EA, Galligan MA, Haussler MR, and Jurutka PW 2013. CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells. Cancer research. DOI: 10.1158/00085472

1064) Jacobs, E.T., Jiang, R., Alberts, D.S. et al. 2004. Colorectal adenoma and selenium results from a pooled analysis. Zeitschrift of the National Cancer Institute. 96(22):1669-1675.

1065) Jacobsen, J., Grankvist, K., Rasmuson, T., Bergh, A., Landberg, G. y Ljunberg, B. 2004. Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU International. 93(3): 297-302

1066) Jaffey, M. 1982. Vitamin C and cancer: examining the value of the results of seven trials using broad inductive reasoning. Medical hypotheses. 8(1):49-84

1067) Jäger, S., Trojan, H., Kopp, T., Laszczyk, M, N., & Scheffler, A. 2009. Distribution of pentacyclic triterpenes in different plant-rich sources for a new group of multipotent plant extracts. molecules. 14(6): 2016-2031

1068) Jagerstad, M. and Skog, K. 2005. Genotoxicity of heat-treated foods. mutate res. 574(1-2): 156-72

1069) Jagtap , J.C. , Parveen , D. , Shah , R.D. , Desai , A. , Bhosale , D. , Chugh , A. , Ranade , D. , Karnik , S. , Khedkar , B. , Mathur , A. , . Natesh, K., Chandrika, G. and Shastry, P. 2015. Prostate secretory (Par)-4 apoptotic response sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death. FEBS OpenBio. 5:8-19, doi:10.1016/j.fob.2014.11.005

1070) Jain, A. 2015. Curcumin inhibits PhIP-induced carcinogenicity by regulating the expression of Nrf2 and Foxo targets and the expression of BRCA-1 and P16 in mammary epithelial cells. J carcinogenic mutagen. 6:4,

1071) Jamali, N., Sorenson, C. & Sheibani, N. 2014. Vitamin D attenuates the proangiogenic properties of pericytes through increased VEGF production. The FASEB Journal. 28:679.1 (Submission Abstract, Supplement 1).

1072) James, S. J., Miller, B. J., Basnakian, A. G., Pogribny, I. P., Pogribna, M. und Muskhelishvil, L. 1997. Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in the liver of folate-deficient rats /methyl. Karzinogenese. 18:287-93

1073) Jamison, J.R. 2003. Licorice (Glyrrhiza glabra). Clinical Guide to Nutrition and Supplements in Disease Management. 587-590, chapter 78.

1074) Jamshidzadeh, A., Aminlari, M., and Rasekh, H. 2001. Rhodanase and arginase activity in normal and cancerous tissues of the human breast, esophagus, stomach, and lung. Anger Med. 4(2):88-89

1075) Janakirsam, BN & Rao, VC 2012. Selective NOS inhibitors for cancer prevention: promise and progress. Future Med Chem. 4(17):2193-2204

1076) Jane, E. P., Premkumar, D. R., Addo-Yobo, S. O. und Pollack, I. F. 2009. Abrogation of mitogen-activated protein kinase and Akt signaling by synergistically enhanced vandetanib potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. Das Journal of Pharmacology and Experimental Therapeutics. 331(1): 327-337

1077) Jang MH, Jun DY, Rue SW, Han Kh, Park W and Kim YH 2002. The arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via Bcl-regulated caspase-3 activation -2 or Bcl-xL . Biochem Biophys Communal Res. 295(2):283-8

1078) Jang, M., Cai-, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C. and Pezzuto, J. M. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275 (5297): 218-220

1079) Jang, S. and Javadov, S. 2014. JNK inhibition impairs the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. Plus one. 9(11): e113526, Doi: 10.1371/journal.pone.0113526, 20 pages.

1080) Jang, S. H., Lim, J. W., and Kim, H. 2009. Beta-carotene inhibits Helicobacter pylori-induced inducible nitric oxide synthase and cyclooxygenase-2 expression in human gastric epithelial AGS cells. J Physiol Pharmacol. 60 (Supplement 7): 131-7

1081) Jani , JP , Finn , RS , Campbell , M , Coleman , KG , Connell , RD , Currier , N , Emerson , EO , Floyd , E , Harriman , S , Kath , JC , Morris , J . , Moyer , J. D. , Pustilnik , L. R. , Rafidi , K. , Ralston , S. , Rossi , A. M. , Steyn , S. J. , Wagner , L. , Winter , S. M. and Bhattacharya , S. K. 2007. Discovery and pharmacological characterization of CP-724,714, 2007 . a selective ErbB2 Tyrosine Kinase Inhibitor. Cancer Res. 67(20): 9887–93

1082) Janoszka, B., Warzecha, L., Blaszczyk, U. & Bodzek, D. 2004. Organic compounds formed in heat-treated protein-rich foods. Part I: Polycyclic Aromatic Hydrocarbons. Chromatographic Act. 14:115-128, doi=10.1080/1573062X.2010.528435

1083) Januel, C., El Hentati, F.Z., Carreras, M., Arthur, J.R., Calzada, C., Lagarde, M. and Vericel, E. 2006. Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization at rest Platelets and compartment switching during platelet activation. Biochim Biophys Act. 1761(10): 1228-34

1084) Jase, C. S., Cabanillas, A., Benitez, J., Carrillo, J. A., Jimenez, M. and Gervasini, G. 2010. CYP1A1 gene polymorphisms increase the risk of lung cancer in a region of high incidence in Spain: learning a control case. BMC cancer. 10: 463-469, doi: 10.1186/1471-2407-10-463

1085) Jasinski, M., Jasinska, L. and Ogrodowczyk, M. 2013. Brief review of resveratrol in prostate diseases. European cent J urol. 66(2):144-9

1086) Jatoi, AM and Lamm, DL 1999. Chemoprevention of urological cancer. The Journal of Urology. 161(6):1748–1760

1087) Jaworska, K., Gupta, S., Durda, K. et al. 2013. Low selenium levels are associated with lung and throat cancer. Plus one. 8(3): 1-6.

1088) Jaworski, K., Kinard, F., Goldstein, D., Holvoet, P., Trouet, A., Schneider, YJ. and Remacle, C. 2001. S-nitrosothiols, unlike other nitric oxide donors, do not show oxidative stress in vascular endothelial cell or smooth muscle cell cultures. Eur J Pharmacol. 425(1):11-19

1089) Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannon D, Ramacher M, Icato M, Overwijk, W. W., Chen, S., Umansky, Y. V. & Sikora, G. A. 2012. Tumor Inducibly expressed nitric oxide synthase controls the induction of functional myeloid suppressor cells through modulation of vascular endothelial growth factor release. The Journal of Immunology. 188(11): 5365-5376

1090) Jayasooriya RGPT, Lee Y, Kang C, Lee K, Choi Y, Park S, Hwang J, and Kim G 2012. Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor α-stimulated DU145 cells by DU145 cells suppress Akt-mediated nuclear factor-kB signaling. Oncology. 5(1): 341-3

1091) Jee, S.H., Ohrr, H., Sull, J.W., Yun, JE, and Ji, M., Samet, J.M. 2005. Fasting serum glucose level and cancer risk in Korean men and women. NEVER. 293(2): 194-202

1092) Jeng, K.C., Yang, CS, Siu, W.Y., Tsai, Y.S., Liao, W.J. and Kuo, J.S. 1996. Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. Bin J Clin Nutr. 64(6):960-965

1093) Jensen, C.L. 2006. Effects of n-3 fatty acids during pregnancy and lactation. American journal of clinical nutrition. 83 (Supplement 6): 1452–1457.

1094) Jensen, C.L., Voigt, R.G., Prager, T.C. et al. 2005. Effects of maternal intake of docosahexaenoic acid on visual function and neurodevelopment in breastfed term infants. American journal of clinical nutrition. 82(1): 125-132.

1095) Jeong, JH, An, JY, Kwon, YT, Li, LY and Lee, YJ 2008. Quercetin-induced ubiquitination and negative regulation of Her-2/neu. J Cell Biochem. 105(2): 585-95

1096) Jeong JH, An JY, Kwon YT, Rhee JG, and Lee YJ 2009. Effects of low-dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. 106(1):73-82

1097) Jeong, SM, Lee, J, Finley, SWL, Schmidt, PJ, Fleming, DM, & Haigis, CM 2015. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 34:2115-2124, doi:10.1038/onc.2014.124

1098) Jeong, S., Woo, M. M., Flockhart, D. A. und Desta, Z. 2009. Inhibition of cytochrome P450 drug metabolism by the aromatase inhibitor drug Letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 64(5): 867-875

1099) Jeong, Y. J., Lee, J. Y., Han, H. J., Park, Y. S., Hwang, W. K., and Sohn, D. U. 2014. The inhibitory effect of PIK-75 on the inflammatory mediator response induced by hydrogen peroxide in feline esophageal epithelial cells . Mediatoren von Inflamm. 2014: 178049, doi: 10.1155/2014/178049

1100) Ji G, Zhang Y, Yang Q, Cheng S, Hao J, Zhao X and Jiang Z 2012. Genistein suppresses LPS-induced inflammatory response by inhibiting NF-kB after AMP kinase activation in RAW 264 macrophages.7 . Plus one. 7(12): e53101, doi: 10.1371/journal.pone.00533101, 7 pages.

1101) Ji Q, Liu X, Fu X, Zhang L, Sui H, Zhou L, Sun J, Cai J, Qin J, Ren J, and Li, Q. 2013. Resveratrol inhibits colon cancer cell invasion and metastasis via MALAT1-Wnt/B-catenin-mediated signaling pathway. Plus one. 8(11): e78700, doi: 10.1371/journal.pone.0078700, 12 pages

1102) Ji, Y., Ji. C., Yue, L. and Xu, H. 2012. Saponins isolated from asparagus induce apoptosis in the human hepatoma cell line HepG2 through a mitochondria-mediated pathway. CurrOncol. 19 (Supplement 2): e51-e59

1103) Jian, L., Xie, L. P., Lee, AH, & Binns, C. W. 2004. Protective effects of green tea against prostate cancer: a case-control study in southeast China. Int J Cancer. 108(1):130-5

1104) Jiang, C., Wang, Z., Ganther, H. und Lü, J. 2002. Distinct effects of methylselenic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in breast cancer cells. human prostate DU145. Mol Cancer Ther. 1(12):1059-66

1105) Jiang, H., Shang, X., Wu, H., Huang, G., Wang, Y., Al-Holou, S., Guatam, S. C., & Chopp, M. 2010. Combination therapy with resveratrol and sulforaphane Induced apoptosis in human U251 glioma cells. neurochemistry Res. 35(1):152-61

1106) Jiang, H., Xie, Z., Koo, H. J., McLaughlin, S. P., Timmermann, B. N. und Gang, D. R. 2006. Metabolic Profiling and Phylogenetic Analyzes of Medical Zingiber Spezies: Tools for Authentication of Ginger (Zingiber officinale Rosc. ) . Phytochemistry. 67(15): 1673-1685

1107) Jiang, J. and Hui, CC 2008. Hedgehog Signaling in Development and Cancer. developer cell. 15(6):801-12

1108) Jiang J, Huang Z, Zhao Q, Feng W, Belikova NA and Kagan VE 2008. Interaction between Bax reactive oxygen species production and cardiolipin oxidation during apoptosis. Biochem Biophys Communal Res. 368(1): 145-50

1109) Jiang J, Kang TB, Shim do W, Oh NH, Kim TJ, and Lee KH 2013. Indole-3-carbinol inhibits the LPS-induced inflammatory response by interfering with the TRIF-dependent signaling pathway in blocked macrophages. Food Chem Toxicol. 57: 256-61, doi: 10.1016/j.fct.2013.03.040

1110) Jiang, Q., Christen, S., Shigenaga, MK, & Ames, BN 2001. Review Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Bin J Clin Nutr. 74(6):714-22

1111) Jiang, Q., Elson-Schwab, I., Courtemanche, C. & Ames, B. N. 2000. Gamma-tocopherol and its major metabolite, unlike alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and cells epithelial. Proc Natl Acad Sci USA. 97(21):11494-9

1112) Jiang, Q., Wong, J. and Ames, B. N. 2004. Gamma-tocopherol induces apoptosis in androgen-sensitive LNCaP prostate cancer cells through caspase-dependent and independent mechanisms. Ann NY Acad. science 1031: 399-400

1113) Jiang, S. Y., Shyu, R. Y., Yeh, M. Y. and Jordan, V. C. 1995. Tamoxifen inhibits the growth of hepatoma cells through an estrogen receptor-independent mechanism. J Hepatol. 23(6): 712-9

1114) Jiao, S. and Zheng, L. 2011. Non-apoptotic role of BAD and BAX in synaptic transmission in long-term depression. neuron. 70(4):758-772

1115) Jieer, Y., Qi, X., Bixia, L., and Xiangdong, C. 2014. PI3K/p-AKT/p-mTOR expression in gastric carcinoma and its correlation with clinicopathological features. Gastrointestinal Cancers Symposium 2014, J Clin Oncol 32, 2014 (Supplement 3; Abs. 73).

1116) Jimeno , A. , Weiss , G. , Miller Jr. , W. H. , Gettinger , S. , Eigl , B. J. C. , Chang , A. L. S. , Dunbar , J. , Devens , S. , Faia , K. , Skliris , G . , Kutok , J. , Lewis , K. D. , Tibes , R. , Shafman , W. H. , Ross , R. W. and Rudin , C. M. 2013. Phase 1 study of the Hedgehog pathway inhibitor IPI-926 in surveillance patients with solid tumors . Clin Cancer Res. 19(10):2766–2774

1117) Jin C, Moon D, Choi YH, Park C, Kim M, Lee J, Lee T and Kim G 2007. Sulforaphane-induced caspase-3 in U937 human leukemia cells by modulating ERK and Akt pathways. research for cancer prevention. 12(4): 246-54

1118) Jin, E. Y., Lim, S., Kim, S., Park, Y., Jang, J. K., Chung, M., Park, H., Shim, K., and Choi, Y. J. 2011. Optimization of different methods of extraction for quercetin from onion skin using response surface methodology. Biotechnology in Food Sciences. 20(6): 1727-1733

1119) Jin H, Park I, An S, Lee H, Woo S, Hong Y, Lee S, Park M, Yoo D, Rhee C and Hong, S. 2006. Upregulation of Bak and Bim via the downstream JNK path in the response to nitric oxide in human glioblastoma cells. Cell Physiology Journal. 206(2): 477-486

1120) Jin, Q., Zhu, K., Xie, Y., and Shen, W. 2013. Heme oxygenase-1 is involved in the alleviation of ascorbic acid-induced cadmium toxicity in root tissues of Medicago Sative. plant and soil. 366(1-2):605-616

1121) Jin S, Park J, Hong J, Kim T, Shin H, Park E and Kim S 2011. Inhibitory effect of (-)-epigallocatechin gallate on titanium article-induced TNF-α release and osteolysis in. 1121) live. Experimental and Molecular Medicine. 43:411–418, doi:10.3858/emm.2011.43.7.045

1122) Jin Y, Cao Q, Chen C, Du X, Jin B, and Pan J 2015. Tenovin-6-mediated SIRT1/2 inhibitor induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates stem cells/ ALL progenitors. BMC cancer. 15:226, doi:10.1186/s128885-015-1282-1, 15 pages

1123) Jisa, E., Dornstauder, E., Ogawa, S., Inoue, S., Muramatsu, M., and Jungbauer, A. 2001. Estrogen receptor alpha and beta transcriptional activities on the yeast properties of raloxifene. Biochem Pharmacol. 62(7):953-61

1124) Jo, C., Kim, S., Cho, S.J., Choi, K.J., Yun, SM, Koh, Y.H., Johnson, G.V. and Park, SI 2014. Sulforaphane induces autophagy through ERK activation in neuronal cells. FEBS Lett. 588(17): 3081-3088

1125) Jo, E.H., Kim, S.H., Ahn, N.S., Park, J.S., Hwang, J.W., Lee, Y.S. and Kang, K.S. 2007. The efficacy of sulforaphane is mediated by activations of p38 MAP kinase and caspase-7 in ER-positive and COX-2-expressing human breast cancer cells. European Journal of Cancer Prevention. 16(6):505-510

1126) Jo, G. H., Kim, G., Kim, W., Park, K. Y., & Choi, Y. H. 2014. Sulforaphane induces apoptosis in T24 human bladder cancer cells via a reactive oxygen species-mediated mitochondrial pathway : the involvement of endoplasmic reticulum stress and Nrf2 - signaling pathway. International Journal of Oncology. 45(4): 1497-1506

1127) Johansson, M., Relton, C., Ueland, M., Vollset, S. et al. 2010. Serum B vitamin levels and risk of lung cancer. NEVER. 303(23):2377-2385 (Author number greater than 10)

1128) Johnson, D.E. 2000. Noncaspase proteases in apoptosis. Leukemia. 14(9):1695-703

1129) Johnson, E., Seachrist, DD, DeLeon-Rodriguez, CM, Lozada, KL, Miedler, J, Abdul-Karim, FW, and Keri, RA 2010. The migration and invasion of breast cancer cells induced by HER2/ ErbB2 requires p120 catenin -Activation of Rac1 and Cdc42. The Journal of Biological Chemistry. 285(38): 29491-29501

1130) Johnson, JJ 2011. Carnosol: a promising anti-inflammatory and anticancer agent. cancer letters 305(1):1-7

1131) Johnson, SM, Gulhati, P, Arrieta, I, Wang, X, Uchida, T, Gao, T, and Evers, BM 2009. Curcumin inhibits colorectal cancer proliferation by modulating Akt/mTOR signaling. Res. against cancer. 29(8):3185-3190

1132) Jordan, M. J., Castillo, J., Banon, S., Martinez-Conesa, C. and Sotomajor, A. J. 2014. Relevance of the carnosic acid/carnosol ratio in the degree of transfer of rosemary diterpenes and in the improvement of antioxidant status of lamb meat. Food Chemistry. 151: 212-218, doi: 10.1016/j.foodchem.201311.068

1133) Joy, C.B., Mumby-Croft, R., and Joy, L.A. 2006. Dietary supplementation with polyunsaturated fatty acids in schizophrenia. The Cochrane Database of Systematic Reviews, 3, CD001257.

1134) Juan, E. M., Wenzel, U., Daniel, H., & Planas, J. M. 2008. Resveratrol induces apoptosis via the ROS-dependent mitochondrial pathway in HT-29 human colorectal carcinoma cells. Journal of agricultural and food chemistry. 56(12): 4813-4818

1135) Juengel E, Thomas A, Rutz J, Makarevic J, Tsaur I, Nelson K, Haferkamp A. & Blaheta, R. 2015. Amygdalin inhibits the growth of renal carcinoma cells in vitro. International Journal of Molecular Medicine. 37(2):526-532

1136) Jung, K., Lee, J.H., Quach, HT, Paik, J., Oh, H., Park, J.W., Lee, E.J., Moon, S., & Lee, K. 2013. Resveratrol suppresses the uptake of glucose by cancer cells by targeting hypoxia-inducible factor 1α activation mediated by reactive oxygen species. The Journal of Nuclear Medicine. 54:12, doi:10.2967/jnumed.112.115436, 7 pages

1137) Jurczyszyn, A., Zebzda, A., Czepiel, J., Perucki, W., Bazan-Socha, S., Cibor, D., Owczarek, D., and Majka, M. 2014. Inhibit geldanamycin and its derivatives the growth of myeloma cells and reduces the expression of the MET receptor. J Cancer. 5(6): 480-90

1138) Kaaks, R. 2004. Diet, insulin, IGF-1 metabolism, and cancer risk: a summary of the epidemiologic evidence. Novartis found Symp.262: 247-260

1139) Kahl, T., Schroder, K., Lawrence, F.R., Marshall, W.J., Hoke, H. and Jackh, R. 2005. Anilines. Ullmann's encyclopedia of industrial chemistry. 1-15, doi:

1140) Kahn, B., Collazo, J., & Kyprianou, N. 2014. The androgen receptor as a driver of therapeutic resistance in advanced prostate cancer. International J. Biol. Sci. 10(6): 588-595

1141) Kai, L. and Levenson, A. S. 2011. The combination of resveratrol and the antiandrogen flutamide has a synergistic effect on the inhibition of androgen receptors in prostate cancer cells. Res. against cancer. 31(10):3323-30

1142) Kai, L., Samuel, S.K., and Levenson, A.S. 2010. Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting the MTA1/NuRD complex. Int J Cancer. 126(7):1538-48

1143) Kaizu, T., Tamaki, T., Tanaka, M., Uchida, Y., Tsuchihashi, S., Kawamura, A. and Kakita, A. 2003 die Rattenniere. Niere International. 63: 1393-1403, doi : 10.1046/j.1523-1755.2003.00882.x

1144) Kalluri, R. y Zeisberg, M. 2006. Fibroblasts in cancer. Nature Reviews 6: 392-40140101, doi:10.1038/nrc1877

1145) Kamangar, F., Qiao, Y., Yu, B., Sun, X., Abnet, CC, Fan, J., Mark, DS, Zhao, P, Dawsey, MS, and Taylor, R.P. 2006. Lung cancer chemoprevention: a randomized, double-blind study in Linxian, China. Epidemiology, biomarkers and cancer prevention. 15(8): 1562-1564

1146) Kang, C. H., Choi, Y. H., Moon, S. K., Kim, W. J., & Kim, G. Y. 2013. Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by repressing the NF-kB signaling pathway and activating the HO dependent on Nrf2 - 1 pathway. Immunopharmaceutical International. 17(3):808-13

1147) Kang, H., Zhang, Y., Yang, J., and Lu, K. 2012. Study on Soy Isoflavone Consumption and Breast Cancer Risk and Survival. Asia Pacific J Cancer Before. 13(3): 995-998

1148) Kang, J. H., Han, I. H., Sung, M. K., Yoo, H., Kim, Y. G., Kim, J. S. Kawada, T. and Yu, R. 2008. Soybean saponin inhibits tumor cell metastasis by modulating the expression of MMP-2, MMP-9 and TIMP-2. Cancer Lett. 261, 84-92

1149) Kang KS, Wang P, Yamabe N, Fukui M, Jay T and Zhu BT 2010. Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo through formation of reactive oxygen species and activation of Caspase 8. Plus one. 5(4): 310296, 13 pages, doi: 10.1371/journal.pone.0010296

1150) Kang, M., Park, S. K., Seo, Y. J., & Kim, H. 2011. Lycopene inhibits IL-6 expression in caerulein-stimulated pancreatic acinar cells. Gene Nutr. 6(2): 117-123

1151) Kang, N.J., Lee, KW, Shin, B.J., Jung, S.K., Hwang, M.K., Bade, A.M., Heo, Y., Lee, H.J. and Dong, Z. 2009. Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. carcinogenesis. 30(2): 325-330

1152) Kani, K., Momota, Y., Harada, M., Yamamura, Y., Aota, K., Yamanoi, T., Takano, H., Motegi, K., and Azuma, M. 2013. ϒ - Tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel by downregulating the expression of NF-kB-regulated antiapoptotic gene products. International Journal of Oncology. 42(1): 75-8

1153) Kanno, S., Kitajima, Y., Kakuta, M., Osanai, Y., Kurauchi, K., Ujibe, M. and Ishikawa, M. 2008. Costunolide-induced apoptosis is caused by receptor-mediated pathways and Inhibition of telomerase activity in NALM-6 cells. BiolPharmBull. 31(5): 1024-8

1154) Kansanen, E., Kuosmanen, S. M., Leinoen, H. and Levonen, A. 2013. The keap1-Nrf2 pathway: mechanism of activation and deregulation in cancer. redox biology. 1(1): 45-4

1155) Kantari, C. and Walczak, H. 2011. Caspase-8 and Bid: caught in the act between death receptors and mitochondria. Biochim Biophys Act. 1813(4): 558-563

1156) Kao B, van Es HJ, van den Born M, and Clevers H 2015. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43; Znrf3 mutant neoplasm. PNAS. 112(24): 7548-7550

1157) Kao TC, Shyu MH and Yen GC 2010. Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation through PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. J Agricultural food chemistry. 58(15):8623-9

1158) Karan, D., Kelly, D. L., Rizzino, A., Lin, M., and Batra, S. K. 2002. Expression profiling of differentiation-regulated genes during androgen-independent growth progress in human prostate cancer cells. Karzinogenese. 23(6): 967-976

1159) Karhadkar, S. S., Bova, G. S., Abdallah, N., Dhara, S., Gardner, D., Maitra, A., Isaacs, J. T., Berman, D. M., and Beachy, P. A. 2004. Hedgehog signaling in the regeneration of prostate, neoplasia and metastasis. Nature 431 (7009): 707-12

1160) Karin, M. 1990. Too many transcription factors: positive and negative interactions. New Biol. 2(2): 126-31

1161) Karin, M. 2006. Nuclear factor kappaB in the development and progression of cancer. Nature 441 (7092): 431-6

1162) Karin, M., Cao, Y., Greten, F.R. and Li, ZW 2002. NF-kappaβ in cancer: from innocent bystander to main culprit. Nat Rev Cancer. 2(4): 301-310

1163) Kasai Y, Maegawa M, Yamamoto S, Kamada M, Yasui T, Uemura H, Kobayashi A, Kaneyama M, Tani A, Matsui S., Kuwahara, A., Matsuzaki, T., Furumoto, H. and Irahara, M. 2011. Effects of raloxifene on stimulated whole blood cytokine production in ex vivo and in vivo studies. JMed Invest. 58(1-2): 110-7

1164) Kasaoka, T., Nishiyama, H., Okada, M., and Nakajima, M. 2008: The matrix metalloproteinase inhibitor, MM1270 (GCS27023A) inhibited hematogenous metastasis of B16 melanoma cells in both experimental and metastasis models. spontaneous. Clin Exp Metastasis. 25(7):827-34

1165) Kasetti, R. B., Nabi, S. A., Swapna, S. and Apparao, C. 2012. Cinnamic acid as one of the antidiabetic agents from Syzgium alternifolium seeds. Food and chemical toxicology. 50(5): 1425-1431

1166) Kaskiw, M. J., Tassotto, M. L., Mok, M., Tokar, S. L., Pycko, R., Thing, J. y Jiang., Z. H. 2009. Structural analogs of diosgenyl saponins: Synthesis and anticancer activity. BioorgMed Chem. 17(22): 7670-9

1167) Katiyar, SK 2015. Hsp90 inhibitor can inhibit UV carcinogenesis. Journal of Investigative Dermatology. 135:945-947, doi:10.1038/jid.2014.504

1168) Katsouyanni, K., Trichopoulou, A., Stuver, S., Vassilaros, S., Papadiamantis, Y., Bournas, N., Skarpou, N., Mueller, N. and Trichopoulos, D. 1994. Ethanol y Breast cancer: an association that can be both confusing and coincidental. International Journal of Cancer. 58(3): 356-361

1169) Kaufman, P.B., Duke, J.A., Brielmann, H., Boik, J., and Hoyt, J.E. 1997. Comparative study of leguminous plants as sources of isoflavones, genistein and daidzein: implications for human nutrition and health. J Aging Supplement Med. 3(1): 7-12

1170) Kaur, R., Kaur, P., Sharma, S., Singh, G., Mehndiratta, S., Bedi, PMS, & Nepali, K. 2015. Anticancer pyrimidines in various scaffolds: a review of the patent literature . Recent patents in cancer drug discovery. 10(1): 23-71

1171) Kaushal, G.P., Kaushal, V., Hong, X. and Shah, S.V. 2001. Role and regulation of caspase activation in cisplatin-induced damage to renal tubular epithelial cells. International Kidney. 60: 1726-1736, doi: 10.1046/j.1523-1755.2001.00026

1172) Kaushal, G.P., Kaushal, V., Hong, X. and Shah, S.V. 2001. Role and regulation of caspase activation in cisplatin-induced damage to renal tubular epithelial cells. International Kidney. 60: 1726-1736, doi: 10.1046/j.1523-1755.2001.00026

1173) Kawa, S., Nikaido, T., Aoki, Y., Zhai, Y., Kumagai, T., Furihata, K., Fujii, S., and Kiyosawa, K. 1997. Vitamin D analogues increase the regulation of p21 and p27 during growth inhibition of pancreatic cancer cell lines. Br J Cancer. 76(7):884-889

1174) Kawagoe J, Ohmichi M, Takahashi T, Ohshima C, Mabuchi S, Takahashi K, Igarashi H, Mori-Abe A, Saitoh M, Du, B., Ohta, T., Kimura, A., Kyo, S. , Inoue, M. and Kurachi, H. 2003. Raloxifene inhibits estrogen-induced upregulation of telomerase activity in a human breast cancer cell line. JBiolChem. 278(44): 43363-72

1175) Kawamura, T., Liu, D., Towle, M.J., Kageyama, R., Tsukahara, N., and Wakabayashi, T. 2003. The antiangiogenic effects of borrelidin are mediated by different pathways: threonyl-tRNA synthetase and Las Caspases are independently involved in suppressing infection proliferation and apoptosis in endothelial cells. The journal of antibiotics. 56(8):709-15

1176) Kawanishi, S., Oikawa, S., and Murata, M. 2005. Safety evaluation of antioxidant chemopreventive agents. Redox-Signal antioxidant. 7(11-12): 1728-1739

1177) Kawasaki, K., Smith, R.S. Jr., Hsieh, CM, Sun, J., Chao, J., and Liao, J.K. 2003. Activation of the Akt phosphatidylinositol-3-kinase/protein kinase pathway mediates nitric oxide activation Endothelial cell migration and angiogenesis. Mol Cell Biol. 23(16): 5726-37

1178) Kawashima , H. , Tanaka , T. , Cheng , J. S. , Sugita , S. , Ezaki , K. , Kurisu , T. and Nakatani , T. 2004 in Prostate Cancer . Urol-Res. 32(6): 406-10

(1179) Kayashima T, Tanaka K, Okazaki Y, Matsubara K, Yanaka N and Kato N 2011. The antitumor targets in mice exposed to 1,2-dimethylhydrazine. Oncol Lett. 2(6): 1243–1246

1180) Kearney, J., Giovannucci, E., Rimm, EB, Ascherio, A., Stampfer, M.J., Colditz, GA, Wing, A., Kampman, E., and Willett, W.C. 1996. Calcium, Vitamin D and Dairy Diet and the occurrence of colon cancer in men. American Journal of Epidemiology. 143(9): 907-917

1181) Keefer, LK, Nims, RW, Davies, KM and Wink, DA 1996. NONates (1-substituted diazene-1-io-1,2-diolates) as nitric oxide donors: practical ways of dosing nitric oxide. Enzymol Methods. 268: 281-293, doi: 10.1016/S0076-6879(96)68030-6

1182) Kelkel, M., Schumacher, M., Dicato, M., & Diederich, M. 2011. Antioxidant and antiproliferative properties of lycopene. Free Radical Res. 45(8): 925-40

1183) Kempuraj, D., Huang, M., Kadere-Grzybowska, K., Basu, S., Boucher, W., Letourneau, R., Athanassiou, A. and Theoharides, TC 2003. Azelastine inhibits Activation secretion of IL-6, TNF-alpha e IL-8 and NF-kappaB and intracellular calcium ion levels in normal human mast cells. Int Arch Allergy Immunol. 132(3): 231-9

1184) Kensler , TW , Egner , PA , Agyeman , AS , Visvanathan , K , Groopman , JD , Chen , JG , Chen , TY , Fahey , JW und Talalay , P 2013. Keap1-nrf2 signaling: a target for cancer Preparation by sulforaphane. Top Curr Chem. 329: 163–77;

(Video) An Integrative Approach to Cancer with Ralph Moss, PhD.

1185) Keri, V., Csorvasi, A. and Aronhime, J. 2003. Preparation of orlistat and crystalline forms of orlistat. Patent publication number: US20030149095

1186) Kerwin, SM 2004. Soy saponins and the anticancer effects of soybeans and soy-based foods. Curr Med Chem. Cancer Drug. 4(3): 263-72

1187) Keshavan, P., Schwemberger, S.J., Smith, DLH, Babcock, GF, and Zucker, S.D. 2004. Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int J Cancer. 112(3): 433-445

1188) Kestwal, R. M., Lin, J. C., Bagal-Kestwal, D. & Chiang, B. H. 2011. Glucosinolates strengthen cruciferous shoots by sulfur supplementation during cultivation to enhance anticancer activity. Food Chemistry. 126(3): 1164-1171.

1189) Keszei AP, Goldbohm RA, Schouten LL, Jakszyn P, and van den Brandt PA 2013. Dietary components of N-nitroso, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands cohort study. American journal of clinical nutrition. 97(1): 135-146

1190) Keum, Y. S., Yu, S., Chang, P. P., Yuan, X., Kim, J. H., Xu, C., Han, J., Agarwal, A., and Kong, AN 2006. Sulforaphane mechanism of action: inhibition of p38 mitogen-activated protein kinase isoforms that contribute to antioxidant response element-mediated heme oxygenase-1 induction in human hepatoma HepG2 cells. cancer res 66(17):8804-13

1191) Keum, Y.S., Yu, S., Chang, PP, Yuan, X., Kim, J.H., Xu, C., Han, J., Agarwal, A., and Kong, AN 2006. Sulforaphane mechanism of action: Inhibition of p38 mitogen-activated protein kinase isoforms that contribute to antioxidant response element-mediated heme oxygenase-1 induction in human hepatoma HepG2 cells. cancer res 66(17):8804-13

1192) Clave , JT , Appleby , NP , Allen , EN , Travis , CR , Roddam , WA , Jenab , M , Egevad , L , Tjoneland , A , Johnsen , FN , Overvad , K , Linseisen , J. , Rohrmann , S , Boeing , H. , Pischon , T. , Psaltopoulou , T. , Trichopoulou , A. , Trichopoulou , D. , Palli , D. , Vineis , P. , Tumino , R. , Berrino , F. , 2005. , Kiemeney , L., Good-of-Mosque, B.H. , Chiros , R.J. , Gonzalez , A.C. , Martinez , C. , Larrañaga , N. , Chirlaque , D.M. , Ardanaz , E. , Stattin , P. , Hallmans , G.A. , Khaw , K. , Bingham , S. , Slimani , N. , Ferrari , P. , Rinaldi , S. and Riboli , E. 2007 to Cancer and Enrichment Studies . . . . . . . . . . . . . Bin J Clin Nutr. 86(3): 672-681

1193) Key, T.J., Appleby, P.N., Masset, G., Brunner, J.E., Cade, J.E., Greenwood, D.C., Stephen, A.M., Kuh, D., Bhaniani, A., Powell, N., and Khaw, K. 2012. Vitamins, minerals, essential fatty acids, and colorectal cancer risk in the UK Dietary Cohort Consortium. Int J Cancer. 131(3): E320-E325

1194) Khaliullina, H., Bilgin, M., Sampaio, J.L., Shevchenko, A., & Eaton, S. 2015. Endocannabinoids are conserved inhibitors of hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 112(11): 3415-3420

1195) Khan, F., Ali, A. & Ali, R. 2005. Enhanced recognition of hydroxyl-modified plasmid DNA by circulating anti-cancer antibodies. J Exp Clínica Cáncer Res. 24 (2): 289-96

1196) Khanduja, K. L., Kumar, S., Varma, N., Varma, S. C., Avti, P. K. und Pathak, C. M. 2008. Enhancement in alpha-tocopherol succinate-induced apoptosis by all-trans-retinotic acid in leukemia primaria Zellen: Role of the antioxidant factors, Bax and c-myc. Mol Cell Biochem. 319(1-2): 133-9

1197) Khanna, S., Parinandi, N. L., Kotha, S.R., Roy, S., Rink, C., Bibus, D., and Sen, C. K. 2010. Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and provides neuroprotection. J Neurochem. 112(5):1249-60

1198) Khanna, S., Rink, C., Ghoorkhanian, R., Gnyawali, S., Heigel, M., Wijesinghe, D.S., Chalfant, CE, Chan, Y.C., Banerjee, J., Huang, Y., Roy , S. and Sen, C. K. 2013. Loss of miR-29b after acute ischemic stroke contributes to nerve cell death and infarct size. J Cereb Blood Flow Metab. 33(8):1197-206

1199) Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swan, P.W., Ratan, R.R. and Sen, C.K. 2003. Molecular Basis of Vitamin E Action: Tocotrienol Modulates 12-Lipoxygenase, a Key Mediator of Glutamate-Induced Neurodegeneration. JBiolChem. 278(44): 43508–1

1200) Khanna, V. G. and Kannabiran, K. 2008. Antimicrobial activity of the saponin fraction of Hemidesmus indicus roots. Research Journal of Medicinal Plants. 2(1): 39-42

1201) Kharel, Y., Lee, S., Synder, A.H., Sheasley-O'Neill, S.L., Morris, M.A., Setiady, Y., Zhu, R., Zigler, M.A., Burcin, T.L., Ley, K. , Tung KSK, Engelhard VH, Macdonald TL, Pearson-White S, and Lynch KR 2005. Sphingosine kinase 2 is required for the modulation of lymphocyte trafficking by FTY720. Journal of Biological Chemistry. 280(44) 36865-36872

1202) Khattab, R., Eskin, M., Aliani, M. and Thiyam, U. 2010. Determination of sinapic acid derivatives in rapeseed extracts by high performance liquid chromatography. Journal of the American Society of Petroleum Chemists. 87(2): 147-155

1203) Ki, W. S., Ishigami, K., Kitahara, T., Kasahara, K., Yoshida, M. and Horinouchi, S. 2000. Radicicol binds and inhibits mammalian ATP citrate lyase. The Journal of Biological Chemistry. 275(50):39231-6

1204) Kikuchi, N., Ohmori, K., Shimazu, T., Nakaya, N., Kuriyama, S., Nishino, Y., Tsubono, Y., and Tsuji, I. 2006. No association between green tea and Prostate Cancer Risk in Japanese Men: The Ohsaki Cohort Study. Br J Cancer. 95(3):371-373

1205) Kilkkinen, A., Knekt, P., Heliövaara, M., Rissanen, H., Marniemi, J., Hakulinen, T. and Aromaa, A. 2008. Vitamin D status and lung cancer risk : a Studium cohort in Finland. Cancer Epidemiology, Biomarkers and Prevention. 17(11): 3274–3278

1206) Kim, B. and Hong, S. H. 2011. Sequential activation of caspase-2 and caspase-8 is essential for saikosaponin-a-induced apoptosis of human colon carcinoma cell lines. apoptosis. 16(2):184-97

1207) Kim, D. H., Jung, W. S., Kim, M. E., Lee, H. W., Youn, H. Y., Seon, J. K., Lee, H. N. und Lee, J. S. 2014 der ERK-Weg. En t. J. Mol. Medicina. 34(6): 1669-74

1208) Kim D S, Kim J H, Lee G H, Kim H T, Lim J M, Chae SW, Chae H J, and Kim H R 2010. P38 mitogen-activated protein kinase is involved in stress-induced endoplasmic reticulum cell death and autophagy in human gingival fibroblasts. BiolPharmBull. 33(4):545-9

1209) Kim, E.J., Park, H., Park, SY, Jun, J.G. and Park, J.H. 2009. The grape constituent piceatannol induces apoptosis in DU145 human prostate cancer cells through activation of intrinsic and extrinsic signaling pathways. Food J Med. 12(5):943-51

1210) Kim, E. Y., Yu, J. S., Yang, M., and Kim, A. K. 2013. A subtoxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent upregulation of the TRAIL receptor DR5. Mole cells. 35(1): 32-40

1211) Kim, G., Kim, E., Kwon, Y., & Jang, H. 2012. Potential mechanism of kaempferol against oxidative stress induced through chelating activity and regulation of factor 2 signaling associated with erythroid nuclear factor-2. Food Science and Biotechnology. 21(5): 1469-1475

1212) Kim, G., Kim, J., Ahn, S., Lee, H., Moon, D., Lee, C., & Park, Y. 2004. Lycopene suppresses phenotypic and functional maturation of lipopolysaccharides of murine dendritic cells by Inhibition of mitogen-activated protein kinases and nuclear factor-kB. Immunology. 113(2): 203-211

1213) Kim, H.G., Hien, T.T., Han.E. H., Hwan, Y.P., Choi, J.H., Kang, KW, Kwon, K., Kim, B., Kim, SK, Song, GY, Jeong, TC, and Jeong, HG 2011. Metformin inhibits glycoprotein expression P through the NF-kB pathway and CRE transcriptional activity by AMPK activation. Br J Pharmacol. 162(5): 1096-1108

1214) Kim, H.G., Hwang, Y.P., Han, E.H., Choi, J.H., Kwon, K., Chung, Y.C., Jeong, M.H., Jeong, TC., Kang, W., and Jeong, H.G. 2012. The coffee diterpene kahweol it inhibits metastasis by modulating the expression of MMP and VEGF through the inactivation of STAT3. Food Chemistry. 133(4): 1521-1529

1215) Kim, H.J., Lee, KW, Kim, MS, & Lee, HJ 2008. Piceatannol attenuates hydrogen peroxide and peroxynitrite-induced apoptosis of PC12 cells by blocking Bcl-xL downregulation and JNK activation. J Nutr Biochem. 19(7): 459-66

1216) Kim, H.R., Park, HS, Kwon, WS, Lee, JH, Tanigawara, Y, Lim, SM, Kim, HS, Shin, SJ, Ahn, JB, and Rha, SY 2013. Pharmacogenetic determinants associated with sunitinib- Toxicity induced and ethnic differences in Korean patients with metastatic renal cell carcinoma. Cancer Chemother Pharmacol. 72(4):825-35

1217) Kim, H., Kim, D., Kim, E., Lee, M., Kundu, J., Na, H., Cha, Y., and Surh, Y. 2014. Sulforaphane inhibits IKK stimulated by phorbol ester - Signaling of NF-kβ and COX-2 expression in human mammary epithelial cells by targeting NF-kβ-activating kinase and ERK. cancer letters 351(1): 41-49

1218) Kim, H., Moon, J.Y., Ahn, KS, and Cho, SK 2013. Quercetin induces mitochondrial-mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxidative medicine and cellular longevity. 2013: 596496, doi: 115/2013/596496, 10 pages.

1219) Kim, H., Yu, R., Kim, J., Kim, Y., & Sung, M. 2004. Antiproliferative crude soybean saponin extract modulates IkBα, protein kinase C, and cyclooxygenase-2 expression in human colon cancer cells. Cancer Lett. 210(1): 1-6

1220) Kim, I.G., Kim, J.S., Lee, J.H. and Cho, EW 2014. Genistein reduces cellular redox potential, partially suppresses cell growth in HL-60 leukemia cells, and sensitizes cells to β-radiation-induced cell death. Molecular Medicine Reports. 10:2786-2792

1221) Kim, J. and Park, J. 2003. ROS-dependent activation of caspase-9 in hypoxic cell death. letters FEBS. 549(1-3): 94-98

1222) Kim, J.E., Kang, J.S. and Lee, W.J. 2012. Vitamin C induces apoptosis in the human colon cancer cell line HCT-8 through modulation of calcium entry into the endoplasmic reticulum and dissociation of Bad from 14-3-3β. Immune system. 12(5):189-195

1223) Kim, JM and Kim, H. 2015. Anticancer effect of lycopine in gastric carcinogenesis. Cancer Prevention Magazine. 20(2): 92-6

1224) Kim, J.Y., Yu, S.J., Oh, H.J., Lee, J.Y., Kim, Y., and Sohn, J. 2011. Panaxydol induces apoptosis through increased activation of JNK and p38 MAPK intracellular calcium levels and NADPH oxidase-dependent generation of reactive oxygen species. apoptosis. 16(4):347-58

1225) Kim, J., Lee, D., Lee, KW, Son, J.E., Seo, S.K., Li, J., Jung, S.K., Heo, Y., Mottamal, M., Bode, AM, Dong, Z and Lee, H.J. 2011. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. research for cancer prevention. 4(4):582-91

1226) Kim, J., Tang, J.Y., Gong, R., Kim, J., Lee, J.J., Clemons, KV, Chong, CR, Chang, KS, Fereshteh, M., Gardner, D., Reya, T. ., Liu, J.O., Epstein, E.H., Stevens, D.A. and Beachy, PA 2010. Itraconazole, a commonly used antifungal drug that inhibits hedgehog signaling pathway activity and cancer growth. cancer cell. 17(4):388-99

1227) Kim, J.E., Jin, D.H., Lee, S.D., Hong, S.W., Shin, J.S., Lee, S.K., Jung, D.J., Kang, J.S. and Lee, W. J. 2008. Vitamin C inhibits p53-induced replicative senescence by suppressing ROS production and p38 MAPK activity. international J. Mol. Med. 22(5):651-5

1228) Kim KR, Park KK, Chun KS and Chung WY 2010. Honokiol inhibits the progression of coillogen-induced arthritis by reducing levels of proinflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage. J. Pharmacol. Science 114(1): 69-78

1229) Kim, N., Lee, M., Park, S., Choi, J., Oh, M., & Kim, I. 2007. Auranofin blocks interleukin-6 signaling by inhibiting JAK1 phosphorylation and STAT3. Immunology. 122(4): 607-614

1230) Kim, R., Ohi, Y., Inoue, H., Aoqi, K., & Toge, T. 1999. Introduction of the gadd153 gene into gastric cancer cells can modulate sensitivity to associated anticancer drugs. with apoptosis. Res. against cancer. 19(3A): 1779-83

1231) Kim, S.A. and Choi, H.C. 2012. Metformin inhibits the inflammatory response through the AMPK-PTEN pathway in vascular smooth muscle cells. Biochem Biophys Communal Res. 425(4):866-72

1232) Kim, S.J., Park, Y.S., Paik, H.D. and Chang, HI 2011. Effect of anthocyanins on matrix metalloproteinase-2 expression in naproxen-induced gastric ulcer disease. Br J Nutr. 106(12): 1792-801

1233) Kim, S.R., Ha, Y.M., Kim, Y.M., Park, E.J., Kim, J.W., Park, S.W., Kim, H.J., Chung, H.T. and Chang, K.C. 2015. Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW264.7 cells and improves survival in septic mice by activating Nrf2/HO-1 signalling. Biochem Pharmacol. 95(4):279-89

1234) Kim, S.W., Kim, H.J., Chun, Y.J. and Kim, M.Y. 2010. Ceramidre causes apoptosis by inducing p27(kip1) via protein phosphatase 2A-dependent dephosphorylation of Akt in PC-3 prostate cancer cells. J Toxicol Environmental Health A. 73(21-22): 1465-76

1235) Kim, S. Y., Hwang, J. S., and Han, I. O. 2013. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by repressing NF-kB and c-Jun activity through a mechanism that is independent of ER stress and N-glycosylation Eur J Pharmacol. 721(1-3): 294-300

1236) Kim, Sandler, Galanko, Martin, & Sandler, R. 2010. Polyunsaturated fatty acid intake and risk of distal colon cancer in whites and African-Americans. Am J Epidemiol. 171(9):969-79.

1237) Kim, TJ, Lee, JW, Song, SY, Choi, JJ, Choi, CH, Kim, BG, Lee, JH, and Bae, D.S. 2006. Increased pAKT expression is associated with radioresistance in cervical cancer. Br J Cancer. 94(11): 1678-82

1238) Kim, TJ, Silva, JL, Kim, MK, and Jung, YS 2010. Increased antioxidant capacity and antimicrobial activity of tannic acid by thermal processing. Food Chemistry. 118(3):760-746

1239) Kim, W.K., Bang, M.H., Kim, E.S., Kang, NE, Jung, K.C., Cho, H.J. and Park, J.H. 2005. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem. 16(3):155-62

1240) Kim, Y. 2003. Role of folic acid in the development and progression of colon cancer. J Nutr. 133(11): 37315-37395

1241) Kim, Y. and Lee, J. 2014. Anti-inflammatory activity of capsaicin and dihydrocapsaicin by induction of heme oxygenase-1 in Raw264.7 macrophages. Journal of Food Biochemistry. 38(4): 381-387

1242) Kim, Y. H., Kwon, H., Kim, D. H., Cho, H. J., Lee, H. S., Jun, J., Park, J. H. Y., and Kim, J. 2008. Piceatannol, a stilbene found in grapes, attenuates sulfate dextran sodium induced colitis. International Immunopharmacology. 8(12): 1695-1702

1243) Kim, Y. H., Park, C., Lee, J. O., Kim, G. Y., Lee, W. H., Choi, Y. H., and Ryu, C. H. 2008. Induction of apoptosis by piceatannol in U937 human leukemia cells through downregulation of Bcl-2 und Aktivierung von Caspasen. Oncol Rep. 19(4): 961-7

1244) Kim, Y. S. und Milner, J. A. 2005. Targets for indole-3-carbinol in cancer prevention. Das Journal of Nutritional Biochemistry. 16(2): 65-73

1245) Kim, Y., Park, Y., Namkoong, S., and Lee, J. 2014. Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes. Nutrition and function. 5(9): 2371-2377

1246) Kim, Y., Wan, Z., Wang, H., & Reynolds, CP 2006. Cytotoxic drugs induced sphingosine kinase 1 mRNA and exhibited synergistic cytotoxicity when combined with sphingosine kinase inhibitors in cell lines of multiresistant neuroblastoma. Proc Amer Assoc Cancer Res. Volume: 47, Abstract: 5425

1247) Kimira, M., Arai, Y., Shimoi, K. & Watanabe, S. 1998. Japanese intake of flavonoids and isoflavonoids from food. J Epidemic. 8(3): 168-75

1248) King MD, Alleyne CH Jr and Dhandapani KM 2013. TNF-alpha receptor antagonist R-7050 improves neurological outcomes after intracerebral hemorrhage in mice. Neurosci Lett. 542: 92-6, doi: 10.1016/j.neulet. 2013.02.051

1249) Kirkegaard, T., Yde, C.W., Kveiborg, M., & Lykkesfeldt, AE 2014. Broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in drug-resistant breast cancer cell lines. fulvestrant. international J Oncol. 45(1): 393-400

1250) Kirsh, A. V., Mayne, T. S., Peters, U., Chatterjee, N., Leitzmann, F. M., Dixon, B. L., Urban, A. D., Crawford, D. E., and Hayes, B. R. 2006. A prospective study on the intake of health food products. tomato and lycopene and Prostatakrebsrisiko. Biomarker for Krebseepidemien Prev. 15(1): 92-8

1251) Kivela, A. M., Kansanen, E., Jyrkkanen, H., Nurmi, T., Yla-Herttuala, S., & Levonen, A. 2008. Enterolactone induces heme oxygenase-1 expression via hemo-oxygenase-related factor nuclear factor E2 2 activation in endothelial cells. The Journal of Nutrition. 138(7): 1263-1268

1252) Klaus, A. and Birchmeier, W. 2008. Wnt signaling and its impact on development and cancer. Nature informs about cancer. 8:387-398, doi:10.1038/nrc2389

1253) Klein, E. A., Thompson, I. M., Lippman, S. M., Goodman, P. J., Albanes, D., Taylor, P. R. und Coltman, C. 2003. SELECT: The Selenium and Vitamin E Cancer Prevention Trial. Urol oncol. 21(1):59-65

1254) Klein-Soyer, C., Ceraline, J., Orvain, C., de la Salle, C., Bergerat, J. P. and Cazenave, J. P. 1997 Vorhautfibroblasten. Biozelle. 89(4): 295-307

1255) Klubes, P., Connelly, K., Cerna, I. y Mandel, H. G. 1978. Effects of 5-Fluorouracil on 5-Fluordeoxyuridin 5'-monophosphat and 2-deoxyuridin 5-monophobia pools and DNA Synthesis in solid mouse L1210 y Rat Walker 256-Tumoren. Krebsres. 38(8): 2325-31

1256) Klymenko, T., Brandenburg, M., Morrow, C., Dive, C., & Makin, G. 2011. The new Bcl-2 inhibitor ABT-737 is more potent in hypoxia and can inhibit hypoxia. induced to reverse drug resistance in neuroblastoma cells. Molecular Cancer Therapeutics. 10(12):2373-83

1257) Knekt, P., Aromaa, A., Maatela, J., Aaran, R., Nikkari, T., Hakama, M., Hakulinen, T., Peto, R. und Teppo, L. 1991. Vitamin E und Krebsprävention. Bin J Clin Nutr. 53(1): 2835-2865

1258) Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Hakulinen, T. und Aromaa, A. 2002. Flavonoid-Einnahme und Risiko chronische Erkrankungen . Bin J Clin Nutr. 76(3): 560-568

1259) Knight, AZ, Gonzales, B., Feldman, EM, Zunder, R.E., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, A.W., Williams, LR, and Shokat, M.K. 2006. A pharmacological map of the PI3-K family defines a role for p110α in insulin signalling. Cell. 125(4):733-747

1260) Knight, D.S., Adams, DN., Burgess, L.J. and Dharak, D. 2010. Discovery of GSK2126458, a highly potent inhibitor of PI3K and the target of rapamycin in mammals. ACS Med. Chem. Lett. 1(1): 39-43

1261) Knockaert, M., Greengard, P. & Meijer, L. 2002. Pharmacological inhibitors of cyclin-dependent kinases. Trends in Pharmacological Sciences. 23(9): 417-425

1262) Knudsen, KE and Penning, TM 2010. Partners in crime: Dysregulation of AR activity and androgen synthesis in prostate cancer. Endocrinol Metab Trends. 21(5):315-324

1263) Ko, K., Park, KS, Park, B., Yang, J.J., Cho, Y.L., Kang, C., Kim, S.C., Gwack, J., Shin, A., Kim, Y., Kim, J., Yang, H., Kang, D., Chang, S., Shin, H., & Yoo, K. 2010. Phytoestrogen isoflavones and gastric cancer risk: a nested case-control study within the Korean multi-cancer cancer cohort. Epidemiology, biomarkers and cancer prevention. 19(5): 1292-1300

1264) Kobayashi, J., Ohhizumi, Y., Nakamura, H. and Hirata, Y. 1986. A new serotonin receptor antagonist, hymenidine, isolated from the marine sponge Hymeniacidon sp. Experience. 42(10):1176-7

1265) Koeffler, H.P., Lowe, L., and Golde, D.W. 1980. Amygdalin (Laetrile): Effect on clonogenic cells of human myeloid leukemia cell lines and normal human bone marrow. Cancer Treatment Rep. 64(1):105-9

1266) Koehne, CH and Dubois, RN 2004. COX-2 inhibition and colorectal cancer. Semin Oncol. 31 (2 supplement 7): 12-21

1267) Kogame, A., Tagawa, Y., Shibata, S., Tojo, H., Miyamoto, M., Tohyama, K., Kondo, T., Prakash, S., Shyu, W.C. and Asahi, S. 2013. Pharmacokinetic and pharmacodynamic modeling of the hedgehog inhibitor TAK-441 for inhibition of Gli1 mRNA expression and antitumor efficacy in xenograft tumor model mice. Elimination of drug metab. 41(4):727-34

1268) Koh, PO 2007. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testis. J Vet Med Sci. 69(9): 969-71

1269) Kohno, M., Hirotsuka, M., Kito, M., and Matsuzawa, Y. 2006. Decreases in serum triacylglycerol and visceral fat mediated by dietary soy beta-conglycinin, J Atheroscler Thromb 13, pp. . 247–255

1270) Kohno, M. und Pouyssegur, J. 2006. Targeting the ERK signaling pathway in cancer therapy. Ana Med. 38(3): 200-11

1271) Kohyama, T., Takizawa, H., Kawasaki, S., Akiyama, N., Sato, M., and Ito, K. 1999. Fourteen-membered macrolides inhibit interleukin-8 release by human eosinophils from donors atopic Antimicrobial chemotherapy. 43(4): 907-911

1272) Koivunen, J., Aaltonen, V., & Peltonen, J. 2006. Protein kinase C (PKC) family in cancer progression. cancer cards 235(1): 1-10

1273) Kokame, K., Agarwala, KL, Kato, H. & Miyata, T. 2000. Herp, a novel ubiquitin-like membrane protein induced by endoplasmic reticulum stress. The Journal of Biological Chemistry. 275(42): 32846-32853

1274) Kokenyesi, R. and Bernfeld, M. 1994. Nuclear protein structure and sequence determine the location and presence of heparin sulfate and chondroitin sulfate in syndecan-1. The Journal of Biological Chemistry. 269(16): 12304-12309

1275) Koli, K. and Keski-Oja, J. 2000. 1α,25-dihydroxyvitamin D3 and its analogues downregulate cell invasion-associated proteases in cultured malignant cells. cell growth and differentiation. 11(4):221-229

1276) Koli, K. and Keski-Oja. 1993. Vitamin D3 and calcipotriol decrease extracellular plasminogen activator activity in cultured keratinocytes. Journal of Investigative Dermatology. 101(5): 706-712

1277) Köller, M., Senkal, M., Kemen, M., König, W., Zumtobel, V. and Muhr, G. 2003. Effect of omega-3 fatty acid-enriched TPN on leukotriene synthesis by leukocytes after operations of one. Clinical Nutrition. 22(1): 59-64.

1278) Kolterud, A. and Toftgard, R. 2007. Strategies for hedgehog inhibition and their potential role in cancer treatment. Drug discovery today. Therapeutic Strategies. 4(4): 229-235

1279) Kommera, H., Kaluderovic, GN, Kalbitz, J. & Paschke, R. 2011. Betulinic acid derivatives and lupane triterpenoids induce apoptosis in tumor cells. Invest in new drugs. 29(2): 266-272

1280) Kondapaka SB, Zarnowski M, Yver DR, Sausville EA & Cushman SW 2004. 7-Hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased stimulated glucose transport by insulin. Cancer Clinic Res. 10(21): 7192-8

1281) Kondo, A., Takeda, T., Li, B., Tsuiji, K., Kitamura, M., Wong, TF, & Yageashi, N. 2013. Epigallocatechin-3-gallate potentiates the ability of curcumin to suppress leiomyosarcoma cells from growing and induce apoptosis. international J. Clin. oncol. 18: 380-388, doi: 10.1007/s10147-012-0387-7

1282) Kong, D. and Yamori, T. 2009. Advances in the development of phosphatidylinositol 3-kinase inhibitors. Curr Med. Chem. 16(22):2839-54

1283) Kong, K., Rajab, F.N., Prasad, N.K., Ismail, A., Markom, M. and Tan, C. 2010. Lycopene-rich fractions derived from pink guava by-product and their potential activity against hydrogen peroxide . induced cell and DNA damage. Food Chemistry. 123(4): 1142-1148

1284) Kongpetch, S., Kukongviriyapan, V., Prawan, A., Senggunprai, L., Kukongviriyapan, U., and Buranrat, B. 2012. Crucial role of heme oxygenase-1 in the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents. Plus one. 7(4): e34994, doi: 10.1371/journal.pone.0034994

1285) Konings, E. J. M., Goldbohm, R. A., Brants, H. A. M., Saris, W. H. M. y van den Brandt, P. A. 2002. Intake of diet folate vitamers and risk of colorrectal carcinoma. Krebs. 95(7):1421-1433.

1286) Koo, C., Chao, A., Tsai, CL, Chuang, W.C., Hwang, W.P., Chen, GC, Lin, C.Y., Wang, TH, Wang, HS, and Lai, CH 2014. Bortezomib improves death by block autophagic flux by stimulating ERK phosphorylation. cell death and disease. 5: e1510, doi: 10.1038/cddis.2014.468, 12 pages.

1287) Koppenol, W. H., Bounds, P. L., & Dang, C. V. 2011. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 11(5):325-337

1288) Korashy, H. M., Anwar-Mohamed, A., Soshilov, A. A., Denison, M. S., and El-Kadi, A. O. S. 2011. The p38 MAPK inhibitor SB203580 induces expression of the cytochrome P450 1A1 gene in murine and human hepatoma cell lines via dependent ligands Activation of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 24(9): 1540-1548

1289) Korolenkova, L.I., Stepanova, E.V., Ermilova, V.D., Baryshnikov, A., & Griuzgin, W. 2012. [pAKt expression in cervical intraepithelial neoplasia (CIN) and microinvasive cervical cancer]. VoprOncol. 58(6):77-80

1290) Kort JE, Farber L, Tretiakova M, Petillo D, Furge KA, Yang XJ, Cornelius A and Teh BT 2008. The E2F3-Oncomir1 axis is activated in Wilms tumor. res of cancer 68(11): 4034-4038

(1291) Kosakowska-Cholody , T. , Lin , J. , Srideshikan , SM , Scheffer , L. , Tarasova , N.I. and Acharya, J.K. 2014. HKH40A down-regulates GRP78/BİP expression in cancer cells. cell death and disease. 5, e1240, 10 pages, doi:10.1038/cddis.2014.203

1292) Kovac, S., Angelova, PR, Holmstrom, KM, Zhang, Y., Dinkova-Kostova, AT, & Abramov, AY 2015. Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochimica et Biophysica Acta (BBA). General Subjects. 1850(4): 794-801

1293) Kovacic, V., Sain, M. and Vukman, V. 2003. Renal dyslipidemia in chronic hemodialysis patients. Lijecnicki Vjesnik. 125(3-4): 77-80.

1294) Kowalski, J., Samojedny, A., Paul, M., Pietsz, G. und Wilczok, T. 2005. Effect of apigenin, kaempferol, and resveratrol on interleukin-1beta and factor gene expression. of alpha tumor necrosis in J774.2-Makrophagen. Pharmacol Rep. 57(3): 390-4

1295) Kramer, H.J., Stevens, J., Grimminger, F., & Seeger, W. 1996. Fish oil fatacities and human platelets. Dose-dependent decrease in diene and increase in triene thromboxane formation. Biochemical Pharmacology. 52(8):1211-1217.

1296) Krasutsky, PA 2006. Birch bark research and development. Nat Prod. Rep. 23(6): 919-942

1297) Krebs, T. E. und Beard, H. H. 1950. The Unitarian or trophoblastic thesis of cancer. Krankenakte. 163(7): 149-174

1298) Krige, D., Needham, L.A., Bawden, L., Flores, N., Farmer, H., Miles, L.E.C., Stone, E., Callaghan, J., Chandler, S., Clark, V.L., Kirwin -Jones P, Legris V, Owen J, Patel T, Wood S, Box G, Laber D, Odedra R, Wright A, Wood M., Eccles, SA, Bone, EA, Ayscough, A and Drummond, AH 2008. CHR -2797: an antiproliferative inhibitor of aminopeptidase leading to amino acid deficiency in human leukemia cells. The journal of cancer research. 68: 6669, doi: 10.1158/0008-5472.CAN-07-6627

1299) Kris-Etherton, P.M. and Innis, S. (2007). Position of the American Dietetic Association and Dietitians of Canada: Dietary Fatty Acids. Journal of the American Dietetic Association. 107(9): 1599-1611.

1300) Krishnamoorthy, G., Selvakumar, K., Venkataraman, P., Elumalai, P., & Arunakaran, J. 2013. Lycopene supplementation prevents reactive oxygen species-mediated apoptosis in Sertoli cells of exposed adult albino rats to polychlorinated biphenyls. . Interdisciplinary toxicol. 6(2): 83-92

1301) Krishnan, A.V., Trump, D.L., Johnson, CS, & Feldman, D. 2010. The role of vitamin D in the prevention and treatment of cancer. Endocrinol Metab Clin North Am. 39(2): 401-18

1302) Krishnan, S., Lakshmanan, S., Iyer, G.K., UmaMaheswari, K. and Krishnakumar, S. 2010. The role of signaling pathways in the expansion of corneal epithelial cells in medium supplemented with B27 without serum. View Mol. 16(130):1169–1177

1303) Kristal, A.R. and Lampe, J.W. 2002. Brassica vegetables and risk of prostate cancer: a review of the epidemiological evidence. Walnut cancer. 42(1): 1-9

1304) Krockenberger, M., Engel, J.B., Schmidt, M., Kohrenhagen, N., Hausler, S.F., Dombrowski, Y., Kapp, M., Dietl, J., and Honig, A. 2010. Expression of transketolase- as 1 protein (TKTL 1) in human endometrial carcinoma. Res. against cancer. 30(5):1653-9

1305) Kröger, E., Verreault, R., Carmichael, P.H. et al. 2009. Omega-3 Fatty Acids and Dementia Risk, Canadian Study on Health and Aging. American journal of clinical nutrition. 90(1): 184-192.

1306) Kromann, N. and Green, A. 1980. Epidemiological studies in the Upernavik district, Greenland: Incidence of some chronic diseases 1950–1974. Scandinavian Medical Act. 208(5): 401-406.

1307) Kroncke, K.D., Fehsel, K. and Kolb-Bachofen, V. 1998. Inducible nitric oxide synthase in human disease. Clin Exp Immunol. 113(2): 147-156

1308) Krone, C. A. y Ely, J. T. 2005. Controlling hypergyciemia as adynt to cancer therapy. Integrar Krebs Ther. 4(1): 25-31

1309) Krop, I., Demuth, T., Guthrie, T., Wen, P.Y., Mason, W.P., Chinnaiyan, P., Butowski, N., Groves, M.D., Kesari, S., Freedman, S.J., Blackman, S., Watters, J., Loboda, A., Podtelezhnikov, A., Beckman, R., and LoRusso, P. 2012. Phase 1 pharmacological and pharmacodynamic study of the gamma-secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. Journal of Clinical Oncology. 30(19):2307-13

1310) Krusch, M., Salih, J., Schlicke, M., Baessler, T., Kampa, KM, Mayer, F., and Salih, H. R. 2009. The kinase inhibitors sunitinib and sorafenib affect the antitumor reactivity of the NK cells in variable in vitro. J Immunol. 183(12):8286-94

1311) Krystof, V. and Uldrijan, S. 2010. Cyclin-dependent kinase inhibitors as anticancer drugs. Current drug targets. 11(3):291-302

1312) Kubo, A., Block, Quesenberry, CP. Buffler and Corley 2009. Effects of fiber, fat, and meat consumption on the risk of Barrett's esophagus. Walnut cancer. 61(5):607-16

1313) Kubola, J., Meeso, N. and Siriamornpun, S. 2013. Lycopene and beta-carotene concentration in Gac (Momardica cochinchinensis Spreng) aril oil under the influence of aril drying and solvent extraction process. International food research. 50(2): 664-669

1314) Kucinska, M., Piotrowska, H., Luczak, M.W., Mikula-Pietrasik, J., Ksiazek, K., Wozniak, M., Wierzchowski, M., Dudka, J., Jager, W., and Murias, M. 2014. Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cell death in human acute T-cell leukemia cell lines: Prooxidative potential of hydroxylated resveratrol analogs. Chem Biol Interact. 209: 96-110, doi: 10.1016/j.cbi.2013.12.009

1315) Kuhajda, F.B., Medghalchi, S.M., McFadden, J.M. and Thupari, S. 2010. Compounds, pharmaceutical compositions that contain them and methods of use thereof. Patent publication number: US7649012

1316) Kuhajda, F. P., Jaffee, E. M. and Townsend, C. A. 2007. Method for inhibiting cancer development using FAS inhibitors. Patent veröffentlichungsnummer: US20070142456

1317) Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., and Townsend, C. A. 2000. Synthesis and antitumor activity of a fatty acid synthase inhibitor. PNAS. 97(7): 3450-3454

1318) Kuhnlein, H.V., Yeboah, F., Sedgemore, M., Sedgemore, S. & Chan, H.M. (1996). Ooligan Grease Nutritional Values: A traditional edible fat from the First Nations of British Columbia. Journal of Food Composition and Analysis. 9(1): 18-31.

1319) Kuiper, G.G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustafsson, J.A. 1997. Comparison of ligand binding specificity and tissue distribution of estrogen receptor alpha and beta transcripts. Endocrinology. 138(3):863-70

1320) Kumar, K. K., AnanthaKUmar, A. A., Ahmad, R., Adhikari, S., Variyar, P. S., and Sharma, A. 2010. Effect of gamma radiation on important aroma compounds and vanillin glycosides of dried vanilla beans (Vanilla planifolia). Food Chemistry. 122(3):841-845

1321) Kumar, S., Bryant, C.S., Chamala, S., Qazi, A., Seward, S., Pal, J., Steffes, C.P., Weaver, D.W., Morris, R., Malone, J.M., Shammas, MA, Prasad, M and Batchu, RB 2009. Ritonavir blocks AKT signaling, activates apoptosis, and inhibits ovarian cancer cell migration and invasion. mole cancer. 8:26, doi: 10.1186/1476-4598-8-26, 12 pages

1322) Kumavat, D. S. and Chaudhari, S. Y. 2013. Lycopene: its role as a chemopreventive agent against prostate cancer. International journal of research in pharmacy and chemistry. 3(3): 545-551

1323) Kumi-Diaka, J. and Butler, A. 2000. Activation of capsize-3 protease during the process of genistein-induced apoptosis in TM4 testicular cells. biocell. 92(2):115-24

1324) Kundsen, KE and Scher, H.I. 2009. Elimination of addiction: new pathways for persistent suppression of AR signaling in prostate cancer. Cancer Clinic Res. 15(15):4792-4798

1325) Kundu , JK , Na , HK , Chun , KS , Kim , YK , Lee , SJ , Lee , SS , Lee , OS , Sim , YC and Surh , YJ 2003. Inhibition of ester-induced COX-2 expression of phorbol by Epigallocatechin Gallate in mouse skin and cultured human mammary epithelial cells. J Nutr. 133 (11 Appendix 1): 38055–38105

1326) Kunnumakkara, A.B., Sung, B., Ravindran, J., Diagaradjane, P., Deorukhkar, A., Dey, S., Koca, C., Yadav, VR, Tong, Z., Gelovani, J.G., Guha , S., Krishnan, S. and Aggarwal, B. B. 2010. ϒ-Tocotrienol inhibits and sensitizes pancreatic tumors to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer research. 70(21):8695-8705

1327) Kuntzen C, Sonuc N, De Toni NE, Opelz C, Mucha RS, Gerbes LA and Eichorst TS 2005. Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces the G2/M cell cycle arrest. cancer res 65(15): 6780-8

1328) Kuo, P. L. and Hsu, Y. L. 2008. Piceatannol, a constituent of grapes and wine, inhibits the proliferation of human bladder cancer cells by blocking cell cycle progression and inducing the Fas ligand-mediated apoptotic pathway bound to the membrane/Fas. Mol Nutr Food Res. 52(4): 408-18

1329) Kuo, W. and Tang, TK 1999. Overexpression of glucose-6-phosphate dehydrogenase (G6PD) in NIH3T3 cells enhances cell proliferation. Taiwan Zoological Act. 10(1): 15-23

1330) Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., & Tsugane, S. 2008. Green tea consumption and risk of prostate cancer in Japanese men: a prospective study. Am J Epidemiol. 167(1):71-77

1331) Kurebayashi, J., Otsuki, T., Kurosumi, M., Soga, S., Akinaga, S., & Sonoo, H. 2001. A radicicol derivative, KF58333, inhibits hypoxia-inducible factor 1 alpha expression and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. Jpn J Cancer Res. 92(12):1342-51

1332) Kuruto-Niwa, R., Inoue, S., Ogawa, S., Muramatsu, M., & Nozawa, R. 2000. Effects of tea catechins on ERE-regulated estrogenic activity. J Agron FoodChem. 48(12): 6355-6361

1333) Kushchayeva, Y., Jensen, K., Recupero, A., Costello, J., Patel, A., Klubo-Gwiezdzinska, J., Boyle, L., Burman, K. & Vasko, V. 2014. The HIV protease inhibitor nelfinavir downregulates RET signaling and induces apoptosis in medullary thyroid cancer cells. J Clin Endocrinol Metab. 99(5): E734-45

1334) Kushi, L.H., Fee, R.M., Sellers, T.A., Zheng, W., and Folsom, A.R. 1996. Consumption of vitamins A, C and E and breast cancer after the menopause. The Iowa Women's Health Study. American Journal of Epidemiology. 144(2):165-169

1335) Kusmic, C., Barsacchi, R., Barsanti, L., Gualtieri, P. and Passarelli, V. 1999. Euglena gracilis as a source of the antioxidant vitamin E. Effects of culture conditions on the wild strain and on the mutant natural strain WZSL. Journal of Applied Physiology. 10(6):555-559

1336) Kusunoki, M., Tsutsumi, K., Hara, T. et al. (2003). Ethylicosapentate (omega-3 fatty acid) causes lipid accumulation in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty. Metabolism. 52(1): 30-34.

1337) Kwak, M., Wakabayashi, N. and Kensler, W. T. 2004. Chemoprevention via the Keap1-Nrf2 pathway using phase 2 enzyme inducers. Investigation of basic and molecular mutations/mechanisms of mutagenesis. 555(1-2): 133-148

1338) Kwon, GT, Jung, JI, Song, HR, Woo, EY, Jun, JG, Kim, JK, Her, S & Park, JH 2012. Piceatannol inhibits prostate cancer cell migration and invasion : possible mediation by decreased interleukin-6 signaling. J Nutr Biochem. 23(3): 228-38

1339) Kwon, H. Y., Hong, S. P., Hahn, D. H. und Kim, J. H. 2003. Induction of apoptosis from Persicae semen extract in human promyelocytic leukemia (HL-60) cells. Arch Pharm. Res. 26(2): 157-61

1340) Kwon, Y.E. and Kim, K.H. 2006. The Pt(IV) K101 octahedral complex induces apoptosis through activation of ERK 1/2 and the p53 pathway in human colon cancer cells. cancer drugs 17(5):553-558

1341) Kwon, YJ, Seo, GS, Heo, Y., Yue, S., Cheng, J., Lee, WK, & Kim, K. 2012. Piceatannol, a naturally occurring polyphenolic stilbene, inhibits adipogenesis by modulating the expansion Mitotic clonal and insulin receptor-dependent insulin signaling in the early phase of differentiation. JBiolChem. 287(14): 11566-11578

1342) Ky, P. T., Huong, P. T., My, T. K., Anh, P. T., Kiem, P. V., Minh, V. C., Cuong, N. X., Thao, N. P., Nhiem, N. X., Hyun, J., Kang, H. K. und Kim, Y. H. 2010. Saponine vom Dammaran-Typ aus Gynostemma pentaphyllum. Fitoquimia. 71(8-9): 994-1001

1343) La Vecchia, C., Negri, E., Pelucchi, C. und Franceschi, S. 2002. Dietary folate ana color rectal cancer. Int J Canver. 102(5): 545-547

1344) Laban, C., Bustin, S.A. and Jenkins, P.J. 2002. The GH-1GF-1 axis and breast cancer. Trends in endocrinology and metabolism. 14(1): 28-34

1345) Lachenmeier, W. D., Godelmann, R., Witt, B., Riedel, K. & Rehm, J. 2014. Can resveratrol in wine protect against ethanol carcinogenicity?. A probabilistic dose-response evaluation. International Journal of Cancer. 134(1): 144-153

1346) Lagares-Garcia, J.A., Moore, RA, Collier, B., Heggere, N., Diaz, F., & Qian, F. 2001. Nitric oxide synthase as a marker in colorectal cancer. At the surgeon. 67(7):709-13

1347) Lagente, V., Manoury, B., Nenan, S., Le Quement, C., Martin-Chouly, C. & Boichot, E. 2005. Role of matrix metalloproteinases in the development of inflammation and airway remodeling. Brazilian journal of medical and biological research. 38(10): 1521-1530

1348) Lahav, M., Levite, M., Bassani, L., Lang, A., Fidder, H., Tal, R., Bar-meir, S., Mayer, L. & Chowers, Y. 2002. Lidocaine inhibits the secretion of IL-8 and IL-1β and stimulates the secretion of IL-1 receptor antagonists by epithelial cells. Clin Exp Immunol. 127(2): 226-233

1349) Lahusen, T., De Siervi, A., Kunick, C., & Senderowicz, AM 2003. Alsterpaulone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activating caspase-9 due to to an alteration of the potential of the mitochondrial membrane. carcinogenic mole 36(4):183-94

1350) Lai YG, Weinstein JS, Albanes D, Taylor RP, Virtamo J, McGlynn AK, and Freedman DN 2014. Association of serum α-tocopherol, β-carotene, and retinol with liver cancer and Inzidenz Mortality from chronic liver disease. British journal of cancer. 111:2163-2171, doi:10.1038/bjc.2014.365

1351) Lai YG, Weinstein JS, Taylor PR, McGlynn AK, Virtamo J, Gail HM, Albanes D, and Freedman DN 2014. Effects of α-tocopherol and β-carotene supplementation on liver cancer Incidence and mortality in the disease Chronic liver disease in the ATBC study. British journal of cancer. 111:2220-2223, doi:10.1038/bjc.2014.514

1352) Lai, Y., Lin, C., Wang, C. and Chao, J.I. 2014. Survival and p53 expression modulate honokiol-induced apoptosis in colorectal cancer cells. Cellular Biochemistry Journal. 115(11): 1888-99

1353) Lain, S., Hollick, J.J., Campbell, J., Staples, O.D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, KE., Baker, L., Thompson, A., Mathers, J., Holland, SJ, Stark, MJ, Pass, G, Woods, J, Lane, DB, and Westwood, NJ 2008. Discovery, in vivo activity, and mechanism of action of a small molecule p53 activator cancer cell. 13(5): 454-63

1354) Lam , K.T. , Rotunno , M. , Lubin , J.H. , Wacholder , S. , Consonni , D. , Pesatori , C.A. , Bertazzi , A.P. , Chanock , J.S. , Burdette , L. , Goldstein , M.A. , Tucker , A.M. , . Caporaso, E.N., Subar, FA., and Landi, TM 2010. Dietary quercetin, quercetin gene interaction, metabolic gene expression in lung tissue and lung cancer risk. carcinogenesis. 31(4): 634-642

1355) Lam KT, Ruczinski I, Helzlsouer JK, Shugart YY, Caulfield EL, and Alberg JA 2010. Cruciferous vegetable intake and risk of lung cancer: a nested case-control study on smoking. Biomarkers of the cancer epidemic Prev. 19(10): 2534-2540

1356) Lam, L., Hu, X., Aktary, Z., Andrews, D. W., & Pasdar, M. 2009. Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit breast cancer cell growth by inhibiting modulation of PI3K/AKT, ERK, and IGF-1R pathways independent of ERalpha. breast cancer treatment. 118(3): 605-21

1357) Lam, T.K., Shao, S., Zhao, Y., Marincola, F., Pesatori, A., Bertazzi, P.A., Caporaso, NE, Wang, E. and Landi, MT 2012. Influence of quercetin-rich uptake of food on microRNA expression in lung cancer tissues. Biomarkers of the cancer epidemic Prev. 21(12): 2176-2184

1358) Lambertini, E., Lampronti, I., Penolazzi., Khan, MT., Ather, A., Giorgi, G., Gambari, R., and Piva, R. 2005. Estrogen receptor alpha gene expression in Breast cancer Transcription factor-treated breakdown cells are modulated by natural plant extracts from Bangladesh. Oncology Res. 15:69-79.

1359) Lamm, D. L., Riggs, D. R., Shriver, J. S., van Gilder, P. F., Rach, J. F., and DeHaven, J. I. 1994. Vitamin megadoses in bubble cancer: a double-blind clinical trial. J Urol. 151(1):21-6

1360) Lampiasi , N , Fodera , D , D'Alessandro , N , Cusimano , A , Azzolina , A , Tripodo , C , Florena , AM , Minervini , MI , Notarbartolo , M , Montalto , G and Cervello, M. 2006. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. international J. Mol. Med. 17(2):245-52

1361) Landgren, R.C., Hussey, D.H., Samuels, ML, and Leary, W.V. 1973. A randomized trial comparing radiation alone with radiation plus procarbazine in inoperable bronchial carcinoma. Radiology. 108(2): 403-406

1362) Lands, W.E. 1992. Biochemistry and physiology of n-3 fatty acids. FASEB Magazine. 6(8): 2530-2536.

1363) Lang, N. P., Chu, D. Z., Hunter, C. F., Kendall, D. C., Flammang, T. J., & Kadlubar, F. F. 1986. Role of aromatic amine acetyltransferase in human colorectal cancer. Chirurg Arch. 121(11): 1259-1261

1364) Lappe, J. M., Travers-Gustafson, D., Davies, KM, Recker, R. R., & Heaney, R. P. 2007. Vitamin D and calcium supplementation reduce cancer risk: results of a randomized study. Bin J Clin Nutr. 85t(6): 1586-1591

1365) Larrosa, M., Thomas-Barberan, FA and Espin, J.C. 2004. The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in SK-Mel-28 human melanoma cells. European Journal of Nutrition. 43(5):275-284

1366) Larsson, DE, Wickstrom, M, Hassan, S, Oberg, K, and Granberg, D. 2010. Cytotoxic drugs NSC-95397, brefeldin A, bortezomib, and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. Cancer research. 30(1): 149-156

1367) Larsson, SC, Giovannucci, E., & Wolk, A. 2005. Vitamin B6 intake, alcohol use, and colorectal cancer: a population-based longitudinal cohort of women. gastroenterology. 128(7):1830-1837

1368) Larsson, S.C., Orsini, N., & Wolk, A. 2010. Vitamin B6 and the risk of colorectal cancer. A meta-analysis of prospective studies. NEVER. 303(11):1077-1083.

1369) Lashner, B. A., Provencher, K. S., Seidner, D. L., Knesebeck, A., & Brzezinski, A. 1997. The effect of folic acid supplementation on the risk of cancer or dysplasia in ulcerative colitis. Gastroenterology. 112(1):29-32

1370) Laster, W. R. and Schabel, F. M. 1975. Experimental studies on the antitumor activity of tonsillar MF (NSC-15780) alone and in combination with β-glucosidase (NSC-128056). Cancer Chemother Rep. 59(5):951-965

1371) Latchman, D.S. 1997. Transcription factors: a review: Int J Biochem Cell Biol. 29(12):1305-12

1372) Laure, B. and Marc, B. 2006. n-3 polyunsaturated fatty acids reduce anxiety in a population of drug addicts. Journal of Clinical Psychopharmacology. 26(6): 661-665.

1373) Lauritzen, L., Jorgensen, MH, Mikkelsen, T.B. et al. 2004. Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes. lipids 39(3): 195-206.

1374) Lavoie, J.N., L'Allemain, G., Muller, B.R. and Pouysségur, M.J. 1996. Cyclin D1 expression becomes positive through the p42/p44 MAPK pathway and negative through the regulated p38/HOG MAPK pathway. The Journal of Biological Chemistry. 271:20608-20616, doi:10.1074/jbc.271.34.20608

1375) Lawlor, M. A. and Rotwein, P. 2000. Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and the cyclin-dependent kinase inhibitor p21. Mol Cell Biol. 20(23): 8983-95

1376) Lawrence , D , Shahrokh , Z , Marsters , S , Achilles , K , Shih , D , Mounho , B , Hillan , K , Totpal , K , DeForge , L , Schow , P ., Hooley , J. , Sherwood , S. , Pai , R. , Leung , S. , Khan , L. , Gliniak , B. , Bussiere , J. , Smith , C. A. , Strom , S. S. , Kelley , S. , . Fox , J. A. , Thomas , D. and Ashkenazi , A. 2001. Differential hepatozygototoxicity of recombinant Apo2L/TRAIL versions. Nat Med. 7(4): 383-5

1377) Lazar, D., Taban, S., Ardeleanu, C., Simionescu, C., Sporea, I., Cornianu, M., and Vernic, C. 2008. Immunohistochemical expression of cyclooxygenase-2 (COX-2) in gastric cancer. Correlations with tumor angiogenesis and patient survival. Rom J Morphol Embryol. 49(3):371-9

1378) Lazenby, M., Hills, R., Burnett, KA, & Zabkiewicz, J. 2015. The Hsp90 inhibitor Ganetespib: a potentially effective drug for acute myeloid leukemia in combination with cytarabine. leukemia research. 39(6): 617-624

1379) Le Marchand, L., White, KK, Nomura, AMY, Wilkens, LR, Selhub, JS, Tiirikainen, M, Goodman, HT, Murphy, SP, Henderson, BE, and Kolonel, LN 2009 Vitamins and cancer risk colon: the multiethnic cohort study. 18(8):2195-2201

1380) Le, H.S., Cho, H.J., Yu, R., Lee, KW, Chun, HS, and Park, J.H. 2014. Mechanisms underlying the apoptosis-inducing effects of kaempferol in human HT-29 colon cancer cells. international J.Mol.Sci. 15(2):2722-37

1381) Lea, M. A. and Koch, M. R. 1979. Effects of cyanate, thiocyanate, and amygdala on metabolite uptake in normal and neoplastic tissues in the rat. J National Cancer Institute 63(5): 1279-83

1382) Leaf, A., Xiao, F.Y., Kang, X.J. and Billman, G.E. 2003. Prevention of Sudden Cardiac Death by n-3 Polyunsaturated Fatty Acids. Drug therapy. 98(3):355-377.

1383) Lebeau, T. and Robert, J.M. 2003. Diatom culture and biotechnologically relevant products. Part II Current and Proposed Products. Applied Microbiology and Biotechnology, 60(6): 624–632.

1384) Lebiedzinska-Arciszewska, M., Oparka, M., Vega-Naredo, I., Karkucinska-Wieckowska, A., Pinton, P., Duszynski, J. and Wieckowski, MR 2015. The interaction between p66Shc, reagent Types of oxygen and metabolism of cancer cells. Eur J Clin Invest. 1:25-31, doi:10.1111/eci.12364

1385) Leblanch, K., Sexton, E., Parent, S., Belanger G., Dery, M.C., Boucher, V., and Asselin, E. 2007. Effects of 4-hydroxytamoxifen, raloxifene, and ICI 182780 on patient survival. uterus Cancer cell lines in the presence and absence of exogenous estrogens. international J Oncol. 30(2): 477-87

1386) Lebrec, H., Ponce, R., Preston, BD, Iles, J., Born, TL, & Hooper, M. 2015. Tumor necrosis factor, tumor necrosis factor inhibition, and cancer risk. Curr Med Res Opinion. 31(3):557-74

1387) Lecerf, JM 2009. Fatty acids and cardiovascular disease. nutritional assessments. 67(5): 273-283.

1388) Lechner, M., Lirk, P. and Rieder, J. 2005. Inducible nitric oxide synthase (iNOS) in tumor biology: two sides of the same coin. Seminars in Cancer Biology. 15(4):277-289

1389) Lederle, W., Depner, S., Schnur, S., Obermüller, E., Catone, N., Fusenig, NE, and Müller, M. M. 2011 autocrine and paracrine cytokines. Int J Cancer. 128(12):2803-14

1390) Lednicer, D. 2002. Tracing the origin of the structure of COX-2 inhibitors. Curr Med. Chem. 9(15): 1457-61

1391) Ledwith, B. J., Pauley, C. J., Wagner, L. K., Rokos, C. L., Alberts, D. W. and Manam, S. 1997. Induction of cyclooxygenase-2 expression by peroxisome proliferators and myristate-like tumor promoters 12,13 not tetradecanoilforbol in immortalisierten Mäuseleberzellen. Das Journal of Biological Chemistry. 272(6): 3707-3714

1392) Lee, A.S. 2007. Induction of GRP78 in cancer: Therapeutic and prognostic implications. Cancer research. 67(8): 3496-3499

1393) Lee, B., Jung, J. H. und Kim, H. S. 2012. Evaluation of red onion on antioxidant activity in rats. Food Chem Toxicol. 50(11): 3912-9

1394) Lee, B., Kim, C. H. and Moon, S. K. 2006. Honokiol causes p21WAF1-mediated G(1) phase cell cycle arrest by inducing p38 mitogen-activated protein kinase in vascular smooth muscle cells. FEBS Lett. 580(22): 5177-84

1395) Lee, CC, Shen, SR, Lai, YJ, & Wu, SC 2013. Rutin and quercetin, bioactive compounds in buckwheat tartare, prevent inflammatory liver damage. Food Function 4(5): 794-802

1396) Lee, C.H., Kwak, S.C., Kim, J.Y., Oh, H.M., Rho, M.C., Yoon, K.H., Yoo, W.H., Lee, M.S. and Oh, J. 2014. c-Fos-mediated protein degradation and suppression of NF-kB activation. J. Pharmacol. science 124(3):344-53

1397) Lee, C.H., Lee, Y., Kim.J. and Row, K. H. 2001. Separation of perillyl alcohol from Unshiu citrus peel by supercritical CO2 and high performance preparative liquid chromatography. Korean J Chem Eng. 18(3):352-356

1398) Lee, DE, Lee, KW, Song, NR, Seo, SK, Heo, YS, Kang, NJ, Bode, AM, Lee, HJ, & Dong, Z. 2010. 7,3,4-Trihydroxyisoflavone inhibits the epidermis Growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by repression of cyclin- and phosphotidylinositol-3-kinase-dependent kinases. JBiolChem. 285(28): 21458-66

1399) Lee, E., Choi, M.K., Lee, Y.J., Ku, J.L., Kim, K.H., Choi, J.S. and Lim, S.J. 2006. Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells. carcinogenesis. 27(11):2308-15

1400) Lee, G., Kim, H., Chae, S., Kim, D., Ha, K., Caddy, M., Kress, C., Reed, J.C., Kim, H., and Chae, H. 2007. Bax Inhibitor-1 regulates stress-associated endoplasmic reticulum reactive oxygen species and heme oxygenase-1 expression. The Journal of Biological Chemistry. 282(30): 21618-21628

1401) Lee HK, Seo IA, Lee SH, Seo S, Kim KS and Park HT 2008. ErbB2 triphostin inhibitors AG825 and AG879 have non-specific silencing effects on gp130/STAT3 signalling. Korean J Physiol Pharmacol. 12(5):281-286

1402) Lee, J. and Safe, S. 2007. Coactivation of estrogen receptor alpha (ERalpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Arch Biochem Biophys. 461(2):200-10

1403) Lee, J. H. and Chun, I. K. 2010. Curcumin inhibits telomerase nuclear localization through dissociation of the p23 Hsp90 cochaperone from hTERT. Cancer Lett. 290(1): 76-86, doi: 10.16/j.canlet.2009.08.026

1404) Lee , JH , Kang , GH , Kim , KC , Kim , KM , Park , DI , Choi , BT , Kang , HS , Lee , YT and Choi , YH 2002. Tetrandrin-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. international J Oncol. 21(6):1239-44

1405) Lee, J. H., Lu, H. F., Wang, D. Y., Chen, D. R., Su, C. C., Chen, Y. S., Yang, J. H. und Chung, J. G. 2004. Effects of tamoxifen on DNA adduct formation and arylamine activity N-acetyltransferase in humans Brustkrebszellen. Res Commun Mol Pathol Pharmacol. 115-116: 217-233, PMID: 17564319

1406) Lee, J., Ahn, J., Kim, J.T., Lee, H.J. and Choi, J. 2015. Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells through β4 integrin and Akt signaling. Scientific reports. 5: 12642, doi: 10.1038/srep12642, 12 pages

1407) Lee, K. H., Jeong, J. and Yoo, C. G. 2013. Long-term incubation with proteasome inhibitors (PIs) induces Ikβα degradation via the lysosomal pathway in an IKB kinase (IKK)-dependent and independent manner. from IKK. JBiolChem. 288(45):32777-86

1408) Lee, KM, Lee, KW, Jung, SK, Lee, EJ, Heo, YS, Bode, AM, Lubet, RA, Lee, HJ, & Dong, Z. 2010 Suppression of Src kinase activity. Biochem Pharmacol. 80(12):2042-9

1409) Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon Y, Park J, Bang SJ, Lee SH Kim, Y. T., Lee, J. J., and Hong, Y. 2008. Synthesis and anticancer activity of Geldanamycin derivatives derived from biosynthetically generated metabolites. Org. Biomol. Chemistry 6(2): 340-8

1410) Lee, K.W. and Lip, G. Y. H. 2003. The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease. Quarterly magazine of medicine. 96(7): 465-480.

1411) Lee, M. H. and Moon, A. 2016. The amygdala regulates apoptosis and adhesion in triple-negative Hs578T breast cancer cells. Biomol Ther (Seoul). 24(1): 62-66

1412) Lee, M.J., Maliakal, P., Chen, L., Meng, X., Bondoc, F.Y., Prabhu, S., Lambert, G., Mohr, S., and Yang, CS 2002. Oharmacokinetics of tea catechins after of human intake of green tea and (-)-epigallocatechin-3-gallate: formation of different metabolites and individual variability. Biomarkers of the cancer epidemic Prev. 11(10Pt1): 1025-32

1413) Lee, S.A., Kim, Y.J. and Lee, C.S. 2013. Brefeldin a induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits focal adhesion kinase-mediated cell invasion. Basic Clin Pharmacol Toxicol. 113(5):329-38

1414) Lee, SH, Cho, JH, Kwon, TG, and Park, YHJ 2014. Kaempferol downregulates insulin-like growth factor receptor-1 and ErbB3 signaling in HT- human colon cancer cells. 29. J Back cancer. 19(3): 161-169

1415) Lee, S.H., Kim, J.K. and Jang, HD 2014. Genistein inhibits osteoclast differentiation of RAW 264.7 cells through regulation of ROS production and clearance. international J.Mol.Sci. 15(6):10605-21

1416) Lee, S. H., Nam, H. J., Kang, H. J., Kwon, HW, and Lim, Y. C. 2013. Epigallocatechin-3-gallate attenuates characteristics of head and neck cancer stem cells by suppressing Notch signaling. European Journal of Cancer. 49(15): 3210-3218

1417) Lee, SY, Song, CH, Xie, YB, Jung, C, Choi, HS, & Lee, K. 2014. Metformin upregulated SMILE inhibits androgen receptor function in prostate cancer cells. Cancer Lett. 354(2):390-7

1418) Lee, S., Choi, E.J., Jin, C., and Kim, D.H. 2005. Activation of the PI3K/Akt pathway through PTEN reduction and PIK3CAmRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecologic oncology. 97(1):26-34

1419) Lee S, Shu X, Li H, Yang G, Cai H, Wen W, Ji B, Gao J, Gao Y, and Zheng W 2009. Adolescent and adult dietary soy intake and risk of breast cancer: results from Shanghai Women's Health Study. Bin J Clin Nutr. 89(6): 1920-1926

1420) Lee, S., Sung, J., Moon, C. and Lee, B. 1999. Antitumor activity of a novel ginseng saponin metabolite in cisplatin-resistant human lung adenocarcinoma cells. cancer letters 144, 39-43.

1421) Lee, S.K., Kang, J.S., Jung, da.J., Hur, D.Y., Kim, J.E., Hahm, E., Bae, S., Kim, HW, Kim, D., Cho, B.J., Cho, D., D.H. Shin, Y.I. Hwang. and Lee, W. J. 2008. Vitamin C suppresses SK-MEL-2 human melanoma cell proliferation by inhibiting cyclooxygenase-2 (COX-2) expression and modulating insulin-like growth factor II (IGF) production -II). Cell Physiol J. 216(1):180-8

1422) Lee WS, Lee EG, Sung MS, and Yoo WH 2014. Kaempferol inhibits IL-1β-stimulated RANKL-mediated osteoclastogenesis by downregulating MAPK, c-Fos, and NFATc1. Inflammation. 37(4):1221-30

1423) Lee, W., Chen, W., Wang, C., Lin, W., & Tseng, T. 2008. Apigenin inhibits HGF-mediated invasive growth and metastasis, affecting the PI3K signaling pathway /Akt and β4 integrin function in MDA-MB-231 breast cancer cells. Toxicology and applied pharmacology. 226(2):178-191

1424) Lee, Y. and Lee, S. 2011. Sulforaphane induces antioxidant and antiproliferative responses that generate reactive oxygen species in human BEAS-2B bronchial epithelial cells. J Korean Med Sci. 26(11): 1474-1482

1425) Lee, Y., Lee, D. M., and Lee, S. 2015. Nrf2 expression and apoptosis in quercetin-treated malignant mesothelioma cells. Mole cells. 38(5): 416-425

1426) Lee, Y., Song, J., Oh, M., Lee, Y., Kim, Y., Im, J., and Lee, S. 2011. ERK 1/2 activation in BEAS-2B treated with Quercetin The cell plays a role in Nrf2-driven HO-1 expression. Molecular and Cellular Toxicology. 7(4):347-355

1427) Lehmann, B., Pietzsch, J., Kampf, A. and Meurer, M. 1998. The HaCaT human keratinocyte line metabolizes 1alpha-hydroxyvitamin D3 and vitamin D3 to 1alpha, 25-dihydroxyvitamin D3 (calcitriol). J Dermatol Sci. 18(2):118-27

1428) Lei X, Chen Y, Du G, Yu W, Wang X, Qu H, Xia B, He H, Mao J, Zong W., Liao, X., Mehrpour, M., Hao, X. and Chen, Q. 2006. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release through a conformational change in Bcl-2. FASEB J. 20(12): 2147-9

1429) Leitner, J. M., Mayr, F. B., Firbas, C., Spiel, A. O., Steinlechner, B., Novellini, R., and Jilma, B. 2007. Reparixin, a specific inhibitor of interleukin-8, has no effect on inflammation during endotoxemia. Int J Immunopathol Pharmacol. 20(1): 25-36

1430) Lemberger, T., Desvergne, B., Wahli, W. 1996. Peroxime proliferator-activated receptors: nuclear receptor signaling pathways in lipid physiology. Ann Rev. Cell Dev Biol. 12(1): 335-363

1431) Lemeshko VV, Haridas V, Quijano JPC and Gutterman JU 2006. Avicins, natural anticancer saponins, permeabilize mitochondrial membranes. Archive of Biochemistry and Biophysics. 454(2):114-122

1432) Lenhard, M., Tsvilina, A., Schumacher, L., Kupka, M., Ditsch, N., Mayr, D., Friese, K., and Jeschke, U. 2012. Human chorionic gonadotropin and its relationship to Grades, stage, and patient survival in ovarian cancer. BMC cancer. 12:2, doi:10.1186/1471-2407-12-2

1433) Lenin, R., Maria, M. S., Agrawal, M., Balasubramanyam, J., Mohan, V., & Balasubramanyam, M. 2012. Enhancement of glycolipotoxicity-induced endoplasmic reticulum stress by a 'chemical chaperone' in human THP - 1 monocytes. Diabetes Research Journal. 2012:356487, doi:10.1155/2012/356487

1434) Lenton, KJ, Sane, AT, Therriault, H, Cantin, AM, Payette, H, Wagner, JR 2003. Vitamin C increases lymphocyte glutathione in ascorbate-deficient individuals. Bin J Clin Nutr. 77(1):189-195

1435) Lesjak, M., Hogue, R., Balesaria, S., Skinner, V., Debnam, ES, Srai, SK, and Sharp, P.A. 2014. Quercetin inhibits intestinal iron absorption and expression of the ferroportin transporter in vivo and in vitro. Plus one. 9(7): e102900, doi: 10.1371/journal.pone.0102900

1436) Leung EL, Fiscus RR, Tung JW, Tin VP, Cheng LC, Silhoe AD, Fink LM, Ma Y, and Wong MP 2010. CD44-expressing non-small cell lung cancer cells are enriched with similar properties to of stem cells. Plus one. 5(11): e14062, doi: 10.1371/journal.pone.0014062, 13 pages

1437) Levander, O.A. 1987. An overview of human selenium nutrition. Rev. Annual Nutr. 7:227-250

1438) Lev-Ari, S., Starr, A., Katzburg, S., Berkovich, L., Rimmon, A., Ben-Yosef, R., Vexler, A., Ron, I., and Earon, G. 2014. Curcumin induces apoptosis and inhibits the growth of orthotopic human non-small cell lung cancer xenografts. J Nutr Biochem. 25(8):843-50

1439) Lev-Ari, S., Strier, L., Kazanov, D., Madar-Shapiro, L., Dvory-Sobol, H., Pinchuk, I., Marian, B., Lichtenberg, D. and Arber, N. 2005. Celecoxib and curcumin synergistically inhibit colon cancer cell growth. Cancer Clinic Res. 11(18): 6738-44

1440) Levy, R. and Herzberg, G.R. 1996. Effects of a fish oil or corn oil meal on bile flow and composition in rats previously adapted to diets containing fish oil or corn oil. nutrition research. 16(5):805-816.

1441) Li, A., Dubey, S., Varney, M.L., Dave, B.J. and Singh, R.K. 2003. IL-8 directly enhanced endothelial cell survival, proliferation, matrix metagalloproteinase production, and angiogenesis. J Immunol. 170(6):3369-76

1442) Li, B., Vik, S.B. and you, Y.Y. 2012. Theaflavins inhibit the respiratory chain without increasing superoxide production. Journal of nutritional biochemistry. 23(8):953-960

1443) Li, C.J., Chang, J.K., Chou, C.H., Wang, G.J. and Ho, ML. 2010. PI3K/Akt/FOXO3a/p27Kip1 signaling contributes to the proliferation of human osteoblasts suppressed by anti-inflammatory drugs. Biochem Pharmacol. 79(6):926-37

1444) Li CY Chao LK Wang SC Chang HZ Tsai ML Fang SH Liao PC Ho CL Chen ST Cheng WC Chiang CS Kuo YH Hua KF and Hsu IC 2011. Honokiol inhibits LPS-induced maturation and inflammatory response of LPS-derived dendritic cells human monocytes. Cell Physiol J. 226(9):2338-49

1445) Li, C., Li, R. W., Kahl, S. & Elsasser, H. T. 2012. Alpha-tocopherol alters transcriptional activities that modulate the inflammatory response induced by tumor necrosis factor alpha (TNF-α) in bovine cells . Gene Reg Syst Bio. 6:1-14, doi:10.4137/GRSB.S8303

1446) Li C, Zhao Y, Yang D, Yu Y, Guo H, Zhao Z, Zhang B, and Yin X 2015. Inhibitory effects of kaempferol on human breast cancer cell invasion by downregulating expression and matrix metalloproteinase-9 activity. biochemistry and cell biology. 93(1):16-27

1447) Li C, Zhou Y, Peng X, Du L, Tian H, Yang G, Niu J and Wu W 2014. Sulforaphane inhibits invasion by activating ERK 1/2 signaling in U87MG human glioblastoma cells and U373MG. Plus one. 9(2): e90520, doi: 10.1371/journal.pone.0090520, 12 pages

1448) Li, D. 2003. Omega-3 fatty acids and noncommunicable diseases. Chinese medical journal. 116(3):453-458.

1449) Li, D., Marchenko, N.D. and Moll, U.M. 2011. SAHA demonstrates preferential cytotoxicity in p53 mutant cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. distinguish cell death. 18(12): 1904-13

1450) Li, E. R., Owens, D. M., Djian, P. and Watt, F. M. 2000. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes. Exp. Dermatol. 9(6): 431-4

1451) Li F, Bai Y, Zhao M, Huang L, Li S, Li X, and Chen Y 2015. Quercetin inhibits vascular endothelial growth factor-induced choroidal and retinal angiogenesis in vitro. Ophthalmology Res. 53(3): 109-16

1452) Li G, Liu L, Shan C, Cheng Q, Budhraja A, Zhou T, Cui H and Gao N 2014. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. cell death and disease. 5: e998, doi: 10.1038/cddis.2013.519, 12 pages

1453) Li, J. and Lee, A.S. 2006. Stress induction of GRP78/BIP and its role in cancer. Curr Mol Med. 6(1): 45-54

1454) Li, L., Fang, J., Ryan, C.J., Niemi, CE, Lebron, A.J., Bjorkman, J.P., Arase, H., Torti, M.F., Torti, V.S., Nakamura, CM, and Seaman, E.W. 2010. Ferritin H binding and uptake is mediated by human receptor transducer 1. PNAS. 107(8): 3505-3510

1455) Li, L., Khan, M.N., Li, Q., Chen, X., Wei, J., Wang, B., Cheng, J.W., Gordon, J.R. and Li, F. 2015. G31P, CXCR1/2 Inhibitor with cisplatin inhibits the growth of hepatocellular carcinoma in mice and mitigates high-dose cisplatin-induced nephrotoxicity. Oncol Rep. 33(2):751-7

1456) Li, M., Wang, J., Jing, J., Hua, H., Luo, T., Xu, L., Wang, R., Liu, D., and Jiang, Y. 2009. Synergistic promotion of breast cancer cell death by targeting the molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 13(11-12): 4540-50

1457) Li, P., Dietz, R. and von Hardsdorf, R. 1999. p53 regulates mitochondrial membrane potential by reactive oxygen species and induces cytochrome c-independent apoptosis, which is blocked by Bcl-2. EMBO magazine. 18(21): 6027-6036

1458) Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, SM, Ahmad, M., Alnemri, E.S. and Wang, X. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91(4): 479-89

1459) Li W, Fan J, Chen M, Guan S, Sawcer D, Bokoch MG and Woodley TD 2004. Mechanism of migration of human dermal fibroblasts driven by type 1 collagen and platelet-derived growth factor-BB. Mol Biol. Cell. 15(1): 294-309, doi: 10.1091/mbc.E03-05-0352

1460) Li W, Zhao Y, Tao B, and Zhang Y 2014. Effects of quercetin on hedgehog signaling in KBM7 chronic myeloid leukemia cells. Chin J. Integral Med. 20(10): 776-81

1461) Li, X., Song, J., Zhang, L., LeMaire, S.A. Hou, X., Zhang, C., Coselli, J.S., Chen, L., Wang, X.L., Zhang, Y., and Shen, YH 2009 Activation of the AMPK-FOXO3 signaling pathway reduces the increase in reactive oxygen species intracellular induced by fatty acids through upregulation of thioredoxin. Diabetes. 58(10):2246-2257

1462) Li, X., Zhang, K., & Li, Z. 2011. Unfolded protein response in cancer: the clinician's view. Journal of Hematology and Oncology. 4:8, doi: 10.1186/1756-8722-4-8

1463) Li, Y. L., Li, Q. X., Liu, R. J., & Shen, X. Q. 2015. In press. Chinese medicine Tonsil and β-glucosidase in combination with an enzyme prodrug antibody system as a viable antitumor therapy. Chin J Integra. Med. Doi: 10.1007/s11655-015-2154-x, 4 pages

1464) Li, Y, He, K, Huang, Y, Zheng, D, Gao, C, Cui, L & Jin, YH 2010. Betulin induces apoptosis associated with the release of mitochondrial cytochrome c in human cancer cells. carcinogenic mole 49(7): 630-40

1465) Li, Y., Karagöz, G.E., Seo, Y.H., Zhang, T., Jiang, Y., Yu, Y., Duarte, A.M., Schwartz, S.I., Boelens, R., Carroll, K., Rudiger, S. G. and Sun, D. 2012. Sulforaphane inhibits pancreatic cancer by disrupting the Hsp90-p50 complex (Cdc37) and direct interactions with Hsp90 amino acid residues. J Nutr Biochem. 23(12): 1617-26

1466) Li, Y., Liu, J., Liu, X., Xing, K., Wang, Y., Li, F., & Yao, L. 2006. Resveratrol-induced cell inhibition of growth and apoptosis in people MCF7 Breast cancer cells are associated with the modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotechnol. 135(3):181-92

1467) Li, Y., Mao, Y., Zhang, Y., Cai, S., Chen, G., Ding, Y., Guo, J., Chen, K. and Jin, M. 2014. Consumption of alcohol and cancer mortality of the upper respiratory tract and digestive tract: a systematic review and meta-analysis. Oral oncology. 50(4):269-275

1468) Li, Y., Wang, Z., Kong, D., Li, R., Sarkar, S. H. und Sarkar, F. H. 2008. Regulation of the Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in cells of prostate cancer. JBiolChem. 283(41): 27707-16

1469) Li, Y., Yuan, Y., Meeran, S. M. & Tollefsbol, T. O. 2010. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenols and histone deactylase inhibitor in breast cancer cells negative for ERα. mole cancer. 9: 274, doi: 1186/1476-4598-9-274, 12 pages

1470) Li, Y., Zhang, J., Ma, D., Zhang, L., Si, M., Yin, H., & Li, J. 2012. Curcumin inhibits Notch signaling proliferation and invasion -one. FEBS Magazine. 279(12): 2247-2259

1471) Li Y, Zhang T, Jiang Y, Lee HF, Schwartz SJ, and Sun D 2009. (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by inhibiting Hsp90-Association with cochaperones Mia impaired pancreatic cancer cell line Bale-2. Mol Pharma 6(4):1152-9

1472) Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H.F., Newman, B., Yu, Y., Clouthier, S.G., Schwartz, S.I., Wicha, M.S. and Sun, D. 2010. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Cancer Clinic Res. 16(9): 2580-90

1473) Li, Z., Hu, X., Wang, Y., & Fang, J. 2009. Apigenin inhibits proliferation of A2780 ovarian cancer cells by Id1. letters FEBS. 583(12): 1999-2003

1474) Li, Z., Wang, Y., Wu, H., Zhang, L., Yang, P., & Li, Z. 2014. GRP78 enhances glutamine metabolism to promote cell survival in glucose starvation by modulating β-catenin signaling. oncotarget 5(14):5369-80

1475) Li Z, Zhang L, Zhao Y, Li H, Xiao H, Fu R, Zhao C, Wu H and Li Z 2013. Cell-Surface GRP78 facilitates colon cancer cell migration and invasion. The International Journal of Biochemistry and Cell Biology. 45(5):987-994

1476) Lian, F., Li, Y., Bhuiyan, M. and Sarkar, FH 1999. Genistein-induced p53-independent apoptosis in lung cancer cells. Walnut cancer. 33(2):125-31

1477) Lian, N., Jiang, Y., Zhang, F., Jin, H., Lu, C., Wu, X., Lu, Y., & Zheng, S. 2015. Curcumin regulates fate and cell metabolism by inhibiting hedgehog signaling in hepatic stellate cells. To invest. 95(7):790-803

1478) Liang W, Li X, Li C, Liao L, Gao B, Gan H, Yang Z, Liao L, and Chen X 2011. Quercetin-mediated apoptosis through activation of mitochondria-dependent signaling in MG osteosarcoma cells -63. Molecular Medicine Reports. 4(5): 1017-23

1479) Liang, Y., Besch-williford, C., Benakanakere, I., and Hyder, M. S. 2007. Reactivation of the p53 signaling pathway inhibits hormone-dependent growth of human breast cancer cells in vivo and in vitro. international J Oncol. 31(4):777-784

1480) Liang, Y., Brekken, R.A. and Hyder, S.M. 2006. Vascular endothelial growth factor induces breast cancer cell proliferation and inhibits the antiproliferative activity of antihormones. Endocrinology connection cancer. 13(3): 905-19

1481) Liang, Y., Huang, Y., Tsai, S., Lin-Shiau, S., Chen, C. und Lin, J. 1999. Suppression of inducible cyclooxygenase and inducible stickoxid synthase by apigenin and related flavonoids in Maus -Makrophagen. Karzinogenese. 20(10): 1945-1952

[PMC Free Article] [PubMed] 1482) Liao, Y., Shen, W., Kong, G., Lv, H., Tao, W., and Bo, P. 2014. Apigenin induces apoptosis and regulates the MAPK signaling pathways in mouse macrophage ANA-1 cells. Plus one. 9:3, Doi: 10.1371/journal.pone.0092007, 8 pages

1483) Liberman, A. C., Druker, J., Refojo, D., Holsboer, F. & Arzt, E. 2009. Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells. FASEB J. 23(5 ): 1558-71

1484) Liby, K.T., Yore, MM, Sporn, MB 2007. Triterpenoids and rexinoids as multifunctional agents in the prevention and treatment of cancer. Nat Rev Cancer. 7,357-369.

1485) Lichtenstein, A.H., Appel, L.J., Brands, M. et al. 2006. Revision of the 2006 Diet and Lifestyle Recommendations: A Scientific Opinion from the American Heart Association Committee on Nutrition. Traffic. 114(1):82-96.

1486) Lickliter, J.D., Wood, N.J., Johnson, L., McHugh, G., Tan, J., Wood, F., Cox, J., and Wickham, N.W. 2003. HA14-1 selectively induces apoptosis in Bcl-2-overexpressed leukemia/lymphoma cells and enhances cytarabine-induced cell death. Leukemia. 17(11): 2074-80

1487) Liggins, J., Bluck, L.J.C., Runswick, S., Atkinson, C., Coward, W.A. and Bingham, S.A. 2000. Daidzein and genistein content in fruits and nuts. The Journal of Nutritional Biochemistry. 11(6):326-331

1488) Lilja, A., Nordborg, C., Brun, A., Salford, L. G. und Aman, P. 2001. Expression of IL-6 family cytokines in human brain tumors. in t. J. Oncol. 19(3): 495-9

1489) Lim, J. S., Adachi, Y., Takahashi, Y., and Ide, T. 2007. Comparative analysis of sesame lignans (sesamin and sesamolin) to influence hepatic fatty acid metabolism in rats. british nutrition magazine. 97(01): 85-95

1490) Lim, S. O., Kim, H., and Jung, G. 2010. P53 inhibits tumor cell invasion through snail protein degradation in hepatocellular carcinoma. FEBS Lett. 584(11):2231-6

1491) Lim, Y.J., Lee, Y.J., Byun, J.B. and Kim, H.S. 2015. Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B-lymphoma Raji cells. Toxicological reports. 2: 984-989, doi: 10.1016/j.toxrep.2015.07.004

1492) Lin, C., Chao, A., Wang, T.H., Hsueh, S., Lee, Y.S., Wu, T.I., Chao, A.S., Hwang, H.J., Chou, H.H., Chang, TC, and Lai, C.H. 2014 A dual tyrosine kinase inhibitor, lapatinib, suppresses matrix metallopeptidase 1 (MMP1) overexpression in endometrial cancer. J Mol Med (Berl). 92(9):969-81

1493) Lin C, Chen P, Chen M, Yang W, Tang C, Yang S and Hsieh Y 2013. Kaempferol reduces matrix metalloproteinase 2 expression by downregulating ERK1/2 and matrix metalloproteinase 2 signaling pathways. activator protein 1 in oral cancer cells. Plus one. 8(11): e80883, doi: 10.1371/journal.pone.0080883, 9 pages

1494) Lin C, Lin C, Ting W, Pai P, Kuo C, Ho T, Kuo W, Chang C, Huang C, and Lin W 2014. Resveratrol enhanced FOXO3 phosphorylation through synergistic activation of SIRT1 signaling and PI3K/Akt to enhance the effects of exercise in the hearts of aged rats. Years. 36: 9701, doi: 10.1007/s11357-014-9705-5, 10 pages

1495) Lin, C., Shen, S., Hou, W., Yang, L., & Chen, Y. 2008. Heme oxygenase-1 inhibits breast cancer invasion by suppressing matrix metalloproteinase-9 expression. Molecular Cancer Therapeutics. 7(5): 1195-206

1496) Lin, C., Whang, E.E., Donner, D.B. Jiang, X., Price, B.D., Carothers, A.M., Delaine, T., Leffler, H., Nilsson, U.J., Nose, V., Moore, F.D. and Ruan, D. T. 2009. Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and improves both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res. 7(10):1655-62

1497) Lin, H. Y., Huang, B. R., Yeh, W. L., Lee, C. H., Huang, S. S., Lai, C. H., Lin, H. und Lu, D. Y. 2014. Anti-neuroinflammatory effects of lycopine through activation of activated protein by adenosine monophosphate kinase-α1/Häm-Oxygenase-1-Wege. Alternate Neurobiol. 35(1): 191-202, doi: 10.1016/j.neurobiolaging.2013.06.020

1498) Lin, H., Chang, T., Yang, D., Chen, Y., Wang, M., and Chang, Y.2012. Regulation of the virus-induced inflammatory response by β-carotene in RAW264.7 cells. Food Chemistry. 134(4):2169-2175

1499) Lin, H., Chiang, M., Chang, P., & Chau, L. 2015. Myeloid heme oxygenase-1 promotes colonization of metastatic tumors in mice. Krebswissenschaft. 106(3):299-306

1500) Lin, H., Moon, B., Yu, F., and Kim, H. 2000. Galectin-3 mediates genistein-induced G2/M arrest and inhibits apoptosis. carcinogenesis. 21(11): 1941-1945

1501) Lin, J. K., Pan, M. H. und Lin-Shiau, S. Y. 2000. Recent studies on the biofunctions and biotransformations of curcumin. Biofactors. 131(1-4): 153-8

1502) Lin, J., Lee, I., Cook, N. R., Selhub, J., Manson, J. E., Buring, J. E. und Zhang, S. M. 2008. Plasma folate, vitamin B-6, vitamin B-12, and risk of Brustkrebs bei Frauen. Bin J Clin Nutr. 87(3): 734-743

1503) Lin, J, Zhang, SM, Wu, K, Willet, WC, Fuchs, CS, & Giovannucci, E. 2006. Flavonoid intake and risk of colon cancer in men and women. Am J Epidemiol. 164(7):644-651

1504) Lin, W., Wu, R. T., Wu, T., Khor, T., Wang, H., & Kong, A. 2008. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages via the pathway Nrf2-dependent signaling. Biochem Pharmacol. 76(8):967-973

1505) Lin X, Wu G, Huo WQ, Zhang Y, and Jin FS 2012. Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells. international J Urol. 19(8):757-64

1506) Lind, SD 2004. Arginine and cancer. J Nutr. 134(10): 2837S-2841S

1507) Ling, M. T., Luk, S. U., Al-Ejeh, F. und Khanna, K. K. 2012. Tocotrienol as a potential anticancer agent. Karzinogenese. 33(2): 233-239

1508) Lingelem, A. B. D., Hjelseth, I. A., Simm, R., Torgersen, M. L., & Sandvig, K. 2015. Geldanamycin enhances Shiga toxin retrograde transport in HEp-2 cells. Plus one. 10(5): e0129214, doi: 10.1371/journal.pone.0129214, 20 pages

1509) Linseeisen, J., Hoffmann, J., Lienhard, S., Jauch, KW. and Wolfram, G. 2000. Antioxidant status of surgical patients receiving TPN with a lipid emulsion containing n-3 fatty acids supplemented with tocopherol. Clinical Nutrition. 19(3):177-184.

1510) Linwong, W., Hirasawa, N., Aoyama, S., Hamada, H., Saito, T. and Ohuchi, K. 2005. Inhibition of rodent mast cell antigen-induced activation by putative Janus kinase- . 3 -Inhibitors WHI-P131 and WHI-P154 independently of Janus kinase 3. Br J Pharmacol. 145(6):818-28

1511) Lioni, M., Noma, K., Synder, A., Klein-Szanto, A., Diehl, J.A., Rustgi, AK, Herlyn, M., and Smalley, KSM 2008. Bortezomib induces apoptosis in squamous cells of the esophageal carcinoma cells by activating the p38 mitogen-activated protein kinase signaling pathway. Mol Cancer Ther. 7(9):2866-75

1512) Liontas, A. and Yeger, H. 2004. Curcumin and resveratrol induce apoptosis and nuclear translocation and p53 activation in human neuroblastoma. Res. against cancer. 24(2B): 987-98

1513) Liou, G. and Storz, P. 2010. Reactive oxygen species in cancer. Free Radicals Res. 44(5): 479-96

1514) Liskova, B., Zerzankova, L., Novakova, O., Kostrhunova, H., Travnicek, Z., and Brabec, V. 2012. Cellular response to CDK inhibitor platinum(II) cis-dichloride antitumor complexes Bohemine and Sena Analogue. Chemical Res. Toxicol. 25(2):500-9

1515) Liu, C. and Russell, R. M. 2008. Diet and gastric cancer risk: an update. Nutr Rev. 66(5): 237-49

1516) Liu, C., Gong, K., Mao, X., and Wenhua, L. 2011. Tetrandrine induces apoptosis by activating reactive oxygen species and suppressing Akt activity in human hepatocellular carcinoma. International Journal of Cancer. 129(6): 1519-1531

1517) Liu C, Li Y, Semenov M, Han C, Baeg G, Tan Y, Zhang Z, Lin X and He X 2002. Control of β-catenin phosphorylation/degradation by a dual kinase mechanism. Cell. 108(6):837-847

1518) Liu, C., Lou, W., Armstrong, C., Zhu, Y., Evans, CP, & Gao, AC 2015. Niclosamide suppresses cell migration and invasion in enzalutamide-resistant prostate cancer cells via inhibition of the Stat3 AR -Axis. The prostate. 75(13): 1341-1353

1519) Liu C, Lou W, Zhu Y, Nadiminty N, Schwartz CT, Evans CP, and Gao AC 2014. Niclosamide inhibits expression of androgen receptor variants and overcomes enzalutamide resistance in drug-resistant prostate cancer. castration. Cancer Clinic Res. 20(12): 3198-210

1520) Liu, C., Russell, M. R. and Wang, X. 2006. Lycopene supplementation prevents smoke-induced changes in p53 phosphorylation and p53 cell proliferation and apoptosis in the ferret gastric mucosa. J Nutr. 136(1): 106-111

1521) Liu, C., Russell, R.M. and Wang, X. D. 2003. Exposure of ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplements enhances pulmonary retinoic acid metabolism in vitro by inducing cytochrome p450 enzymes. J Nutr. 133(1):173-9

1522) Liu, G., Bibus, D.M., Bode, AM, Ma, W., Holman, R.T. and Dong, Z. 2001a. Omega-3, but not omega-6, fatty acids inhibit AP-1 activity and cell transformation in JB6 cells. Proceedings of the National Academy of Sciences. 98(13): 7510-7515.

1523) Liu, H., Nishitoh, H., Ichijo, H., and Kyriakis, J.M. 2000. Activation of apoptosis signal regulatory kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol. Mar 20(6):2198-2208

1524) Liu, J., Li, H., Gao, Z., Wang, Y., and Wei, W. 2014. Inhibitory effect of metformin on human hepatoma HepG2 cell proliferation and its possible mechanism. Chinese-German J Clin Oncol. 13(8): P370-P374

1525) Liu, J, Wu, N, Ma, LN, Zhong, JT, Liu, G, Zheng, LH, and Lin, XK 2014. P38 MAPK signaling mediates oleanolic acid-induced mitochondrial apoptosis in cancer cells. Asia Pacific J Cancer Before. 15(11): 4519-25

1526) Liu, J., Xia, H., Kim, M., Xu, L., Li, Y., Zhang, L., Cai, Y., Norberg, H.V., Zhang, T., Furuya, T. , Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, and Yuan J. 2011. Beclin 1 controls p53 levels by regulating USP10 deubiquitination activity and USP13. Cell. 147(1):223-34

1527) Liu K, Liu H, Qi J, Liu Q, Liu Z, Xia M, Xing G, Wang S and Wang Y 2012. SNX-2112, an inhibitor of Hsp90, induces apoptosis and autophagy through the degradation of clint Hsp90 proteins in human A-371 melanoma cells. cancer letters 318(2): 180-188

1528) Liu, LZ, Fang, J, Zhou, Q, Hu, X, Shi, X & Jiang, BH 2005. Apigenin inhibits vascular endothelial growth factor expression and angiogenesis in human lung cancer cells: implication of lung cancer chemoprevention. Mol Pharmacol. 68(3): 635-43

1529) Liu, M., Wallin, R. & Saldeen, T. 2001b. Effect of stable fish oil bread on plasma phospholipid fatty acids, triglycerides, HDL cholesterol, and malondialdehyde in patients with hyperlipidemia. nutrition research. 21(11): 1403-1410.

1530) Liu, N., Rowley, B.R., Bull, CO., Schneider, C., Haegebarth, A., Schatz, CA., Fracasso, P.R., Wilkie, D.P., Hentemann, M., Wilhelm, S.M., Scott, W.J., Numberg, D. and Ziegelbauer, K. 2013. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in xenograft models and tumor cell lines. Mol Cancer Ther. 12(11): 2319-30

1531) Liu, P., Cheng, H., Roberts, M. T. und Zhao, J. J. 2009. Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer. Nat Rev Drug Discovery. 8(8): 627-44

1532) Liu, Q., Chen, X., Yang, G., Min, X., & Deng, M. 2011. Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells . biocell. 35(3):71-9

1533) Liu, RY, Fan, C, Liu, G, Olashaw, NE & Zuckerman, KS 2000. Activation of p38 mitogen-activated protein kinase is essential for proliferation of leukemia and lymphoma cells promoted by alpha factor. Necessary tumor necrosis. JBiolChem. 275(28): 21086-21093

1534) Liu, W., Asa, SL & Ezzat, S. 2005. 1α,25-dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesion. Molecular endocrinology. 19(9): 2349-2357

1535) Liu, W., Cheng, S., Asa, SL & Ezzat, S. 2008. Melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer research. 68(19): 8104-8112

1536) Liu, W., Kou, B., Ma, Z., Tang, X., Lv, C., Ye, M., Chen, J., Li, L., Wang, X., and He, D 2015. Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion of human prostate cancer cells. Asian J Androl. 17(5):850-853

1537) Liu, W., Litwack, E.D., Stanley, J.M., Langford, K.J., Lander, DA & Sanderson, DR 1998. Heparan sulfate proteoglycans as adhesive and anti-invasive molecules. Syndecans and Glypican have different functions. The Journal of Biological Chemistry. 273(35): 22825-22832

1538) Liu, X., Allen, J.D., Arnold, J.T. and Blackman, MR. 2008. Lycopene inhibits IGF-I signaling and growth in normal prostate epithelial cells by inhibiting DHT-modulated IGF-I production in cocultured reactive stromal cells decreased carcinogenesis. 29(4):816-23

1539) Liu, X., Li, L., Lv, L., Chen, D., Shen, L., & Xie, Z. 2015. Apigenin inhibits osteosarcoma cell proliferation and invasion by repressing osteosarcoma signaling. Wnt/B-catenin pathway Oncol Rep. 34(2):1035-41

1540) Liu, X., Wilcken, R., Joerger, C. A., Chuckowree, S. I., Amin, J., Spencer, J., and Fersht, R. A. 2013. Small molecule-induced reactivation of mutant p53 in cancer cells. Nucleinsäureres. 41(12): 6034-6044

1541) Liu, X., Yue, P., Chen, S., Hu, L., Lonial, S., Khuri, F.R. and Sun, S.Y. 2007. Proteasome inhibitor PS-341 (bortezomib) increases DR5 expression, resulting in induction of apoptosis and enhancement of TRAIL-induced apoptosis despite upregulation of c-FLIP and expression survivor in human NSCLC cells. cancer res 67(10): 4981-8

1542) Liu Y, Liu X, Chen L, Du W, Cui Y, Piao X, Li Y, and Jiang C 2014. Targeting glioma stem cells via the Hedgehog signaling pathway. Neuroimmunology and Inflammation. 1(2): 51-59

1543) Liu, Y., Yang, C., Chen, J., Liao, J., and Hu. M. 2015. Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro and suppresses lung metastasis and tumor growth in combination with taxol in C57BL/6 tumor xenograft mice. Journal of nutritional biochemistry. 26:6, doi=10.1016/j.nutbio.2014.12.012, 9 pages.

1544) Liu, Z. G., Hsu, H., Goeddel, D. V., and Karin, M. 1996. Dissection of effector functions of TNF receptor 1: JNK activation is not associated with apoptosis, while NF- activation kappa B prevents cell death. Cell. 87(3):565-76

(1545) Liu , Z.J. , Shirakawa , T. , Li , Y. , Soma , A. , Oka , M. , Dotto , G.P. , Fairman , R.M. , Velazquez , O.C. and Herlyn, M. 2003. Regulation of Notch 1 and DII4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulation of arteriogenesis and angiogenesis. Mol Cell Biol. 23(1):14-2

1546) Liu, Z., Chen, G.G., Ng, E.KW., Leung, W., Sung, J.JY. and Chung, SC. S. 2004. Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene 23(2):503-513

1547) Liu, Z., Saarinen, New Mexico and Thompson, LU 2006

1548) Liyana-Pathirana, CM and Shahidi, F. 2006. Importance of insoluble bound phenols for the antioxidant properties of wheat. Journal of agricultural and food chemistry. 54(4): 1256-1264

1549) Lof, Y.H., Jakszyn, P., Luben, RN, Mulligan, AA, Mitrou, PN, & Khaw, K. 2011. N-nitroso compounds and cancer incidence: the European prospective survey of cancer and nutrition (EPIC ) – Norfolk to learn. Bin J Clin Nutr. 953(5):1053-1061

1550) Loganathan, R., Selvaduray, KR, Nesaretnam, K. & Radhakrishnan, AK 2013. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and ribose activity. nuclear factor kappa- inhibit B. cell proliferation. 46(2):203-213

1551) Logston , CD , Sources , MK , Huang , EH and Arumugam , T. 2007. RAGE and RAGE ligands in cancer . Curr Mol Med. 7(8):777-89

1552) Lonergan, PE and Tindall, DJ 2011. Androgen receptor signaling in the development and progression of prostate cancer. J Carcinog. 10:20, doi: 10.4103/1477-3163.83937

1553) Lonetti, A., Antunes, L. I., Chiarini, F., Orsini, E., Buontempo, F., Ricci, F., Tazzari, L. P., Pagliaro, P., Melchionda, F., Pession, A., Bertaina, A., Locatelli, F., McCubrey, A. J., Barata, T. J. und Martelli, M. A. 2014. Aktivität des Pan-Klasse-I-Phosphoinositid-3-Kinase-Inhibitors NVP-BKM120 bei akuter Lymphoblastischer T-Zell-Leukämie. Leukemia. 28(6): 1196-206

1554) Long, Yang, Lin, Situ, & Liu, 2013. Fish oil-supplemented parenteral nutrition in patients after oesophageal cancer surgery: effect on inflammation and immune function. Walnut cancer. 65(1):71-5.

1555) Long, X. and Nephew, K. P. 2006. Fulvestrant-dependent interacting proteins (ICI182,780) mediate estrogen receptor alpha immobilization and degradation. JBiolChem. 281(14):9607-9615

1556) Lopes, N., Paredes, J., Costa, J.L., Ylstra, B. and Schmitt, F. 2012. Vitamin D and the mammary gland: a review of its role in normal development and in breast cancer . breast cancer research. 14(3): 211-218

1557) G Lopez, J Liu, W Ren, W Wei, S Wang, G Lahat, Q Zhu, G W Bornmann, J D McConkey, E R Pollock and Lev, CD 2009. The combination of PCI-24781, a novel histone deactylase inhibitor , with chemotherapy for the treatment of soft tissue sarcomas. Clinical cancer research. 15(10):3472-83

1558) López, W. H., Leenhardt, F., Coudray, C. and Remesy, C. 2002. Interactions between minerals and phytic acid: is it a real problem for human nutrition? International Journal of Food Science and Technology. 37(7):727-739

1559) Lopez-Guerra, M., Sargay-Torrent, S., Rosich, L., Montraveta, A., Roldan, J., Matas-Cespedes, A., Vilamor, N., Aymerich, M., Lopez- Otin, C., Perez-Galano, P., Roue, G., Campo, E. und Colomer, D. 2015. Leukämie. 29: 96-106, doi: 10.1038/leu.2014.143

1560) Lord, R. S., Bongiovanni, B. & Bralley, J. A. 2002. Estrogen metabolism and the link between diet and cancer: rationale for assessing the proportion of hydroxylated estrogen metabolites in urine. Alternative medicine review. 7(2): 112-129

1561) Lorenz, M. and Urban, J. 2009. Green tea and black tea are equally potent stimuli for NO production and vasodilation: new insights into the tea components involved. Basic research in cardiology. 104(1): 100-110

1562) Losa, J.H., Cobo, C.P., Viniegra, J.G., Lobo, V.J.S., and Cajal, S.R. and Sanchez-Prieto. 2003. Role of the p38 MAPK signaling pathway in cisplatin-based therapy. oncogene 22:3998-4006, doi:10.1038/sj.onc.1206608

1563) Losonczy, K. G., Harris, T. B., & Havlik, R. J. 1996. Use of vitamin E and vitamin C supplements and risk of all-cause mortality and mortality from coronary artery disease in the elderly: populations established for epidemiological studies of the elderly. Bin J Clin Nutr. 64(2):190-6

1564) Lowe , J. , Araujo , J. , Yang , M. , Reich , M. , Oldendorp , A. , Shiu , V. , Quarmby , V. , Lowman , H. , Lien , S. , Gaudreault , J. , and Maia, M. 2007. Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo. Res. ocular exp. 85(4): 425-30

1565) Lowman, H., Hymowitz, S. and Ashkenazi, A. 2008. Structural and functional analysis of the interaction between the agonist monoclonal antibody Apomab and the pro-apoptotic receptor DR5. distinguish cell death. 15(4):751-61

1566) Lox, C.D. (1990). The effects of dietary marine fish oils (omega-3 fatty acids) on coagulation profiles in men. Genetic pharmacology. 21(2): 241-246.

1567) Lu, A. L., Li, X., Gu, Y., Wright, P. M., & Chang, D. Y. 2001. Repair of oxidative DNA damage. Zellbiochemie und Biophysik. 35(2): 141-170

1568) Lu G, Xiao H, Li G, Picinich SC, Chen Y, Liu A, Lee M, Loy S and Yang CS 2010. A mixture of γ-tocopherol-rfich tocopherols inhibits chemically induced lung tumorigenesis in A/mice J and xenograft tumor growth. carcinogenesis. 31(4):687-694

1569) Lu, G., Windsor, S.L. and Harris, W. S. 1999. Omega-3 fatty acids by lipoprotein subfraction distributions and the conversion of very low-density lipoproteins to low-density lipoproteins in vitro. The Journal of Nutritional Biochemistry. 10(3): 151-158.

1570) Lu, H.F., Chie, Y.J., Yang, M.S., Lee, CS, Fu, J.J., Yang, J.S., Tan, TW, Wu, SH, Ma, Y.S., Ip, SW, and Chung, J.G. 2010. Apigenin induces caspase-dependent apoptosis in A549 human lung cancer cells via Bax- and Bcl-2-triggered mitochondrial signaling pathways. international J Oncol. 36(6): 1477-84

1571) Lu HF, Tung WL, Yang JS, Huang FM, Lee CS, Huang YP, Liao WY, Chen YL, and Chung JG 2012. In vitro suppression of WEHI-3 murine leukemia cell growth and in vivo promotion of phagositosis in a mouse leukemia model by indole-3-carbinol. J Agricultural food chemistry. 60(31): 7634-43

1572) Lu H, Chie Y, Yang M, Lee C, Fu J, Yang J, Tan T, Wu S, Ma Y, Ip S and Chung, J. 2010. Apigenin induces caspase-dependent apoptosis in lung A549 cells human cancer via mitochondrial signaling pathways triggered by Bax and Bcl-2. International Journal of Oncology. 36: 1477-1484, doi:

1573) Lu, H., Ouyang, W. y Huang, C. 2006. Inflammation, a key event in carcinogenesis. Mol Cancer Res. 4(4):221-33

1574) Lu, KH, Lin, KL, Hsiao, YM and Chung, JG 2001. Tamoxifen inhibits arylamine-N-acetyltransferase activity and DNA-2-aminofluorene adduct in HL-60 human leukemia cells. Res CommunMol Pathol Pharmacol. 109(5-6): 319-331

1575) Lu, K., Shih, C. and Teicher, B. A. 2000. Expression of pRB, cyclin/cyclin-dependent kinases, and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to agents of the cellular cycle . Cancer Chemother Pharmacol. 46(4): 293-304

1576) Lu, Q., Hung, J., Heber, D., Go, V.L.W., Reuter, V.E., Cordon-Cardo, C., Scher, HI, Marshall, J.R. and Zhang, Z. 2001. Inverse association between plasma lycopene and other carotenoids and prostate cancer. Epidemiology, biomarkers and cancer prevention. 10(7): 749-56

1577) Lu, S., Wang, A., Lu, S., and Dong, Z. 2007. A new synthetic compound that disrupts androgen receptor signaling in human prostate cancer cells. Mol Cancer Ther. 6(7): 2057-64

1578) Lu, Y. L., Ou, N., and Lu, Q. 2013. Antioxidant induces DNA damage, cell death, and mutagenicity in human lung and skin cells. Scientific reports. 3:3169, doi:10.1038/srep03169

1579) Lu, Z. and Xu, S. 2006. Erk1/2 MAP kinases in cell survival and apoptosis. IUBMB-Leben. 58(11): 621-631

1580) Lundgren, K., Zhang, H., Brekken, J., Huser, N., Powell, ER, Timple, N., Busch, J.D., Neely, L., Sensintaffar, L.J., Yang, Y., McKenzie , A., Friedman, J., Scannevin, R., Kamal, A., Hong, K., Kasibhatla, R. S., Boehm, F. M., and Burrows, J. F. 2009. BIIB021, a fully synthetic small molecule inhibitor available via Oral Hsp90 Heat Shock Protein. Mol Cancer Ther. 8(4):921-9

1581) Luo, H., Daddysman, M.K., Rankin, GO, Jiang, B., and Chen, Y.C. 2010. Kaempferol enhances the effect of cisplatin on ovarian cancer cells by promoting apoptosis caused by cMyc downregulation. Cancer Cell International. 10:16, doi: 10.1186/1475-2867-10-16, 9 pages

1582) Luo, H., Jiang, BH, King, SM, and Chen, Y.C. 2008. Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. Walnut cancer. 60(6):800-9

1583) Luo, H., Jiang, B., Liu, L., and Chen, Y. 2008. Kaempferol inhibits VEGF and HIF-1α gene expression via the PI-3-kinase/Akt pathway in cancer cells of ovary. AACR Annuls Meeting - April 12-16, San Diego, CA, Cancer Res. 68:1758

1584) Luo, H., Yang, A., Schulte, BA, Wargovich, M.J. and Wang, GY 2013. Resveratrol induces premature senescence in lung cancer cells through ROS-mediated DNA damage. Plus one. 8(3): e60065, doi: 10.1371/journal.pone.0060065

1585) Luo W, Hershberger PA, Trump DL and Johnson CS 2013. 24-Hydroxylase in cancer: implications for vitamin D-based cancer therapeutics. J Steroid Biochem Mol Biol. 136:252-257. Doi: 10.1016/j.jsbmb.2012.09.031

1586) Lupini, A., Araniti, F., Sunseri, F. and Abenavoli, M. R. 2013. Coumarin-induced gravitropic response. System Signal Behavior 8(2): e23156, doi: 10.4161/psb.23156, 4 pages

1587) Lv, J.C., Wang, G., Pan, SH, Bai, X.W. and Sun, B. 2015. Lycopene protects pancreatic acinar cells from severe acute pancreatitis by reducing oxidative stress via the JNK pathway. Free Radicals Res. 49(2):151-63

1588) Lv, W., Ding, M. and Zheng, R. 2005. Isolation and quantification of amygdalin in apricot seed and Prunus tomentosa thunb. Using HPLC with solid phase extraction. Journal of Chromatographic Sciences. 43(7):383-7

1589) Lv, X., Qiu, M., Chen, D., Zheng, N., Jin, Y., & Wu, Z. 2014. Apigenin inhibits enterovirus 71 replication by suppressing viral IRES activity and modulating the JNK cell signaling pathway. Antiviral Res. 109:30-41, Doi:10.1016/j.antiviral.2014.06.004

1590) Lyons, J., Rauh-Pfeiffer, A., Yu, Y.M., Lu, X.-Mu., Zurakowski, D., Tompkins, R.G., Ajami, AM, Young, V.R. and Castillo, L. 2000. Blood Glutathione synthesis rates in healthy adults fed a diet free of sulfur amino acids. PNAS (Proceedings of the National Academy of Sciences). 97(10):5071-5076

1591) Lyons, M.M., Yu, C., Toma, R.B., Cho, S.Y., Reiboldt, W., Lee, J., and van Breeman, R.B. 2003. Resveratrol in raw and baked blueberries and blueberries. J Agricultural food chemistry. 51(20): 5867-5870

1592) Ma, D., Fang, Q., Wang, P., Gao, R., Wu, W., Lu, T., CaO, L., Hu, X. & Wang, J. 2015. The induction Heme oxygenase-1 via Na+-H+-1 exchanger protein plays a crucial role in imatinib-resistant CML cells. The Journal of Biological Chemistry. 290(20): 12558-71

1593) Ma, J.W., Zhang, Y., Li, R., Ye, J.C., Li, HY, Zhang, Y.K., Ma, Z.L., Li, J.Y., Zhong, XY, and Yang, X. 2015. Tetrandrine suppresses the human glioma Growth by inhibiting cell survival, proliferation, and tumor angiogenesis by attenuating STAT3 phosphorylation. Eur J Pharmacol. 764: 228-239, doi: 10.1016/j.ejphar.2015.06.017

1594) Ma, L., Tao, Y., Duran, A., Llado, V., Galvez, A., Barger, F.J., Kastilien, A.E., Chen, J., Yajima, T., Porollo, A., Medvedovic, M., Brill, M. L., Plas, R. D., Riedl, J. S., Leitges, M., Diaz-Meco, T. M., Richardson, D. A. und Moscat, J. 2013 tumorigenesis. Zelle. 152(3): 599-611

1595) Ma, Q. and Anthony, YH Lu. 2007. CYP1A induction and risk assessment in humans: An evolving story of in vitro and in vivo studies. Metabolism and disposition of drugs. 35(7): 1009-1016

1596) Ma Z , Otsuyama K , Liu S , Abroun S , Ishikawa H , Tsuyama N , Obata M , Li F , Zheng X , Maki Y ., Miyamoto, K. and Kawano, M.M. 2005. Baicalein, a component of Huang-Lian-Jie-Du-Tang (HLJDT) Scutellaria radix, leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood. 105(8):3312-3318

1597) Maayah, Z H, El Gendy, MA, El-Kadi, AO, & Korashy, HM 2013. Sunitinib, a tyrosine kinase inhibitor, induces the cytochrome P4501A1 gene in human breast cancer cells MCF7 via receptor activation ligand-independent aryl hydrocarbon. Arc Toxicol. 87(5):847-56

1598) Machida, K., Tsukamoto, H., Mkrtchyan, H., Duan, L., Dynnyk, A., Liu, H.M., Asahina, K., Govindarajan, S., Ray, R., Ou, J.J., Seki, E., Deshaies, R., Miyake, K., and Lai, MMC 2009 Toll-like receptor 4 mediates synergy between alcohol and HCV in hepatic oncogenesis involving the stem cell marker Nanog. PNAS. 106(5): 1548-1553

1599) Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S.W., and Aaronson, S.A. 2003. Influence of induced reactive oxygen species on p53-mediated cell fate decisions. mole cell biological 23(23):8576-8585

1600) MacLachlan KT, Somasundaram K, Sgagias M, Shifman Y, Mussel JR, Cowan HK and El-Deiry SW 2000. The effects of BRCA1 on the cell cycle and DNA damage response are associated with altered gene expression. The Journal of Biological Chemistry. 275(4): 2777-2785

1601) MacLean, C.H., Newberry, S.J., Mojica, W.A. et al. (2006). Effects of omega-3 fatty acids on cancer risk. The Journal of the American Medical Association. 295(4): 403-415.

1602) Madeira SM, Pires RMV, Alfaia MC, Luxton R, Doran O, Bessa BJR and Prates MAJ 2013. Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue from crossbred pigs. british nutrition magazine. 11(9): 1521-1535

1603) Madhujith, T. and Shahidi, F. 2006. Optimization of the extraction of antioxidant components from six barley varieties and their antioxidant properties. Journal of agricultural and food chemistry. 54(21): 8048-8057

1604) Madureira , A.M. , Duarte , M.T. , Piedade , M.F.M. , Promotion , J.R. . and Ferreira, MU 2004. Isoprenoid compounds of Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene. J Brass Chem Soc. 15(5):742-747

1605) Maechler, H., Hoefler, G., Landwirtschafter, T., Samonigg, H., Hutterer, G., Kass, DA, Pieske, B., von Lewinski, D. y Pichler, M., Cromie, M.M. y Gao, W. 2015. La epigalocatequina-3-galato mejora el efecto terapéutico de la leptomicina 8 en las células de cáncer de pulmón humano A549. Medicina oxidativa y longevidad celular. Vol. 2015, ID de artículo: 217304, doi: 10.1155/2015/217304, 10 páginas

1606) Maeda, H. & Saito, A. 2014. Enzalutamide: a novel androgen receptor inhibitor offering treatment options for patients with castration-resistant prostate cancer. They beat Kagaku Ryoho. 41(7):805-10

1607) Maes, M., Stevens, W.J., Declerek, L.S. et al. 1993. Significantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: further evidence for an inflammatory process during this illness. Advances in Neuro-Psychopharmacology and Biological Psychiatry. 17(2):241-255.

1608) Maes, M., Verkerk, R., Vandoolaeghe, E. et al. 1997. Serotonin-immunity interactions in major depression: lower serum tryptophan as a marker of an immunoinflammatory response. European Archives of Psychiatry and Clinical Neuroscience. 247(3):154-161.

1609) Mahmoed, MY and Rezq, AA 2013. Hepatoprotective effect of avocado fruits against carbon tetrachloride-induced liver injury in male rats. Journal of Applied Sciences of the World. 21(10):1445-1452

1610) Mahyar-Roemer, M., Katsen, A., Mestres, P. & Roemer, K. 2001. Resveratrol induces apoptosis of colon tumor cells independently of p53 and precedes epithelial differentiation, mitochondrial proliferation and the collapse of the membrane potential. Int J Cancer. 94(5): 615-622

1611) Maira , SM , Stauffer , F , Brüggen , J , Furet , P , Schnell , C , Fritsch , C , Brachmann , S , Chene , P , De Pover , A , Schoemaker , K ., Fabbro, D., Gabriel, D., Simonen, M., Murphy, L., Finan, P., Sellers, W. and Garnia-Echeverria, C. 2008. Identification and characterization of NVP-BEZ235, a novel Orally available mammalian target dual phosphatidylinositol-3-kinase/rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther. 7(7): 1851-6

1612) Makarevic, J., Rutz, J., Juengel, E., Kaulfuss, S., Reiter, M., Tsaur, I., Bartsch, G., Haferkamp, ​​​​​​A. and Blaheta, AR 2014. Amygdalin blocks bladder cancer cell growth in vitro by decreasing cyclin A and cdk2. 9(8): e105590, doi: 10.1371/journal.pone.0105590, 9 pages

1613) Makpol, S., Durani, L.W., Chua, K.H., Mohd Yusof, YA and Ngah, WZ 2011. Tocotrienol-rich fraction prevents cell cycle arrest and lengthens telomerase in senescent human diploid fibroblasts. J Biomed Biotechnol. Doi: 10.1155/2011/506171, 11 pages

1614) Malafa, MP and Neitzel, LT 2000. Vitamin E succinate promotes the resting phase of breast cancer tumors. J SurgRes. 93(1):163-170

1615) Malaviya, A. and Sylvester, P.W. 2013. Mechanisms mediating the effects of ϒ-tocotrienol when used in combination with PPARϒ agonists or antagonists on MCF-7 and MDA-MB-231 breast cancer cells. International Journal of Breast Cancer. Entry ID: 101705, 17 pages, doi: 10.1155/2013/101705

1616) Malhotra, V., Shanley, T.P., Pittet, J.F., Welch, W.J. and Wong, H.R. 2001. Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human airway epithelium. Am J Respir Cell Mol Biol. 25(1):92-7

1617) Malila N, Taylor RP, Virtanen JM, Korhonen P, Huttunen KJ, Albanes D and Virtamo J 2002. Effects of alpha-tocopherol and beta-carotene supplementation on gastric cancer disease in male smokers (ATBC Finland study) . Causes and control of cancer. 13(7):617-623

1618) Malka, F., Dairou, J., Ragunathan, N., Dupret, J. M. & Rodrigues-Lima, F. 2009. Mechanisms and kinetics of inhibition of human arylamine N-acetyltransferase 1 by disulfiram. FEBRUARY J. 276(17): 4900-4908

1619) Manach, C., Scalbert, A., Morand, C., Remesy, C. & Jimenez, L. 2004. Polyphenols: dietary sources and bioavailability. Bin J Clin Nutr. 79(5):727-47

1620) Manach, C., Williamson, G., Morand, C., Scalbert, A., & Remesy, C. 2005. Bioavailability and bioefficacy of polyphenols in humans. I Review of 97 bioavailability studies. Bin J Clin Nutr. 81 (1 supplement): 230S-42S

1621) Manda, G., Nechifor, M. T., & Neagu, T. 2009. Reactive oxygen species, cancer, and cancer therapies. Current chemical biology. 3(1): 342-366

1622) Mandler, R., Kabayashi, H., Hinson, E.R., Brechbiel, M.W. and Waldmann, T.A. 2004. Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity. cancer res 64(4): 1460-7

1623) Maneechotesuwan, K., Yao, X., Ito, K., Jazrawi, E., Usmani, OS, Adcock, I.M. and Barnes, P.J. 2009. Repression of GATA-3 Nuclear Phosphorylation and Import: A Novel Mechanism of Effects of Corticosteroids in Allergic Diseases. For medicine. 6(5): e1000076, doi: 10.1371/journal.pmed.1000076, 12 pages

1624) Manich G, Cabezon I, del Valle J, Duran-Vilaregut J, Camins A, Pallas M, Pelegri C and Vilaplana J 2013. Study of the transcytosis of an anti-transferrin receptor antibody with a Fab' cargo through the blood-brain barrier in mice. Eur.J.Pharm.Sci. 49(4): 556-64

1625) Manna, P. and Jain, S. 2015. Vitamin D (VD) inhibits oxidative stress through regulation of the NOX4/Nrf2/Trx signaling cascade and regulates the AMPK/IRS1/GLUT4 pathway mediated by SIRT1 and glucose uptake in high glucose-treated 3T3L1 adipocytes. Biology and medicine of free radicals. 76 (Supplement 1): S114, Journal ISSN: 0891-5849, doi: 10.16/j.freeadmiomed.2014.10.242

1626) Manna, S., Singha, B., Phyo, S.A., Gatla, H.R., Chang, T.P., Sanacora, S., Ramaswami, S., and Vancurova, I. 2013 Androgen-independent prostate cancer cells: the role from IKKα. J Immunol. 191(5):2837-46

1627) Mannick, B. J., Schonhoff, C., Papeta, N., Ghafourifar, P., Szibor, M., Fang, K. and Gaston, B. 2001. S-Nitrosylation of mitochondrial caspases. J CellBiol. 154(6): 1111–1116

1628) Manning, BD and Cantley, LC 2007. AKT/PKB Signalling: Downstream Navigation. Cell. 129(7):1261-74

1629) Mannisto, S., Smith-Warner, S.A., Spiegelman, D.A. et al. 2004. Dietary carotenoids and lung cancer risk in a pooled analysis of seven cohort studies. Biomarkers and prevention of cancer epidemiology. 13(1): 40-48.

1630) Mantena, SK, Sharma, SD & Katiyar, S. K. 2006. Berberine, a natural product, induces G1 phase cell cycle arrest and caspase-3 dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther. 5(2): 296-308

1631) Mao, Y., Dinnen, R.D. and Fine, R.L. 2013. B30 Abstract: Induction of the BRCAness phenotype by curcumin and hydroxyurea in WT BRCA ovarian cancer cells [Abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; September 18-21, 2013, Miami, Florida. Philadelphia (PA): AACR, Clinic Cancer Res 2013; 19 (19 Supplement): Abstract No. B30.

1632) Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF and Firestone GL 2010. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER) α protein degradation in cells of breast cancer with a transcriptional interruption cross-regulatory loop of ERα-GATA3. Mol Biol. Cell. 21(7):1166-1177

1633) Marconett, N.C., Sundar, NS, Tseng, M., Tin, SA, Tran, QK, Kelly, M., Mahuron, M.K., Bjeldanes, F.L. and Firestone, L.G. 2011. Indole-3-carbinol downregulation of telomerase gene expression requires inhibition of estrogen receptor alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates G1 cell cycle arrest of human breast cancer cells . carcinogenesis. 32(9):1315-1323

1634) Marcu, G. M., Schulte, W. T. and Neckers, L. 2000. Novobiocin and related coumarins and depletion of heat shock protein-dependent signaling proteins 90. J National Cancer Institute. 92(3): 242-248

1635) Marcus, PM and Newcomb, PA 1998. The Association of Calcium and Vitamin D and Colon and Rectal Cancer in Wisconsin Women. International Journal of Epidemiology. 27(5):788-793

1636) Marfe, G., Tafani, M., Indelicato, M., Sinibaldi-Salimei, P., Reali, V., Pucci, B., Fini, M. and Russo, M. A. 2009. Kaempferol induces apoptosis in two Cell lines via Akt inactivation, Bax and SIRT3 activation and mitochondrial dysfunction. J Cell Biochem. 106(4): 643-50

1637) Marik, R., Allu, M., Anchoori, R., Stearns, V., Umbricht, C. B. & Khan, S. 2011. Potent genistein derivatives as inhibitors of estrogen receptor alpha-positive breast cancer. Cancer Biol. Ther. 11(10):883-92

1638) Marinissen, M. J., Tanos, T., Bolos, M., de Sagarra, M. R., Coso, O. A., and Cuadrado, A. 2006. Inhibition of heme oxygenase-1 interferes with the transforming activity of encoded Kaposi sarcoma herpesvirus by G Proteingekoppelter Receiver. Das Journal of Biological Chemistry. 281(16): 11332-11346

1639) Markman, B., Atzori, F., Perez-Garcia, J., Tabernero, J., & Baselga, I. 2010. PI3K inhibition status and biomarker development in cancer therapeutics. Ana Oncól. 21(4): 683-691

1640) Marsh, SA, Pat, BK, Gobe, GC and Coombes, JS. 2005. Evidence for a dose-dependent, non-oxidative role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells. apoptosis. 10(3): 657-65

1641) Marsili, V., Calzuola, I. and Gianfranceschi, GL 2004. Nutritional relevance of wheat sprouts high in organic phosphates and antioxidant compounds. J Clin Gastroenterol. 38 (6 supplements): S123-6

1642) Marti, N., Mena, P., Canovas, J.A., Micol, V. and Saura, D. 2009. Vitamin C and the role of citrus juices as a functional food. Nat Prod Comm. 4(5):677-700

(1643) Martin , C.J. , Gaisser , S. , Challis , IR , Carletti , I. , Wilkinson , B. , Gregory , M. , Prodromou , C. , Roe , S.M. , Pearl , L.H. , Boyd , S.M. and Zhang, M.Q. 2008. Molecular characterization of macbecin as an Hsp90 inhibitor. J MedChem. 51(9): 2853-7

1644) Martin, D., Rojo, A.L., Salinas, M., Diaz, R., Gallardo, G., Alam, J., De Galarreta, CM and Cuadrado, A. 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. JBiolChem. 279(20):8919-29

1645) Martin, R. C. G., Aiyer, H. S., Malik, D., & Li, Y. 2012. Effect on pro-inflammatory and antioxidant genes and bioavailable distribution of turmeric vs. curcumin: similar root but different effects. Food and chemical toxicology. 50(2):227-231

1646) Martin, R. K. 2006. Targeting of apoptosis with dietary bioactive agents. Exp. Biol. Medicine. 231(2): 117-129

1647) Martinelli , E. , Troiani , T. , Morgillo , F. , Rodolico , G. , Vitagliano , D. , Morelli , M.P. , Tuccillo , C. , Vecchione , L. , Capasso , A. , Orditura , M. , . , De Vita, F., Eckhardt, SG, Santoro, M., Berrino, L. and Ciardiello, F. 2010. Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and de cancer cells lung. Clinical cancer research. 16(20): 4990–5

1648) Martinez, M.E., Jacobs, E.T., Ashbeck, E.L., Sinha, R., Lance, P., Alberts, D.S. and Thompson, P. A. 2007. Meat consumption, preparation methods, mutagens, and colorectal adenoma recurrence. carcinogenesis. 28(9):2019-27

1649) Martinez-Gonzales, J. and Badimon, L. 2007. Mechanisms underlying the cardiovascular effects of COX inhibition: benefits and risks. Curr Pharm Des. 13(22):2215-27

1650) Martinez-Valverde, I., Periago, J.M., Provan, G. and Chesson, A. 2002. Phenolic compounds, lycopene and antioxidant activity in commercial tomato cultivars (Lycopersicum esculentum). Journal of Agricultural and Food Sciences. 82(3):323-330

1651) Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S., and Doetsch, P. W. 2013. Cisplatin induces a mitochondrial ROS response that, depending on the cytotoxicity, leads to cytotoxicity, contributes to mitochondrial redox state and bioenergetic functions. Plus one. 8(11): e81162, doi: 10.1371/journal.pone.0081162, 15 pages

1652) Maruti, S.S., Ulrich, C.M. and White, E. 2009. Folate and one-carbon metabolism nutrients from dietary supplements and diet in relation to breast cancer risk. Bin J Clin Nutr. 89(2):624-33

1653) Maser, E. 1997. Stress, hormonal changes, alcohol, food components and drugs; Factors that predispose to cancer related to smoking? Trends Pharmacol Sci. 18(8):270-275

1654) Mashiyama, S. T., Hansen, C. M., Roitman, E., Sarmiento, S., Leklem, J. E., Shultz, T. D., and Ames, B. N. 2008. A baseline human DNA uracil assay: effect of the vitamin B6 marginal fehlen. Analytische Biochemie. 372(1): 21-31

1655) Mastro, AM, Chen, Y., Sosnoski, DM, & Prabhu, KS 2012. Poster presentations: metastatic models: from cell-autonomous genes to niche. Abstract 1401: Dietary selenium and metastasis in a mouse model. res of cancer 72 (8 supplement): 1401

1656) Masur, K., Vetter, C., Hinz, A., Tomas, N., Henrich, H., Niggemann, B., & Zanker, K. S. 2011. Diabetogenic glucose and insulin concentrations modulate transcriptome levels and protein, which Tumors participate in cell migration, adhesion and proliferation. Br J Cancer. 104(2): 345-352

1657) Mates, JM 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology. 153(1-3): 83-104

1658) Matesic DF, Sidorova TS, Burns TJ, Bell AM, Tran PL, Ruch RJ, and May SW 2012. P38 MAPK activation, JNK inhibition, neoplastic growth inhibition, and increased gap function communication in lung carcinoma human and cells transformed Ras by 4-phenyl-3-butenoic acid. J Cell Biochem. 113(1): 269-81

1659) Mathiasen, I. S., Serqeev, I. N., Bastholm, L., Elling, F., Norman, A. W., & Jaattela, M. 2002. Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in cancer of breast cells. Zeitschrift für Biologische Chemie. 277(34):30738-45

1660) Matsubara, K., Komatsu, S., Oka, T. und Kato, N. 2003. Vitamin B6-mediated suppression of colon tumor cell proliferation and angiogenesis. J Nutr Biochem. 14(5): 246-50

1661) Matsuo Y, Sawai H, Ochi N, Yasuda A, Sakamoto M, Takahashi H, Funahashi H, Takeyama H, and Guha S 2010. Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF- activity kappaB. Dig Dis Sci. 55(4):1167-76

1662) Matsuzaki , J. , Suzuki , H. , Tsugawa , H. , Watanabe , M. , Hossain , S. , Arai , E. , Saito , Y. , Sekine , S. , Akaike , T. , Kanai , Y . ., Mukaisho, K., Auwerx, J. and Hibi, T. 2013. Bile acids increase microRNA 221 and 222 levels, leading to CDX2 degradation during esophageal carcinogenesis. gastroenterology. 145(6): 1300–1311

1663) Mattila, P., Hellstrom, J., and Torronen, R. 2006. Phenolic acids in berries, fruits, and beverages. J Agricultural food chemistry. 54(19): 7193-7199

1664) Matura, M., Groossens, A., Bordalo, O., Garcia-Bravo, B., Magnusson, K., Wrangsjo, K. and Karlberg, T. 2002. Oxidized citrus oil (R-Limonene): A Most common skin sensitizer in Europe. Jelly. dermatol academy. 47(5): 709-714

1665) Mayerhofer , M. , Florian , S. , Krauth , M.T. , Aichberger , K.J. , Bilban , M. , Marcelescu , R. , Printz , D. , Fritsch , G. , Wagner , O. , Selzer , E. , . Sperr, W. R., Valent, P. and Sillaber, C. 2004. Identification of hemoxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia. Cancer res 64(9):3148-54

1666) Mayne, TS, Cartmel, B, Lin, H, Zheng, T, & Goodwin, JW 2004. Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior pharyngeal or laryngeal cancer. Journal of the American College of Nutrition. 23(1): 34-42

1667) Mazhar, D., Gilmore, R. y Waxman, J. 2005. COX y Krebs. QJ Med. 98(10): 711-718

1668) Mazza, G. and Cottrell, T. 2008. Carotenoids and cyanogenic glycosides in Saskatoon berries (Amelanchier alnifolia Mutt). Journal of Food Composition and Analysis. 21(3): 249-254

1669) Mc IIroy, M., Fleming, F.J., Buggy, Y., Hill, A.D. & Young, L.S. 2006. Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2-positive human breast cancer; a possible mechanism for the specific recurrence of the ER isoform. Endocrinology connection cancer. 13(4):1135-45

1670) McCarty, M.F. 2000. Parathyroid hormone may be a cancer promoter: an explanation for decreased cancer risk associated with exposure to ultraviolet light, calcium, and vitamin D. Med Hypotheses. 54(3):475-82

1671) McClue, S.J., Blake, D., Clarke, R., Cowan, A., Cummings, L., Fischer, P.M., MacKenzie, M., Melville, J., Stewart, K., Wang, S., Zhelev, N., Zheleva, D., and Lane, D. P. 2002. In vitro and in vivo antitumor properties of the cyclin-dependent kinase inhibitor CYC202 (R-roscovitine). Int J Cancer. 102(5): 463-8

1672) McCullough, K.D., Martindale, J.L., Klotz, L., Aw, T., and Holbrook, N.J. 2001. Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and disrupting the cellular redox state. Mol Cell Biol. 21(4):1249-1259

1673) McCullough, M.L., Robertson, AS, Rodriguez, C., Jacobs, E.J., Chao, A., Jonas, C., Calle, EE, Willett, W.C. and Thun, M.J. 2003. Calcium, vitamin D, dairy products, and colon cancer risk in the Cancer Prevention Study II dietary cohort (USA). Causes and control of cancer. 14(1):1-12

1674) McFadyen, M. C. E., Melvin, W. I. und Murray, G. I. 2004. Cytochrome P450 enyzmes: Novel options for cancer therapys. Mol Cáncer Ther März. 3(3): 363-71

1675) McGirt, M.J., Chaichana, KL, Gathinji, M., Attenello, F., Than, K., Ruiz, A.J., Olivi, A., Quinones-Hinojosa, A. 2008. Persistent ambulatory hyperglycemia is independent with a Decreased survival associated with primary resection of malignant brain astrocytomas. neurosurgery. 63(2): 286-291

1676) U B McGovern, R E Francis, B Peck, SK Guest, J Wang, SS Myatt, J Krol, J M Kwok, A Polchronis, RC Coombes and EW Lam 2009 Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in the breast cancer. Mol Cancer Ther. 8(3): 582-91

1677) McIIwain, CC, Townsend, DM & Tew, KD 2006. Glutathione-S-transferase polymorphisms: cancer incidence and therapy. Oncogene 25(11): 1639-1648

1678) McLean, L., Soto, U., Agama, K., Francis, J., Jimenez, R., Pommier, Y., Sowers, L., and Brantley, E. 2008. Aminoflavone induces oxidative damage in the DNA and reactive oxidative species-mediated apoptosis in breast cancer cells. Int J Cancer. 122(7): 1665-74

1679) Mclntyre, B. S., Briski, K. P., Gapor, A. and Sylvester, P. W. 2000. Antiproliferative and apoptotic effects of tocopherols and tocotrienols in mouse preneoplastic mammary epithelial cells. Proc Soc Exp. Biol. Medicine. 224(4): 292-301

1680) Meeran SM, Patel SN and Tollefsbol TO 2010. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. Plus one. 5(7): e11457, 13 pages, doi: 10.1371/journal.pone.0011457

1681) Meijer, L., Thunnissen, A.M., White, A.W., Garnier, M., Nikolic, M., Tsai, L.H., Walter, J., Cleverley, KE, Salinas, P.C., Wu, YZ, Biernat, J. , Mandelkow, E. M., Kim, S. H., and Pettit, G. R. 2000. Inhibition of cyclin-dependent kinases, GSK-3beta, and CK1 by hymenialdisine, a component of a marine sponge Chem Biol. 7(1): 51-63

1682) Meiners, S., Hocher, B., Weller, A., Laule, M., Stangl, V., Guenther, C., Godes, M., Mrozikiewicz, A., Baumann, G. and Stangl, K 2004. Downregulation of collagen and matrix metalloproteinases and suppression of cardiac fibrosis by proteasome inhibition. Hypertension. 44: 471-477, doi: 10.1161/01.HYP.0000142772.71367.65

1683) Meissner, M., Reichenbach, G., Stein, M., Hrgovic, I., Kaufmann, R., & Gille, J. 2009. Downregulation of vascular endothelial growth factor receptor 2 is a determinant important molecular of proteasome inhibitor. antiangiogenic effect mediated in endothelial cells. Cancer research. 69(5): 1976-84

1684) Meldrum, DR, McIntyre, RC, Sheridan, BC, Cleveland, JC, Jr, Fullerton, DA & Harken, AH 1997. L-arginine decreases proinflammatory monokine production by alveolar macrophages during acute lung injury from a nitric oxide synthase. dependent mechanism. J trauma. 43(6):888-93

1685) Melendez-Colon, V.J., Lunch, A., Seidel, A. and Baird, WM 1999. Cancer initiation by polycyclic aromatic hydrocarbons results from the formation of stable DNA adducts instead of apurinic sites. carcinogenesis. 20(10): 1885-1891

1686) Meli, M., Pennati, M., Curto, M., Daidone, G.M., Plescia, I., Toba, S., Altieri, C.D., Zaffaroni, N., and Colombo, G. 2006. Orientation of small molecules of the chaperone function of heat shock protein 90: rational identification of a new guide against cancer. J MedChem. 49(26): 7721-7730

1687) Melzig, M. F., Bader, G. and Loose, R. 2001. Studies on the mechanism of membrane activity of selected triterpenoid saponins. Plan Med. 67(1): 43-8

1688) Menezes, D.L., Javerna, P., Jensen, M.R., Abrams, T., Stuart, D., Yu, G.K., Duhl, D., Machajewski, T., Sellers, W.R., Pryer, N.K. and Gao, Z 2012. The novel oral Hsp90 inhibitor NVP-HSP990 shows potent broad-spectrum antitumor activities in vitro and in vivo. Mol Cancer Ther. 11(3):730-9

1689) Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzales FJ, Weinstein J and Pommier Y 2006. Activation of aminoflavone (NSC 686288) by a sulfotransferase is necessary for the antiproliferative effect of the drug and for the induction of histone gamma-H2AX. res of cancer 66(19): 9656-64

1690) Mind, A., Koning, L., Shannon, H.S. and Anand, S.S. 2009. A systematic review of the evidence supporting a causal relationship between dietary factors and coronary heart disease. Internal Medicine Archive. 169(7): 659-669.

1691) Mereles, D. and Hunstein, W. 2011. Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? international J. Mol.Sci. 12(9): 5592–5603

1692) Messina, M., Nagata, C. and Wu, A. H. 2006. Estimated intake of soy protein and isoflavones by Asian adults. Diet and cancer. 55(1):1-12

1693) Mettey, Y., Gompel, M., Thomas, V., Garnier, M., Leost, M., Ceballos-Picot, I., Noble, M., Endicott, J., Vierfond, J. M., and Meijer, L. 2003. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystalline structure in complex with CDK2, enzymatic selectivity and cellular effects. J MedChem. 46(2): 22-36

1694) Meyerson, M. 2000. Role of telomerase in normal and cancer cells. Journal of Clinical Oncology. 18(13): 2626-2634

1695) Miao, W., Hu, L., Kandouz, M. & Batist, G. 2003. Oltipraz is a bifunctional inducer that targets both phase I and phase II drug-metabolizing enzymes via the element activated xenobiotic response. Mol Pharmacol. 64(2):346-54

1696) Michaud-Levesque, J., Bousquet-Gagnon, N. & Beliveau, R. 2012. Quercetin abrogates IL-6/STAT3 signaling and inhibits the growth and migration of glioblastoma cell lines. Exp. cell res. 318(8):925-35

1697) Micheau, O. and Tschopp, J. 2003). Induction of TNF receptor I-mediated apoptosis through two sequential signaling complexes. 114(2): 181-190

1698) Middleton, Jr. E., Kandaswami, C., and Theoharides, C. T. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological reviews. 52(4): 673-751

1699) Miean, K. H. and Mohamed, S. 2001. Flavonoid content (myricetin, quercetin, kaempferol, luteolin and apigenin) of edible tropical plants. J Agricultural food chemistry. 49(6): 3106-12

1700) Miekus, K., Kijowski, J., Sekula, M., and Majka, M. 2012. 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration, and invasion. Oncology. reports. 28(5): 1903-1909

1701) Miki, H., Uehara, N., Kimura, A., Sasaki, T., Yuri, T., Yoshizawa, K., & Tsubura, A. 2012. Resveratrol induces apoptosis through drug-activated autophagy. ROS in human colon cancer cells International J Oncol. 40(4): 1020-8

1702) Mikirova, N., Casciari, J., Rogers, A., & Taylor, P. 2012. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J trans. Med. 10(189): 1-10

1703) Mikstacka, R., Przybylska, D., Rimando, AM and Baer-Dubowska, W. 2007. P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers. Molecular nutrition and food research. 51(5):517-524

1704) Milder, IEJ, Arts, ICW, van de Putte, B., Venema, DP y Hollman, PCH 2005. British Journal of Nutrition. 93(03): 393-402

1705) Miller, S.C., Huang, R., Sakamuru, S., Shukla, S.J., Attene-Ramos, M.S., Shinn, P., Van Leer, D., Leister, W., Austin, C.P. and Xia, M 2010. Identification of drugs known to act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol. 79(9):1272-80

1706) Mimura , N. , Fulciniti , M. , Gorgun , G. , Tai , Y. , Cirstea , D. , Holy , L. , Hu , Y. , Fabre , C. , Minami , J. , Oghuchi , H. . . . . , . . . . . . . . . . . . . , ., Kızıltepe , T. , Ikeda , H. , Kawano , Y. , French , M. , Blumenthal , M. , Tam , V. , Kertesz , N. L. , Nalyankar , U. M. , Hokenson , M. , Pham , T. , 2008 . , Zeng , Q. , Patterson , J.B. , Richardson , P.G. , Munshi , N.C. and Anderson , K.C. Blut. 119(24): 5772–5781

1707) Min, B. S., Gao, J. J., Nakamura, N., Hattori, M. 2001. Triterpenes from Ganoderma lucidum spores and their cytotoxicity against meth-A and LLC tumor cells. ChemoPharm-Bull. 48, 1026–1033.

1708) Min, H., Ghatnekar, GS, Ghatnekar, AV, You, X., Bu, M., Guo, X., Bu, S., Shen, B. & Huang, Q. 2012. Induced by 2- methoxyestradiol Bax phosphorylation and apoptosis in human retinoblastoma cells through p38MAPK activation. carcinogenic mole 51(7):576-85

1709) Min, YD, Choi, CH, Bark, CH, Son, HY, Park, HH, Lee, S, Park, JW, Park, EK, Shin, HI, and Kim, SH 2007. Quercetin inhibits the expression of inflammations Cytokines by attenuating NF-kB and p38 MAPK in the human HMC-1 mast cell line. Inflammation. Resolution 56(5): 210-215

1710) Minai, L., Yeheskely-Hayon, D., and Yelin, D. 2013. High concentrations of reactive oxygen species in cancer cells targeting gold nanoparticles after femtosecond pulsed irradiation. Scientific reports. 3: 2146-2156, doi: 10.1038/srep02146

1711) Minai, L., Yeheskely-Hayon, D., and Yelin, D. 2013. High concentrations of reactive oxygen species in cancer cells targeting gold nanoparticles after femtosecond pulsed irradiation. Scientific reports. 3: 2146-2156, doi: 10.1038/srep02146

1712) Ming-Ju, H., Te-Lung, T., Yih-Shou, H., Chau-Jong, W., and Hui-Ling, C. 2013. Dioscin-induced autophagy attenuates cell apoptosis by modulating P13K / Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Toxicology Archive. 87(11): 1927-1937

1713) Minucci, S. and Pelicci, G. 2006. Histone deactylase inhibitors and the promise of epigenetic (and other) treatments for cancer. Nat Rev Cancer. 6(1): 38-51

1714) Miodovnik, M., Koren, R., Ziv, E., & Ravid, A. 2012. The inflammatory response of keratinocytes and its modulation by vitamin D: the role of MAPK signaling pathways. Cell Physiol J. 227(5): 2175-2183

1715) Miodownik, C., Lerner, V., Vishne, T., Sela, BA, & Levine, J. 2007. High doses of vitamin B6 reduce serum homocyte levels in patients with schizophrenia and schizoaffective disorders: a preliminary study . Neuropharmaceutical Clinic. 30(1):13-7

1716) Mirandola, L., Yu, Y., Chui, K., Jenkins, MR, Cobos, E., John, CM and Chiriva-Internati, M. 2011. Galectin-3C inhibits tumor growth and increases anticancer activity of bortezomib in a mouse model of human multiple myeloma. More one. 6(7): e21811, doi:10.1371/journal.pone.0021811, 14 pages.

1717) Miriel, A.V., Allen, P.S., Schriver, D.S. and Prewitt, L.R. 1999. Genistein inhibits pressure-induced c-fos expression in isolated mesenteric arteries. Hypertension. 34: 132-137, doi: 10.1161/01.HYP.34.1.132

1718) Mirmiranpour, H., Khaghani, S., Zandieh, A., Khalilzadeh, O.O., Gerayesh-Nejad, S., Morteza, A., & Esteghamati, A. 2012. Amygdala inhibits angiogenesis in cultured endothelial cells of diabetic rats. Indian Journal of Pathology and Microbiology. 55(2): 211-214

1719) Mishra, S. and Palanivelu, K. 2008. The effect of curcumin (turmeric) on Alzheimer's disease. A general vision. Annals of the Indian Academy of Neurology. 11(1): 13-19

1720) Misra, R. N., Xiao, H. Y., Kim, K. S., Lu, S., Han, W. C., Barbosa, S. A., Hunt, J. T., Rawlins, D. B., Shan, W., Ahmed, S. Z., Qian, L., Chen, L. , B. C. , Zhao , R. , Bernarz , M. S. , Kellar , K. A. , Mulheron , J. G. , Batorsky , R. , Roongta , U. , Kamath , A. , Marathe , P. , Ranadive , S. A. , Sack , J. S. , Tokarski , J. . J. S. , Pavletich , N. P. , Lee , F. Y. , Webster , K. R. , and Kimball , S. D. 2004 . 1-Dimethylethyl)-2-oxazolyl]thio]methyl]thio]-2-thiazolyl]-4-piperidinacarboxamida (BMS-387032), un agente antitumoral altamente activo y selectivo. J MedChem. 47(7): 1719-2

1721) Mistry, N., Drobni, P., Naslund, J., Sunklari, VG, Jenssen, H., and Evander, M. 2007. The anti-papillomavirus activity of human and bovine lactoferricin. Antiviral Research. 75(3):258-265

1722) Mitchell, C., Park, M.A., Zhang, G., Han, S.I., Harada, H., Franklin, R.A., Yacoub, A., Li, P.L., Hylemon, P.B., Grant, S., and Dent, P 2007. 17-allylamino-17-demethoxygeldanamcin increases the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. Mol Cancer Ther. 6(2): 618-32

1723) Mitchell, S.H., Zhu, W. and Young, CYF 1999. Resveratrol inhibits androgen receptor expression and function in LNCaP prostate cancer cells. cancer res 59(23): 5892-5895

1724) Miyagoshi, M., Amagaya, S. and Ogihara, Y. 1986. Antitussive effects of L-ephedrine, amygdala, and makyokansekito (traditional Chinese medicine) using a mouse model of sulfur dioxide gas-induced cough. Plant Med. 4: 275-8, doi: 10.1055/s-2007-969151

1725) Miyake M, Fujimoto K, Anai S, Ohnishi S, Nakai Y, Inoue T, Matsumura Y, Tomioka A, Ikeda T, Okajima E., Tanaka, N. and Yoshihiko, H. 2010. Heme oxygenase-1 inhibition increases the cytotoxic effects of gemcitabine on urothelial cancer cells. Cancer research. 30(6): 2145-2152

(1726) Miyamoto N, Izumi H, Miyamoto R, Kondo H, Tawara A, Sasaguri Y, and Kohno K 2011. Quercetin induces peroxiredoxin 3 and 5 expression through the Nrf2/NRF1 transcription pathway. Investigative ophthalmology and visual science. 52(2): 1055-1063

1727) Miyamoto, N., Izumi, H., Miyamoto, R., Kubota, T., Tawara, A., Sasaguri, Y. and Kohno, K. 2009. Nipradilol und Timolol induce Foxo3a and Peroxiredoxin 2 expression and protect Trabekelwerkzellen from oxidative stress. Research Ophthalmology and Visual Sciences. 50(6):2777-2784

1728) Miyamoto, R., Miyamoto, N., Izumi, H., Kohno, K., & Tawara, A. 2010. Quercetin induces peroxiredoxin 3 and 5 expression via the Nrf2/NRF1 transcription pathway: Investigative Ophthalmology and Visual Science. 51:13, Summary of the meeting. Abstract No.: 6120

1729) Miyashita, K., Oyama, T., Sakuta, T., Tokuda, M., & Torii, M. 2012. Anandamide induces matrix metalloproteinase 2 production via cannabinoid receptor 1 and receptor transient potential vanilloid -1 in human teeth Pulp cells in culture. J Endod. 38(6): 786-90

1730) Miyata, Y. 2005. Hsp90 inhibitor Geldanamycin and its derivatives as new cancer chemotherapeutic agents. Curr Pharm Des. 11(9):1131-8

1731) Miyata, Y., Kanda, S., Mitsunari, K., Asai, A., & Sakai, H. 2014. Heme oxygenase-1 expression is associated with tumor aggressiveness and outcome in patients with bladder cancer : a correlation with smoking intensity. Translational Research. 164(6): 468-476

1732) Miyata, Y., Nakamoto, H., & Neckers, L. 2013. The Hsp90 therapeutic target and cancer marker. Curr Pharm Des. 19(3) 347-65

1733) Miyato, Y. and Ando, ​​K. 2004. Apoptosis of human melanoma cells by a combination of lonidamine and radiation. J Radiat Res. 45(2): 189-194

1734) Miyazaki, H., Morishita, J., Ueki, M., Nishina, K., Shiozawa, S., & Maekawa, N. 2012. The effects of a selective inhibitor of c-Fos/activator protein-1 on the endotoxin induced acute renal failure in mice. BMC Nephrol. 13: 153, doi: 10.1186/1471-2369-13-153, 12 pages

1735) Miyazaki, T., Kirino, Y., Takeno, M., Samukawa, S., Hama, M., Tanaka, M., Yamaji, S., Ueda, A., Tomita, N., Fujita, H. und Ishigatsubo, Y. 2010. Heme oxygenase-1 expression in human leukemia cells and its regulation by the Bach 1 transcription repressor. Cancer Sci. 101(6): 1409-16

1736) Miyoshi, N., Naniwa, K., Kumagai, T., Uchida, K., Osawa, T., & Nakamura, Y. 2005. Alpha-tocopherol-mediated upregulation of caspase-3 increases susceptibility to apoptotic stimuli. Biochem Biophys Communal Res. 334(2): 466-73

1737) Miyoshi, Y., Takahashi, Y., Egawa, C., & Noguchi, S. 2002. Breast cancer risk associated with CYP1A1 gene polymorphisms in Japanese women. Mama J. 8(4): 209-15

1738) Mladenka, P., Macakova, K., Filipsky, T., Zatloukalova, L., Jahodar, L., Bovicelli, P., Silvestri, PI, Hrdina, R., and Saso, L. 2011. In vitro analyze the iron chelating activity of flavonoids. Journal of Inorganic Biochemistry. 105(5): 693-701

1739) Mo, W., Xu, X., Xu, L., Wang, F., Ke, A., Wang, X., & Guo, C. 2011. Resveratrol inhibits proliferation and induces apoptosis via Hedgehog signaling in the pancreatic cancer cell. pancreatology. 11(6): 601-9

1740) Mobh, p. 1938. Research for vitamin P. The Journal of Biochemistry. 29(3): 487-501

1741) Mocellin, S. and Nitti, D. 2008. TNF and cancer: the two sides of the coin. Biosci front. 1(13):2774-83

1742) Mody, R. 2013. Targeting Kill Receptors: Is This Trail Still Active? Translational Pediatrics. 2(2): 66-69

1743) Moellering ER, Cornejo M, Davis NT, Del Bianco C, Aster CJ, Blacklow CS, Kung LA, Gilliland GD, Verdine LG, and Bradner EJ 2009 NOTCH transcription factor complex. Nature. 462(7270):182-188

(1744) Moertei GC, Fleming RT, Rubin J, Kvols KL, Sarna G, Koch R, Currie EV, Young WC, Jones ES and Davignon PJ 1982 Amygdalin (laetrile) in the treatment of human cancer. N Engl. J Med. 306(4):201-6

1745) Mohan, K. and Das, NU 2000. Effect of the L-arginine nitric oxide system on essential fatty acid metabolism in chemically induced diabetes mellitus. Prostaglandins, leukotrienes and essential fatty acids (PLEFA). 62(1): 35-46

1746) Mohler, J. L., Chen, Y., Hamil, K., Hall, S. H., Cidlowski, J. A., Wilson, E. M., French, F. S. und Sar, M. 1996. Androgen and glucocorticoid receptors in the stroma and epithelium of prostatic hyperplasia and Karzinom. Cancer Clinic Res. 2(5): 889-895

1747) Mojsin, M., Vicentic, J. M., Schwirtlich, M., Topalovic, V., & Stevanovic, M. 2014. Quercetin reduces pluripotency, migration, and adhesion of the human teratocarcinoma cell line NT2/D1 by inhibition of Wnt/B-catenin signaling. Food Function 5(10): 2564-73

1748) Molenaar, J. J., Ebus, M. E., Koster, J., van Sluis, P., van Noesel, C. J., Versteeg, R. und Caron, H. N. Cancer Res. 68(8): 2599-609

1749) Molina-Arcas, M., Hancock, D.C., Sheridan, C., Kumar, MS, & Downward, J. 2013. Coordinate direct entry of KRAS and the IGF1 receptor for PI3 kinase activation in lung cancer KRAS mutant. Discovery of cancer. 3(5): 548-63

1750) Moncada, S., Palmer, R.M. and Higgs, E.A. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 43(2): 109-42

1751) Montaner, B. and Perez-Tomas, R. 2002. Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome c release in Jurkat T cells. Annals of the New York Academy of Sciences. 973:246-9, doi:10.1111/j.1749-6632.2002.tb04642.x

1752) Moon , H.M. , Jeong , K.J. , Lee , J.Y. , Seol , W.J. , Jackson , J.C. . and Park, Y.S. 2013. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes. osteoarthritis and cartilage. 21(3): 470-480

(1753) Mooradian , A. D. , Morley , J. E. , Morley , J. E. and Korenman , S. G. 1987. Endor. 8(1): 1-2

1754) Morais, C. 2014. Sunitinib resistance in renal cell carcinoma. Kidney Cancer Magazine and VHL. 1(1): 1-11

1755) Moretti, M., Budni, J., Freitas, AE, Rosa, PB, & Rodrigues, AL 2014. The antidepressant action of ascorbic acid is associated with the modulation of the rapamycin pathway in mammals. psychiatrist j Res. 48(1): 16-24

1756) Mori-Abe A, Tsutsumi S, Takahashi K, Toya M, Yoshida M, Du B, Kawagoe J, Nakahara K, Takahashi T, Ohmichi, M. & Kurachi, H. 2003. Estrogen and raloxifene induce apoptosis by activation of the p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol. 178(3): 417-426

1757) Morin, PJ 1999. Beta-catenin signaling and cancer. bioassays. 21(12): 1021-30

1758) Moriya, R., Uehara, T. and Nomura, Y. 2000. Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells. letters FEBS. 484(3): 253-260

1759) Morley, R. 1998. Nutrition and cognitive development. Nutrition, 14 (10): 752-754.

1760) Morrow, L.A., O'Brien, M., and Clemmons, D.R. 1996. Recombinant human insulin-like growth factor I increases sensitivity and improves glycemic control in type II diabetes. Diabetes. 45(1): 91-100

1761) Mortenson MM, Schlieman MG, Virudachalam S, Lara PN, Gandara DG, Davies AM and Bold RJ 2005. Reduction of Bcl-2 levels by inhibition of the 26S proteasome with bortezomib is associated with induction of apoptosis in small cell lung cancer. lung cancer. 49(2):163-70

1762) Moses, M.A., Henry, E.C., Ricke, W.A. and Gasiewicz, T.A. 2015. The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a new model of human prostate cancer progression. Cancer Previous Res. 8(3): 249-57

1763) Moshinsky, D. J., Bellamacina, C. R., Boisvert, D. C., Huang, P., Hui, T., Jancarik, J., Kim, S. H., and Rice, A. G. 2003. SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. Biochem Biophys Communal Res. 310(3): 1026-31

1764) Mosses AC, Young SC, Morrow LA, O'Brien M and Clemmons DR 1996. Recombinant human insulin-like growth factor increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes. 45(1): 91-100

1765) Moyad, MA 2003. The use of complementary/preventive medicine to prevent recurrence/progression of prostate cancer after definitive therapy Part I: lifestyle changes. Current opinion in urology. 13(2): 137-145.

1766) Mu, M. M., Chakravortty, D., Sugiyama, T., Koide, N., Takahashi, K., Mori, I., Yoshida, T., and Yokochi, T. 2001. The inhibitory action of quercetin on the Lipopolysaccharide- induced Stickoxidproduktion in RAW 264.7-Makrophagenzellen. J Endotoxin-Res. 7(6): 431-8

1767) Mueck, A. O. & Seeger, H. 2007. Breast cancer: are estrogen metabolites carcinogenic? mature. 57(1): 42-6

(1768) Mukae, N., M. Enari, H. Sakahira, Y. Fukuda, J. Inazawa, H. Toh, and S. Nagata. Proc Natl Acad Sci USA. 95(16):9123–9128

1769) Mukai, K., Nishimura, M., Kikuchi, S. 1991. Stopped flow study of the reaction of vitamin C with tocopheroxyl radicals in TritonX-100 micellar aqueous solutions. The structure-activity relationship of the tocopherol regeneration reaction by vitamin C. J. Biol. Chem. 266(1):274-278

1770) Mukherjee, S., Lekli, I., Gurusamy, N., Bertelli, A. A. A. und Das, D. K. 2009. Expression of longevity proteins in red and white wines and their cardioprotective components, resveratrol, tyrosol and hydroxytyrosol. Freie Radikale Biologie und Medizin. 46(5): 573-578

1771) Murai, M., Miki, K. and Ohe, K. 2009. A new route to 3-acyl-2-aminobenzofurans: palladium-catalyzed cycloisomerization of 2-(cyanomethyl)phenyl esters. common chemistry 23: 3466-3468, address: 10.1039/B904127C

1772) Murakami, A., Ashida, H., and Terao, J. 2008. Multitargeted Cancer Prevention by Quercetin. cancer letters 269(2): 315-325

1773) Murakami, Y., Kawata, A., Seki, Y., Koh, T., Yuhara, K., Maruyama, T., Machino, M., Ho, S., Kadoma, Y., and Fujisawa, S 2012. Comparative inhibitory effects of magnolol, honokiol, eugenol, and bis-eugenol on cyclooxygenase-2 expression and nuclear factor kappa-β activation in RAW264.7 macrophage-like cells stimulated with Porphyromonas gingivalis fimbriae. Live. 26(6):941-50

1774) Murata, A. and Morishige, F. 1981. International Conference on Nutrition, Taijin, China Report in Medical Tribune (22/61/81). Prolongation of survival time in patients with terminal cancer by the administration of large doses of ascorbate. International journal of research on vitamins and nutrition. 23 (1982 Supplement): 103-13

1775) Murphy, L. C. & Leygue, E. 2012. The role of the estrogen receptor-β in breast cancer. Semin Reprod Med. 30(1):5-13

1776) Murphy, L.O., Smith, S., Chen, R.H., Fingar, DC, & Blenis, J. 2002. Molecular interpretation of the duration of ERK signaling by immediate early gene products. National Cell Biol. 4(8):556-64

1777) Murray, G. I., Taylor, M. C., McFadyen, M. C., Mckay, J. A., Greenlee, W. F., Burke, M. D. and Melvin, W. T. 1997. Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. 57(14):3026-31

(Video) Lycopene Supplements vs. Prostate Cancer

1778) Murtaza, I., Saleem, M., Adhami, VM, Hafeez, BB, Mukhtar, H. 2009. Suppression of cFLIP by Lupeo, a dietary triterpene, is sufficient to induce resistance to TRAIL-mediated apoptosis in pancreas chemoresistant human overcome cancer cells. res of cancer 69, 1156-1165

1779) Mustafi, BS, Chakraborty, KP & Raha, S. 2010. Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myeloid leukemia (CML) cells leads to downregulation of Hsp70. Plus one. 5(1): e8719, doi: 10.1371/journal.pone.0008719, 8 pages

1780) Na, HK, Kim, EH, Jung, JH, Lee, HH, Hyun, JW & Surh, YJ 2008. Epigallocatechin (-)-gallate induces Nrf2-mediated antioxidant enzyme expression through activation of PI3K and ERK in human breast epithelial cells. Arch Biochem Biophys. 476(2):171-7

1781) Nadin, L. and Murray, M. 1999. Participation of CYP2C8 in the 4-hydroxylation of retinoic acid in human liver microsomes. Biochemische Pharmakologie. 58(7): 1201-1208

1782) Nagaoka, S., Kakiuchi, T., Ohara, K. and Mukai, K. 2007. Kinetics of the reaction by which natural vitamin E is regenerated by vitamin C. Chemistry and physics of lipids. 146(1):26-32

1783) Nagasawa, J., Mizokami, A., Koshida, K., Yoshida, S., Naito, K. and Namiki, M. 2006. Novel HER2-selective tyrosine kinase inhibitor, TAK 165, inhibits bladder, kidney , and androgen - unrelated prostate cancer in vitro and in vivo. international J Urol. 13(5):587-9

1784) Nagata, C., Takatsuka, N., Kawakami, N., & Shimizu, H. 2002. A prospective cohort study of soy product intake and death from gastric cancer. British journal of cancer. 87(1):31-36

1785) Nageswari, K., Banerjee, R. and Menon, V.P. 1999. Effect of w-3 and w-6 saturated polyunsaturated fatty acids on myocardial infarction. Journal of nutritional biochemistry. 10(6): 338-344.

1786) Naidu KA, Karl RC, Naidu KA and Coppola D 2003. Antiproliferative and proapoptotic effect of ascorbyl stearate on human pancreatic cancer cells. Digestive Diseases and Sciences. 48(1): 230-2

1787) Nail-Shalliker, V., Fenech, M., Forder, PM, Clements, MS, and Armstrong, BK. 2012. Sunlight and vitamin D affect DNA damage, cell division, and cell death in human lymphocytes: a cross-sectional study in South Australia. mutagenesis. 27(5): 609-614

1788) Nakai , K. , Fujii , H. , Kono , K. , Goto , S. , K. tazawa , R. , Kitazawa , S. , Hirata , M. , Shinohara , M. , Fukagawa , M. and Nishi , Pg. 2014. Vitamin D activates the Nrf2-Keap1 antioxidant pathway and ameliorates nephropathy in diabetic mice. I am J Hypertensive. 27(4):586-95

1789) Nakai R, Iida S, Takahashi T, Tsujita S, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H ., ., Akinaga, S., Murakata, C., Honda, S., Nitta, M., Saya, H., and Yamashita, Y. 2009. K858, a novel mitotic kinesin E95 inhibitor and antitumor agent, induces cell death in cancer cells. cancer res 69(9):3901-9

1790) Nakamura, T., Arduino, A., Baccaro, B., Furuhashi, M., & Hotamisligil, S. G. 2014. Small molecule PKR inhibitors improve glucose homeostasis in obese diabetic mice. Diabetes. 63(2): 526-534

1791) Nakamura T, Okabe M, Kashihara Y, Sato S, Furuno A, Saitoh S, Haga N, Tsuruo T, and Tomida A. 2007. DNA microarray analysis of tumors in MKN74 xenograft nude mice administered vercipelostatin (VST). cancer res 67:4830, AACR Annual Meeting, October 14-18. April, Los Angeles, CA.

1792) Nakamura, Y., Yoshida, C., Murakami, A., Ohigashi, H., Osawa, T., and Uchida, K. 2004. Zerumbone, a sesquiterpene from tropical ginger activates FEBS Phase II drug-metabolizing enzymes - Letters. 572(1-3): 245-250

1793) Nakanishi, A., Minami, A., Kitagishi, Y., Ogura, Y., and Matsuda, S. 2015. BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease. international J.Mol.Sci. 16(2): 2879-2892

1794) Nakano, K. and Vousden, K. H. 2001. PUMA, a new pro-apoptotic gene, is induced by p53. molecular cell. 7(3): 683-694

1795) Nakashima, T., Ishii, T., Tagaya, H., Seike, T., Nakagawa, H., Kanda, Y., Akinaga, S., Soga, S., and Shiotsu, Y. 2010. New Mechanism Molecular and Biological Analysis of the Antitumor Activities of KW-2478, a Novel Non-Ansamycin Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells. Cancer Clinic Res. 16(10): 2792-802

1796) Nakayama A, Takagi S, Yusa T, Yaguchi M, Hayashi A, Tamura T, Kawakita Y, Ishikawa T, and Ohta Y 2013. Antitumor activity of TAK-285, a non-Pgp substrate HER2/EGFR kinase inhibitor under investigation , in cultured tumor cells, mouse and rat xenograft tumors, and in a HER2-positive model of brain metastasis. J Cancer. 4(7):557-565

1797) Nam TW, Yoo CI, Kim HT, Kwon CH, Park JY and Kim YK 2008. The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts. J Bone Miner Metab. 26(6):551-60

1798) Namiki, M. 2007. Nutraceutical functions of sesame: a review. Critical Reviews in Food Science and Nutrition. 47(7): 651-673.

1799) Nappi, A.J. and Vass, E. 1998. Methylated catechols inhibit hydroxyl radical formation through iron-mediated Fenton chemistry. Biochim Biophys Act. 1425(1): 159-67

1800) Nappi, A.J. and Vass, E. 1998. Methylated catechols inhibit hydroxyl radical formation through iron-mediated Fenton chemistry. Biochim Biophys Act. 1425(1): 159-67

1801) Narayanan, R., Sepúlveda, VA, Falzon, M. and Weigel, N.L. 2004. The functional consequences of crosstalk between vitamin D receptor and ERK signaling pathways are cell-specific. JBiolChem. 279(45): 47298-310

1802) Nardini, M., DAquino, M.D., Gentili, V., DiFelice, M., and Scaccini, C. 1995. Dietary fish oil enhances oxidative modification of plasma and LDL in rats. Journal of nutritional biochemistry. 6(9): 474-480.

1803) Nargi, J.L., Ratan, R.R. and Griffin, DE. 1999. Inhibition of P-53-independent proliferation and induction of p21 (WAF1/Cip1)-modulated cell death by the antioxidants N-acetylcisgeine and vitamin E. 1 (6 ): 544-556

1804) Narjoz, C., Favre, A., McMullen, J., Kiehl, P., Montemurro, M., Figg, W.D., Beaune, P., de Waziers, I. and Rochat, B. 2014. Important paper of CYP2I2 in the degradation of protein kinase inhibitors: a possible role in the disposition and resistance to intratumoral drugs. Plus one. 9(5): e95532, doi: 10.1371/journal.pone.00955532, 10 pages

1805) Nasu , Y. , Nishida , K. , Miyazawa , S. , Komiyama , T. , Kadota , Y. , Abe , N. , Yoshida , A. , Hirohata , S. , Ohtsuka , A. and Ozaki , T. 2008. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a mouse model of arthritis induced by antibodies against collagen. cartilage of the osteoarthritis. 16(6):723-3

1806) Natarajan, R., Esworthy, R., Bai, W., Gu, J.L., Wilczynski, S., and Nadler, J. 1997. Increased expression of 12-lipoxygenase in breast cancer cells and tissues. Regulation by epidermal growth factor. J Clin Endocrinol Metab. 82(6): 1790-8

1807) Navarro, M.D. 1959. Five years of experience with laetrile therapy in advanced cancer. Act Union Int Against Cancrum. 15 (Supplement 1): 209-21

1808) Nechuta S, Lu W, Chen Z, Zheng Y, Gu K, Cai H, Zheng W, and Shu X O 2011. Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study. Biomarkers of the cancer epidemic Prev. 20(2):262-271

1809) Nechuta S, Shu X, Li H, Yang G, Ji B, Xiang Y, Cai H, Chow W, Gao Y, and Zheng W 2012. Prospective cohort study on tea consumption and risk of digestive system cancers : Results of the Shanghai Women's Health Study. Bin J Clin Nutr. 96(5): 1056-1063

1810) Neckers, L. and Workman, P. 2012. Molecular inhibitors of the Hsp90 chaperone: are we there yet? Cancer Clinic Res. 18(1):64-76

1811) Negi, G., Kumar, A. and Sharma, S. S. 2011. Modulation of Nrf2 and NF-kB by sulforaphane counteracts multiple manifestations of rat diabetic neuropathy and changes induced by high glucose. Current neurovascular research. 8(4):294-304

1812) Nelin, K.D. and Hoffman, GM. 1998. The use of inhaled nitric oxide in a variety of clinical problems. Children's Hospital of North Am. 45(3):531-548

1813) Nelson, CH, Buttrick, BR, & Isoherranen, N. 2013. Therapeutic potential of inhibition of retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics. Curr Top Med. Chem. 13(12): 1402-28

1814) Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H, Chauhan D, Anderson KC, and Frank DA 2008. Nifuroxazide inhibits multiple myeloma cell survival by direct inhibition of STAT3. 112(13): 5095-102

1815) Nelson, V., Ziehr, J., Agulnik, M. and Johnson, M. 2013. Afatinib: Emerging next-generation tyrosinkinase inhibitor for NSCLC. Objectives Onco Ther. 6: 135-43, doi: 10.2147/OTT.S23165

1816) Nemets, H., Nemets, B., Apter, A., Bracha, Z., and Belmaker, R.H. 2006. Omega-3 treatment of childhood depression: a controlled double-blind pilot study. American Journal of Psychiatry. 163(6): 1098-1100.

1817) Nesaretnam, K. and Meganathan, P. 2011. Tocotrienols: inflammation and cancer. Ann NY Acad Sci. 1229(1):18-2

1818) Nesaretnam, K., Guthrie, N., Chambers, A.F., and Carroll, K.K. 1995. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. lipid. 30(12): 1139-43

1819) Nestel, P., Bouis, HE, Meenakshi, J.V. and Pfeiffer, W. 2006. Biofortification of stable food crops. Nutrition Magazine. 136(4): 1064-1067

1820) Neto, CC 2007. Cranberry and its phytochemicals: a review of in vitro anticancer studies. J Nutr. 137(1): 1865-1935

1821) Netsch, M. I., Gutmann, H., Aydogan, C. & Drewe, J. 2006. Green tea extract induces interleukin-8 (IL-8) protein and mRNA expression, but specifically inhibits interleukin-8 (IL-8) secretion. IL-8 on Caco-2. cells. Plant Med. 72(8): 697-702

1822) Neubauer, S., Cifaldi, M., Mittendorf, T., Ganguli, A., Wolff, M., & Zeidler, J. 2014. Biological TNF inhibitors for the treatment of rheumatoid arthritis: persistence and dosing patterns in Germany. Health economics journal. 4: 32, doi: 10.1186/s13561-014-00324, 11 pages

1823) Neuzil , J. , Weber , T. , Schröder , A. , Lu , M. , Ostermann , G. , Gellert , N. , Mayne , GC , Olejnicka , B. , Negre-Salvayre , A. , Sticha , M., Coffey, R. J. and Weber, C. 2001. Induction of cancer cell apoptosis by α-tocopheryl succinate: molecular pathways and structural requirements. The FASEP Journal. 15(2): 403-4

1824) Nguyen B, Luong L, Naase H, Vives M, Jakaj G, Finch J, Boyle J, Mulholland JW, Kwak J, Pyo S., de Luca, A., Athanasiou, T., Angelini, G., Anderson , J., Haskard, D.O. and Evans, PC 2014. Sulforaphane pretreatment prevents systemic inflammation and kidney damage in response to cardiopulmonary bypass. 148(2): 690-697

1825) Nguyen, H.M., Ruppender, N., Zhang, X., Brown, L.G., Gross, T.S., Morrissey, C., Gulati, R., Vesella, R.L., Schimmoller, F., Aftab, D.T. and Corey, E 2013. Cabozantinib inhibits the growth of androgen-sensitive and castration-resistant prostate cancer and affects bone remodeling. Plus one. 8(10): e78881, doi: 10.1371/journal.pone.0078881

1826) Nguyen, TK and Grant, S. 2014. Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism. Mol Cancer Ther. 13(3): OF1-OF13, doi: 10.1158/1535-7163.MCT-13-0714

1827) Nguyen, T. T. T., Tran, E., Nguyen, T. H., Do, P. T., Huynh, T. H., and Huynh, H. 2004. The role of the activated MRK-ERK pathway in growth inhibition and induction of apoptosis of quercetin in A549 lung cancer cells. Karzinogenese. 25(5): 647-656

1828) Nichols, H.B., Trentham-Dietz, A., Newcomb, PA, Egan, KM, Titus, LJ, Hampton, JM, & Visvanathan, K. 2013. Prediagnosis Oophorectomy, Estrogen Therapy, and Mortality in a Cohort of Women diagnosed with breast cancer. breast cancer research. 15(5):R99, doi:10.1186/bcr3560, 10 pages

1829) Nie, D., Krishnamoorthy, S., Jin, R., Tang, K., Chen, Y., Qiao, Y., Zacharek, A., Guo, Y., Milanini, J., Pages, G. and Honn, K.V. 2006. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. JBiolChem. 281(27):18601-9

1830) Nielsen, S.E., Young, J.F., Daneshvar, B., Lauridsen, S.T., Knuthsen, P., Sandstrom, B., and Dragsted, L.O. 1999. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes, and oxidative stress biomarkers in humans. Br J Nutr. 81(6): 447-55

(1831) Nielsen VG, Lemole GM Jr, Natika RW, Weinand ME, Hussaini S, Baaj AA and Steinbrenner EB 2014. Brain tumors enhance plasma coagulation: the role of hemoxygenase-1. Analgesic Anesth. 118(5):919-24

1832) Niemeyer, H. B., Honig, D. M., Kulling, S. E. and Metzler, M. 2003. Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol. J Agron FoodChem. 51(21): 6317-25

1833) Nishimuro H, Ohnishi H, Sato M, Ohnishi-Kameyama M, Matsunaga I, Naito S, Ippoushi K, Oike H, Nagata T, Akasaka, H., Saitoh, S., Shimamoto, K. and Kobori, M . Estimated daily intake and seasonal dietary sources of quercetin in Japan, Nutrients, 7(4): 2045-2358

1834) Nitenberg, G. and Raynard, B. 2000. Nutritional support of the problems and dilemmas of cancer patients. Critical reviews in oncology/hematology. 34(3): 137-168.

1835) Niu, G., Yin, S., Xie, S., Li, Y., Nie, D., Ma, L., Wang, X., and Wu, Y. 2011. Quercetin induces apoptosis by activating the caspase-3 and regulation of the Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells. Acta Biochimica and Biophysica Sinica. 43(1): 30-37

1836) Nkondjock, A., Shatenstein, B., Maisonneuve, P., & Ghadirian, P. 2003. Specific fatty acids and human colorectal cancer: a review. Detection and prevention of cancer. 27(1):55-66.

1837) Nkosi, C.Z., Opoku, AR and Terblanche, S.E. 2006. Antioxidant effects of pumpkin seed (Cucurbita pepo) protein isolate on CC14-induced liver damage in low-protein-fed rats. Phytother Res. 20(11):935-40

1838) Nkosi, C.Z., Opoku, AR and Terblanche, S.E. 2006. Antioxidant effects of pumpkin seed (Cucurbita pepo) protein isolate on CC14-induced liver damage in low-protein-fed rats. Phytother Res. 20(11):935-40

1839) Nobta, M., Tsukazaki, T., Shibata, Y., Xin, C., Moriishi, T., Sakano, S., Shindo, H., and Yamaguchi, A. 2005. Critical regulation of bone morphogenetic protein - Osteoblastic differentiation induced by Notch1 signaling activated by Delta1/Jagged1. JBiolChem. 280(16): 15842-8

1840) Nogueira, V. and Hay, N. 2013. Molecular signaling pathways: homeostasis of reactive oxygen species in cancer cells and implications for cancer therapy. Cancer Clinic Res. 19(16): 4309-4314

1841) Nohl, H., Kozlov, A.V., Gille, L., & Staniek, K. 2003. Cellular respiration and formation of reactive oxygen species: facts and artifacts. Biochem Soc Trans. 31 (Part 6): 1308-11

1842) Nomura DK, Long JZ, Niessen S, Heather SH, Ng S and Cravatt BG 2010. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 140(1): 49-61

1843) Nonaka, M., Ikeda, H., Fujisawa, A., Uehara, M. and Inokuchi, T. 2006. Induction of apoptosis by paclitaxel in human oral carcinoma cells. Int J Oral Maxillofac Surg. 35(7): 649-652

1844) Nonn, L., Peng, L., Feldman, D., & Peehl, DM 2006. Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via activated protein phosphatase kinase 5 by mitogen: implications for prostate cancer Prevention by vitamin D. Cancer Res. 66(8): 4516-24

1845) Norman, KE, Williams, TJ, Feldmann, M. and Rossi, A.G. 1996. Effect of soluble P55 tumor necrosis factor-binding fusion protein on local Shwartzman and Arthus reactions. british journal of pharmacology. 117(3): 471-478

1846) Normanno, N., Bianco, C., De Luca, A., Maiello, M. R., & Salomon, D. S. 2003. Review of target-based drugs against Erbβ receptors and their ligands: a new approach for the treatment of cancer. Endocrinology connection cancer. 10(1): 1-21

1847) Nöthlings, U., Murphy, P.S., Wilkens, RL, Henderson, EB and Kolonel, N.L. 2007. Flavonols and pancreatic cancer risk. The multi-ethnic cohort study. Am J Epidemiol. 166(8):924-931

1848) Nour, V., Trandafir, I. and Ionica, ME 2013. Antioxidant compounds, mineral content and antioxidant activity of various tomato varieties grown in southwestern Romania. No Bot Horti Agrobo. 41(1): 136-142

1849) Nowak-Sliwinska, P., Weiss, A., van Beijnum, J.R., Wong, T.J., Kilarski, W.W., Szewczyk, G., Verheul, H.M.W., Sarna, T., van den Bergh, H. and Griffioen, AW 2015. Photoactivation of sunitinib sequestered in lysosomes after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition. cell death and disease. 6: e1641, doi: 10.1038/cddis.2015.4

1850) Nozaki, S., Sissons, S., Chien, D. S., & Sledge, G. W. Jr. 2003. Activity of the biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in an orthotopic model of human breast cancer. Clin Exp Metastasierung. Clin Exp Metastasierung. 20(5): 407-12

(1851) Nuhn , P. , Künzli , B.M. , Hennig , R. , Mitkus , T. , Ramanauskas , T. , Nobiling , R. , Meuer , SC , Friess , H. and Berberat , P.O. 2009. Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo. molecular cancer. 8:37, doi:10.1186/1476-4598-8-37

1852) Nutrient Data Laboratory, Food Composition Laboratory. USDA database for the flavonoid content of selected foods. Beltsville, MD: Beltsville Human Nutrition Research Center, USDA Agricultural Research Service; January 2007.

1853) address)

1854) O'Brien, D. I., Nally, K., Kelly, R. G., O'Connor, T. M., Shanahan, F. und O'Connell, J. 2005. Guidance of the Fas/Fas ligand pathway in cancer. Expertenmeinung Ther Targets. 9(5): 1031-44

1855) O'Connor, L., Huang, D. C., O'reilly, L. A. und Strasser, A. 2000. Apoptgosis and cell division. Curr Opin Cell Biol. 12(2): 257-263

1856) O'Keefe, JH. Jr. and Harris, W. S. 2000. From Inuit to implementation: the coming of age of omega-3 fatty acids. Mayo Clinic procedures. 75(6): 607-614.

1857) O'Keefe, S.J.D. 2008. Nutrition and intestinal health: the crucial role of the microbiota. Current opinion in gastroenterology. 24(1): 51-58

1858) O'Keefe, S. F., Proudfoot, F. G. and Ackman, R. G. 1995. Lipid oxidation in meat from broilers enriched with omega-3 fatty acids. International food research. 28(4): 417-424.

1859) O'Leary , K. A. , de Pascual-Teresa , S. , Needs , P. W. , Bao , Y. P. , O'Brien , N. M. and Williamson , G. 2004 ) Transcription. Mutat-Res. 551(1-2): 245-5

1860) O'toole, P. and Lombard, M. 1996. Vitamin C and gastric cancer: dietary supplements for some or fruit for all?. Colon. 39(3):345-347

1861) Oberley, TD 2002. Oxidative damage and cancer. American journal of pathology. 160(2):403-408

1862) Ociepa-Zawal, M., Rubis, B., Lacinski, M. und Trzeciak, H. W. 2007. The effect of indole-3-carbinol on CYP1A1, CYP1B1 and AhR gene expression and MCF-cell proliferation 7. Polish Biochemical Act. 54(1): 113-117

1863) O'Conner, P.M., Jackman, J., Bae, I., Myers, TG, Fan, S., Mutoh, M., Scudiero, DA, Monks, A., Sausville, EA, Weinstein, J.N., Friend , S., Fornace, A.J. Jr. and Kohn, KW 1997. Characterization of the p53 tumor suppressor pathway in cell lines from the National Cancer Institute cancer drug detection and correlations with the growth inhibitory potency of 123 cancer drugs. cancer res 57(19): 4285-300

1864) Ogawa M, Kariya Y, Kitakaze T, Yamaji R, Harada N, Sakamoto T, Hosotani K, Nakano Y and Inui H 2013. Prevention Effect of beta-carotene on denervation-induced soleus muscle atrophy in mice.

1865) Ogiwara, H., Ui, A., Shiotani, B., Zou, L., Yasui, A., & Kohno, T. 2013. Curcumin suppresses multiple DNA damage responses and has potency as a sensitizer for inhibitors from PARP. carcinogenesis. 34(11):2486-97

1866) Ogretmen, B. and Hannun, YA 2004. Biologically active sphingolipids in the pathogenesis and treatment of cancer. Nat Rev Cancer. 4(8): 604-616

1867) Ogrunch, M., Micco, R. Di., Liontos, M., Bombardelli, L., Mine, M., Fumagalli, M., Gorgoulis, V. G., and di Fagagna, F. 2014. Oncogene-induced reactive oxygen The species promote hyperproliferation and activation of the DNA damage response. cell death and differentiation. 21(6): 998-1012

1868) Oh, S., Gwak, J., Park, S., & Yang, C. S. 2014. Green tea polyphenol EGCG suppresses Wnt/B-catenin signaling via PP2A-independent GSK-3β and β inhibition - Promotes catenin phosphorylation/degradation. biofactors. 40(6): 586-95

1869) Ohgami, R.S., Campagna, D.R., Greer, E.L., Antiochus, B., McDonald, A., Chen, J., Sharp, J.J., Fujiwara, Y., Barker, J.E. and Fleming, M.D. 2005. Identification of an iron reductase required for efficient transfer-dependent iron uptake into erythrocytes. Nat Genet. 37(11): 1264-9

1870) Ohnishi, K., Inaba, H., Yasumoto, J., Yuki, K., Takahashi, A. and Ohnishi, T. 2004. C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in p53 mutant human Cancer cells. apoptosis. 9(5):591-7

1871) Ohshima-Hosoyama , S. , Davare , MA , Hosoyama , T. , Nelon , L.D. and Keller, C. 2011. Bortezomib stabilizes NOXA and induces ROS-associated apoptosis in medulloblastoma. J Neuroncol. 105(3): 475-83

1872) Ohtani, S., Iwamaru, A., Deng, W., Ueda, K., Wu, G., Jayachandran, G., Kondo, S., Atkinson, E.N., Minna, J.D., Roth, J.A. and Ji, L. 2007. The tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit the growth of non-small cell lung cancer through caspase-independent apoptosis and autophagy. Cancer. Resolution 67(13):6293-6303

1873) Ohyama, Y. and Okuda, K. 1991. Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3. JBiolChem. 266(14):8690-5

1874) Oishi, M., Iizumi, Y., Taniguchi, T., Goi, W., Miki, T., & Sakai, T. 2013. Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting the nucleotide of adenine translocase 2. . Plus one. 8(2): e55922, doi: 10.1371/journal.pone.0055922, 9 pages.

1875) Okano, J. and Rustgi, AK 2001. Paclitaxel induces prolonged activation of the Ras/MEK/ERK signaling pathway independently of activation of the programmed cell death machinery. The Journal of Biological Chemistry. 276(22): 19555-19564

1876) Okawa, Y., Hideshima, T., Steed, P., Vallet, S., Hall, S., Huang, K., Rice, J., Barabasz, A., Foley, B., Ikeda, H. ., Raje, N., Kızıltepe, T., Yasui, H., Enatsu, S., and Anderson, K. C. 2009. SNX-2112, a selective inhibitor of Hsp90, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating Akt and ERK signaling. Blood. 113(4):846-855

1877) Okechukwu PCU, Okwesili FCN, Parker EJ, Abubakar B, Emmanuel CO, Christian O and Celestine A 2013. Antinutrient survey of three maize varieties grown in Abakaliki, Metropolitan Nigeria, for consumption. International J. Pharm Med and Bio Sc. 2(2): 12-17

1878) Olguin-Reyes, S., Camacho-Carranza, R., Hernandez-Ojeda, S., Elinos-Baez, M. and Espinosa-Aguirre, J.J. 2012. Bergamottine is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames tests. Food and chemical toxicology. 50(9): 3094-3099

1879) Oliva, J., Bardag-Gorce, F., Tillman, B., and French, S. W. 2011. Protective effect of quercetin, EGCG, catechin, and betaine against ethanol-induced oxidative stress in vitro. Exp. Mol Pathol. 90(3):295-299

1880) Olmos, G. and Llado, J. 2014. Alpha tumor necrosis factor: association between neuroinflammation and excitotoxicity. inflammatory mediators. Entry ID 861231, doi:10.1155/2014/861231, 12 pages

1881) Olson, J.A. and Krinsky, N.I. 1995. Introduction: The colorful and fascinating world of carotenoids: important physiological modulators. FASEB Magazine. 9(15):1547-1550

1882) Olsson, M. and Zhivotovsky, B. 2011. Caspases and Cancer. distinguish cell death. 18(9): 1441-1449

1883) Olthof, MR, Hollman, PC, Vree, TB and Katan, MB 2000. The bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. J Nutr. 130(5): 1200-3

1884) Omenn, S.G., Goodman, E.G., Thornquist, D.M., Balmes, J., Cullen, R.M., Glass, A., Keogh, P.J., Meyskens, L.F., Valanis, B., Williams, H.J., Barnhart, S., Cherniack, GM, Brodkin, AC, & Hammar, S. 1996. Lung cancer risk factors and intervention effects in CARET, the beta-carotene and retinol efficacy study. J National Cancer Institute 88(21):1550-1559

1885) Onwude, J.L., Lilford, R.J., Hjartardottir, H., Staines, A. & Tuffnell, D. 1995. A randomized, double-blind, placebo-controlled study of fish oil in high-risk pregnancies. British journal of obstetrics and gynecology. 102(2): 95-100.

1886) Oommen, S., Gupta, S. K. and Vlahakis, N. E. 2011. Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration by direct binding to integrin α9β1. The Journal of Biological Chemistry. 286(2): 1083-1092

1887) Orita, H., Coulter, J., Lemmon, C., Tully, E., Vadlamudi, A., Medghalchi, SM, Kuhajda, FP, and Gabrielson, E. 2007. Selective inhibition of fatty acid synthase in lungs cancer treatment. Cancer Clinic Res. 13(23): 7139-45

1888) Ormanns , S. , Siveke , J.T. , Heinemann , V. , Haas , M. , Sipos , B. , Schlitter , AM , Esposito , I. , Jung , A. , Laubender , R. , Kruger , S. , Vehling-Kaiser , U. , Winkelmann , C. , von Weikersthal , L.F. , Clemens , MR , Gauler , TC , Marten , A. , Geissler , M. , Greten , TF , Kirchner , T. and Boeck , S. 2014 . pERK, pAKT and p53 as tissue biomarkers in patients with advanced pancreatic cancer treated with erlotinib: a translational subgroup analysis of AIO-PKO104.BMC Cnacer. 14:624, doi:10.1186/1471-2407-14-624

1889) Ortega, AM, Montoya, EM, Zarranz, B, Jaso, A, Aldana, I, Leclerc, S, Meijer, L and Monge, A. 2002. Pyrazolo[3,4-b]quinoxalines. . . . A new class of cyclin-dependent kinase inhibitors. Bioorganic and Medicinal Chemistry. 10(7): 2177-2184

1890) Osada, M., Imaoka, S. and Funae, Y. 2004. Apigenin suppresses the expression of VEGF, an important factor in angiogenesis, in endothelial cells by degrading the HIF-1α protein. letters FEBS. 575(1-3): 59-63

1891) Osborne, J.E. y Hutchinson, PE. 2002. Vitamin D and systemic cancer: is this relevante to malignant melanoma? Br J Dermatol. 147(2): 197-213

1892) Ossovzkaya, V. and Sherman, B. 2011. Inhibition of fatty acid synthesis by PARP inhibitors and treatment methods for it. Patent application number: US79994222

Ouchi, M., T. Ikeda, K. Nakamura, S. Harino, and S. Kinoshita. ophthalmology. 216(5):363-367.

1894) Ovejera, A.A., Houchens, D.P., Barker, AD and Venditti, J.M. 1978. Inactivity of DL-amygdalin against human breast and colon tumor xenografts in athymic (nude) mice. Cancer Treat Rep. 62(4):576-8

(1895) Ownby, SL, Fortune, LV, Au, AY, Grzanna, MW, Rashmir-Raven, AM and Frondoza, CG 2014. The expression of proinflammatory mediators is inhibited by a combination of avocado/soy unsaponifiables and epigallocatechin gallate . . . . Journal of inflammation. 11:8, doi: 10.1186/1476-9255-11-8, 7 pages

1896) Ozasa K, Nakao M, Watanabe Y, Hayashi K, Miki T, Mikami K, Mori M, Sakauchi F, Washio M, Ito Y ..., Suzuki, K., Wakai, K. y Tamakoshi, A para el grupo de estudio JACC, Cancer Sci. 95(1): 65-71

1897) Ozturk, H., Tuncer, C. M. and Ozturk, H. 2009. Nitric oxide regulates the expression of sonic hedgehog and hypoxia-inducible factor 1α in an experimental model of renal ischemia-reperfusion. renal insufficiency. 29(3): 249-256

1898) Pacher, P., Beckman, J. S. and Liaudet, L. 2007. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 87(1): 315-424

1899) Packer, L. 1991. Protective role of vitamin E in biological systems. Am. J.Clin. nutrition 53, 1050S-1055S.

1900) Padayatty, S.J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.H., Chen, S., Corpe, C., Dutta, A., Dutta, S.K. and Levive, M. 2003. Vitamin C as an antioxidant: evaluation of its role in disease prevention. Jelly. cabbage. nutrition 22(1):18-35

(1901) Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, and Banerjee SK 2014. Garlic attenuates cardiac oxidative stress through activation of the PI3K/AKT/Nrf2-Keap1 signaling pathway in diabetic rats fructose fed. Plus one. 9(5): e94228, doi:10.1371/Journal.pone.0094228

1902) Padley FB, Gunstone FD and Harwood JL 1994 Occurrence and properties of oils and fats. In The lipid handbook (eds. F.D. Gunstone, J.L. Harwood, and F.B. Padley), pp. 47-223. Chapman and Hall, London, UK.

1903) Paech, K., Webb, P., Kuiper, G.G., Nilsson, S., Gustafsson, J., Kushner, PJ, and Scanlan, T.S. 1997. Differential activation of ERalpha and ERbeta estrogen receptor ligands at AP1 sites. Science. 277 (5331): 1508-10

1904) Paek AR, Kim SH, Kim SS, Kim KT and You HJ 2010. IGF-1 induces zinc finger 143 protein expression in colon cancer cells by phosphotidylinositide-3-kinase and reactive oxygen species. Experimental and Molecular Medicine. 42(10): 696-702

1905) Page, E.L., Chan, DA, Giaccia, A.J., Levine, M., and Richard, DE. 2008. Hypoxia-inducible factor 1α stabilization under non-hypoxic conditions: role of intracellular ascorbate oxidation and degradation. Molecular biology of the cell. 19(1):86-94

1906) Paine, A., Eiz-Vesper, B., Blasczyk, R. und Immenschuh, S. 2010. Heme oxygenase-1 signaling and its potential for anti-inflammatory therapy. Biochem Pharmacol. 80(12): 1895-903

1907) Paiva, S.A. and Russell, R. M. 1999. Betacarotene and other carotenoids as antioxidants. Jelly. cabbage. nutrition 18(5):426-33

1908) Pakpahan, E.N., Isa, M.H., Kutty, R.M. and Malakahmad, A. 2009. Effect of temperature on the formation and degradation of polycyclic aromatic hydrocarbons. International Congress of Emerging Technologies in Environmental Sciences and Engineering. 26-28 October, Aligarh Muslim University, Aligarh, India. PAGE: 569-574

1909) Palazza , P. , Serini , S. , Maggiano , N. , Tringali , G. , Navarra , P. , Ranelletti , F.O. and Calviello, G. 2005. Beta-carotene down-regulates herregulin-alpha-induced and steady-state COX-2 pathways in colon cancer cells. J Nutr. 135(1):129-36

1910) Palmer, R. L. and Kroening, P. M. 1978. Comparison of low-dose radiotherapy alone or in combination with procarbazine (NSC-77213) in unresectable squamous cell carcinoma of the lung, condition T3, N1, N2 or M1. Cancer. 42(2): 424-428

1911) Palmer, S.S., Altan, M., Denis, D., Tos, EG, Gotteland, J.P., Osteen, KG, Bruner-Tran, KL, and Nataraja, SG 2015. Bentamapimod (JNK inhibitor AS602801) induces regression of endometriosis lesions in animal models. Reproduction Science. Doi: 10.1177/1933719115600553, 13 pages.

1912) Palozza, P. and Krinsky, N.I. 1992. Astaxanthin and canthaxanthin are potent antioxidants in a membrane model. Arch Biochem Biophys. 297(2): 291-295

1913) Palozza, P., Colangelo, M., Simone, R., Catalano, A., Boninsegna, A., Lanza, P., Monego, G., and O. Ranelletti, F. 2010. Lycopene induces inhibition of cell growth by altering mevalonate signaling and Ras signaling in cancer cell lines. carcinogenesis. 31 (10): 1813-1821

1914) Palozza, P., Serini, S., Di Nicuolo, F., Boninsegna, A., Torsello, A., Maggiano, N., Ranelletti, F.O., Wolf, F.I., Calviello, G. and Cittadini, A. 2004. Beta-carotene exacerbates oxidative DNA damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. carcinogenesis. 25(8): 1315-25

1915) Palozza, P., Serini, S., Torsello, A., Di Nicuolo, F., Maggiano, N., Ranelletti, F.O., Wolf, F.I. and Calviello, G. 2003. Mechanism of caspase activation, cascade during beta-carotene-induced apoptosis in human tumor cells. Walnut cancer. 47(1):76-87

1916) Palozza, P., Serini, S., Di Nucuolo, F., Boninsegna, A., Torsella, A., Maggiano, N., Ranelletti, FO., Wolf, FI., Calviello, G. and Cittadini, A. 2004. Beta-carotene exacerbates oxidative DNA damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate. carcinopenosis. 25(8):1315-1325

1917) Palozza, P., Sestito, R., Picci, N., Lanza, P., Monego, G. and Ranelletti, FO 2008. Sensitivity to the growth inhibitory and pro-apoptotic effects of beta-carotene is regulated by caveolin - 1 expression in human colon and prostate cancer cells. carcinogenesis. 29(11):2153-61

1918) Palozza, P., Sheriff, A., Serini, S., Boninsegna, A., Maggiano, N., Ranelletti, O.F., Calviello, G., and Cittadini, A. 2005 Tobacco smoke condenses by stopping the cell cycle and negative regulation of cyclin D1, pAKT and pBad. apoptosis. 10(6): 1445-1456

1919) Palozza, P., Simone, E. R., Catalano, A. and Mele, C. M. 2011. Tomato lycopene and lung cancer prevention: from experimental studies to humans. Cancer. 3(2): 2333-2357

1920) Palozza, P., Simone, E. R., Catalano, A. and Mele, C. M. 2011. Tomato lycopene and lung cancer prevention: from experimental studies to humans. Cancer. 3(2): 2333-2357

1921) Palozza , P. , Simone , R. , Catalano , A. , Boninsegna , A. , Bohm , V. , Frohlich , K. , Mele , M.C. , Monego , G. and Ranelletti , F.O. 2010. Lycopene prevents 7- Ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem. 21(1): 34-4

(1922) Pan, G., Ni, J., Wei, Y. F., Yu, G., Gentz, R. and Dixit, V. M. 1997. A decoy receptor antagonist and a death domain-containing receptor for TRAIL. Wissenschaft. 277 (5327): 815–8.

1923) Pan HC, Jiang Q, Yu Y, Mei JP, Cui YK and Zhao WJ 2015. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin through the AKT and ERK signaling pathways in cells of human glioma. Neurochemistry Int. 80: 60-71, doi: 10.1016/j.neuint.2014

1924) Pan, M., Chang, W., Lin-Shiau, S., Ho, C., and Lin, J. 2001. Induction of apoptosis by Garcinol and curcumin through release of cytochrome c and activation of caspases in the HL-60 cell human leukemia. Journal of agricultural and food chemistry. 49(3): 1464-1474

1925) Pan, S., An, P., Zhang, R., He, X., Yin, G., and Min, W. 2002. Etk/Bmx as a tumor necrosis factor type 2 receptor-specific kinase: paper in Endothelzel migration und Angiogenesis. Mol Cell Biol. 22(21): 7512-7523

1926) Pan, Sai. Yi., Zhou, Jia, Gibbons, L., Morrison, H., Wen, Shi. Wu und die Canadian Cancer Registries Epidemiology Research Group (CCRERG).2011. BMC-Krebs. 11(372):1-12

1927) Pan, Y. N., Hui, S. W., Tipoe, L. G., Taylor, W. G., Leung, H. Y. R., Lam, K. W., Tsang, T. W. K., and Mak, W. C. J. 2006. Inhibition of pyocyanin-enhanced IL-8 release by steroids in cells bronchial epithelials. Beatmungsmedicine. 100(9): 1614-1622

1928) Pan Y, Xu Y, Feng S, Luo S, Zheng R, Yang J, Wang L, Zhong L, Yang H Y, Wang BL, Yu Y, Liu J, Cao Z, Wang X, Ji P, Wang Z, Chen X, Zhang S, Wei YQ, and Yang SY 2012. SKLB1206, a novel orally available multikinase inhibitor that targets T790M mutants and activators of EGFR, ErbB2, ErbB4, and VEGFR2, shows potent antitumor activity both in vitro and in alive. Mol Cancer Ther. 11(4):952-62

1929) Pandey, P. R., Liu, W., Xing, F., Fukuda, K., & Watabe, K. 2012. Anticancer drugs targeting fatty acid synthase (FAS). Current Discovery of Anticancer Drugs Pat. 7(2):185-97

1930) Panno, M.L., Giordano, F., Rizza, P., Pellegrino, M., Zito, D., Giordano, C., Mauro, L., Catalano, S., Aquila, S., Sisci, D. , . , De Amicis, F., Vivacqua, A., Fuqua, S.W.A., and Ando, ​​S. 2012. Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination. breast cancer treatment. 136(2): 443-455

(1931) Paoletti , I. , De Gregory , V. , Baroni , A. , Tufano , AM , Donnarumma , G. and Perez , J.J. 2013. Amygdalin analogs inhibit IFN-ϒ signaling and reduce inflammatory response in human epidermal keratinocytes. Inflammation. 36(6): 1316-26

1932) Paolini, M., Abdel-Rahman, S.Z., Sapone, A., Pedulli, G.F., Perocco, P., Cantelli-Forti, G. and Legator, M.S. 2003. B-caroteno: a cancer quimiopreventive agent or carcinógeno. Investigate. 543(3):195-200

(1933) Paolini , M. , Antelli , L. Pozzetti , Spetlova , D. , Perocco , P. , Valgimigli , L. , Pedulli , G.F. and Cantelli-Forti, G. 2001. Induction of cytochrome P450 enzymes and overgeneration of oxygen radicals in beta-carotene-supplemented rats. carcinogenesis. 22(9):1483-95

1934) Paolini, M., Barillari, J., Broccoli, M., Pozzetti, L., Perocco, P. and Cantelli-Forti, G. 1999. Effect of licorice and glycyrrhizin on rat liver carcinogen-metabolizing enzymes . cancer letters 145:35-42.

1935) Paolini, M., Biagi, GL, Cantelli-Forti, G. and Bauer, C. 1994. Other mechanisms of non-genotoxic carcinogenesis. Phenobarbitone induction of cytochrome P450-bit may contribute to carcinogenesis. Trends in Pharmacological Sciences. 15(9):322-323

1936) Paolini, M., Cantelli-Forti, G., Perocco, P., Pedulli, G.F., Abdel-Rahman, S.Z. und Legator, M.S. 1999. Co-kanzerogene Wirkung von Beta-Carotin. Por naturaleza 398(6730):760-761

1937) Papandreou, I., Denko, N.C., Olson, M., Melckebeke, H.V., Lust, S., Tam, A., Solow-Cordero, DE, Bouley, DM, Offner, F., Niwa, M. and Koong, A.C. 2011. Identification of a specific Ire1alpha endonuclease inhibitor with cytotoxic effects against human multiple myeloma. Blood. 117(4): 1311-1314

1938) Pardo VG, Boland R and de Boland AR 2006. 1alpha,25(OH)(2)-Vitamin D(3) stimulates the p38 MAPK activity of intestinal cells and increases the expression of c-Fos. Int J Biochem CellBiol. 38(7):1181-90

1939) Park, E.J., Min, H.Y., Chung, H.J., Hang, J.Y., Kang, Y.J., Hung, TM, Youn, U.J., Kim, Y.S., Bae, K., Kang, S.S. and Lee, S.K. 2009. Down-regulation of c-Src/EGFR-mediated signaling activation is implicated in honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 277(2):133-40

1940) Park, G. B., Choi, Y., Kim, S. Y., Lee, H., Kim, D., & Hur, D. Y. 2013. ROS and ERK1/2-mediated activation of caspase-9 increases XAF1 expression in the Dexamethasone-induced apoptosis of EBV B-Zellen Transformer. in t. J. Oncol. 43(1): 29-38

1941) Park GB, Kim D, Kim YS, Kim JW, Sun H, Roh KH, Yang JW and Hur DY 2015. Upregulation of ADAM10 and ADAM17 by sorafenib inhibits epithelial to mesenchymal transition in virus-infected retinal pigment. Epstein-Barr epithelial cells. Reverse Ophthalmol Vis Sci. 56(9):5162-73

1942) Park, G. S., Cheon, Y. J., Lee, H. Y., Park, J., Lee, Y. K., Lee, H. C. und Lee, K. S. 1996. A specific inhibitor of the cyclin-dependent protein kinases, CDC2 and CDK2. Mol-Zellen. 6(6): 679-683

1943) Park, H.J., Yoon, S.H., Han, LS, Zheng, L.T., Jung, K.H., Uhm, Y.K., Lee, J.H., Jeong, J.S., Joo, WS, Yim, SV, Chung, J.H. and Hong, S.P. 2005 Amygdalin inhibits cell cycle-associated genes in SNU-C4 human colon cancer cells. World J Gastroenterol. 11(33): 5156-61

1944) Park, H. S., Han, M. H., Kim, G. Y., Moon, S. K., Kim, W. J., Hwang, H. J., Park, K. Y. und Choi, Y. H. 2014 Krebs 5637 Zellen. Alimentos Chem Toxicol. 64: 157-65, doi: 10.1016/j.fct.2013.11.034

1945) Park HS, Jun do Y, Han CR, Woo HJ and Kim YH 2011. Apoptosis induced by the proteasome inhibitor MG132 via the ER stress-mediated apoptotic pathway and its potentiation by p56lck protein tyrosine kinase in Jurkat T cells human. Biochem Pharmacol. 82(9):1110-25

1946) Park, H. Y., Kim, M. K., Moon, S., Chao, Y. and Lee, C. 2006. Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, by via. cancer science 97(5): 430-436

1947) Park, H., Im, Y. J., Kim, J., Choi, S. W., and Kim, S. H. 2008. Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-transformed mammary epithelial cells -ras. in t. J. Mol. Medicine. 21(3): 325-333

1948) Park, H., Lee, J., Lim, J., Jo, D., Park, S., Suh, P., & Kang, H. B. 2014. Combination treatment with doxorubicin and gamitrinib synergistically increases anticancer activity at through a Bim-enhanced activation. BMC cancer. 14: 431, doi: 10.1186/1471-2407-14-431, 9 pages

1949) Park, H.J., Ock, S.M., Kim, H.J., Park, H.J., Lee, Y.B., Choi, J.M., Cho, CS, Lee, J.Y., Cho, B.K. and Cho, D. H. 2010. Vitamin C attenuates ERK signaling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts. Exp. Dermatol. 19(8):e258-e264, doi:10.1111/J.1600-0625.2010.01070.x

1950) Park IJ, Lee YK, Hwang JT, Kwon DY, Ha J and Park OJ 2009. Green tea catechin controls apoptosis in colon cancer cells by attenuating COX-2 expression through the AMPK pathway in low doses of H2O2. Ann N. Y Acad Sci. 1171(1): 538-44

1951) Park J, Kwok S, Lim M, Kim E, Ryu J, Kim S, Oh H, Ju JH, Park S, Kim H, and Cho, M. L. 2014. STA-21, a promising STAT-3 inhibitor that regulates reciprocally. Th17 and Treg cells inhibit osteoclastogenesis in mice and humans and alleviate autoimmune inflammation in an experimental model of rheumatoid arthritis. Arthritis and Rheumatology. 66(4):918-929

1952) Park, J., Kwon, S., Han, Y., Hahm, K., & Kim, E. 2013. Omega-3 polyunsaturated fatty acids as a potential chemopreventive agent against gastrointestinal cancer. J Back cancer. 18(3): 201-208

1953) Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., & Kwon, T. K. 2007. Resveratrol induces pro-apoptotic endoplasmic reticulum stress in cancer of human colon Zellen. Onkologische Berichte. 18(5): 1269-1273.

1954) Park, M. and Kim, H. 2017. Anticancer mechanism of docosahexaenoic acid in pancreatic carcinogenesis: a brief review. Cancer Prevention Magazine. 22:1-5, 5 pp.

1955) Park, S. 2013. The effects of high concentrations of vitamin C on cancer cells. Nutritious. 5(9):3496-3505

1956) Park, S. und Cho, J. 2010. Inhibition of beta-catenin/Tcf signaling by flavonoids. J Cell Biochem. 110(6): 1376-85

1957) Park, S. Y., Kim, G. Y., Bae, S., Yoo, Y. H., and Choi, Y. H. 2007. Induction of apoptosis by sulforaphane isothiocyanate in HeLa human cervical carcinoma and HepG2 hepatocarcinoma cells by caspase-3 activation. Onkologische Berichte. 18(1): 181-187

1958) Park, S., Lee, S., Song, S., Heo, D., Park, B., Lee, D., Kim, K., and Sung, M. 2003. The effect of nitric oxide on Cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. Int J Cancer. 107(5): 729-738

1959) Park S, Murphy SP, Wilkens L R, Henderson BE & Kolonel L N 2008. Legume and isoflavone intake and risk of prostate cancer: the multi-ethnic cohort study. International Journal of Cancer. 123(4):927-932.

1960) Park, W. H. and Kim, S. H. 2012. MG132, a proteasome inhibitor, induces cell death of human lung fibroblasts through increased levels of ROS and GSH deficiency. oncology reports. 27(4): 1284-1291

1961) Parnaud, G., Li, P., Cassar, G., Rouimi, P., Tulliez, J., Combaret, L. and Gamet-Payrastre, L. 2004. Mechanism of cell cycle arrest and apoptosis induced by sulforaphane and human Dickdarmkrebszellen. Nutr Cancer. 48(2): 198-206

1962) Parody , JP , Ceballos , MP , Quiroga , AD , Frances , DE , Carnovale , CE , Pisani , GB , Alvarez , ML . and Carrillo, M. C. 2014. Fox03a modulation and promotion of apoptosis by interferon-α2b in mouse preneoplastic liver. Liver Int. 34(10):1566-77

1963) Parsonnet, J. 1995. Bacterial infection as a cause of cancer. Environment Day Health Perspectives. 103 (Supplement 8): 263-268

1964) Pastrakuljic, A., Tang, BK, Roberts, EA and Kalow, W. 1997. Distinction of CYP1A1 and CYP1A2 activity by selective inhibition with fluvoxamine and isosafrole. Biochem Pharmacol. 53(4):531-8

1965) Paszt, A., Szabolcs, A., Tiszlavicz, L., Duda, E., Takacs, T., and Lazar, G. 2006. Effect of glucocorticoids on L-arginine-induced acute pancreatitis: the mechanism of Nf - kB activation. Gastroenterol Z. CongresoAbstract/44-A93, doi: 10.1055/s-2006-943459

1966) Patel, V., Rink, C., Khanna, S. und Sen, C. K. 2011. Tocotrienol: The lesser-known form of natural vitamin E. Indian Journal of Experimental Biology. 49(10): 732-738

1967) Paterson PG, Lyon AW, Kamencic HS, Andersen LB and Juurlink BH 2001. Sulfur amino acid deficiency reduces glutathione concentration in the brain. Nutr Neurosci. 4(3):213-22

1968) Pati, S., Pelser, CB, Dufraine, J, Bryant, JL, Reitz, MS, and Weichold, FF 2002. Antitumor effects of the HIV protease inhibitor ritonavir: inhibition of Kaposi's sarcoma. Blood. 99(10): 3771-3779

1969) Patil RH, Babu RL, Naveen Kumar M, Kiran Kumar KM, Hegde SM, Ramesh GT and Chidananda Sharma S 2015. Apigenin inhibits PMA-induced expression of proinflammatory cytokines and AP-1 factors in A549 cells. Mol Cell Biochem. 403(1-2): 95-106

1970) Patlolla, J.M.R. and Rao, C.V. 2012. Triterpenoids for the prevention and treatment of cancer: current status and future prospects. Current pharmaceutical biotechnology. 13(1): 147-155

1971) Patwardhan, CA, Faug, A, Peterson, LB, Miller, C, Blagg, BS, & Chadli, A. 2013. Gedunin inactivates the p23 co-chaperone protein that causes cancer cell death by apoptosis. JBiolChem. 288(10): 7313-25

1972) Paugh, S.W., Paugh, B.S., Rahmani, M., Kapitonov, D., Almenara, J.A., Kordula, T., Milstien, S., Adams, J.K., Zipkin, R.E., Grant, S., and Spiegel, S. 2008. A selective inhibitor of sphingosine kinase-1 integrates multiple molecular therapeutic targets in human leukemia. Blood. 112(4): 1382-1391

1973) Pavan, R., Jain, S., Shraddha, & Kumar, A. 2012. Therapeutic properties and uses of bromelain: a review. International biotechnological research. Article number: 976203, 6 pages.

1974) Pavese, J.M., Farmer, R.L., and Bergan, R.C. 2010. Inhibition of cancer cell invasion and metastasis by genistein. Cancer metastasis Rev. 29(3): 465-482

1975) Pearson, S., Jia, H. and Kandachi, K. 2004. China approves first gene therapy. national biotechnology 22(1):3-4

1976) Peer , A. , Gottfried , M. , Sinibaldi , V. , Carducci , MA , Eisenberger , MA , Sella , A. , Leibowitz-Amit , R. , Berger , R. and Keizman , D. 2014. Comparison of Abiraterone acetate versus ketoconazole in patients with metastatic castrated prostate cancer refractory to docetaxel. Prostate. 74(4): 433-40

1977) Peet, M., Laugharne, J.D.E., Ahluwalia, N. & Mellor, J. 1997. Fatty acid supplementation in schizophrenic patients. schizophrenia research. 24(1-2): 209.

1978) Peet, M., Murphy, B., Shay, J., and Horrobin, D. 1998. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressed patients. Biological Psychiatry. 43(5):315-319.

1979) Pei, X., Dai, Y. and Grant, S. 2003. The proteasome inhibitor bortezomib promotes mitochondrial damage and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. Leukemia. 17: 2036-2045, doi: 10.1038/sj.leu.2403109

1980) Pelicano, H., Carney, D. and Huang, P. 2004. ROS stress in cancer cells and therapeutic implications. Drug resistance update. 7(2): 97-110

1981) Pendas-Franco, N., Aguilera, O., Pereira, F., Gonzales-Sancho, J. M. and Muñoz, A. 2008. Vitamin D and Wnt/beta-catenin route in colon cancer: role and Regulation of DICKKOPF- genes Res. against cancer. 28(5A): 2613-23

(1982) Pendas-Franco N, Gonzales-Sancho JM, Suarez Y, Aquilera O, Steinmeyer A, Gamallo C, Berciano MT, Lafarga M and Muñoz A 2007 Vitamin D regulates the phenotype of human breast cancer cells. Differentiation. 75(3):193-207

1983) Peng G, Dixon DA, Muga SJ, Smith TJ and Wargovich MJ 2006. Green tea, polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. carcinogenic mole 45(5): 309-19

1984) Peng, H.C., Chen, J.R., Chen, Y.L., Yang, S.C. and Yang, S. S. 2010. Beta-carotene exhibits antioxidant and antiapoptotic properties to prevent ethanol-induced cytotoxicity in isolated rat hepatocytes. Phytother Res. 24 (Annex 2): S183-9

1985) Pennati, M., Campbell, A.J., Curto, M., Binda, M., Cheng, Y., Wang, LZ., Curtin, N., Golding, BT, Griffin, R.J., Hardcastle, IR, Henderson, A ., Zaffaroni, N. and Newell, D. R. 2005. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role in downregulation of survival. Mol Cancer Ther. 4(9):1328-37

1986) Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ and Ma J 2010 A large prospective study on the genetic variation of SEP15, its interaction with the plasma selenium levels and the risk and survival of prostate cancer. Cancer Previous Res. 3(5): 604-610

1987) Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., and Goeddel, D. V. 1984. Human tumor necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 312 (5996): 724–729

1988) Perabo FG, Frossler C, Landwehrs G, Schmidt DH, von Rucker A, Wirger A, and Muller SC 2006. Indirubin-3-monoxime, a CDK inhibitor induces growth inhibition and apoptosis, an independent upregulation of survival in transitional cell cancer. Res. against cancer. 26(3A): 2129-35

1989) Perchellet, J. P., Perchellet, E. M., Abney, N. L., Zirnstein, J. A., and Belman, S. 1986. Effects of Knollauch and onion oils on glutathione peroxidase activity, reduced/oxidized glutathione ratio, and induction of of ornithine decorboxylase in isolated mouse epidermal cells. mit Tumor promoter in behandelte Zellen. Krebs Biochem Biophys. 8(4): 299-312

1990) Pereira, C., Calhelha, R.C., Barros, L. and Ferreira, ICFR 2013. Antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututu. Industrial plants and products. 49:61-65

1991) Pereira, S.L., Leonard, A.E., Huang, Y.-S., Chuang, L.-T. and Mukerji, P. 2004. Identification of two new microalgal enzymes involved in the conversion of the omega-3 fatty acid, eicosapentaenoic acid, to docosahexaenoic acid. The Biochemical Journal. 384 (part 2): 357–366.

1992) Perepechaeva ML and Grishanova AY 2012. In vivo effects of genistein, herbimycin a and geldanamycin on rat hepatic cytochrome P4501A. Biophysical Chemistry Journal. 3(4): 334-340

1993) Perepechaeva, M., Kolosova, N. and Grishanova, A. 2011. Molecular mechanisms of cold-induced CYP1A activation in rat liver microsomes. J Physiol. Biochemistry 67(4): 499-510

1994) Perona, R., Moncho-Amor, V., Machado-Pinilla, R., Belda-Iniesta, C., and Sanchez Perez, I. 2008. Role of CHK2 in cancer development. Clin Transl Oncol. 10(9):538-42

1995) Perron, N. R. and Brumaghim, J. L. 2009. A review of the antioxidant mechanisms of iron-binding related polyphenol compounds. cell biochemistry biophys. 53(2): 75-100

Platform G Hideshima T Ikeda H Okawa Y Calebrese E Gorgun G Santa L Cirstea D Raje N Chauhan D 1996), Baccarani, M., Cavo, M. and Anderson, K.C. 2009. Ascorbic acid inhibits the antitumor activity of bortezomib in vivo. Leukemia. 23(9):1679–1686

1997) Perry, A., Rasmussen, H., and Johnson, E.J. 2009. Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables, and corn and egg products. Journal of Food Composition and Analysis. 22(1): 9-15

1998) Persson, V., Ahmed, F., Gebre-Medhin, M., and Greiner, T. 2001. Elevation of serum beta-carotene after dietary supplementation with dark green leafy vegetables in mebendazole-treated schoolchildren in Bangladesh. EDur J Clin Nutr. 55(1):1-9

1999) Perva-Ununalic, A., Skerget, M., Weinreich, B., and Knez, Z. 2004. Chili pepper (var. byedige) extraction for capsaicinoid and color extraction efficiency. Food Chemistry. 87(1):51-58

2000) Peters, U., Foster, B.C., Chatterjee, N., Schatzkin, A., Reding, D., Adriole, GL, Crawford, E.D., Sturup, S., Chanock, S.J. and Hayes, R.B. 2007. Serum selenium and risk of prostate cancer: a nested case-control study. Bin J Clin Nutr. 85(1):209-217.

2001) Peters, U., Littman, A. J., Kristal, A. R., Patterson, R. E., Potter, J. D. und White, E. 2008. Vitamin E and selenium supplementation and risk of prostate cancer in the vitamin and lifestyle study (VITAL) Kohorte. Krebs verursacht Kontrolle. 19(1):75-87

2002) Petruzzelli, R., Christensen, DR, Parry, KL, Sanchez-Elsner, T, and Houghton, FD 2014. HIF-2α regulates Nanog expression in human embryonic stem cells after hypoxia and reoxygenation by interacting with a Oct-Sox Cis regulatory element. Plus one. 9(10): e108309, doi: 10.1371/journal.pone.0108309, 11 pages

2003) Peyregne, V. P., Kar, S., Ham, S. W., Wang, M., Wang, Z., and Carr, B. I. 2005. Novel hydroxyl naphthoquinones with potent Cdc25 antagonist and growth inhibitory properties. Mol Cancer Ther. 4(4): 595-602

2004) Phan, N. H. T., Thuan, N. T. D., Ngoc, N. T., Huong, P. T. M., Thao, N. P., Cuong, N. X., Thanh, N. V., Nam, N. H., Kiem, P. V. and Minh, C. V. 2014 ihre zytotoxische Aktivität. Phytochemie Briefe. 9: 78-81, doi: 10.1016/j.phytol.2014.04.011

2005) Phillips, D. H. 1999. Polycyclic aromatic hydrocarbons in the diet. mutate res. 443(1-2): 139-47

2006) Phongmaykin, J., Kumamoto, T., Ishikawa, T., Suttisri, R., and Saifah, E. 2008. A new sesquiterpene and other terpenoid components of Chisocheton penduliflorus. Arch Pharm Res. 31(1): 21-7

2007) Pillai, K., Akhter, J., Chua, TC, and Morris, DL 2013. Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelium. reverse cancer. 31(4):241-50

2008). 5-Fu in malignant peritoneal mesothelioma cells. J Glycobiol.

2009). Primary cultures of human hepatocytes relevant to HIV cancer patients. Elimination of drug metab. 41(10): 1843-1851

2010) Pinnix, C. C. and Herlyn, M. 2007. The many faces of Notch signaling in skin cells. Cel Pigment Res. 20(6): 458-65

2011) Piotrowska, H., Kucinska, M., and Murias, M. 2012. Biological activity of piceatannol: stepping out of the shadow of resveratrol. mutate res. 750(1):60-82

2012) Piotrowska H, ​​​​​​Myszkowski M, Amarowicz R, Murias M, Kulcenty K, Wierzchowski M and Jodynis-Liebert J 2013. Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a resveratrol analogue. In vitro toxicology. 27(8):2127-34

2013) Pipinikas, C. P., Nair, S. B., Kirby, R. S., Carter, N. D. & Fenske, C. D. 2007. Measurement of E2F3 mRNA in blood in prostate cancer by quantitative RT-PCR: a primary study. Biomarker. 12(5): 541-557

2014) Pirnia, F., Schneider, E., Betticher, D.C. and Borner, MM 2002. Mitomycin c induces apoptosis and caspase 8 and 9 processing via a caspase 3 and Fas independent pathway. distinguish cell death. 9(9): 905-14

2015) Pledgie-Tracy, A., Sobolewski, MD, & Davidson, NE 2007. Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther. 6(3): 1013-21

2016) Plenchette, S, Cheung, HH, Fong, WG, LaCasse, EC, & Korneluk, RG 2007. The role of XAF1 in cancer. Curr Opin Investigating Drugs. 8(6): 469-76

2017) Plumb, G. W., Price, K. R., and Williamson, G. 1999. Antioxidant properties of green bean flavonol glycosides. Redox Rep. 4(3): 123-7

2018) Pobst, L.J. and Ames, M.M. 2006. Aminoflavone activation by CYP1A1 causes DNA damage in human tumor cell lines. Cancer Chemother Pharmacol. 57(5): 569-576

2019) Pocock TM, Williams B, Curry FE and Bates DO 2000. VEGF and ATP act through different mechanisms to increase microvascular permeability and endothelial [Ca(2+)] (I). I am J Physiol Heart Circ Physiol. 279(4): H1625-34

2020) Podder, B., Kim, Y., Zerin, T., and Song, H. 2012. Antioxidant effect of silymarin on the paraquat-induced human lung adenocarcinoma cell line A549. Food and chemical toxicology. 50(9): 3206-3214

2021) Podmore, I.D., Griffiths, H.R., Herbert, KE, Mistry, N., Mistry, P., Lunec, J. 1998. Vitamin C exhibits pro-oxidant properties. Nature. 392(6676):559-559

2022) Poisson, J. P. 1990. Sources of omega-3 polyenic acids, inclusion. Nutritio et Diet Library. 46:70-86.

2023) Polakis, P. 2012. Wnt signaling in cancer. Cold Spring Harb Perspect Biol. 4(5): a008052, doi: 10.1101/cshperspect.a008052, 13 pages

2024) Polimeni, M., Voena, C., Kopecka, J., Riganti, C., Pescarmona, G., Bosia, A. und Ghigo, D. 2011. Modulation of doxorubicin resistance by glucose-6 -phosphate dehydrogenase Aktivität . Biocehm J. 439(1): 141-9

2025) Polly, P., Carlberg, C., Eisman, J.A. and Morrison, N.A. 1996. Identification of a vitamin D3 response element gene that is bound by a vitamin D3 receptor homodimer. J Cell Biochem. 60(3):322-33

2026) Ponnampalam, EN, Trout, GR, Sinclair, AJ, Egan, AR. and Leury, B.J. 2001. Comparison of color stability and oxidative lipid stability of fresh and vacuum-packed lamb muscle containing increased levels of omega-3 and omega-6 fatty acids through dietary manipulation. Meat Science 58(2):151-161.

2027) Popa, C., Netea, M.G., van Riel, PLCM, van der Meer, JWM, & Stalenhoef, AFH 2007. The role of TNF-α in chronic inflammation, intermediate metabolism, and cardiovascular risk. J Lipidres. 48(4):751-62

2028) Popovich, D. G., Li, L. & Zhang, W. 2010. Bitter melon (Momardica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food and chemical toxicology. 48:1619-1626.

2029) Pot, K. G., Geelen, A., van Heijningen, EB, Siezen, CL E, van Kranen, H. J., & Kampman, E. 2008. Contrasting associations of serum n-3 and n-6 ​​polyunsaturated fatty acids with colorectal risk of adenoma: an endoscopy-based case-control study. Int J Cancer. 123(8):1974-1977

2030) Potente, M., Urbich, C., Sasaki, K., Hofmann, KW, Heeschen, C., Aicher, A., Kollipara, R., DePinho, AR, Zeiher, MA, & Dimmeler, S. 2005. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. The Journal of Clinical Investigation. 115(9): 2382-2392

2031) Pothier, L., Lane, W.W., Bhargava, A., Michielson, C., and Douglass, Ho. Jr. 1987. Plasma selenium levels in patients with advanced upper gastrointestinal cancer. Cancer. 60(9): 2251-1260.

2032) Potter, G.A., Patterson, L.H., Wanogho, E., Perry, P.J., Butler, P.C., Ijaz, T., Ruparelia, K.C., Lamb, J.H., Farmer, PB, Stankey, L.A. and Burke, M.D. 2002. Das The anticancer agent Resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. British journal of cancer. 86(5): 774-778, doi: 10.1038/sj/bjc/6600197

2033) Poulsen, HE, Prieme, H. & Loft, S. 1998. Review of the role of oxidative DNA damage in the development and promotion of cancer. Eur J Cancer Prev. 7(1): 9-16

2034) Powers, M. V., Valenti, M., Miranda, S., Maloney, A., Eccles, S. A., Thomas, G., Clarke, P. A., and Workman, P. 2013. Mode of cell death produced by the HSP90 inhibitor 17 -AAG (Tanspimycin) is the complement of the expression of the expression of proapoptotischem BAX. Oncotarget. 4(11): 1963-75

2035) Powles, T.J., Ashley, S., Tidy, A., Smith, I.E. and Dowsett, M. 2007. Twenty-year follow-up of the Royal Marsden Randomized, Double-Blind, Tamoxifen Breast Cancer Prevention Study. J National Cancer Int. 99(4):283-90

2036) Prasad, K. 1997. Flaxseed in the prevention of hypercholesterolemic atherosclerosis. atherosclerosis 132(1): 69-76.

2037) Prasad, S.B., Yadav, S.S., Das, M., Govardhan, H.B., Pandey, LK, Singh, S., Pradhan, S., and Narayan, G. 2014. Downregulation of FOXO1 promotes cell proliferation in cervical cancer. J Cancer. 5(8): 655-662

2038) Prasad, V., Chandele, A., Jagtap, J.C., Sudheer Kumar P., and Shastry, P. 2006. ROS-triggered caspase2 activation and feedback amplification loop in beta-carotene-induced apoptosis. Free Radicals Biol. Med. 41(3):431-42

2039) Pratheeshkumar, P., Budhraja, A., Son, YO, Wang, X., Zhang, Z., Ding, S., Wang, L., Hitron, A., Lee, J.C., Xu, M., Chen, G., Luo, J., and Shi, X. 2012. Quercetin inhibits angiogenesis-mediated growth of human prostate tumors by targeting VEGFR-2-regulated AKT/mTOR/P70S6K signaling pathways. Plus one. 7(10): e47516, doi: 10.1371/journal.pone.0047516, 10 pages

2040) Preet R, Mohapatra P, Das D, Satapathy SR, Choudhuri T, Wyatt MD, and Kundu CN 2013. Lycopene synergistically enhances the action of quinacrine to enhance Wnt-TCF signaling in breast cancer cells via APC. carcinogenesis. 34(2): 277-86

2041) Preiss, D. and Sattar, N. 2009. Lipids, lipid-modifying agents, and cardiovascular risk: a review of the evidence. Clinical endocrinology. 70(6):815-828.

2042) Prince, M. Li, Y., Childers, A., Hoh, K., Yamamoto, M., and Kleiner, HE 2009. Comparison of citrus coumarins with carcinogenic detoxifying enzymes in Nrf2 knockout mice. Toxicology Letters. 185(3): 180-186

2043) Priyanka, B., Soma, P., Amit, KS, Mohan, KRM, Yogeshwer, S., Amulya, KP, Aditya, BP, Pradeep, K., and Kailash, CG 2014. Anticancer activity of bromelain nanoparticles by oral administration. Biomedical Nanotechnology Magazine. 10(12): 3558-3575

2044) Pross, C., Faroog, M. M., Angle, N., Lane, J. S., Cerveira, J. J., Xavier, A. E., Freischlag, J. A., Law, R. E., and Gelabert, H. A. 2002. Dexamethasone inhibits the migration of cells from the vascular smooth muscle through the modulation of the Matrix-Metalloproteinase-Aktivität. J SurgRes. 102(2): 57-62

2045) Prousek, J. 2007. Fenton Chemistry in Biology and Medicine. Pure App Chem. 79(12):2325-2338

2046) Pu, L., Amoscato, AA, Bier, ME, Lazo, J. S., and Dual, J. S. 2002. Dual phase G1 and G2 inhibition by a novel selective inhibitor of Cdc25 6-chloro-7- [corrected] (2nd - morpholine (4-ylethylamino)-quinoline-5,8-dione JBiolChem 227(49): 46877-46885

2047) Puca, R., Nardinocchi, L., Porru, M., Simon, A.J., Rechavi, G., Leonetti, C., Givol, D. and D'orazi, G. 2011. Restoring p53 active conformation by zinc increases the response of p53 mutant tumor cells to anticancer drugs. cellular cycle. 10(10): 1679-89

2048) Puiggros, C., Chacon, P., Armadans, J.I., Clapes, J. and Planas, M. 2002. Effects of high oleic and omega-3 diets on the pattern of serum lipids and lipid oxidation in mildly hypercholesterolemic patients. Clinical Nutrition, 21(1):79-87.

2049) Pullikotil, P., Chen, H., Munyappa, R., Greenberg, C. C., Yang, S., Reiter, CE, Lee, J. W., Chung, J. H., and Quon, M. J. 2012. Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2, which suppresses the pro-inflammatory effects of TNF-α. J Nutr Biochem. 23(9):1134-45

2050) Purow, B. 2012. Notch inhibition as a promising new approach in cancer therapy. Adv Exp Med Biol. 727: 305-19, doi:

2051) Puupponen , R. , Seppanen-Laakso , T. , Kankainen , M. , Maukonen , J. , Törrönen , R. , Kolehmainen , M. , Leppanen , T. , Moilanen , E. , Nohynek , L. , Aura , A., Poutanen, K., Tomas-Barberan, F. A., Espin, J. C. und Oksman-Caldentey, K. 2013. Effects of ellagitannin-rich berries on blood lipids, gut microbiota and urolitin production in human subjects with symptoms of metabolic syndromes . Molecular Nutrition and Lebensmittelforschung. 57(12): 2258–2

2052) Puupponen-Pimia, R., Nohynek, L., Meier, C., Kahkonen, M., Heinonen, M., Hopia, A. und Oksman-Caldentey, K. M. 2001. Antimicrobial properties of phenolic components of berries . J Appl Microbiol. 90(4): 494-507

2053) Qi, W., Weber, CR, Wasland, K. & Savkovic, SD 2011. Genistein inhibits colon cancer cell proliferation by attenuating a negative effect of epidermal growth factor on FOXO3 tumor suppressor activity. BMC cancer. 11:219, doi:10.1186/1471-11-219

2054) Qi, X., Pramanik, R., Wang, J., Schultz, MR, Maitra, KR, Han, J., DeLuca, FH, and Chen, G. 2002. p38 and JNK pathways cooperate for transactivation of the vitamin D receptor through c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D3-induced growth inhibition. The Journal of Biological Chemistry. 277(29): 25884-25892

2055) Qian, L., Xie, B., Wang, Y., and Qian, J. 2015. Amygdalin-mediated inhibition of non-small cell lung cancer cell invasion in vitro. international J. Clin. Exp. Pathol. 8(5): 5363-5370

2056) Qian Y, CaO L, Guan T, Chen L, Xin H, Li Y, Zheng R, and Yu D 2015. Genistein protection in cortical neurons against oxidative stress injury by inhibiting NF signaling pathways -kappaB, JNK and ERK. PharmBiol. 53(8):1124-32

2057) Qiu , J. X. , He , Y. Q. , Wang , Y. , Xu , R. L. , Qin , Y. , Shen , X. , Zhou , S. F. and Mao , Z. F. 2013 -vectors Weg. Med Sci Basic Monit Res. 19:228–36, doi:10.12659/MSMBR.884004

2058) Qiu, X., Yuan, Y., Vaishnav, A., Tessel, A. M., Nonn, L., & van Breemen, B. R. 2013. Effects of lycopene on protein expression in human primary prostatic epithelial cells. Cancer Prev Res (Row). 6(5): 419-427

2059) Qiu, Y., Dou, D., Cai, L., Jiang, H., Kang, T., Yang, B., Kuang, H. and Li. M.ZC. 2009. Dammarane-type saponins from Panax quinquefolium and their inhibitory effect on MCF-7 cells of human breast cancer Phytotherapy.80, 219-222

2060) Queiroz EAIF, Puukila S, Eichler R, Sampaio SC, Forsyth HL, Lees SJ, Barbosa AM, Dekker RF, Fortes ZB and Khaper N 2014. Metformin Induces Apoptosis and Cell Cycle Stop Mediated by Oxidative Stress, AMPK and FOXO3a in MCF -7 breast cancer cells. More one. 9(5): e98207, doi:10.1371/journal.pone.0098207

2061) Querfeld, U., Hoffmann, M. M., Klaus, G., Eifinger, F., Ackerschott, M., Michalk, D., & Kern, P. A. 1999. Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. Jelly. Soc. nephrol. 10(10): 2158-64

2062) Qui, X., Yuan, Y., Vaishnav, A., Tessel, A. M., Nonn, L., & van Breemen, B. R. 2013. Effects of lycopene on protein expression in human primary prostate epithelial cells. Cancer Prev Res (Phila). 6(5): 419-427

2063) Quin, J., Engle, D., Litwiller, A., Peralta, E., Grasch, A., Boley, T., & Hazelrigg, S. 2005. Vitamin E succinate reduces breast cancer tumor growth. lung in mice. Surgical Research Journal. 127(2):139-143

2064) Rader, D.J. (2003). Effects of non-statin lipid drug therapy on high-density lipoprotein metabolism. The American Journal of Cardiology. 91 (Supplement 1), 18-23.

2065) Radha, V., Nambirajan, S. and Swarup, G. 1996. Association of Lyn's tyrosine kinase with nuclear matrix and cell cycle-dependent changes in matrix-associated tyrosine kinase activity. Eur. J. Biochem. 236(2):352-9

2066) Radisky DC, Kenny PA and Bissell MJ 2007. Fibrosis and cancer: do myofibroblasts also originate from epithelial cells via EMT?. J Cell Biochem. 101(4):830-9

2067) Radjabi, A. R., Sawada, K., Jagadeeswaran, S., Eichbichler, A., Kenny, H. A., Montag, A., Bruno, K., and Lengyel, E. 2008. Thrombin induces tumor invasion by induction and association of matrix metalloproteinase 9 and integrin β1 on the cell surface. The Journal of Biological Chemistry. 283(5): 2822-2834

2068) Raes, K., De Smet, S. and Demeyer, D. 2003. Effect of dietary fatty acids on incorporation of long-chain polyunsaturated fatty acids and conjugated linolenic acid in lamb, beef, and pork. Science and technology of animal nutrition. 113 (1-4): 199-221.

2069) Rafi, M. M., Yadav, N. P. & Reyes, M. 2007. Lycopene inhibits LPS-induced proinflammatory mediator-inducible nitric oxide synthase in mouse macrophage cells. Food Science Magazine. 72(1): S069-S074, doi: 10.1111/j.1750-3841.2006.00219

2070) Ragunathan, N., Dairou, J., Pluvinage, B., Martins, M., Petit, E., Janel, N., Dupret, J.M. and Rodrigues-Lima, F. 2008. Identification of the xenobiotic metabolizer Enzyme arylamine N-acetyltransferase 1 as a new cisplatin target in breast cancer cells: molecular and cellular mechanisms of inhibition. Mol Pharmacol. 73(6): 1761-1768

2071) Raha, P., Thomas, S., Thurn, T. K., Park, J., & Munster, N. P. 2015. Combined inhibition of histone deacetylase and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models by reversing overexpression of Bcl-2. breast cancer research. 17:26, doi:10.1186/s13058-015-0533-z, 16 pages

2072) Rahman KM, Aranha O, Glazyrin A, Chinni SR and Sarkar FH 2000. Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C)-treated breast cancer cells. Oncogene 19(50):5764-71

2073) Rainer, P. P., Doleschal, B., Kirk, J. A., Sivakumaran, V., Saad, Z., Groschner, K. 2012. Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes. International BJU 110(10): 1455-62

2074) Raitt, M.H., Connor, W.E., Morris, C. et al. 2005. Fish oil supplements and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators. The Journal of the American Medical Association. 293(23):2884-2891.

2075) Rajendran, M., Thomes, P., Zhang, L., Veeramani, S., & Lin, M. 2010. P66Shc: a long-lived redox protein in the progression and metastasis of human prostate cancer. P66Shc in cancer progression and metastasis. Cancer Metastasis Rev. Mar 29(1):207-222

2076) Rajendran, P., Ho, E., Williams, DE, & Dashwood, R. H. 2011. HDAC inhibition of dietary phytochemicals and DNA damage/repair defects in cancer cells. Clinical epigenetics. 3:4, doi: 10.1186/1868-7083-3-4, 23 pages

2077) Rajendran, P., Li, F., Shanmugam, M.K., Vali, S., Abbasi, T., Kapoor, S., Ahn, KS, Kumar, AP, & Sethi, G. 2012. Honokiol inhibits the transducer of signal and activator of hepatocellular carcinoma cell transcription-3 signaling, proliferation, and survival through the protein tyrosine phosphate SHP-1. Cell Physiol J. 227(5):2184-95

2078) Ramadoss, P., Marcus, C. & Perdew, G. 2005. Role of the aryl hydrocarbon receptor in drug metabolism. Opinion Metab Toxicol. 1(1): 9-21

2079) Ramaswamy , B. , Fiskus , W. , Cohen , B. , Pellegrino , C. , Hershman , DL , Chuang , E. , Luu , T. , Somlo , G. , Goetz , M. , Swaby , R . , Shapiro, CL, Stearns, V, Christos, P, Espinoza-Delgado, I, Bhalla, K and Sparano, JA 2012. Phase I-II trial of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence of induced vorinostat tubulin acetylation and Hsp90 inhibition in vivo. treatment of breast cancer. 132(3): 1063-72

2080) Ramirez, M. C. and Singletary, K. 2009. Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. J Nutr Biochem. 20(3): 195-201

2081) Ranieri, G., Patruno, R., Ruggieri, E., Montemurro, S., Valerio, P. und Ribatti, D. 2006. Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the Biologie in die Klinik. Curr Med.Chem. 13(16): 1845-57

2082) Rankin, E. B. & Giaccia, A. J. 2008. The role of hypoxia-inducible factors in tumorigenesis. Cell death differs. 15(4):678-685

2083) Ranzato, E., Martinotti, S., Magnelli, V., Murer, B., Biffo, S., Mutti, L. and Burlando, B. 2012. Epigallocatechin-3-gallate induces mesothelioma cell death through H2O2- .- Dependent opening of Ca2+ channels by T-Type. J Cell Mol Med. 16(11): 2667-78

2084) Rao, M. S. A., Suresh, G., Yadav, P. A., Prasad, K. R., Nayak, V. L., Ramakrishna, S., Rao, C. V. and Babu, K. S. 2012. New apo-tirucallane triterpenoids from walsura trifoliate. Tetrahedron-Buchstaben. 53(46): 6241–6244

2085) Rao, P. R., Calhoun, J. D., Qin, X. T., Rekaya, R., Clark, J. K., and Stice, S. L. 2004. Comparison of transcriptional profiles of the two human embryonic stem cell lines. Biotechnology and Bioengineering. 88(3): 273-286

2086) Rao, V.A. and Agarwal, S. 2000. Role of the antioxidant lycopene in cancer and heart disease. Journal of the American College of Nutrition. 19(5):563-569

2087) Rasalkar DD, Chu CW, Cheung K, Yeung KD, Shi L, Wang D, Ng P and Ahuja TA 2010. Changes in magnetic resonance spectroscopy and diffusion tensor imaging after acute cyanide poisoning in a child. European Journal of Radiology Extra. 73:e5-e8, doi:10.16/j.ejrex.2009.08.006

2088) Raso, M. G., Meli, R., Di Carlo, G., Pacilio, M., and Di Carlo, R. 2001. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in J774A.1 macrophage . Life sciences. 68(8):921-931

2089) Rasul, A., Khan, M., Yu, B., Ma, T., & Yang, H. 2011. Xanthoxyletin, a coumarin, induces S-phase arrest and apoptosis in adenocarcinoma stomach cells human SGC-7901. Asia Pacific J Cancer Before. 12(5):1219-23

2090) Rath, P. C. and Aqqarwal, B. B. 1999. TNF-induced signaling in apoptosis. J. Clin. immunol. 19(6):350-64

2091) Rathel, T. R., Leikert, J. F., Vollmar, A. M. & Dirsch, V. M. 2005. The soy isoflavone genistein induces a delayed but sustained activation of the endothelial nitric oxide synthase system in vitro. Br J Pharmacol. 144(3):394-9

2092) Rauf, S. M., Endou, A., Takaba, H., and Miyamoto, A. 2013. Effect of Y220C mutation on p53 and its rescue mechanism: a computational chemistry approach. Protein J. 32(1): 68-74

2093) Rautenkranz, A. A. F., Li, L., Machler, F., Matinoia, E. and Oertli, J. J. 1994. Transport of ascorbic acid and dehydroascorbic acids across proroplast membranes and vacuoles isolated from Gerley leaves (Hordeum vulgare L . cv Gerbel) . Pflanzenphysiology. 106(1):187-193

2094) Ravi, S., Zhang, R., Sanjay, B., Shi, Y. & Sanjay, S. 2009. Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis by activating MAPK in human pancreatic cancer cells. carcinogenesis. 30(10): 1744-1753

2095) Reay, PF and Lancaster, JE 2001. Accumulation of anthocyanins and quercetin glycosides in skins of 'Gala' and 'Royal Gala' apples with visible UV-B radiation: modifying effects of fruit maturity, side of the fruit and the temperature. Science Horticulture. 90(1-2):57-68

2096) Reed, G., Peterson, K., Smith, H.J., Gray, J.C., Sullivan, D.K., Mayo, MS., Crowell, J.A. and Hurwitz, A. 2005. A phase 1 study of indole-3-carbinol in women: tolerance and effects. Epidemiology, biomarkers and cancer prevention. 14(8): 1953-60

2097) Reedijk, M., Odorcic, S., Chang, L., Zhang, H., Miller, N., McCready, DR., Lockwood, G., and Egan, SE 2005. High-level co-expression of JAG1 and NOTCH1 it is seen in human breast cancer and is associated with poor overall survival. cancer res 65(18):8530-7

2098) Rege, S.D., Kumar, S., Wilson, D.N., Tamura, L., Geetha, T., Mathews, S.T., Huggins, KW, Broderick, TL, and Babu, J.R. 2013. Resveratrol protects the brain of obese mice from oxidative damage. Oxidative medicine and cellular longevity. Vol. 2013, Article ID: 419092, 7 pages

2099) Regensburger, J., Knak, A., Maisch, T., Landthaler, M., & Baumler, W. 2012. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. Exp. Dermatol. 21(2):135-9

2100) Reichrath, S., Müller, L. S. C., Gleissner, B., Pfreundschuh, M., Vogt, T. and Reichrath, J. 2010. Notch and vitamin D signaling in 1.25(OH)2D3-resistant Glioblastoma multiforme (GBM). ) Zelllinien. Das Journal of steroid biochemistry and molecular biology. 121(1-2): 420-4

2101) Reid , M.E. , Duffield-Lillica , A.S. , Slate , E. , Natarajan , N. , Turnbull , B. , Jacobs , E. , Combs , Jr. , GF , Alberts , D.S. , Clarck , L.C. and Marshall , J.R. 2008 Dietary Cancer Prevention: 400 mcg per day of selenium treatment. Diet and cancer. 60(2):155-163

2102) Reid, T. M. and Loeb, L. A. 1993. Effect of DNA repair enzymes on oxygen free radical mutagenesis. Mutat-Res. 289(2): 181-6

2103) Reinicke KE, Kuffel MJ, Goetz MP and Ames MM 2010. Synergistic interactions between aminoflavone, paclitaxel and camptothecin in human breast cancer cells. Cancer Chemother Pharmacol. 66(3):575-83

2104) Reitzer, J.L., Wice, M.B. and Kennel, D. 1979. Evidence that glutamine, not sugar, is the main source of energy for cultured HeLa cells. The Journal of Biological Chemistry. 254(8): 2669-2676

2105) Relic, B., Zeddou, M., Desoroux, A., Begin, Y., de Seny, D. & Malaise, MG 2009. Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. lab exam 89(7):811-822

2106) Ren, F., Zhang, S., Mitchell, S. H., Butler, R., & Young, C. Y. F. 2000. Tea polyphenols downregulate androgen receptor expression in LNCaP prostate cancer cells. Oncogene 19(15): 1924-1932

2107) Rennie, K.L., Hughes, J., Lang, R., and Jebb, S.A. 2003. Nutritional management of rheumatoid arthritis: a review of the evidence. Journal of Human Nutrition and Dietetics. 16(2): 97-109.

2108) Reshkin, S.J., Bellizzi, A., Cardone, RA, Tommasino, M., Casavola, V., and Paradiso, A. 2003 Na+/H+ (NHE) exchanger NHE isoform 1 in human breast cancer cells. Cancer Clinic Res. 9(6): 2366-73

2109) Retterstol, K., Stugaard, M., Gorbitz, C. & Ose, L. 1996. Results of long-term intensive treatment of familial hypercholesterolemia. The American Journal of Cardiology. 78(12): 1369-1374.

2110) Reya, T. and Clevers, H. 2005. Wnt signaling in stem cells and cancer. Nature. 434: 843-850, doi: 10.1038/natur03319

2111) Reykens , KMSE , Fisher , T. , Schisler , J.C. , O'Connor , W.G. , Rogers , A.B. , Willis , M.S. , Planesse , C. , Boyer , F. , Rondeau , P. , Bourdon , E. and Essop , M. F. 2013. Cardiometabolic effects of HIV protease inhibitors (liponavir/ritonavir). More one. 8(9):e73347, doi:10.1371/journal.pone.00733347

2112) Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J.P. and Passeque, E. 2011 IL-6 controls the fate of multipotent leukemia progenitor cells and contributes to the development of chronic myeloid leukemia. cancer cell. 20(5): 661-73

2113) Reynolds, K., Lewis, L.B., Nolen, D.L.J., Kinney, G.L., Sathya, B., & He, J. 2003. Alcohol use and risk of stroke. Journal of the American Medical Association. 289(5): 579-588.

2114) Riboli, E., Slimani, N. and Kaaks, R. 1996. Identifiability of food components for cancer chemoprevention. IARC Sci Pub. 139: 23-31

2115) Rice, S., Pellatt, L., Ramanathan, K., Whitehead, S.A. and Mason, HD 2009. Metformin inhibits aromatase through an ERK (extracellular signal-regulated kinase)-mediated pathway. Endocrinology. 150(10): 4794-4801

2116) Richardson , R. D. , Ma , G. , Oyola , Y. , Zancanella , M. , Knowles , L. M. , Cieplak , P. , Romo , D. and Smith , J. W. 2008 synthase. J MedChem. 51(17): 5285-96

2117) Richters, A. and Richters, V. 1989. Inhalation of nitrogen dioxide (NO2), microthrombus formation in the lungs, and cancer metastasis. J Environment Pathol Toxicol Oncol. 9(1): 45-51

2118) Ridlon, J. M., Kang, D. J. y Hylemon, P. B. 2006. Bile salt biotransformations by human gut bacteria. J Lipidres. 47(2): 241-59

2119) Ridnour, AL, Isenberg, SJ, Espey, GM, Thomas, DD, Roberts, DD, & Wink, AD 2005. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci. UNITED STATES OF AMERICA. 102(37): 13147-13152

2120) Riedl, MA, Saxon, A & Diaz-Sanchez, D. 2009. Oral sulforaphane increases phase II antioxidant enzymes in the human upper respiratory tract. Clin Immunol. 130(3):244-51

2121) Riegsecker, S. and Ahmed, S. 2013. Chronic low-dose administration of EGCG inhibits TNF-α-induced IL-6 and IL-8 production in synovial fibroblasts in rheumatoid arthritis. Journal of the Federation of American Societies for Experimental Biology. 2013, Session Summary, 27:643.18

2122) Rigas, AC, Robson, CN and Curtin, NJ 2007. Therapeutic potential of the CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene 26(55): 7611-9

2123) Rigas, B. and Williams, J.L. 2008. Non-donor NSAIDs and cancer: a review with an indication of whether NO is required for its action. Nitric oxide. 19(2): 199-204

2124) Rini, BI and Small, EJ 2005. Biology and clinical development of vascular endothelial growth factor-directed therapy in renal cell carcinoma. J Clin Oncol. 23(5):1028-43

2125) Rittenhouse HG, Finlay JA, Mikolajczyk SD and Partin AW 1998. Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related but distinct kallikreins in the prostate. Crit Rev Clin. Laboratory Science 35(4): 275-368

2126) Rittmaster, R.S. 2011. Chemoprevention of prostate cancer. Oncolo Act. 50 (Supplement 1): 127-136

2127) Robaszkiewicz, A., Balcerczyk, A. and Bartosz, G. 2007. Antioxidant and pro-oxidant effects of quercetin on A549 cells. International Cell Biology. 31(10): 1245-1250

2128) Robbana-Barnat, S., Rabache, M., Rialland, E. and Fradin, J. 1996. Heterocyclic amines: Occurrence and prevention in cooked foods. Environmental Health Perspectives. 104(3): 280-288

2129) Roberts, D. D. 1996. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J. 10(10): 1183-91

2130) Roccaro, A.M., Hideshima, T., Raje, N., Kumar, S., Ishitsuka, K., Yasui, H., Shiraishi, N., Ribatti, D., Nico, B., Vacca, A. , Dammacco, F., Richardson, PG, and Anderson, K. C. 2006. Bortezomib mediates antiangiogenesis in multiple myeloma through direct and indirect effects on endothelial cells. Cancer Res 66(1): 184-91

2131) Rodland, K.D., Wersto, R.P., Hobson, S., and Kohn, E.C. 1996. Thapsigargin-induced gene expression in non-excitable cells is dependent on calcium input. Molecular endocrinology. 11(3):281-291

2132) Rodriguez, C., Jacobs, J. E., Mondul, M. A., Calle, E. E., McCullough, L. M., & Thun, J. M. 2004. Vitamin E supplementation and risk of prostate cancer in American men. Biomarker for Krebseepidemien Prev. 13(3): 378-82

2133) Rodríguez-Antona, C. and Ingelman-Sundberg, M. 2006. Pharmacogenetics and cytochrome P450 cancer. Oncogene 25(11): 1679-1691

2134) Rodriguez-Serrano, M., Barany, J., Prem, D., Coronado, M. J., Risueno, M. C., and Testillano, P. S. 2012. NO, ROS, and cell death associated with enhancement of caspase-like activity in stress-induced embryogenesis by barley microspores. J Exp Bot. 63(5): 2007-24

2135) Roh, M., Zhang, Y., Murakami, Y., Thanos, A., Lee, SC, Vavvas, DG, Benowitz, L.I. and Miller, J.W. 2012. Etanercept, a generalized tumor necrosis factor-α (TNF-α) inhibitor, prevents retinal ganglion cell loss in a rat model of glaucoma. Plus one. 7(7): e40065, doi: 10.1371/journal.pone.0040065, 13 pages

2136) Rohan, E. T., Howe, R. G., Friedenreich, M. C., Jain, M. und Miller, B. A. 1992. Dietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort study. Krebsursachen und-kontrolle. 4(1): 29-37

2137) Rohan ET, Jain M, Howe RG, and Miller BA 2002. A cohort study of dietary carotenoids and lung cancer risk in women (Canada). Causes and control of cancer. 13(3): 231-237

2138) Rojas, A., Figuerosa, H. and Morales, E. 2010. Triggering inflammation in the tumor microenvironment: the role of the multiligand/rabies axis. carcinogenesis. 31(3): 334-341

2139) Rokhlin OW, Glover RB, Guseva NV, Taghivev AF, Kohlgraf KG and Cohen MB 2006. Mechanisms of cell death induced by histone deactylase inhibitors in androgen receptor-positive prostate cancer cells. Mol Cancer Res. 4(2):113-23

2140) Rokka, T., Allen, K., Valaja, J., and Ryhanen, E.-L. 2002. The effect of a diet enriched with Camelina sativa on the composition and sensory quality of chicken eggs. International food research. 35(2-3): 253-256.

2141) Romano, G. 2013. The role of the dysfunctional Akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future drug development strategies. Scientific. 2013:317186, doi: 1155/2013/317186, 12 pages

2142) Romanova, D., Vachalkova, A., Cipak, L., Ovesna, Z., and Rauko, P. 2001. Syudy of antioxidant effects of apigenin, luteolin, and quercetin by DNA protection method. neoplasm. 48(2):104-7

2143) Roma-Vaquero, M., Selma, M., Larrosa, M., Obiol, M., Garcia-Vilalba, R., Gonzalez-Barrio, R., Issaly, N., Flanagan, J., Roller, M., Tomas-Barberan, F.A. and García-Conesa, M. 2014. An extract of rosemary rich in carnosic acid selectively modulates the microbiota of the cecum and inhibits the activity of beta-glucosidase, thus altering fecal fiber and the excretion of short-chain fatty acids in female rats. thin and obese. Plus one. 9(4):e 94687, 11 pages, doi=10.1371/journal.pone. 0094687

2144) Rooprai , HK , Kyriazis , I , Nuttall , RK , Edwards , DR , Zicha , D , Aubyn , D , Davies , D , Gullan , R and Pilkington , GJ 2007. Inhibition of invasion and induction of apoptosis by selenium in human Malignant brain tumor cells in vitro. International Journal of Oncology. 30(5):1263-1271

2145) Rosch, S., Ramer, R., Brune, K. & Hinz, B. 2005. R(+)-methanandamide and other cannabinoids induce expression of cyclooxygenase-2 and matrix metalloproteinases in non-pigmented ciliary epithelial cells human . The Journal of Pharmacology and Experimental Therapeutics. 316(3): 1219-1228

2146) Rose, D.P. and Connolly, J.M. 1999. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacology and Therapeutics. 83(3): 217-244.

2147) Rosenkranz-Weiss, P., Sessa, W.C., Milstien, S., Kaufman, S., Watson, CA, and Pober, J.S. 1994. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels increase the specific activity of endothelial nitric oxide synthase. J Clin Invest. 93(5):2236-43

2148) Roskoski, R. 2007. Sunitinib: a VEGF and PDGF receptor protein kinase and inhibitor of angiogenesis. Communications on biochemical and biophysical research. 356(2):323-328

2149) Ross, CA 2015. The trophoblastic model of cancer. Walnut cancer. 67(1): 61-7, doi: 10.1080/01635581.2014.956257

2150) Rossi, E., Hung, J., Beilby, J., Knuman, M.W., Divitini, M.L. and Bartholomew, H. 2006. Folate levels and cancer morbidity and mortality: a prospective cohort study from Busselton, Western Australia. Ann Epidemiol. 16(3):206-212

2151) Rossi, V., Bellastella, G., DeRosa, C., Abbondanza, C., Visconti, D., Maione, L., Chieffi, P., DellaRagione, F., Prezioso, D., De Bellis, A. , Bellastella , A. and Sinisi , A.A. 2011. Raloxifene induces cell death and inhibits proliferation through multiple signaling pathways in prostate cancer cells expressing differential amounts of estrogen receptors α and β. Cell Physiol J. 226(5):1334-9

2152) Rössig, L., Fichtlscherer, B., Breitschopf, K., Haendeler, J., Zeiher, AM, Mülsch, A. and Dimmeler, S. 1999. Nitric oxide inhibits caspase-3 by S-nitrosation in live. J Biol Chem. 274(11): 6823–6

2153) Rössig, L., Jadidi, AS, Urbich, C., Badorff, C., Zeiher, AM and Dimmeler, S. 2001. Akt-dependent p21 (Cip1) phosphorylation regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol. 21(16): 5644-57

2154) Rostoka, E., Baumane, L., Isajevs, S., Line, A., Dzintare, M., Svirina, D., Sharipova, J., Silina, K., Kalvinsh, I., and Syakste, N. 2010. Effects of kaempferol and myricetin on inducible nitric oxide synthase expression and nitric oxide production in rats. Basic Clin Pharmacol Toxicol. 106(6): 461-6

2155) Rostoka, E., Isajevs, S., Baumane, L., Line, A., Silina, K., Dzintare, M., Sharipova, J., Svirina, D., Kalvinsh, I., and Syakste, N. 2010. The effects of lycopene, indole-3-carbinol, and luteolin on nitric oxide production and iNOS expression are oxygen-specific in rats. High Arch Rada Toksikol. 61(3):275-85

2156) Roswall, N., Olsen, A., Christensen, J., Dragsted, L.O., Overvad, K. & Tjoneland, A. 2010. Source-specific effects of micronutrients in lung cancer prevention. lung cancer. 67(3):275-281

2157) Roth, M. D., Margues-Magallanes, J. A., Yuan, M., Sun, W., Tashkin, D. P. und Hankinson, O. 2001. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and Delta(9 ) -Tetrahydrocannabiol. Am J Respir Cell Mol Biol. 24(3): 339-44

2158) Rothen, J.P., Haefeli, W.E., Meyer, UA, Todesco, L. and Wenk, M. 1998. Paracetamol is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. pharmacogenetics. 8(6):553-9

2159) Roudat, H., Traiffort, E, Goroyankina, T., Vincent, L., Faure, H., Schoenfelder, A., Mann, A., Manetti, F., Solinas, A., Taddei, M. and Ruat, M. 2011. Identification and mechanism of action of acylguanidine MRT-83, a novel potent smoothing antagonist. Mol Pharmacol. 79(3): 453-60

2160) Rouzaud, G., Young, S.A. and Duncan, A.J. 2004. Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Biomarkers of the cancer epidemic Prev. 13(1): 125-131

2161) Rowe, D. L., Ozbay, T., O'Regan, R. M. und Nahta, R. 2009. Modulation of the BRCA1 protein and induction of apoptosis in triple-negative breast cancer cell lines by the polyphenolic compound curcumin. Brustkrebs. 3: 61-75, doi: 10.1186/1471-2407-14-73

2162) Rowe, J., Greenblatt, J. R., Liu, D., & Moffat, F. J. 2010. Compounds that target host cell proteins prevent varicella zoster virus replication in culture, ex vivo, and in SCID mice -Huh. Antiviral Research. 86(3):276-285

2163) Roy, A. K., Lavrovsky, Y., Song, C. S., Chen, S., Jung, M. H., Velu, N. K., Bi, B. Y. und Chatterjee, B. 1999. Regulation of androgen action. Hormona de vitamina. 55: 309-52, doi: 10.1016/S0083-6729(08)60938-3

2164) Roy, D. and Liehr, J.G. 1988. Characterization of drug metabolic enzymes in estrogen-induced renal tumors in male Syrian hamsters. cancer res 48(20): 5726-5729

2165) Roy, M., Pear, WS, and Aster, JC 2007. The multifaceted role of Notch in cancer. Current Opinion Genet Dev. 17(1): 52-9

2166) Royer, GP and Townsend, CA 1996. Cerulenin compounds for the inhibition of fatty acid synthesis. Patent publication number: US5539132

2167) Rudin, C.M., Hann, C.L., Laterra, J., Yauch, R.L., Callahan, C.A., Fu, L., Holcomb, T., Stinson, J., Gould, S.E., Coleman, B., LoRusso, P.M. , von Hoff, D. D., de Sauvage, F. J., and Low, J. A. 2009. Treatment of medulloblastoma with the hedgehog pathway inhibitor GDC-0449. no english J Med. 361(12): 1173-8

2168) Rudolf, K., Cervinka, M., and Rudolf, E. 2014. Sulforaphane-induced apoptosis affects p53 and p38 in melanoma cells. apoptosis. 19(4):734-47

2169) Ruiz, P. A., Braune, A., Holzlwimmer, G., Quintanilla-Fend, L., & Haller, D. 2007. Quercetin inhibits TNF-induced recruitment of the transcription factor NF-kappaB to promoters of proinflammatory genes in mouse intestinal epithelium cells. J Nutr. 137(5):1208-15

2170) Rump, P., Mensink, R.P. and Kester Dm. Hornstra, G. 2001. Essential fatty acid composition of plasma phospholipids and birth weight: a study in term infants. American journal of clinical nutrition. 73(4): 797-806.

2171) Russell, A.J., Westwood, I.M., Crawford, M.H., Robinson, I., Kawamura, A., Redfield, C., Laurieri, N., Lowe, E.D., Davies, S.G. and Sim, E. 2009. Small selective selection Molecular inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med. 17(2): 905-918

2172) Russo, G.L. 2009. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochemical Pharmacology. 77(6):937-946.

2173) Russo, J., Fernandez, S. V., Russo, P. A., Fernbaugh, R., Sheriff, F. S., Lareef, H. M., Garber, J. und Russo, I. H. 2006. 17-beta-estrodiol induces transformation and tumorigenesis in human breast Epithelial cells. FASEB J. 20(10):1622-34

2174) Rutkowska, J. and Stolyhwo, A. 2009. Application of subcritical carbon dioxide (LCO2) for the extraction/fractionation of carotenoids from red peppers. Food Chemistry. 115(2):745-752

2175) Ruxton, C.H.S., Reed, S.C., Simpson, M.J.A. and Millington, K.J. 2007. The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence. Journal of Human Nutrition and Dietetics, 20(3): 275-285.

2176) CS Ryu, H. C. Kwak, K. S. Lee, K. W. Kang, SJ Oh, K.Ho breast cancer cells. Toxicology and applied pharmacology. 255(1):94-102

2177) Ryu, K., Lee, B., Lee, I., Oh, S., & Kim, D. 2010. Anti-scratch behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice. lipids 45(7):613-618

2178) Sachweh CC, Drummond JC, Higgins M, Campbell J, and Lain S 2013. Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. cell death and disease. 4: e533, doi: 10.1038/cddis.2013.61, 10 pages

2179) Sadar, M.D. 2011. Small molecule inhibitors targeting the Achilles heel of androgen receptor activity. cancer res 71(4): 1208-1213

2180) Safa, AR 2012. c-FLIP, a masterful anti-apoptotic regulator. Exp. Onc. 34(3):176-84

2181) Safeukui, I., Mangou, F., Malvy, D., Vincendeau, P., Mossalayi, D., Haumont, G., Vatan, R., Oliaro, P. and Millet, P. 2004. Plasmodium berghei : dehydroepiandroterone sulfate reverses chloroquine resistance in experimental malaria infection; Correlation with the glucose-6-phosphate dehydrogenase and glutathione synthesis pathway. Biochemical Pharmacology. 68: 1903-1910, doi: 10.1016/j.bcp.2004.05.049

2182) Sahoo, S. K., Sawa, T., Fang, J., Tanaka, S., Miyamoto, Y., Akaike, T., and Maeda, H. 2002. Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with the ability to target the tumor. Biokonjug Chem. 13(5):1031-8

2183) Sain N, Krishnan B, Ormerod MG, De Rienzo A, Liu WM, Kaye SB, Workman P and Jackman AL 2006. Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in cell lines of human ovarian carcinoma with high levels of activated AKT. Mol Cancer Ther. 5(5): 1197-208

2184) Saito, M., Kato, H., Tsuchida, T. und Konaka, C. 1994. Effects of chemoprevention of bronchial squamous metaplasia by folate and vitamin B12 in heavy smokers. brusque 106(2): 496-499

2185) Saito, S., Furuno, A. Sakurai, J., Sakamoto, A., Park, H., Shin-ya, K., Tsuruo, T., and Tomida, A. 2009. Chemical genomics identifies the development Targeted protein response to selectively kill cancer cells during glucose starvation. cancer res 69(10): 4225-4234

2186) Saito, Y., Tanaka, Y., Aita, Y., Ishii, KA., Ikeda, T., Isobe, K., Kawakami, Y., Shimano, H., Hara, H., and Takekoshi, K 2012. Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting the VEGFR2/Akt/mTOR/S6K1 signaling pathways by modulating Bcl-2 and BAD. I'm J Physiol Endocrinol Metab. 302(6):E615-25, doi:10.1152/ajpendo.00035.2011

2187) Sakauchi, F., Khan, M.M., Mori, M., Kubo, T., Fujino, Y., Suzuki, S., Tokudome, S., Tamakoshi, A., and JACC Sudy Group. 2007. Dietary habits and risk of death from ovarian cancer in a large-scale cohort study (JACC study) in Japan. Walnut cancer. 57(2):138-45

2188) Saleem, A., Husheem, M., Harkonen, P. and Pihlaja, K. 2002. Inhibition of cancer cell growth by crude extract and phenols of Terminalia chebula retz. Fruit. J Ethnopharmac. 81(3):327-36

2189) Saleem, M., Murtaza, I., Tarapore, R., Suh, Y., Adhami, V.M. Johnson, J.J. Siddiqui, I.A., Khan, N., Asim, M., Hafeez, B.B., Shekhani, M.T., Li, B., & Mukhtar, H. 2009. Lupeol inhibits human prostate cancer cell proliferation by targeting signaling of (beta)-catenin. carcinogenesis. 30,808-817.

2190) Salehi, A.H., Morris, S.J., Ho, W.C., Dickson, KM, Doucet, G., Milutinovic, S., Durkin, J., Gillard, J.W. and Barker, P.A. 2006. AEG3482 is an antiapoptotic compound identified by Jun Kinase Activity and cell death by induced expression of heat shock protein 70. Chem Biol. 13(2):213-23

2191) Salerno, C., Capuozzo, E., Crifo, C. & Siems, W. 2007. Alpha-tocopherol induces caspase-3 upregulation and apoptosis by beta-carotene cleavage products in human neutrophils. Biochim Biophys Act. 1772(9): 1052-6

2192) Salmans, M. L., Zhao, F., & Andersen, B. 2013. Estrogen-regulated anterior gradient protein 2 (AGR2) in breast cancer: a potential drug target and biomarker. breast cancer research. 15(2): 204-215

2193) Salvi, M., Brunati, AM, Clari, G. and Toninello, A. 2002. The interaction of genistein with the mitochondrial electron transport chain leads to the opening of the membrane transition pore. bioenergetics. 1556 (2-3): 187-196

2194) Sam F, Kerstetter DL, Pimental DR, Mulukutla S, Tabaee A, Bristow MR, Colucci WS and Sawyer DB 2005 Human myocardial insufficiency. Card Error J. 11(6): 473-80

2195) Sameshima, T., Nabeshima, K., Toole, B.P., Yokogami, K., Okada, Y., Goya, T., Koono, M., and Wakisaka, S. 2000. Cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates the production of membrane-type matrix metalloproteinases and activated gelatinase A in cocultures with brain-derived fibroblasts. Caner lett. 157(2):177-84

2196) Samudio, I.J., Duvvuri, S., Clise-Dwyer, K., Watt, J.C., Mak, D., Kantarjian, H., Yang, D., Ruvolo, V. and Borthakur, G. 2010. Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells. Lymphoma Leuk. 51(5):911-9

2197) Samuels-Lev , Y. , O'Connor , D.J. , Bergamaschi , D. , Trigiante , G. , Hsieh , J.K. , Zhong , S. , Campargue , I. , Naumovski , , L. , Crook , T. and Lu , X. 2001. ASPP proteins specifically stimulate the apoptotic function of p53. Cell Mol. 8(4): 781-9

2198) Sanchez, A., Tripathy, D., Yin, X., Luo, J., Martinez, J. M., & Grammas, P. 2013. Sunitinib improves neuronal survival in vitro through NF-kB-mediated signaling and the expression of cyclooxygenase-2 and inducible nitric oxide synthase. Neuroinflammation Journal. 10:93, Doi: 10.1186/1742-2094-10-93

2199) Sánchez, Y., Amran, D., Fernández, C., de Blas, E. and Aller, P. 2008. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells through generation of reactive oxygen species and reactive oxygen species activation-inducible protein kinases (p38-MAPK, AMPK). Int J Cancer. 123(5):1205-14

2200) Sanderson, S., Valenti, M., Gowan, S., Patterson, L., Ahmad, Z., Workman, P., and Eccles, S. A. 2006. The ansamycin and benzoquinone heat shock protein 90 inhibitors they modulate multiple functions, which are necessary for tumor angiogenesis. Mol Cancer Ther. 5(3): 522-32

2201) Sandhu, M.S., Dunger, D.B., and Giovannucci, EL. 2002. Insulin, insulin-like growth factor-1 (IGF-1), IGF-binding proteins, their biological interactions, and colon cancer. J National Cancer Institute 94(13):972-80

2202) Sandler, AB and Dubinett, SM 2004. COX-2 inhibition and lung cancer. Semin Oncol. 31 (2 supplement 7): 41-52

2203) Santisteban, G. A., Ely, J. T., Hamel, E. E., Read, D. H. y Kozawa, S. W. 1985. Glycemic modulation of tumortoleranz in a mouse model of breast cancer. Biochem Biophys Res Comun. 132(3): 1174-1179

2204) Santoli, D., Phillips, PD, Colt, TL and Zurier, RB 1990. Suppression of interleukin-2-dependent growth of human T cells in vitro by prostaglandin E (PGE) and its precursor fatty acids. Evidence for a PGE-independent fatty acid inhibition mechanism. The Journal of Clinical Investigation. 85(2): 424-432.

2205) Saramaki, A., Banwell, C. M., Campbell, M. J. and Carlberg, C. 2006. Regulation of the promoter of the human p21 gene (waf1/cip1) through multiple binding sites for p53 and the vitamin D3 receptor. Nucleinsäureres. 34(2): 543-54

2206) Sarangi, U., Paithankar, KR, Kumar, J.U., Subramaniam, V., and Sreedhar, A.S. 2012. 17AAG treatment accelerates doxorubicin-induced cellular senescence. Hsp90 disrupts the forced senescence of tumor cells. Prospects of drug targets. 6:19-39, doi:10.4137/DTI.S9943

2207) Sarek, J., Klinot, J., Dzubak, P., Klinotova, E., Noskova, V., Krecek, V., Korinkova, G., Thomson, J.O., Janostakova, A., Wang, S. , Parsons, S., Fischer, P. M., Zhelev, N. Z., and Hajduch, M. 2003. Novel lupan-derived compounds with proapoptotic activity in cancer cells: synthesis and structure-activity relationships. J MedChem. 46(25): 5402-5415

2208) Sarkar, F. H. und Yiwei, L. 2004. Indole-3-Carbinol and prostate cancer. J Nutr. 134(2): 3493S–3498S

2209) Sarkar, H. F., Li, Y., Wang, Z., & Kong, D. 2010. The role of nutraceuticals in the regulation of Wnt and hedgehog signaling in cancer. Cancer metastasis Rev. 29(3): 383-394

2210) Sarris, G.E., Mitchell, R.S., Billingham, M.E., Glasson, J.R., Cahill, P.D. and Miller, D.C. 1989. Inhibition of accelerated cardiac allograft atherosclerosis by fish oil. The Journal of Thoracic and Cardiovascular Surgery. 97(6):841-854.

2211) Sarris, J. 2009. Major Depression and Nutritional Medicine: a review of monotherapies and adjunctive treatments. Ernährungsbewertungen. 67(3): 125–131.

2212) Sasaki, T., S. Takahashi, K. Uchida, S. Funayama, M. Kainosho and A. Nakagawa 2006. Biosynthesis of quinolactacin A, an inhibitor of TNF production. J Antibot (Tokyo). 59(7): 418-27

2213) Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Takachi R, Tsugane S; Prospective study group based at the Japan Public Health Center. Intake of n-3 and n-6 ​​polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center prospective study. international j

2214) Satoh, M., Takemura, Y., Hamada, H., Sekido, Y., & Kubota, S. 2013. EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy. Cancer Cell International. 1:19 p.m. Doi: 10.1186/1475-13-19, 8 pages

2215) Sauci, Fahman, and Kraut. 1994. Food Composition and Nutrition Tables, eds.

2216) Saw, C.L.L., Guo, Y., Yang, A.Y., Paredes-Gonzales, X., Ramirez, C.N., Pung, D., and Kong, A.N. 2014. Berry compounds quercetin, kaempferol, and pterostilbene synergistically quench reactive oxygen species: implication of the Nrf2-ARE signaling pathway. Food and chemical toxicology. 72: 303-11, doi: 10.1016/j.fct.2014.07.038

2217) Scales, S.J. and de Sauvage, F.J. 2009. Mechanisms of activation of the Hedgehog signaling pathway in cancer and implications for therapy. Trends Pharmacol Sci. 30(6):303-12

2218) Scaltriti, M., Serra, V., Normant, E., Guzman, M., Rodriguez, O., Lim, A.R., Slocum, K.L., West, K.A., Rodriguez, V., Prudkin, L., Jimenez , J., Aura, C. and Baselga, J. 2011. Antitumor-Aktivität des Hsp90-Inhibitors IPI-504 bei HER2-positivem Trastuzumab-resistentem Brustkrebs. Mol Cancer Ther. 10(5): 817-24

2219) Schacky, C., Angerer, P., Kothny, W., Theisen, K., & Mudra, H. 1999. The effect of dietary omega-3 fatty acids on coronary arteriosclerosis. A randomized, double-blind, placebo-controlled study. Annals of Internal Medicine. 130(7):554-562.

2220) Schauer, I. E., Siriwardana, S., Langan, T. A., & Sclafani, A. 1994. Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for evasion of growth control in non-small cell and small cell lung cancer. small cells. Proc Natl Acad Sci USA. 91(16): 7827-7831

2221) Schernhammer, E. S., Ogino, S., & Fuchs, CS 2008. Folate and vitamin B6 intake and risk of colorectal cancer in relation to p53 expression. gastroenterology. 135(3):770-780

2222) Schernhammer, E., Wolpin, B., Rifai, N., Cochrane, B., Manson, J.A., Ma, J., Giovannucci, E., Thomson, C., Stampfer, M.J. and Fuchs, C. 2007 Plasma folate, vitamin B6, vitamin B12, and risk of pancreatic and homocytic cancer in four large cohorts. cancer res 67(11):5553-5560

2223) Schlessinger, J. 2000. Review of cell signaling by receptor tyrosine kinases. Cell. 103(2): 211-25

2224) Schley, P.D., Jijón, H.B., Robinson, L.E. and Field, C.J. 2005. Mechanism of omega-3 fatty acid-inducing growth inhibition in MDA-MB-231 human breast cancer cells. breast cancer treatment. 92(2):187-95

2225) Schmidt, M., de Mattos, S.F., van der Horst, A., Klompmaker, R., Kops, G.J.P.L., Lam, E.W.F., Burgering, B.M.T. and Medema, R.H. 2002. Inhibition of the Cell Cycle by FoxO Forkhead Transcription Factors Includes Downregulation of Cyclin D. Molecular and Cellular Biology. 25(22): 7842-7852

2226) Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF and Watkins PB 2001. CYP3A4 induction by 1 alpha,25-dihydroxyvitamin D3 is human cell line specific and the Pregnane X receptor is unlikely to be involved . Elimination of drug metab. 29(11):1446-53

2227) Beautiful, N.O. 2001. Beyond deficiency: new roles for vitamins. Vitamin E and w-3 fatty acids: effectors of the platelet response. Nutrition, 17(10): 793-796.

2228) Schon, M., Bong, AB, Drewniok, C., Herz, J., Geilen, CC, Reifenberger, J., Benninghoff, B., Slade, H.B., Gollnick, H. & Schon, MP 2003. Induction of selective tumor apoptosis and the small molecule immune response modifier imiquimod. J National Cancer Institute 95(15): 1138-1149

2229) Schonafinger, K. 1999. Heterocyclic prodrugs of NO. Drug. 54(5): 316-320

2230) Schoonjans, K., Staels, B., Auwerx, J. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipidres. 37(5): 907-925

2231) Schrauzer, G. N. 2008. Interactive effects of selenium and cadmium on the development and growth of mammary tumors in MMTV-infected female mice. A model study of the role of cadmium and selenium in human breast cancer. Research of biological trace elements. 123(1-3): 27-34

2232) Schroeder, R. L., Stevens, C. L. und Sridhar, J. 2014. ErbB2/HER2/Neu small molecule tyrosine kinase inhibitors in the treatment of aggressive breast cancer. Moleküle. 19: 15196-15212, doi: 10.3390/molecules 190915196

2233) Schuerwegh, A. J., Stevens, W. J., Bridts, C. H., and De Clerck, L. S. 2001. Evaluation of monensin and brefeldin A for flow cytometric estimation of interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha in monocytes . zytometry. 46(3): 172-6

2234) Schulte, W. T., Akinaga, S., Soga, S., Sullivan, W., Stensgard, B., Toft, D., and Neckers, M. L. 1998. The antibiotic radicicol binds to the N-terminal domain of Hsp90 and cleaves important biological activities with geldanamycin. cellular stress chaperones. 3(2): 100-108

2235) Schultz, T.D. and Leklem, J.E. 1983. Selenium status of vegetarians, non-vegetarians, and hormone-dependent cancer patients. Bin J Clin Nutr. 37(1): 114-118

2236) Schulz, V. 1984. Clinical pharmacokinetics of nitroprusside, cyanide, thiosulfate and thiocyanate. Clin Pharmacokinet. 9(3):239-51.

2237) Schulze-Gahmen, U., Brandsen, J., Jones, HD, Morgan, D.O., Meijer, L., Vesely, J., and Kim, S.H. 1995. Multiple modes of ligand recognition: crystal structures of cyclin-dependent proteins kinase 2 in complex with ATP and two inhibitors, olomucine and isopentenyladenine. proteins 22(4):378-91

2238) Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., and Fiers, W. 1993. Depletion of mitochondrial electron transport abolishes the gene-inducing and cytotoxic effects of TNF. EMBO J. 12(8):3095-104

2239) Schumacker, P. T. 2006. Reactive oxygen species in cancer cells: living by the sword, dying by the sword. cancer cell. 10(3): 241-252

2240) Schust, J., Sperl, B., Hollis, A., Mayer, TU, & Berg, T. 2006. Static: a small molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 13(11):1235-42

2241) Schuster, I., Egger, H., Astecker, N., Herzig, G., Schuessler, M., & Vorisek, G. 2001. Selective CYP24 inhibitors: mechanistic tools for studying vitamin D metabolism in keratinocytes humans. Steroids 66(3-5): 451-462

2242) Schuurman, A.G., Goldbohm, A., Brants, H.A.M. and van den Brandt, P.A. 2002. A prospective cohort study on retinol, vitamins C and E, and carotenoid intake and risk of prostate cancer (Netherlands). Causes and control of cancer. 13(6):573-582

2243) Schuurmans, M.M., Hoffmann, F., Lindberg, R.L. and Meyer, UA 2001. Zinc mesoporphyrin suppresses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria. hepatology. 33(5):1217-22

2244) Schwartz, G. G. 2008. Prostate cancer, serum parathyroid hormone, and progression of skeletal metastases. Biomarkers of the cancer epidemic Prev. 17(3): 478-83

2245) Schwartz, H., Ollilainen, V., Piironen, V. and Lampi, A. 2008. Tocopherol, tocotrienol and plant sterol content in vegetable oils and industrial fats. Journal of Food Composition and Analysis. 21(2):152-161

2246) Scicinski, J., Oronsky, B., Ning, S., Knox, S., Peehl, D., Kim, M. M., Langecker, P., & Fanger, G. 2015. No to Cancer: The Complex and Multifaceted Role of nitric oxide and the epigenetic nitric oxide donor RRx-001. redox biology. 6:1-8, doi:

2247) Scorolli, L., Scalinci, S.Z., Limoli, P.G. et al. 2002. Photodynamic therapy for age-related macular degeneration with and without antioxidants. Canadian Journal of Ophthalmology. 37(7): 399-404.

2248) Scott KF, Sajinovic M, Hein J, Nixdorf S, Galettis P, Liauw W, de Souza P, Dong Q, Graham GG, and Russell PJ 2010 Novel roles of phospholipase A2 enzymes in cancer. Biochemistry. 92(6): 601-10

2249) Scotter, M.J., Roberts, D.P.T., Wilson, L.A., Howard, F.A.C., Davis, J., & Mansell, N. 2007. Free salicylic acid and aspirin content of foods by gas chromatography-mass spectrometry. Analytical, nutritional and clinical methods. Food Chemistry. 105(1): 273-279

2250) Sebolt-Leopold, J. S. 2000. Development of anticancer drugs that target the MAP kinase signaling pathway. Oncogene 19(56): 6594-6599

2251) Seddon, J.M., Rosner, B., Sperduto, R.D. et al. (2001). Dietary fat and risk of advanced age-related macular degeneration. Archives of Ophthalmology. 119(8): 1191-1199.

2252) Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, and Shirai T 2008. Suppression of prostate cancer growth by resveratrol in the transgenic rat for prostate adenocarcinoma (TRAP) model. Asia Pacific Cancer Before. 9(1):7-14

2253) Segersten, U., Holm, P.K., Björklund, P., Hessman, O., Nordgren, H., Binderup, L., Akerstrom, G., Hellman, P., and Westin, G. 2005. 25-Hydroxyvitamin Expression of D3-1-alpha-hydroxylase in breast cancer and use of non-1-alpha-hydroxylated vitamin D analogues. breast cancer res. 7(6): R980-R986

2254) Seifert, A., Taubert, H., Hombach-Klonisch, S., Fischer, B., & Santos, N. A. 2009. TCDD mediates p53 inhibition and activation of the ERalpha signaling pathway in MCF-7 cells in moderate hypoxic conditions. international J Oncol. 35:417-424, doi:10.3892/ijo-00000354

2255) Şeker, M. E., Çelik, A. & Dost, K. 2012. Determination of vitamin E isomers from grape seeds by high performance liquid chromatography UV detection. Journal of Chromatographic Sciences. 50(2):97-101

2256) Selimovic, D., Porzig, BB, El-Khattouti, A., Badura, HE, Ahmad, M., Ghanjati, F., Santourlidis, S., Haikel, Y. and Hassan, M. 2013. Bortezomib/ The proteasome inhibitor triggers both apoptosis and autophagy-dependent signaling pathways in melanoma cells. cell signal. 25(1):308-1

2257) Selvan KV, Vijayakumar A, Kumar SK and Singh NG 2011. Effects of lycopene on health and disease. A comprehensive review of the literature. Naturopathy Magazine. 3(3): 2157-69

2258) Semba, DR, Ferrucci, L, Bartali, B, Urpi-Sarda, M, Zamora-Ros, R, Sun, K, Cherubini, A, Bandinelli, S, and Andres-Lacueva, C 2014. Resveratrol levels and all - Cause mortality among the elderly who live in the community. JAMA Intern Med. 174(7): 1077-1084

2259) Sen, T., Dutta, A. & Chatteriee, A. 2010. Epigallocatechin-3-gallate (EGCG) regulates gelatinase-B (MMB-9) through the involvement of FAK/ERK/NFkappaB and AP -1 in humans down MDA-MB 231 breast cancer cell line. Anticancer drugs. 21(6): 632-44

2260) Seo, HS, Ku, JM, Choi, HS, Woo, JK, Jang, BH, Go, H, Shin, YC & Ko, SG 2015. Apigenin induces caspase-dependent apoptosis by inhibiting the signal converter and Signaling activator of transcription 3 in SKBR3 breast cancer cells that overexpress HER2. Mol Med Rep. 12(2):2977-84

2261) Seo, J. Y., Yu, J. H., Lim, J. W., Mukaida, N., and Kim, H. 2009. Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells . J Physiol Pharmacol. 60 (Supplement 7): 101-6

2262) Seo, Y. R., Kelley, M. R. und Smith, M. L. 2002. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proceedings of the National Academy of Sciences der Vereinigten Staaten von Amerika. 99(22): 14548-14553

2263) Seow, A., Zhao, B., Lee, E.I.D., Poh, W., Teh, M., Eng, P., Wang, Y., Tan, W., and Lee, H. 2001. Cytochrome P4501A2 ( CYP1A2) activity and risk of lung cancer: preliminary study among Chinese women in Singapore. carcinogenesis. 22(4): 673-677

2264) Serafim, T. L., Carvalho, F., Bernardo, T. C., Pereira, G. C., Perkins, E., Holy, J., Krasutsky, D. A., Kolomitsyna, O. N., Krasutsky, P. A. and Oliveira, P. J. 2014. New Lupane Derivatives Triterpenoids disrupt breast cancer mitochondria and induce cell death. BioorgMed Chem. Proof of proof corrected in press. Doi: 10.1016/j.bmc.2014.08.013

2265) Sergeev, IN 2004. Genistein induces Ca2+-mediated calpain/caspase-12-dependent apoptosis in breast cancer cells. Biochem Biophys Communal Res. 321(2): 462-7

2266) Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, Boninsegna A, Picci N, Ranelletti FO and Calviello G, 2008. Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1. 1 and regulate to low p -Expression of ERK1/2 and p-p38. apoptosis. 13(9):1172-83

2267) Serra, A.T., Seabra, I.J. Braga, M.E.M., Bronze, M.R., de Sousa, HC and Duarte, CMM 2010. Cherry (Prunus avium) processing using supercritical fluid technology. Part 1: Recovery of extract fractions rich in bioactive compounds. The journal of supercritical fluids. 55(1): 184-191

2268) Serra, V., Markman, B., Scaltriti, M., Eichhorn, A.J.P., Volero, V., Guzman, M., Botero, L.M., Llonch, E., Altzori, F., Di Cosimo, S. , Maira, M., Garcia-Echeverria, C., Parra, L. J., Arribas, J., and Baselga, J. 2008. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. res of cancer 68(19):8022-30

2269) Serradilla, J.M., Hernandez, A., Lopez-Corrales, M., Ruiz-Moyano, S., Cordoba, de GM and Martin, A. 2016. Chapter 6 – Cherry composition (Prunus avium L. and Prunus cerasus L., Rosaceae, Nutritional composition of fruit crops, 0:127-147, doi:10.1016/B978-0-12-408117-8.00006-4

2270) Serventi, L., Chichumroonchokchai, C., Riedl, KM, Kerem, Z, Berhow, MA, Vodovotz, Y, Schwartz, SJ, and Failla, ML 2013. Soybean and chickpea saponins: stability during baking and bioaccessibility in vitro . Journal of agricultural and food chemistry. 61(27): 6703-6710

2271) Sesso, D.H., Buring, E.J., Zhang, MS., Norkus, PE. and Gaziano, M.J. 2005. Dietary and plasma lycopene and the risk of breast cancer. Biomarkers of the cancer epidemic Prev. 14(5):1074-81

2272) Setalo, G., Singh, M., Guan, X., and Toran-Allerand, CD 2002. Estradiol-induced phosphorylation of ERK 1/2 in mouse cerebral cortex explants: the role of heat shock protein 90 (Hsp90) and MEK2. Developmental neurobiology. 50(1): 1-12

2273) Setzer, W. N. and Setzer, MC 2003. Plant-derived triterpenoids as potential antineoplastic agents. Brief review Med. Chem. 3: 540-556.

2274) Severson, R.K., Nomura, AM, Grove, J.S., & Stemmermann, GN 1989. A prospective study of demography, diet, and prostate cancer in men of Japanese descent in Hawaii. cancer res 49(7): 1857-60

2275) Sexton, E., Van Themsche, C., Leblanc, K., Parent, S., Lemoine, P., & Asselin, E. 2006. Resveratrol disrupts AKT activity and induces apoptosis in uterine cancer cells human. molecular cancer. 5:45, doi:10.1186/1476-4598-5-45, 13 pages

2276) Seyfried TN, Sanderson TM, El-Abbadi MM, McGowan R, and Mukherjee P 2003. Role of glucose and ketone bodies in the metabolic control of experimental brain tumor. Br J Cancer. 89(7): 1375-1382

2277) Shah, S.J. and Sylvester, P.W. 2005. Gamma-tocotrienol inhibits the proliferation of neoplastic mammary epithelial cells by decreasing the activity of Akt and nuclear factor kappaβ. Exp Biol Med (Maywood). 230(4):235-41

2278) Shahar, S, Normah, H, Fatimah, A, Fadilah, RN, Rohi, GA, Amin, I, Cham, BG, Rizal, RM, & Fairulnizal, MN 2008. Antioxidant intake and status and oxidative stress in relation to Breast cancer risk: a case-control study. Asian Pacific Journal of Cancer Prevention. 9(2):343-350

2279) Shakibaei, M., John, T., Seifarth, C. and Mobasheri, A. 2007. Resveratrol inhibits IL-1-beta-induced caspase-3 stimulation and PARP cleavage in human articular chondrocytes in vitro . . . . Ann NY Acad. science 1095:554-63, doi:10.1196/annals.1397.060

2280) Shan J, Shen J, Liu L, Xia F, Xu C, Duan G, Xu Y, Ma Q, Yang Z, Zhang Q., Ma, L., Liu, J., Xu, S., Yan, X., Bie, P., Cui, Y., Bian, X. W., & Qian, C. 2012. Nanog regulates cancer stem cell self-renewal, insulin-like growth factor pathway in human hepatocellular carcinoma. hepatology. 56(3): 1004-14

2281) Shan, Y., Wang, X., Wang, W., He, C., & Bao, Y. 2010. P38 MAPK plays a particular role in sulforaphane-induced upregulation of ARE-dependent enzymes and the regulation COX-2 negative in human bladder cancer cells. Oncol Rep. 23(4):1133-8

2282) Shan Y, Wu K, Wang W, Wang S, Lin N, Zhao R, Cassidy A, & Bao Y 2009. Sulforaphane downregulates COX-2 expression by activating p38 and inhibiting activity DNA binding of NF-kappa in human bladder T24 cells. international J Oncol. 34(4):1129-34

2283) Shanahan, F., Niederlehner, A., Carramanzana, N. and Anton, P. 1990. Sulfasalazine inhibits the binding of TNF alpha to its receptor. Immunopharmacology. 20(3): 217-24

2284) Shangary, S., Ding, K., Qiu, S., Nikolovska-Coleska, Z., Bauer, J.A., Liu, M., Wang, G., Lu, Y., McEachern, D., Bernard, D., Bradford, CR, Carey, TE, and Wang, S. 2008. Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in breast cancer. colon. Mol Cancer Ther. 7(6):1533-42

2285) Shankar, S., Chen, Q. & Srivastava, R. K. 2008. Inhibition of the PI3K/Akt and Mek/Erk signaling pathways acts synergistically to enhance the antiangiogenic effects of EGCG through transcription factor activation FOXO. Journal of Molecular Signaling. 3:7, doi: 10.1186/1750-2187-3-7, 11 pages.

2286) Shao, Z., Alpaugh, ML, Fontana, J.A. and Barsky, S.H. 1998. Genistein similarly inhibits proliferation in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1Induction, G2/M arrest and apoptosis. Cellular Biochemistry Journal. 69(1): 44-54

2287) Shapiro, G.I., Bell-McGuinn, KM, Molina, J.R., Bendell, J., Spicer, J., Kwak, E.L., Pandya, S.S., Millham, R., Borzillo, G., Pierce, K.J., Han, L., Houk, BE, Gallo, J.D., Alsina, M., Brana, I., and Tabernero, J. 2015. First human study of PF-05212384(PKI-587), a small molecule, intravenous, dual inhibitor of PI3K and mTOR in patients with advanced cancer. Cancer Clinic Res. 21(8):1888-95

2288) Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. 2001. Chemoprotective glucosinolates and isothiocyanates from broccoli sprouts: metabolism and excretion in humans. Biomarkers of the cancer epidemic Prev. 10(5):501-508

2289) Sharma, AK and Rohrer, B. Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line. JBiolChem. 279(34):35564-72

2290) Sharma, C., Kaur, J., Shishodia, S., Aggarwal, B. B., & Ralhan, R. 2006. Curcumin regulates smokeless tobacco-induced NF-kappa B activation and COX-2 expression in human oral precancerous lesions and cancer cells Toxicology. 228(1):1-15

2291) Sharma, M., Li, L., Celver, J., Killian, C., Kovoor, A., & Seeram, N. P. 2010. Effects of fruit ellagitannin extracts, ellagic acid and its colonic metabolite, urolithin A on wnt signage. J Agron FoodChem. 58(7):3965-3969

2292) Sharma, P.S., Sharma, R., & Tyagi, R. 2008. Cyclin-dependent kinase inhibitors: useful targets for cancer treatment. Curr targets for cancer drugs. 8(1): 53-75

2293) Sharma, S.K., Le Maguer, M. 1996. Lycopene in tomatoes and tomato paste fractions. JFoodSci. 8(2): 107-113

2294) Sharma, S.L., Chokshi, S.A., Desai, D., Mewada, H., & Singh, A. 2013. Non-enzymatic antioxidants, malondialdehyde, and total antioxidant activity as markers of oxidative stress in arthritis and rheumatoid arthritis. NHL Magazine of Medical Sciences. 2(1):57-60

2295) Sharma, V. and Paliwal, R. 2013. Isolation and characterization of saponins from Moringa oleifera (Moringaeceae) pods. International Journal of Pharmacy and Pharmaceutical Sciences. 5 (Supplement 1): 179-183

2296) Sharp , SY , Prodromou , C , Boxall , K , Powers , MV , Holmes , JL , Box , G , Matthews , TP , Cheung , KM , Kalusa , A , James , K , Hayes , A ., Hardcastle , A. , Dymock , B. , Brough , P. A. , Barrel , X. , Cansfield , J. E. , Wright , L. , Surgenor , A. , Foloppe , N. , Hubbard , R. E. , Aherne , W. , Pearl , L. , Jones , K. , McDonald , E. , Raynaud , F. , Eccles , S. , Drysdale , M. und Workman , P. 2007. Inhibition of heat shock protein 90 Molecular Chaperon in vitro and in vivo by Neuartige, synthetic, potent Resorcinyl-Pyrazole/Isoxazole-Amide-Analog. Mol Cancer Ther. 6(4): 1198-211

2297) Shats, I., Gatza, M.L., Liu, B., Angus; SP, You, L. and Nevins, J.R. 2013. FOXO transcription factors control the transcriptional specificity and apoptotic function of E2F1. res of cancer 73(19):6056-67

2298) Shelton, N.S., Shawgo, EM, Mathews, B.S., Lu, Y., Donnelly, CA, Szabla, K., Tanol, M., Vielhauer, A.G., Rajewski, A.R., Matts, L.R., Blagg, J.S.B., and Robertson, D. J. 2009. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90 kDa heat shock protein, exerts potent antiproliferative effects in human leukemia cells. Mol Pharmacol. 76(6): 1314-1322

2299) Shen, Q. and Christakos, S. 2005. Vitamin D receptor, Runx2, and Notch signaling cooperate in the transcriptional regulation of osteopontin. JBiolChem. 280(49): 40589-98

2300) Sheppard, K., Kinross, K.M., Solomon, B., Pearson, R.B., and Phillips, W.A. ​​​​2012. Targeting PI3 kinase/AKT/mTOR signaling in cancer. Crit Rev Oncog. 17(1): 69-95

2301) Sheptovitsky, Y. G. and Brudviq, G. W. 1986. Isolation and characterization of spinach photosystem II membrane-associated catalase and polyphenol oxidase. Biochemistry. 35(50):16255-63

2302) Sheth, S., Jajoo, S., Kaur, T., Mukherjea, D., Sheehan, K., Rybak, L. P., & Ramkumar, V. 2012. Resveratrol reduces the growth and metastasis of prostate cancer by inhibit Akt/MicroRNA-21 pathway. Plus one. 7(12): e51655, doi: 10.1371/journal.pone.0051655, 14 pages

2303) Sheweita, S. A. und Tilmisany, A. K. 2003. Cancer and Phase II Drug-Metabolizing Enzyme. Curr Metab de drogas. 4(1): 45-58

2304) Shi, J. and Maguer, M. 2000. Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Biotechnology. 20(4):293-334

2305) Shi JG, Chen X, Emm T, Scherle PA, Mcgee R, and Lo Y 2011. The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCBO18424 phosphate) in healthy subjects. The Journal of Clinical Pharmacology. 52(6): 809-18

2306) Shi, J., Arunasalam, K., Yeung, D., Kakuda, Y., Mittal, G., and Jiang, Y. 2004. Saponins from edible legumes: chemistry, processing, and health benefits. Food J Med. 7(1): 67-78

2307) Shi, M., Shiao, C., Lee, Y., and Shih, Y. 2015. Apigenin, a dietary flavonoid, inhibits human bladder cancer T-24 cell proliferation by blocking cell cycle progression and induced apoptosis. Cancer Cell International. 15:33, doi:10.1186/s12935-015-0186-0, 12 pages

2308) Shi W, Leong M, Cho E, Farrell J, Chen H, Tian J, & Zhang, D. 2009. Suppressive effects of resveratrol on androgen receptor transcriptional activity. Plus one. 4(10): e7398, 10 pages

2309) Shibanuma, M., Kuroki, T. and Nose, K. 1987. Inhibition of c-fos proto-oncogene transcription by inhibitors of protein kinase c and ion transport. EUR. J. Biochemistry. 164(1): 15-19

2310) Shibata, A., Nakagawa, K., Sookwong, P., Tsuduki, T., Tomita, S., Shirakawa, H., Komai, M., and Miyazawa, T. 2008. Tocotrienol inhibits the secretion of factors Angiogenic human colorectal adenocarcinoma cells by hypoxia-inducible factor 1α suppression. J Nutr. 138(11):2136-2142

2311) Shida, D., Takabe, K., Kapitonov, D., Milstien, S., and Spiegel, S. 2008. Targeting SphK1 as a new anticancer strategy. Curr drug targets. 9(8): 662-673

2312) Shigeoka, S., Onishi, T., Nakano, Y. and Kitaoka, S. 1986. Content and subcellular distribution of tocopherols in Euglena gracilis. Agricultural and biological chemistry. 50(4):1063-1065

2313) Shim HY, Park JH, Paik HD, Nah SY, Kim DS and Han YS 2007. Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain caspase and apoptosis kinase 1-p38 signaling Activation cascades of mitogen-activated protein kinase. Cancer Drugs 18(6): 649-57

2314) Shim, H., Chun, Y. S., Lewis, B. C. and Dang, C. V. 1998. A unique glucose-dependent apoptotic pathway produced by c-Myc. Proc Natl Acad Sci. 95(4): 1511-1516

2315) Shim, M. S. and Xia, Y. 2013. A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells. Angew. Chem. Int. ed. 52(27): 6926-6929

2316) Shimamoto, K., Hayashi, H., Taniai, E., Morita, R., Imaoka, M., Ishii, Y., Suzuki, K., Shibutani, M., and Mitsumori, K. 2011. Antioxidant N -acetyl-L-cysteine ​​(NAC)-reactive oxygen species (ROS) supplementation mediated indole-3-carbinol (I3C) hepatocellular tumor promotion in rats. J. Toxicol. Science 36(6): 775-86

2317) Shimazu, T., Inoue, M., Sasazuki, S., Iwasaki, M., Sawada, N., Yamaji, T., and Tsugane, S. for the Japan Health Center prospective study group. Bin J Clin Nutr. doi: 10.3945/ajcn.2009.28161, 7 pages.

2318) Shimizu, M., Deguchi, A., Joe, AK, Mckoy, J.F., Moriwaki, H., & Weinstein, IB 2005. EGCG inhibits HER3 activation and cyclooxygenase-2 expression in human colon cancer cells . J Exp Ther Oncol. 5(1): 69-78

2319) Shimizu S, Takehara T, Hikita H, Kodama T, Miyagi T, Hosui A, Tatsumi T, Ishida H, Noda T, Nagano H ., Doki, Y., Mori, M. and Hayashi, N. 2010. The let-7 microRNA family inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol. 52(5): 698-704

2320) Shimomoto T, Luo Y, Ohmori H, Chihara Y, Fujii K, Sasahira T, Denda A, and Kuniyasu H 2012. Advanced glycation end-products (AGEs) induce the AGE receptor in the colonic mucosa of injected Fischer 344 rats with azoxymethane fed a diet high in linoleic acid and high in glucose. J Gastroenterol. 47(10): 1073-83

2321) Shin, A., Camilleri, M., Vijayvargiya, P., Busciglio, I., Burton, D., Ryks, M., Rhoten, D., Lueke, A., Saenger, A., Girtman, A. and Zinsmeister, A. R. 2013. Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome. 11(10): 1270-1275.e1

2322) Shin, D.S., Kim, H.N., Shin, K.D., Yoon, Y.J., Kim, S.J., Han, D.C. and Kwon, B.M. 2009. Cryptotan Shinone inhibits constitutive signal converter and activator 3 transcript function by inhibiting dimerization in prostate DU145 blocks cancer cells. Cancer Res 69(1): 193-202

2323) Shin, GC, Kim, C, Lee, JM, Cho, WS, Lee, SG, Jeong, M, Cho, J & Lee, K. 2009. Apigenin-induced apoptosis is mediated by reactive oxygen species and the ERK1/2 activation in rheumatoid fibroblast-like synoviocytes. Chem Biol Interact. 182(1):29-36

2324) Shin, I. and Arteaga, CL 2006. Active Akt expression protects against tamoxifen-induced apoptosis in MCF-7 cells. IUBMB Life. 58(11): 664-669

2325) Shin , J.W. , Ohnishi , K. , Murakami , A. , Lee , J.S. , Kundu , J.K. , Na , HK , Ohigashi , H. and Surh , YJ 2011. Zerumbone induces hemoxygenase-1 expression in mouse skin and culture murine epidermal cells by activation of Nrf2. Cancer Res. anterior 4(6): 860-70

2326) Shinkai, Y., Sumi, D., Fukami, I., Ishii, T., & Kumagai, Y. 2006. Sulforaphane, an activator of Nrf2, suppresses cellular arsenic accumulation and cytotoxicity in primary mouse hepatocytes . letters FEBS. 580(7): 1771-1774

2327) Shin-Kang, S., Ramsauer, VP, Lightner, J., Chakraborty, K., Stone, W., Campbell, S., Reddy, S.A. and Krishnan, K. 2011. Tocotrienols AKT inhibitor and ERK activation and suppression of pancreatic cell proliferation by suppression of the ErbB2 signaling pathway. Free radical Biol Med. 51(6):1164-74

2328) Shiota, C., Woo, J., Lindner, J., Shelton, D.K. and Magnuson, AM 2006. Multiallelic disruption of the rictor gene in mice demonstrates that the mTOR 2 complex is essential for fetal growth and viability is essential. development cell. 11(4):583-589

2329) Shirazi, F. and Kontoyiannis, P. 2014. Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans by inducing apoptosis. microbial cell. 1(6): 179-189

2330) Shishodia, S., Koul, D. and Aggarwal, B. B. 2004. The cyclooxygenase (COX)-2 inhibitor celecoxib inhibits TNF-induced NF-kappaB activation by inhibiting I kappa B alpha-kinase activation and Akt in non-human humans. Small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 173(3): 2011-22

2331) Shklar, G., Schwartz, J., Trickler, D., & Cheverie, S. R. 1993. The efficacy of a mixture of beta-carotene, alpha-tocopherol, glutathione, and ascorbic acid for cancer prevention. Walnut cancer. 20(2):145-51

2332) Shoda, R., Matsueda, K., Yamato, S. & Umeda, N. 1996. Epidemiological analysis of Crohn's disease in Japan Increased dietary intake of n-6 polyunsaturated fatty acids and animal protein is related with the increasing incidence of Crohn's disease in Japan. American journal of clinical nutrition. 63(5):741-745.

2333) Shon, Y., Park, S. and Nam, K. 2006. Effective chemopreventive activity of genistein against human breast cancer cells. Journal of Biochemistry and Molecular Biology. 39(4): 448-451

2334) Shukla, S. and Gupta, S. 2006. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenografts. Mol Cancer Ther. 5(4):843-852

2335) Shukla, S. & Gupta, S. 2008. Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radical Biol Med. 44(10): 1833-1845

2336) Shukla, S. and Gupta, S. 2010. Apigenin: a promising molecule for cancer prevention. Pharmaceutical Res. 27(6): 962-978

2337) Shukla, S., Bhaskaran, N., Babcook, AM, Fu, P., MacLennan, TG, & Gupta, S. 2013. Apigenin inhibits prostate cancer progression in TRAMP mice through PI3K signaling /Akt/FoxO path. carcinogenesis. 35(2): 452-60

2338) Shukla, S., Chaurasiya, D.N., Walker, A.L. and Tekwani, L.B. 2013. Vorinostat, a panhistone deacetylase inhibitor, stimulates neuritic growth in PC12 cells through activation of the MAPK and PI3K signaling pathways. conference summary. Plant Med 2013; 79-P90, doi: 10.1055/s-0033-1336532

2339) Shukla V, Chandra V, Sankhwar P, Popli P, Kaushal BJ, Sirahi KV and Dwivedi A 2015. The phytoestrogen genistein inhibits EGFR/PI3K/NF-kB activation and induces apoptosis in human endometrial hyperplasia cells. CSR progress. 5(69): 56075-56085

2340) Si, M. S., Reitz, B. A. und Borie, D. C. 2005. Effects of the kinase inhibitor CG41251 (PKC412) on lymphocyte activation and TNF-alpha production. in t. immunopharmaceutical 5(7-8): 1141-9

2341) Sicilia, T., Niemeyer, H. B., Honig, D. M. and Metzler, M. 2003. Identification and stereochemical characterization of lignans in flax and pumpkin seeds. J Agron FoodChem. 51(5): 1181-8

2342) Siddiquee, K., Zhang, S., Guida, W.C., Blaskovich, M.A., Greedy, B., Lawrence, H.R., Yip, M.L.R., Jove, R., McLaughlin, M.M., Lawrence, N.J., Sebti, S.M. and Turkson, J. 2007. Selective inhibitor of STAT3 probe chemistry identified by structure-based virtual screening induces antitumor activity. Proc Natl Acad Sci USA. 104(18): 7391-7396

2343) Siddiqui, I.A., Asim, M., Hafeez, BB, Adhami, VM, Tarapore, RS, & Mukhtar, H. 2011. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. PHASEB. 25(4):1198-1207

2344) Siednienko, J., Nowak, J., Moynagh, N. P. & Gorczyca, AW 2011. Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells, implicating a modulation of NF- activity cGMP-dependent kB. Cytokine 54(3): 282-288

2345) Siegenberg, D., Baynes, D.R., Bothwell, H.T., Macfarlane, J.B., Lamparelli, D.R., Car, GN, MacPhail, P., Schmidt, U., Tal, A. & Mayet, F. 1991. Ascorbic acid prevented the dose-dependent inhibitory effect of polyphenols and phytates on non-heme iron absorption. American journal of clinical nutrition. 53(2):537-541

2346) Siegfried JM, Gubisch CT, Rothstein ME, Henry C, and Stabile LP 2012. Combining the multitarget tyrosine kinase inhibitor vandetanib with the anti-estrogen fulvestrant enhances its antitumor effects in non-small cell lung cancer. J Thorac Oncol. 7(3): 485-95

2347) Sikora, E., Bielak-Zmijewska, A., Magalska, A., Piwocka, K., Mosieniak, G., Kalinowska, M., Widlak, P., Cymerman, IA and Bujnicki, J.M. 2006. Curcumin induces Caspase-3-dependent apoptotic Pathway, but inhibits caspase-activated DNA fragmentation factor 40/DNase endonuclease in human Jurkat cells. Mol Cancer Ther. 5(4): 927-9

2348) Simile, M., Pascale, R. M., De Miglio, M. R., Nufris, A., Daino, L., Seddaiu, M. A., Muroni, M. R., Rao, K. N., and Feo, F. 1995. Dehydroepiandrosterone inhibition of growth and Persistent Leberknotchen progression in experimental lebercarcinogenesis in rats. Int J Cancer. 62(2):210-2

2349) Simone, E.R., Russo, M., Catalano, A., Monego, G., Froehlich, K., Boehm, V. and Palozza, P. 2011. Lycopine inhibitors NF-kB-mediated IL-8 expression and Redox changes and PPARϒ signaling in cigarette smoke-stimulated macrophages. More one. 6(5): e19652, doi:10.1371/journal.pone.0019652, 11 pages

2350) Simopoulos, A.P. 2002a. Omega-3 fatty acids for inflammation and autoimmune diseases. Journal of the American College of Nutrition, 21(8): 495-505.

2351) Simopoulos, A.P. 2002b. The importance of the omega-6/omega-3 essential fatty acid ratio. biomedicine and pharmacotherapy. 56(8): 365-379.

2352) Simopoulos, A.P. 2008. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular and other chronic diseases. Biology and Experimental Medicine. 233(6): 674-688.

2353) Simopoulos, A.P., Kifer, R.R., Martin, R.E. and Barlow, S.M. (1991). Health effects of ω-3 polyunsaturated fatty acids in fish and shellfish. World report on nutrition and dietetics. 66:488-503.

2354) Singh, AV, Xiao, D, Lew, KL, Dhir, R & Singh, SV 2004. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards the growth of PC xenografts -3 in vivo. carcinogenesis. 25(1): 83-90

2355) Singh A, Singh A, Sand JM Bauer SJ, Hafeez BB, Meske L and Verma AK 2015. Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinoma. J Invert dermatol. 135(4): 1098-107

2356) Singh, B. and Lucci, A. 2002. Role of cyclooxygenase-2 in breast cancer. J SurgRes. 108(1):173-9

2357) Singh, B.N., Shankar, S. and Srivastava, R.K. 2011. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives, and clinical applications. Biochem Pharmacol. 82(12): 1807-21

2358) Singh, B. N., Singh, B. R., Singh, R. L., Prakash, D., Dhakarey, R., Upadhyay, G. und Singh, H. B. 2009. Oxidative DNA damage protective activity, antioxidants, and anti-quorum sensing potentials from Moringa oleifera. Food Chem Toxicol. 47(6): 1109-1116

2359) Singh, M., Parent, S., Leblanc, V., & Asselin, E. 2011. Resveratrol modulates PTGS2 expression and cell proliferation in normal rat endometrium in an AKT-dependent manner. reproductive biology. 84(5): 1045-1052

2360) Singh, N., Chaudhry, P., Parent, S., and Asselin, E. 2012. Ubiquitin-Cox-2 proteasome degradation in TGF-β-stimulated human endometrial cells is mediated by reticulum mannosidase I endoplasmic. Endocrinology. 153(1): 426-37

2361) Singh, P. K. and Shukla, P. 2012. Preliminary report on the molecular docking of HER2 proteins to understand the anticancer properties of Solanum tuberosum saponins. precedents of nature. Doi: 10.1038/npre.2012.7147.1

2362) Singh, R., Ahmed, S., Islam, N., Goldberg, VM, & Haggi, TM 2002. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced nitric oxide synthase expression and nitric oxide production in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of nuclear factor kappaB inhibitor. Arthritis Rheumatism. 46(8): 2079-86

2363) Singh, S. P., Wahajuddin., Ali, M. M., and Jain, G. K. 2010. High-throughput quantification of isoflavones, biochanin A, and genistein, and their conjugates in female rat plasma by LC-ESI-MS/MS: study application pharmacokinetic . J Sep Sci. 33(21): 3326-34

2364) Singh, S.V., Srivastara, S.K., Choi, S., Lew, K.L., Antosiewicz, J., Xiao, D., Zeng, Y., Watkins, S.C., Johnson, C.S., Trump, D.L., Lee, Y.J., Xiao, H. and Herman-Antosiewicz, A. 2005. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. The Journal of Biological Chemistry. 280(20): 19911-19924

2365) Singh, T. and Katiyar, S. K. 2013. Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE2-mediated activation of B-catenin signaling. Plus one. 8(4): e60749, doi: 10.1371/journal.pone.0060749, 12 pages

2366) Singh, U., Devaraj, S. and Jialal, I. 2005. Vitamin E, oxidative stress and inflammation. Rev. Annual Nutr. 25:151-74, doi:10.1146/annurev.nutr.24.012003.132446

2367) Sinha, R., Kulldorf, M., Chow, W., Denobile, J., & Rothman, N. 2001. Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenoma. Epidemiology, biomancers and cancer prevention. 10(5):559-562

2368) Sinicrope, F. A. and Gill, S. 2004. Role of cyclooxygenase-2 in colorectal cancer. Krebs Metastasis. 23(1-2): 63-75

2369) Sinno, M., S. Biagioni, MA Ajmone-Cat, I. Pafumi, P. Caramanica, V. Medda, G. Tonti, L. Minghetti, F. Monello and F. Cacci, 2369) E. 2013 Der The matrix metalloproteinase inhibitor marimastat promotes the differentiation of neural progenitor cells into neurons through gelatinase-independent TIMP-2-dependent mechanisms. Stem Cell Developers 22(3): 345-58

2370) Sioulas, V.D., Politi, E., Rizos, D.A., Augoulea, A., Kyroudi, A. and Sergantanis, T.N. 2011. Does hormone therapy, tibolone, or raloxifene modify VEGF expression in cervical epithelial cells? Climacteric. 15(2):181-5

(Video) Vital Strategies in Cancer

2371) Sirois, I., Cheung, A.M. and Ward, W. E. 2003. Biochemical bone strength and bone mass in fish oil-fed young male and female rats. prostaglandins, leukotrienes and essential fatty acids. 68(6): 415-421.

2372) Skariyachan, S., Krishnan, R.S. and Biradar, UB 2010. In silico investigation and coupling studies of the tumor marker E2F3: discovery and evaluation of potential inhibitors for prostate and breast cancer. International Journal of Pharmaceutical Sciences and Drug Research. 2(4): 254-260

2373) Skikne, SB 2008. Serum Transfer Recipient. American Journal of Hematology. 83(11):872-875

2374) Skinner HG, Michaud DS, Giovannucci E, Willett WC, Colditz GA, and Fuchs CS 2006. Vitamin D intake and risk of pancreatic cancer in two cohort studies. Biomarkers of the cancer epidemic Prev. 15(9):1688-1695

2375) Skobe, M., Hawighorst, T., Jackson, D.G., Prevo, R., Janes, L., Velasco, P., Riccardi, L., Alitalo, K., Claffey, K., and Detmar, M. 2001. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. naturopathy. 7(2): 192-198

2376) Skupinska, K., Misiewicz-krzeminska, I., Stypulkowski, R., Lubelska, K. y Kasprzycka-Guttman, T. 2009. Sulforaphane and its analogs Inhibición de la actividad de CYP1A1 y CYP1A2 inducida por benzo[a] pyrene. J. Bioquimica. Polilla. toxicol. 23(1): 18-28

2377) Slim, R., Hammock, D.B., Toborek, M. et al. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the enhanced toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicology and applied pharmacology. 171(3):184-193.

2378). cancer res 70(8):3382-90

2379) Smith, A. B., Sperry, J. B. and Han, Q. 2007. Synthesis of (-)-oleocanthal, a natural NSAID found in extra virgin olive oil, (-)-deacetoxy-oleuropein aglycone and analogs related. J.Org.Chem. 72(18): 6891-6900

2380) Smith, G., Stubbins, M. J., Harries, L. W. y Wolf, C. R. 1998. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica. 28(12): 1129-65

2381) Smorenburg SM, Griffini P, Tiggelman AB, Moorman AF, Boers W and Van Noorden JF 1996. Alpha2-macroglobulin is mainly produced by cancer cells and not by hepatocytes in rats with liver metastatic colon carcinoma. hepatology. 23(3): 560-70

2382) Smyth, T., Looy, V.T., Curry, E.J., Rodriguez-Lopez, M.A., Wozniak, A., Zhu, M., Donsky, R., Morgan, G.J., Mayeda, M., Fletcher, A.J., Schöffski , P., Lyons, J., Thompson, TN, and Wallis, GN 2012. The Hsp90 inhibitor AT13387 is active against imatinib-sensitive and resistant gastrointestinal stromal tumor models. Molecular Cancer Therapeutics. 11(8): 1799-808

2383) Smyth, T., Van Looy, T., Curry, J.E., Rodriguez-Lopez, A.M., Wozniak, A., Zhu, M., Donsky, R., Morgan, J.G., Mayeda, M., Fletcher, J.A. , Schoffski, P., Lyons, J., Thompson, N. T., and Wallis, N. G. 2012. The HSP90 inhibitor AT13387 is active against imatinib-sensitive and resistant gastrointestinal stromal tumor models. Mol Cancer Ther. 11(8): 1799-1808

2384) So, Y.J., Wahler, E.J., Yoon, T., Smolarek, KA, Lin, Y., Shih, J.W., Maehr, H., Uskokovic, M., Liby, T.K., Sporn, B.M. and Suh, N 2013. Oral administration of a gemini vitamin D analogue, synthetic triterpenoid, and the combination prevents ErbB2 overexpression-driven breast tumorigenesis. Cancer Prev Res (Phila). 6(9): 959-70

2385) Soares, L.A., Olivo, R., Shimokomaki, M., and Ida, I. 2004. Synergism between dietary vitamin E and exogenous phytic acid to prevent overheated flavor development in chicken breast meat, Pectoralis major M. Brazilian Archives of Biology and Engineering. 47(1): 57-62

2386) Soares , P.C.N. , Theodore , J.A. , Oliveira , L.F. , Takiya , M.C. , Junior , P.A. , Nasciutti , E.L. , Lotsch , F.P. , Farmer , M.J. , Ferreira , BL , Gimba , P.R.E. and Borojevic, R. 2014. Lycopene induces Apoptosis in human prostate cells and alters the expression of Bax and Bcl-2 genes. LWT Food science and technology. 59(2): 1290–1297

2387) Soghoian, D., Jayaraman, V., Silane, M., Berenstein, A., & Jayaraman, T. 2005. Inositol 1,4,5-triphosphate receptor phosphorylation in breast cancer. Tumor Biol 26(4): 207-12

2388) Solit, OB, Zheng, FF, Drobnjak, M, Munster, PN, Higgins, B, Verbel, D, Heller, G, Tong, W, Cordon-Cardo, C, Agus, DB, Scher, HI and Rosen, N. 2002. 17-allylamino-17-desmethoxygeldanamycin induces androgen receptor and HER-2/neu degradation and inhibits the growth of prostate cancer xenografts. Cancer Clinic Res. 8(5): 986-93

2389) Soltaninassab, S. R., Sekhar, K. R., Meredith, M. J. and Freeman, M. L. 2000. Multi-faceted Regulation of Gamma-Glutamylcysteine ​​Synthetase. J Cell Phsiol. 182(2): 163-70

2390) Somerset, S. M. and Johannot, L. 2008. Dietary sources of flavonoids in Australian adults. Diet and cancer. 60(4): 442-449

2391) Sommerburg , O. , Keunen , J.E.E. , Bird , A.C. , van Kuijk , F.J.G.M. 1998. Fruits and vegetables that are sources of lutein and zeaxanthin: the macular pigment in the human eye. Br J Ophthalmol. 82(8): 907-9

2392) Song Lin Bonaccorso Heide Verkerk Kenis Bosmans Scharpe Whelan Cosyns de Jongh R and Maes 1998. The inflammatory response system and plasma tryptophan availability in patients with primary sleep disorders and major depression. Journal of Mood Disorders. 49(3):211-219.

2393) Song, G., Mao, Y.B., Cai, Q.F., Yao, LM, Ouyang, GL, and Bao, S.D. 2005. Curcumin induces apoptosis of HT-29 human colon adenocarcinoma cells through activation of p53 and regulated apoptosis-associated protein expression. Brazilian journal of medical and biological research. 38(12): 1791-1798

2394) Song, Z. and Xu, X. 2014. Advanced research on the antitumor effects of the amygdala. Journal of Cancer Research and Therapeutics. 10(5):3-7

2395) Sorensen, M., Jensen, B. R., Poulsen, H. E., Deng, X., Tyqstrup, N., Dalhoff, K. y Loft, S. 2001. Effects of a Brussels spouts extract on oxidative DNA Damage and metabolizing Enzyms in Rattenleber. Alimentos Chem Toxicol. 39(6): 533-40

2396) Sorrenti, V., Guccione, S., Di Giacomo, C., Modica, M.N., Pittala, V., Acquaviva, R., Basile, L., Pappalardo, M. and Salerno, L. 2012. Evaluation of Imidazole-based compounds as inhibitors of hemoxygenase-1. Chem Biol Drug Des. 80(6):876-886

2397) Sowbhagya, H. B., Srinivas, P. & Krishnamurthy, N. 2010. Effect of enzymes on volatile matter extraction from celery seeds. Food Chemistry. 120(1): 230-234

2398) Speizer, EF, Colditz, A.G., Hunter, J.D., Rosner, B. & Hennekens, C. 1999. Prospective study on smoking, antioxidant intake and lung cancer in middle-aged women (USA). ). Causes and control of cancer. 10(5): 475-482

2399) Spencer, A., Yoon, S.S., Horrison, S.J., Morris, SR, Smith, DA, Brigandi, RA, Gauvin, J., Kumar, R., Opalinska, J.B. and Chen, C. 2014. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 124(14):2190-5

2400) Spirli , C. , Morell , CM , Locatelli , L. , Okolicsanyi , S. , Ferrero , C. , Kim , AK , Fabris , L. , Fiorotto , R. and Strazzabosco , M. 2012. Cyclic AMP/PKA paradoxical Raf/MEK/ERK-dependent activation in polycystin-2-deficient mice treated with sorafenib. hepatology. 56(6):2363-74

2401) Sporn, M. and Suh, N. 2000. Cancer chemoprevention. carcinogenesis. 21,525-530.

2402) Sprowl, J.A., Reed, K., Armstrong, SR, Lanner, C., Guo, B., Kalatskaya, I., Stein, L., Hembruff, SL, Tam, A. and Parissenti, AM 2012. Amendments in tumor necrosis factor signaling pathways are associated with cytotoxicity and resistance to taxanes: a study in isogen-resistant tumor cells. breast cancer research. Vol:14, Number:1, doi:10.1186/bcr3083, 18 pages.

2403) Spychalla, J.P. and Desborough, SL 1990. Superoxide dismutase, catalse and α-tocopherol content in stored potato tubers. plant physiology 94(3):1214-1218

2404) Squires, M. S., Feltell, R. E., Wallis, N. G., Lewis, E. J., Smith, D. M., Cross, D. M., Lyons, J. F., and Thompson, N. T. 2009. Biological characterization of AT7519, a small molecule inhibitor of cyclin-dependent kinases , in menschlichen Tumorzellinien. Mol Cancer Ther. 8(2): 324-32

2405) Stähelin, HB, Gey, KF, Eichholzer, M and Lüdin, E. 1989. Brubacher G. Cancer Mortality and Vitamin E Status. Ann NY Acad. science 570, 391-399

2406) Stan, S.D., Hahm, E., Warin, R., and Sirigh, S.V. 2008. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits the growth of human breast cancer cells in vivo. Cancer Res. 68(18):7661-7669

2407) Stanciu, M., Wang, Y., Kentor, R., Burke, N., Watkins, S., Kress, G., Reynolds, I., Klann, E., Angiolieri, MR, Johnson, J.W. and DeFranco, DB 2000. Prolonged ERK activation contributes to glutamate-induced oxidative toxicity in a neuronal cell line and cultures of primary cortical neurons. JBiolChem. 275(16): 12200-12206

2408) Staples, O.D., Hollick, J.J., Campbell, J., Higgins, M., McCarthy, A.R., Appleyard, V., Murray, KE, Baker, L., Thompson, A., Ronseaux, S., Slawin, AM, Lane, DP, Westwood, NJ, & Lain, S. 2008. Characterization, chemical optimization, and antitumor activity of a tubulin toxin identified by p53-based phenotypic screening. cellular cycle. 7(21): 3417-27

2409) Stattin, P., Bjor, O., Ferrari, P., Lukanova, A., Lenner, P., Lindahl, B., Hallmans, G. und Kaaks, R. 2007. Prospective study of hyperglycemia and risk of cancer . Diabetes-Treatment. 30(3): 561-567

2410) Staudt, L. M. 2010. Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol. 2(6): a000109, doi: 10.1101/cshperspec.a000109, 30 pages

2411) Steadman, J.K., Burgoon, SM, Lewis, AB, Edwardson, E.S. and Obendorf, LR 2001. Minerals, phytic acid, tannin, and rutin in mill fractions of book wheat seeds. Journal of Agricultural and Food Sciences. 81(119): 1094-1100

2412) Stebbins, L.J., De, KS, Machleidt, T., Becathini, B., Vazquez, J., Kuntzen, C., Chen, L., Cellitti, F.J., Riel-Mehan, M., Emdadi, A. , Solinas, G., Karin, M., and Pellecchia, M. 2008. Identification of a novel JNK inhibitor targeting the JNK-JIP interaction site. PNAS. 105(43):16809-16813

2413) Steers, W. D. 2001. 5 alpha-reductase activity in the prostate. Urology. 58(6 Supplement 1):17-24)

2414) Stein, Riedl, Rüthnick, Nötzold, & Bauer, 2012. The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids 40(19):9522-33.

2415) Steinmetz, A. K., Potter, D. J. und Folsom, R. A. 1993. Vegetables, fruits, and lung cancer in the Iowa Healthy Women's Study. Krebsforschung. 53(3): 536-543

2416) Stenman, U., Alfthan, H. and Hotakainen, K. 2004. Human chorionic gonadotropin in cancer. Clinical Biochemistry. 37(7):549-561

2417) Stenson Cort Rodgers Burakoff DeSchryver-Kecskemeti Gramlich TL and Beeken 1992. Fish oil supplementation in ulcerative colitis. Annals of Internal Medicine. 116(8): 609-614.

2418) Stervbo, U., Vang, O. and Bonnesen, O. 2007. A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chemistry. 101(2): 449-457

2419) Stevens VL, McCullough ML, Sun J, and Gapstur SM 2010. Folic acid and other nutrients associated with one-carbon metabolism and risk of postmenopausal breast cancer in the dietary cohort of the Cancer Prevention Study II 91(6) :1708-15

2420) Stevens VL, McCullough ML, Sun J, Jacobs EE, Campbell PT, & Gapstur SM 2011. High levels of folic acid from dietary supplements and fortifications are not associated with increased risk of colorectal cancer. gastroenterology. 141(1):98-105

2421) Stock, C. C., Martin, D. S., Sugiura, K., Fugmann, R. A., Mountain, I. M., Stockert, E., Schmid, F. A. and Tarnowski, G. S. 1978. Antitumor tests of amygdalin in spontaneous staggered tumor systems. J Surg Oncol. 10(2): 89-123

2422) Stock, C. C., Tarnowski, G. S., Schmid, F. A., Hutchison, D. J., and Teller, M. N. 1978. Antitumor tests of tonsillar in transplantable animal tumor systems. J Chirurg Oncol. 10(2): 81-8

2423) Stojkovic, D., Petrovic, J., Sokovic, M., Glamoclija, J., Kukic-Markovic, J., & Petrovic, S. 2013. In situ antioxidant and antimicrobial activities of natural caffeic acid, p-coumaric acid and routine, using food systems. Journal of Agricultural and Food Sciences. 93(13):3205-3208

2424) Stolzenberg-Solomon RT, Chang S, Leitzmann MF, Johnson KA, Johnson C, Buys SS, Hoover RN, and Ziegler RG 2006. Folate intake, alcohol consumption, and postmenopausal breast cancer risk in cancer of the prostate, lung, colon and ovary Screening study. American journal of clinical nutrition. 83(4):895-904

2425) Stolzenberg-Solomon, Z.R., Sheffler-Collins, S., Weinstein, S., Garabrant, H.D., Mannisto, S., Taylor, P., Virtamo, J., & Albanes, D. 2009. Vitamin E intake, α -Tocopherol status and pancreatic cancer in a cohort of male smokers. Bin J Clin Nutr. 89(2): 584-591

2426) Stolzenburg, S., Rots, M. G., Beltran, A. S., Rivenbark, A. G., Yuan, X., Qian, H., Strahl, B. D. und Blancafort, P. 2012. Targeted silencing of the oncogenic transcription factor SOX2 in cancer from mom Nuclsäuren res. 40(14): 6725-6740

2427) Strandas, C., Kamal-Eldin, A., Andersson, R. and Aman, P. 2008. Phenolic glycosides in flaxseed bread. Food Chemistry. 110(4):997-999

2428) Stricklin, G. P. 1986. Human fibroblast tissue inhibitor of metalloproteinases: glycosylation and function. Coll Relat Res. 6(2): 219-28

2429) Ström, A., Hartman, J., Foster, J.S., Kietz, S., Wimalasena, J., & Gustafsson, J. 2004. Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the cell line of T47D breast cancer. PNAS. 10(6):1566-1571

2430) Stuart HT, van Oosten AL, Radzisheuskaya A, Mortello G, Miller A, Dietmann S, Nichols J, and Silva JC 2014. Nanog enhances STAT3 activation and synergistically induces the Naive Pluripotent program. Curr Biol. 24(3):340-6

2431) Studzinski, G.P., McLane, J.A. and Uskokovic, M. 1993. Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases. Crit Rev Eukaryote Gene Expr. 3(4): 279-312

2432) Stupack, D. G. and Cheresh, D. A. 2002. Get a ligand, get a life: integrins, signaling, and cell survival. Cell Science J. 115 (Part 19): 3729-38

2433) Sturm , S. , Gil , R.R. , Chai , H.B. , Ngassapa , O.D. , Santisuk , T. , Reutrakul , V. , Howe , A. , Moss , M. , Besterman , J.M. , Yang , S.L. , Farthing , J.E. . , Tait , RM , Lewis , JA , O'Neill , MJ , Farnsworth , NR , Cordell , GA , Pezzuto , JM and Kinghorn , AD 1996 . J Nat Prod. 59(7): 658-63

2434) Su C, Lin J, Chung C, Yang J, Ip S, Lin W and Chen G 2006. Curcumin-induced apoptosis of human colon cancer colo 205 cells through production of ROS, Ca2+ and activation of caspase-3. Cancer research. 26(6B): 4379-4390

2435) Su, K.P., Huang, S.Y., Chiu, CC, and Shen, W.W. 2003. Omega-3 fatty acids in major depression. A preliminary double-blind placebo-controlled study. European neuropsychopharmacology. 13(4): 267-271.

2436) Su, R. Y., Chi, K. H., Huang, D. Y., Tai, M. H., & Lin, W. W. 2008. 15-deoxy-delta 12,14-prostaglandin J2 increases death receptor 5 gene expression in HCT 116 cells: participation of cells reactive oxygen species and transcription of the gene of the homologous transcription factor C/EBP. Mol Cancer Ther. 7(10): 3429-40

2437) Su R, Li Z, Li H, Song H, Bao C, Wei J, and Cheng L 2010. Grp78 promotes hepatocellular carcinoma invasion. BMC cancer. 10:20, doi: 10.1186/1471-2407-10-20

2438) Suarez-Quiroz, M.L., Campos, A.A., Alfaro, G.V., Gonzales-Rios, O., Villeneuve, P. and Figueroa-Espinoza, M.C. 2014. Isolation of chlorogenic acids from green coffee using activated carbon. Journal of Food Composition and Analysis. 33(1): 55-58

2439) Suchard, J.R., Wallace, KL. and Gerkin, RD. 1998. Acute cyanide toxicity from ingestion of apricot kernels. Ann Emerg.Med. 32(6):742-4

2440) Sugiyama, M., Fujita, K., Murayama, N., Akiyama, Y., Yamazaki, H., and Sasaki, Y. 2011. Two anticancer drugs, sorafenib and sunitinib, inhibit CYP3A4 mediation and activate CY3A5- 1'-Hydroxylation mediated by midazolam. Metabolism and disposition of drugs. 39(5):757-762

2441) Sui, T., Li, M. A., Bai, X., Qing, L. and Xu, X. 2014. Resveratrol hemmt the Phosphatidylinositide-3-kinase/Proteinkinase B/mammalian target of rapamycin signaling pathway in human chronic myeloid Leukemia K562-Zellinie. Oncol Lett. 7(6): 2093-2098

2442) Sullivan, L.B. and Chandel, N.S. 2014. Mitochondrial reactive species and cancer. Cancer and metabolism. 2:17, doi: 10.1186/2049-3002-2-17

2443) Sun, A., Liu, C., Sun, Z., & Wei, Z. 2014. Nanog: a promising target for digestive malignancies. World Journal of Gastroenterology. 20(36): 13071-13078

2444) Sun, F., Shyu, H., Lee, M., Lee, M., & Lai, Y. 2013. Participation of calcium-mediated reactive oxygen species in the inductive expression of GRP78 by geldanamycin in brain tumor cells of rat 9L. international J.Mol.Sci. 14(9): 19169-19185

2445) Sun, H., Hu, Y., Gu, Z., Qwens, TR, Chen, Q. Y., & Edwards, J. I. 2011. Omega-3 fatty acids induce apoptosis in human breast cancer cells and human breast tissue. mouse via syndecan-1 inhibition of the MEK-Detect signaling pathway. carcinogenesis. 32(10): 1518-1524

2446) Sun, J.Y., Tseng, H., Xu, L., Hunter, Z., Ciccarelli, B., Fulciniti, M., Zhu, B., Maghsoudi, K., Yang, G., Gong, P. , Zhou , Y , Liu , X , Munshi , North Carolina , Patterson , C.J. and Treon, S.P. 2011. Vorinostat-induced cellular stress disrupts p38 mitogen-activated protein kinase and extracellular signaling-regulated kinase pathways, leading to apoptosis in Waldenstorm macroglobulinemia cells. Leuk lymphoma. 52(9): 1777-86

2447) Sun, J., Huang, Y.R., Harrington, W.R., Sheng, S., Katzenellenbogen, J.A. and Katzenellenbogen, B.S. 2002. Selective estrogen receptor alpha antagonists. Endocrinology. 143(3):941-7

2448) Sun J, Sun G, Meng X, Wang H, Luo Y, Qin M, Ma B, Wang M, Cai D, Guo P and Sun, X. 2013. Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in in vitro More one. 8(5): e64526, doi:10.1371/journal.pone.0064526, 14 pages

2449) Sun, J., Sun, Q., Brown, M.F., Dudgeon, C., Chandler, J., Xu, X., Shu, Y., Zhang, L. and Yu, J. 2012. The multi- The targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells through PUMA. Plus one. 7(8):e43158, doi=10.1371/journal.pone.0043158, 10 pages.

2450) Sun, L., Chen, T., Wang, X., Chen, Y., & Wei, X. 2011. Bufalin induces reactive oxygen species-dependent Bax translocation and apoptosis in ASTC-a cells -one. Evidence-based alternative supplement. Med. 2011: 249090, doi: 10.1093/ecam/nep082, 12 pages

2451) Sun, S., Han, J., Ralph, WM. Jr., Chandrasekaran, A., Liu, K., Auborn, KJ, and Carter, TH 2004. Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro. cellular stress chaperones. 9(1):76-87

2452) Sun, X., Bristol, A.J., Iwahori, S., Hagemeier, R.S., Meng, Q., Barlow, AE, Fingeroth, D.J., Tarakanova, L.V., Kalejta, F.R. and Kenney, C.S. 2013. DMAG reduces the expression of conserved herpesvirus protein kinases and reduces virus production in Epistein-Barr virus-infected cells. J Virol. 87(18): 10126-10138

2453) Sun X, Mao Y, Wang J, Zu L, Hao M, Cheng G, Qu Q, Cui D, Keller ET, Chen X., Shen, K., and Wang, J. 2014. IL-6 secreted by the cancer Associated fibroblasts induce tamoxifen resistance in luminal breast cancer. oncogene 33:4450, doi:10.1038/onc.2014.224

2454) Sun, Y., Lehmbecker, A., Kalkuhl, A., Deschl, U., Sun, W., Rohn, K., Tzvetanova, I.D., Nave, KA, Baumgartner, W., and Ulrich, R. 2015 STAT3 represents a molecular switch that can induce astroglial rather than oligodendroglial differentiation of oligodendroglial progenitor cells in mouse Theiler's encephalomyelitis. Neuropathol Appl Neurobiol. 41(3): 347-70

2455) Sunamura , M. , Doubt , D.G. , Ghattas , M.H. , Lozonschi , L. , Motoi , F. , Yamauchi , J. , Matsuno , S. , Shibahara , S. and Abraham , N.G. 2003. Heme-oxygenase- 1 accelerates human pancreatic cancer tumor angiogenesis. angiogenesis. 6(1): 15-2

2456) Sundar, SN, Kerekatte, V, Equinozio, CN, Doan, VB, Bjeldanes, LF & Firestone, GL 2006. Indole-3-carbinol selectively uncouples the expression and activity of estrogen receptor subtypes in cancer cells of human breast. Minor endocrinol. 20(12): 3070-82

2457) Sundaram, S., Beckman, M.J., Bajwa, A., Smith, KM, Posner, GH, & Gewirtz, DA 2006. QW-1624F2-2, a synthetic 1,25-dihydroxyvitamin D3 analogue, enhances response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells. Mol Cancer Ther. 5(11):2806-14

2458) Sundl, I., Murkovic, M., Bandoniene, D. & Winklhofer-Roob, B. M. 2007. Vitamin E content of foods: comparison of results from food composition tables and HPLC analysis. Clinical Nutrition. 26(1):145-153

2459) Sunters, A., Madureira, PA, Pomeranz, K.M., Aubert, M., Brosens, J.J., Cook, S.J., Burgering, B.M., Coombes, R.C. and Lam, E. W. 2006. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by the NH2 terminal kinase c-Jun and Akt. cancer res 66(1):212-220

2460) Suppipat, K., Park, CS, Shen, Y., Zhu, X. & Lacorazza, H. D. 2012. Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. Plus one. 7(12): e51251, doi: 10.1371/journal.pone.0051251, 12 pages

2461) Suppipat, K., Park, CS, Shen, Y., Zhu, X., & Lacorazza, H. D. 2012. Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. Plus one. 7(12):e51251, doi: 10.1371/journal.pone.0051251

2462) Surekha, D., Sailaja, K., Rao, DN, Padma, T., Raghunadharao, D., & Vishnupriya, S. 2009. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case study and controls. Indian J med. Science 63(1): 13-20

2463) Surget, S., Khoury, MP and Bourdon, J.C. 2013. Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. Onco Ther objectives. 7:57-68, doi:10.2147/OTT.S53876

2464) Suzuki, H., Ueda, T., Ichikawa, T., & Ho, H. 2003. Involvement of androgen receptors in the progression of prostate cancer. Cancer related to the endocrine system. 10(2): 209-216

2465) Suzuki, H., Park, S.J., Tamura, M., and Ando, ​​S. 1998. Effect of long-term feeding of dietary lipids on learning ability, fatty acid composition of brainstem phospholipids, and synaptic membrane fluidity in adult mice a comparison of sardine oil diet with the palm oil diet. Mechanism of aging and development. 101(1-2): 119-128.

2466) Suzuki, S., Akechi, T., Kobayashi, M. et al. 2004. Daily intake of omega-3 fatty acids and depression in Japanese patients with newly diagnosed lung cancer. British journal of cancer. 90(4):787-793.

2467) Suzuki, T., Aoyama, J., Hashimoto, M., Ohara, M., Futami-Suda, S., Suzuki, K., Ouchi, M., Igari, Y., and Nakano, H. 2014 Correlation between postprandial bile acids and body fat mass in healthy individuals of normal weight. Clinical Biochemistry. 47(12) 1128-1131

2468) Suzuki, Y., Aoki, K., Saito, H., Umeda, M., Nitta, H., Baron, R., & Ohya, K. 2006. A tumor necrosis factor-alpha antagonist inhibits bone inflammation induced respiration Porphyromonas gingivalis infection in mice. J Periodontal Res. 41(2): 81-91

2469) Swami, S., Krishnan, A.V., Moreno, J., Bhattacharyya, R.B., Peehl, DM, & Feldman, D. 2007. Actions of calcitriol and genistein to inhibit prostaglandin signaling: potential combination therapy for cancer treatment of prostate. J Nutr. 137 (1 supplement): 205S-210S

2470) Swami, S., Krishnan, A.V., Moreno, J., Bhattacharyya, R.S., Gardner, C., Brooks, J.D., Peehl, D.M. and Feldman, D. 2008. Inhibition of prostaglandin synthesis and the effects of genistein in human prostate cancer cells and by soy isoflavones in patients with prostate cancer. Int J Cancer. 124(9): 2050-2059

2471) Swamy, M.V., Citineni, B., Patlolla, J.M.R., Mohammed, A., Zhang, Y., and Rao, C.V. 2008. Prevention and treatment of pancreatic cancer with curcumin in combination with omega-3 fatty acids. Diet and cancer. 60 (S1): 81-89

2472) Sweeney, C., Freeman, J., Gee, D.L. et al. 1999. Changes in the risk of coronary artery disease among Japanese exchange students. Journal of the American Dietetic Association. 99 (Supplement 1): A77.

2473) Sylvester, P. W. and Ayoub, N. M. 2013. Tocotrienols target PI3K/Akt signaling in breast cancer therapy. Antikrebsmittel Chemical Med. 13(7):1039-47

2474) Syrigos, KN, Rowlinson-Busza, G. and Epenetos, AA 1998. In vitro cytotoxicity following specific activation of amygdalin by monoclonal antibody-conjugated beta-glucosidase associated with bladder cancer. Int J Cancer. 78(6):712-9

2475) Szatmari, T., Ötvös, R., Hjerpe, A. and Dobra, K. 2015. Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation and Prognosis. markers of disease. Article ID 796052, 13 pages,

2476) Szturmowicz, M., Wiatr, E., Sakowicz, A., Slodkowska, J., Roszkowski, K., Filipecki, S. y Rowinska-Zakrzewska, E. R. 1995. The role of human chorionic gonadotropin beta subunitelevation in small - Zellungenkrebspatienten. J Cancer Res Clin Oncol. 121(5): 309-12

2477) Szuster-Ciesielska, A., Plewka, K., Daniluk, J. & Kandefer-Szerszen, M. 2011. Betulin and betulinic acid attenuate ethanol-induced activation of hepatic stellate cells through inhibition of reactive oxygen species (ROS), cytokines (TNF-α, TGF-β) and affecting intracellular signaling. Toxicology. 280(3):152-63

2478) Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., Scott, M. P. and Beachy, P. A. 2000. The effects of oncogenic mutations on smoothing and patching can reverse by cycloamine. Nature 406(6799): 1005-9

2479) Takabe, K., Paugh, S.W., Milstien, S., & Spiegel, S. 2008. Sphingosine-1-phosphate inside-out signaling: therapeutic targets. Pharmacological reviews. 60(2): 181-195

2480) Takada, Y., Bharwaj, A., Potdar, P., & Aggarwal, BB 2004. Nonsteroidal anti-inflammatory drugs differ in their ability to target NF-kappaB activation, cyclooxygenase-2 inhibition, and suppression of cyclin D1 expression, and suppression of tumor cell proliferation. oncogene 23(57):9247-58

2481) Takahashi, K., Newburger, P.E. and Cohen, H.J. 1986. Glutathione peroxide protein. Absence in selenium deficiency states and correlation with enzymatic activity. J Clin. To invest. 77(4):1402-1404

2482) Takahashi, R., Hirata, Y., Sakitani, K., Nakata, W., Kinoshita, H., Hayakawa, H., Sakamoto, K., Hikiba, Y., Ijichi, H., Moses, HL ., Maeda, S. and Koike, K. 2013. Therapeutic effects of c-Jun N-terminal kinase inhibition in pancreatic cancer. Cancer Science 104(3):337-44

2483) Takahashi, S., Uchiyama, T., & Toda, K. 2009. Differential effect of resveratrol on nitric oxide production in f-2 endothelial cells. BiolPharmBull. 32(11): 1840-3

2484) Takeda, K., Stagg, J., Yagita, H., Okumura, K. und Smyth, J. M. 2007. Targeting of death-inducing receptors in cancer therapy. Onkogen. 26: 3745-3757, doi: 10.1038/sj.onc.1210374

2485) Takeoka, G. R., Dao, L., Flessa, S., Gillespie, D. M., Jewell, W. T., Huebner, B., Bertow, D. and Ebeler, S. E. 2001. Effects of processing on lycopene content and activity antioxidant of tomatoes. J Agricultural food chemistry. 49(8):3713-7

2486) Takimoto, R., Wang, W., Dicker, D.T., Ratinejad, F., Lyssikatos, J., and el-Deiry, W.S. 2002. The mutant p53 conformation-modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize the wild-type p53 protein. Cancer Biol. Ther. 1(1): 47-55

2487) Takino, J., Yamagishi, S. & Takeuchi, M. 2010. Cancer malignancy is enhanced by glyceraldehyde-derived advanced glycation endproducts. Oncology Journal. 2010: 739-852, doi: 10.1155/2010/739852

2488) Taldone, T., Sun, W. & Chiosis, G. 2009. Discovery and development of heat shock protein 90 inhibitors. BioorgMed Chem. 17(6): 2225-2235

2489) Tamimi MR, Hankinson ES, Campos H, Spiegelman D, Zhang S, Colditz AG, Willett CW y Hunter JD 2005. Plasma carotenoides, retinol and tocopherols and risk of breast cancer. American Journal of Epidemiology. 161(2): 153-160-

2490) Tan, S.S.L., Khin, L.W., Wong, L., Yan, B., Ong, C.W., Datta, A., Salto-Tellez, M., Lam, Y., and Yap, CT 2014. Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of colon cancer patients using a risk-competitive approach in the South Asian population. Clinical and translational gastroenterology. 5: e51, doi: 10.1038/ctg.2013.21, 11 pages

2491) Tanaka, R., Tomosugi, M., Horinaka, M., Sowa, Y., & Sakai, T. 2015. Metformin causes G1 phase arrest by downregulating MİR-221 and improves the sensitivity of TRAIL by DR5-Up - Regulation in pancreatic cancer cells. Plus one. 10(5): e0125779, doi: 10.1371/journal.pone.0125779, 15 pages

2492) Tang, F. Y., Pai, M. H., Kuo, Y. H., & Wang, X. D. 2012. Concomitant intake of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. Mol Nutr Food Res. 56(10):1520-31

2493) Tang FY, Shih CJ, Cheng LH, Ho HJ, and Chen HJ 2008. Lycopene inhibits human colon cancer cell growth by suppressing Akt signaling. Mol Nutr Food Res. 52(6): 646-54

2494) Tang G, Zhang Z, Qian H, Chen J, Wang Y, Chen X, Chen B, and Chen Y 2015. (-)-Epigallocatechin-3-gallate inhibits osteosarcoma cell invasiveness by inhibiting the signaling pathway MEK/ERK in human osteosarcoma cells. J Environment Pathol Toxicol Oncol. 34(1):85-93

2495) Tang J, Jiang C, Xiao X, Fang Z, Li L, Han L, Mei A, Feng Y, Guo Y, Li H, and Jiang, W. 2015. Changes in red blood cell membrane structure in G -6- PD deficiency: an atomic force microscopy study. Clin Chim Act. 444: 264-70, doi:10.1016/j.cca.2015.02.042

2496) Tang SN, Fu J, Nall D, Rodova M, Shankar S, and Srivastava RK 2012. Inhibition of sonic hedgehog signaling and factors that maintain pluripotency regulate the properties of pancreatic cancer stem cells. Int J Cancer. 131(1): 30-40

2497) Tang, S., Fu, J., Shankar, S., & Srivastava, R. K. 2012. EGCG enhances the therapeutic potential of gemcitabine and CP69055o by inhibiting STAT3 signaling in human pancreatic cancer. Plus one. 7(2): e31067, doi: 10.1371/journal.pone.0031067, 11 pages

2498) Tang X, Zhu Y, Han L, Kim AL, Kopelovich L, Bickers DR, and Athar M 2007. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest. 117(12):3753-64

2499) Tang, Y.J., Xiao, Z.T., Oda, Y., Chang, SK, Shpall, E., Wu, A., So, P., Hebert, J., Bikle, D., and Epstein, Jr. H.E. 2011 Vitamin D3 inhibits hedgehog signaling and proliferation in murine basal cell carcinoma. research for cancer prevention. 4(5): 744-51

2500) Tanya, S., Hinds, G.L., West, W.L. and Knight, E.M. 1997. Carotenoids and retinoids: a review of research, clinical, and public health applications. The Journal of Clinical Pharmacology. 37(7):551-558

2501) Tao, S., Justiniano, R., Zhang, DD & Wondrak, TG 2013. Nrf2 inducers tanshinone 1 and dihydrotanshinone protect human skin cells and reconstructed human skin from sun-stimulated UV rays. redox biology. 1(1): 532-541

2502) Tapiero, H., Nguyen Ba, G., Couvreur, P. and Tew, K.D. 2002. Polyunsaturated Fatty Acids (PUFA) and Eicosanoids in Health and Human Pathologies. Biomedical Pharmacotherapy. 56(5): 215-222.

2503) Tarryn-Lee, F. 2014. The effects of HIV protease inhibitors (lopinavir/ritonavir) on non-oxidative pathways of glucose metabolism. Diploma Thesis (MSc)-University of Stellenbosch, 2014/URI:

2504) Tashiro, E., Yokouchi, Y., Yamamoto, K., and Imoto, M. 2009. Abstract B150: Toyocamycin inhibits ER stress-induced XBP1 mRNA splicing through IRE1α activation. Molecular Cancer Therapeutics. 8 (12 supplements): B150, doi: 10.1158/1135-7163.TARG-09-B150

2505) Tatsuta, K., Misawa, H. and Chikauchi, K. 2001. Biometric total synthesis of quinolactacin B, an inhibitor of TNF production and its analogues. J Antibiot (Tokyo). 54(1): 109-12

2506) Tavani, A., Bertuccio, P., Bosetti, C., Talamini, R., Negri, E., Franceschi, S., Montella, M. and LaVecchia, C. 2005. Dietary calcium, vitamin D intake , phosphorus and the risk of prostate cancer. european urology. 48(1):27-3

2507) Taylor, S. Y., Dixon, H. M., Yoganayagam, S., Price, N. and Lang, D. 2013. Folic acid modulates eNOS activity via effects on post-translational modifications and protein interactions. Eur J Pharmacol. 714(1-3):193-201

2508) Taylor-Harding, B., Agadjanian, H., Nassanian, H., Kwon, S., Guo, X., Miller, C., Karlan, B.Y., Orsulic, S., and Walsh, C.S. 2012. Indole - 3-Carbinol synergistically sensitizes ovarian cancer cells to bortezomide treatment. Br J Cancer. 106(2):333-43

2509) Tayyem R F, Heath D D, Al-Delaimy W K and Rock CL 2006. Curcumin content in turmeric and curry powders. Diet and cancer. 55(2):126-131

2510) Temple, J.N. 1996. Dietary fats and coronary artery disease. biomedicine and pharmacotherapy. 50(6-7): 261-268.

2511) Temple, J.N. 2002. Nutrition and disease: challenges of research design. Nutrition. 18(4): 343-345.

2512) Teng CL, Yu CT, Hwang WL, Tsai JR, Liu HC, Hwang GY, and Hsu SL 2013. Sunitinib-induced G1 cell cycle effector mechanisms arrest differentiation and apoptosis in HL60 and KG human acute myeloid leukemia cells -one. Ann Hematol. 92(3):301-13

2513) Teodorczyk, M. & Schmidt, MHH 2015. Notches in the Cancer Door: Notches Signaling Brain Tumors. Frontiers in oncology. 4: 341, doi: 10.3389/fonc.2014.00341, 14 pages

2514) Teodoro JA, Oliveira LF, Martins BN, Maia de AG, Martucci BR and Borojevic R 2012. Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines. cancer cell int. 12:36, doi: 10.1186/1475-2867-12-36, 9 pages

2515) Teranishi, F., Takahashi, N., Gao, N., Akamo, Y., Takeyama, H., Manabe, T., and Okamoto, T. 2009. The phosphoinositide-3-kinase inhibitor (Wortmannin) inhibits pancreatic motility and migration of cancer cells induced by hyaluronan in vitro and peritoneal metastases in vivo. Cancer Science 100(4): 770-7

2516) Terry, P., Wolk, A., Persson, I., & Magnusson, C. 2001. Brassica and breast cancer risk. NEVER. 285(23): 2975-2977

2517) Tesei, A., Zoli, W., Fabbri, F., Leonetti, C., Rosetti, M., Bolla, M., Amadori, D., and Silvestrini, R. 2008. NCX 4040, a NO donor Derivative of acetylsalicylic acid: efficacy and mechanisms of action in cancer cells. Nitric oxide. 19(2): 225-236

2518) Thakur, V. S., Gupta, K. & Gupta, S. 2012. Green tea polyphenols increase p53 transcriptional activity and acetylation by repressing class I histone deacetylases. International J Oncol. 41(1):353-61

2519) Thangaraju, M., Kaufmann, S.H., and Couch, F.J. 2000. BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines. JBiolChem. 275(43):33487-96

2520) Alpha-Tocopherol-Beta-Carotene Cancer Prevention Study Group. 1994. The effect of vitamin E and beta-carotene on the incidence of lung and other cancers in male smokers. N Eng J Med. 330(15): 1029-1035

2521) The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. 1994. The effect of vitamin E and beta-carotene on the incidence of lung and other cancers in male smokers. The New England Journal of Medicine. 330(15): 1029-1035

2522) Thelen, P., Wuttke, W., & Seidlova-Wuttke, D. 2014. Estrogen receptor beta-selective phytoestrogens exert antiandrogenic effects in castration-resistant prostate cancer. The journal of steroid biochemistry and molecular biology. 139:290-293, doi:10.1016/j.jsbmb.2013.06.009

2523) Theodoratou McNeill Cetnarskyj Farrington Tenesa Barnetson Porteous Dunlop and Campbell 2007. Dietary fatty acids and colorectal cancer: a case-control study. American Journal of Epidemiology. 166(2):181-195.

2524) Theodoratou, E., Farrington, SM, Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, RA, Porteous, ME, Dunlop, MG, & Campbell, H. 2008. Vitamin B6 intake via of diet and the risk of colon cancer. Biomarkers and prevention of cancer epidemiology. 17(1):171-182

2525) Theriault, A., Chao, J. T., & Gapor, A. 2002. Tocotrienol is the most potent vitamin E in reducing endothelial expression of adhesion molecules and adhesion to monocytes. atherosclerosis 160(1): 21-30

2526) Thews, O., Lambert, C., Kelleher, D. K., Biesalski, HK., Vaupel, P. & Frank, J. 2007. Influence of therapeutically induced reactive oxygen species and alpha-tocopherol radical scavengers in tumor cell adhesion. Oncol Rep. 18(4):965-71

2527) Thibeault, D., Gauthier, C., Legault, J., Bouchard, J., Gagne, L., & Pichette, A. 2012. Synthesis and cytotoxicity of lupan-type triterpenoid glyceryl esters: Bioorg Med Chem Lett. 22(14): 4735-4739

2528) Thielemann, L.E., Oberhauser, EW, Rosenblut, G., Videla, L.A. and Valenzuela, A. 1990. Sulfur-containing amino acids that increase renal glutathione protect the kidney from 2-bromoethylamine-induced papillary necrosis. Cellular Biochemistry Function 8(1): 19-24

2529) Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J. und Schoonjans, K. 2008. Targeting of Galician acid signaling for metabolic diseases. Nat Rev Drug Discovery. 7(8): 678-93

2530) Thomas, R. and Kim, M. H. 2005. Epigallocatechin gallate inhibits HIF-1alpha degradation in prostate cancer cells. Biochem Biophys Communal Res. 334(2):543-8

2531) Thorpe, M. L., Yuzugullu, H., and Zhao, J. J. 2015. PI3K in cancer: different roles of isoforms, modes of activation, and therapeutic targeting. Nature informs about cancer. 15:7-24, doi:10.1038/nrc3860

2532) Thummel, KE, Brimer, C, Yasuda, K, Thottassery, J, Senn, T, Lin, Y, İshizuka, H, Kharasch, E, Schütz, J, and Schütz, E. 2001. Transcriptional control of intestinal cytochrome P -450 3A for 1 alpha, 25-dihydroxy vitamin D3. Mol Pharmacol. 60(6):1399-406

2533) Thygesen, L., Thulin, J., Mortensen, A., Skibsted, L. H., & Molgaard, P. 2007. Antioxidant activity of cichoric acid and alkamides from Echinacea purpurea, alone and in combination. Lebensmittelchemie. 101(1): 74-81

2534) Tian F, Wu H, Li Z, Wang N, Huang J, Li C and Xie F 2009. Activated PKCalpha/ERK 1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells. reverse cancer. 27(7):802-808

2535) Tiffon, CE, Adams, JE, van der Fits, L, Townsend, PA, Ganesan, A, Hodges, E, Vermeer, MH, and Packham, G. 2011. Histone deactylase inhibitors vorinostat and romidepsin reduce expression of IL-10 in Cutaneous T-Cell Lymphoma Cells. British Journal of Pharmacology. 162(7): 1590-1602

2536) Tinhofer, I., Bernhard, D., Senfter, M., Anether, G., Löffler, M., Kroemer, G., Kofler, R., Csordas, A., and Greil, R. 2001. Resveratrol, a tumor suppressor compound from grapes, induces apoptosis via a novel Bcl-2-controlled mitochondrial signaling pathway. The FASEB Journal. 15(9):1613-5

2537) Toiyama, Y., Inoue, Y., Hiro, J., Ojima, E., Watanabe, H., Narita, Y., Okigami, M., Hosono, A., Miki, C., and Kusunoki, M 2009. Paclitaxel inhibits radiation-induced VEGF secretion and enhances radiosensitizing effects in HT29 human colon cancer cells. cancer therapy 123-132 (published electronically only).

2538) Tokizane , T. , Shiina , H. , Igawa , M. , Enokida , H. , Urakami , S. , Kawakami , T. , Ogishima , T. , Okino , S. T. , Li , L. C. , Tanaka , Y. , . Nonomura, N., Okuyama, A. and Dahiya, R. 2005. Cytochrome P450 1B1 is overexpressed in prostate cancer and is regulated by hypomethylation. Cancer Clinic Res. 11(16): 5793-801

2539) Tolman, J. R., Lephart, E. D., Setchell, K. D. R., Eggett, D. L., & Christensen, M. J. 2008. Timing of selenium and isoflavone supplementation determines prostate cancer risk factor reduction in rats. nutrition and metabolism. 5(31):1-10

2540) Tominaga, Y., Wang, A., Wang, R. H., Wang, X., Cao, L., & Deng, C. X. 2007. Genistein inhibits Brca1 mutant tumor growth through activation of damage checkpoints in DNA, cell cycle arrest, and mitotic catastrophe. distinguish cell death. 14(3): 472-9

2541) Tommasino, M., Accardi, R., Caldeira, S., Dong, W., Malanchi, I., Smet, A., and Zehbe, I. 2003. The role of TP53 in cervical carcinogenesis. Hum Mutat. 21(3): 307-12

2542) Tongers, J., Fiedler, B., Konig, D., Kempf, T., Klein, G., Heineke, J., Kraft, T., Gambaryan, S., Lohmann, SM, Drexler, H. and Wollert, K. C. 2004. Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiomyocytes. cardiovascular research. 63(3): 545-552

2543) Toppo, S., Flohe, L., Ursini, F., Vanin, S., & Maiorino, M. 2009. Catalytic mechanisms and specificities of glutathione peroxidases from a basic scheme. Biochim Biophys Act. 1790(11):1486-1500

2544) Torkin, R., Lavoie, J., Kaplan, R. D. und Yeger, H. 2005. Induction of caspase-dependent p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 4(1): 1-11

2545) Tornatore , L , Sandomenico , A , Raimondo , D , Low , C , Rocci , A , Tralau-Stewart , C , Capece , D , D'Andrea , D , Bua , M . , Boyle , E. , van Duin , M. , Zoppoli , P. , Jaxa-Chamiec , A. , Thotakura , A.K. , Dyson , J. , Walker , B.A. , Sonneveld , P. , Morgan , G. , Palumbo , A. , Tramontano , A. , Rahemtulla , A. , Ruvo , M. and Franzoso , G. 2014 GADD45β/MKK7- . Krebszelle inhibitors. 26:495–508,

2546) Tornio , A. , Niemi , M. , Neuvonen , M. , Laitila , J. , Kalliokoski , A. , Neuvonen , P.J. . and Backman , J.R. 2008. The effect of gemfibrozyl on repaglinide pharmacokinetics lasts at least 12 hours per dose: Evidence for a mechanism-based inhibition of CYP2C8 in vivo. Clin Pharmacol Ther. 84(3): 403-11

2547) Torozzi, A., Morroni, F., Merlicco, A., Hrelia, S., Angeloni, C., Cantelli-Forti, G., & Hrelia, P. 2009. Sulforaphane as glutathione inducer prevents oxidative stress . Induced cell death in a dopamine-like neuroblastoma cell line. Neurochemistry Journal. 111(5): 1161-1171

2548) Torti, V.S. and Torti, M.F. 2013. Iron and cancer: more to consider. Nat Rev Cancer. 13(5):342-355

2549) Totusek, J., Triska, J., Lefnerova, D., Strohalm, J., Vrchotova, N., Zendulka, O., Pruchova, J., Chaloupkova, J., Novotna, P., and Houska, M 2011. Sulforaphane and Total Isothiocyanate Levels, Antimutagenic Activity, and Inhibition of Clastogenicity in Cruciferous Vegetable Pulp Juices. Czech J Food Sci. 29(5):548-556

2550) Tournier, C. 2013. The 2 faces of JNK signaling in cancer. cancer genes 4(9-10): 397-400

2551) Touvier, M., Kesse, E., Clavel-Chapelon, F., Boutron-Ruault, M. 2005. Dual association of beta-carotene with the risk of tobacco-related cancers in a cohort of French women. J National Cancer Institute 97(18): 1338-44

2552) Trautwein, E. A. 2001. n-3 fatty acids - physiological and technical aspects for their use in foods. European journal of lipid science and technology. 103(1):45-51.

2553) Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, AL, Pronzato, MA, Marinari, U. M. and Domenicotti, C. 2013. Role of glutathione in cancer progression and the chemoresistance. Oxidative medicine and cellular longevity. Vol. 2013. Id. of article 972913, doi:10.1155/2013/972913

2554) Travis , CR , Allen , EN , Appleby , NP , Price , A , Kaaks , R , Chang-Claude , J , Boeing , H , Aleksandrova , K , Tjoneland , A , Johnsen , FN . Overvad , K. , Quiros , R. J. , Gonzales , A. C. , Molina-Montes , E. , Sanchez , J. M. , Larranaga , N. , Castano , H. M. J. , Ardanaz , E. , Khaw , K. , Wareham , N. , Trichopoulou , A , Karapetyan , T , Rafnsson , BS , Palli , D , Krogh , V , Tumino , R , Vineis , P , Mesquita , BH , Stattin , P , Johansson , M , Fedirko , V . , ., Norat , T. , Siddia , A. , Riboli , E. and Key , J.T. Cancer verursacht control. 23(7): 1163-1171

2555) Traxler, P., Allegrini, P.R., Brandt, R., Brueggen, J., Cozens, R., Fabbro, D., Grosios, K., Lane, H.A., McSheehy, P., Mestan, J., Meyer, T., Tang, C., Wartmann, M., Wood, J., and Caravatti, G. 2004. AEE788: a bifamily epidermal growth receptor/ErbB2 and active vascular endothelial growth receptor tyrosine kinase inhibitor. antitumor and antiangiogenic. cancer res 64(14): 4931-41

2556) Trejo-Solis, C., Pedraza-Chaverri, J., Torres-Ramos, M., Jimenez-Farfan, D., Salgado, CA., Serrano-Garcia, N., Osorio-Rico, L., and Satelo, J. 2013. Evidence-Based Complementary and Alternative Medicine. Vol. 2013, 17 pages, Entry ID: 705121;

2557) Tremblay, M.R., Nesler, M., Weatherhead, R., and Castro, A.C. 2009. Recent patents on hedgehog pathway inhibitors for the treatment of malignancies. Expert opinion Ther Pat. 19(8): 1039-56

2558) Trepel, J., Mollapour, M., Giaccone, G. und Neckers, L. 2010. Targeting of the dynamic HSP90 complex in cancer. Naturberichte Krebs. 10(8): 537-549

2559) Trinh, K., Andrews, L., Krause, J., Hanak, T., Lee, D., Gelb, M., & Pollanck, L. 2010. Decaffeinated coffee and non-nicotine tobacco provide neuroprotection in models of Drosophila from Parkinson's disease through a Nrf2-dependent mechanism. The Journal of Neuroscience. 30(16): 5525-5532

2560) Trock, J. B., Hilakivi-Clarke, L., & Clarke, R. 2006. Meta-analysis of soy intake and breast cancer risk. J National Cancer Institute 98(7): 459-471

2561) Troyer, D. and Fernandes, G. 1996. Nutrition and apoptosis. nutrition research. 16(11-12): 1959-1987.

2562) Truscott, T. G. 1996. Beta-carotene and disease: a proposed pro-oxidant mechanism and speculations about its role in smoking. J Photochem Photobiol. 35(3):233-235

2563) Tsai, C.Y., Chen, Y.H., Chien, Y.W., Huang, W.H. and Lin, S. 2010. Effect of soybean saponin on the growth of human colon cancer cells. World J Gastroenterol. 16(27):3371-3376

2564) Tse, A. K., Wan, C. K., Shen, X. L., Yang, M., & Fong, W. F. 2005. Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression by repressing activation from IKK. Biochem Pharmacol. 70(10): 1443-57

2565) Tse, AK, Zhu, GY, Wan, CC, Shen, XL, Yu, ZL & Fong, WF 2010. 1alpha,25-dihydroxyvitamin D3 inhibits the transcriptional potential of nuclear factor kappa β in breast cancer cells. Mol Immunol. 47(9): 1728-38

2566) Tsui, K., Feng, T., Hsieh, W., Chang, P. & Juang, H. 2008. Interleukin-6 expression is down-regulated by 17-(allylamino)-176-desmethoxygeldanamycin in human prostate carcinoma cells. Acta Pharmacologica Sinica. 29(11): 1334-1341

2567) Tsuruga, E., Irie, K. & Yajima, T. 2007. Degradation of fibrillin-2 by matrix metalloproteinase-2 in the periodontium. J Dent Res. 86(4): 352-6

2568) Tunçel, G., Nout, R. J. M. & Brimer, L. 1995. The effects of grinding, soaking and cooking on amygdala breakdown of bitter apricot kernels. Food Chemistry. 53(4): 447-451

2569) Turner, D.N., Braby, L.A., Ford, J., and Lupton, R.J. 2002. Possibilities for dietary radiation amelioration of radiation-induced cell damage. Nutrition. 18(10): 904-912.

2570) Tyagi, S., Sharma, S. and Budhiraja, R.D. 2012. Effect of the ϒ-phosphatidylinositol-3-kinase inhibitor CAY10505 on hypertension and associated vascular endothelial dysfunction in rats. Can J Physiol Pharmacol. 90(7):881-5

2571) US-Landwirtschaftsministerium, Agricultural Research Service..2011. USDA National Nutrient Database for Standard Reference, Version 24. Nutrient Data Laboratory Home Page,

2572) US Department of Agriculture, Agricultural Research Service. 2012. USDA National Nutrient Database for Standard Reference, 25th Edition

2573) US-Landwirtschaftsministerium, Agricultural Research Service. 2011. National Nutrient Database for Standard Reference, Version 24. Nutrient Data Laboratory Home Page,

2574) Uchiyama, T., Otani, H., Okada, T., Ninomiya, H., Kido, M., Imamura, H., Nogi, S., & Kobayashi, Y. 2002. Nitric oxide induces drug dependence Caspase Apoptosis and Necrosis in Newborn Rat Cardiomyocytes. Journal of Molecular and Cellular Cardiology. 34(8): 1049-1061

2575) Udomratn, T., Steinberg, MH, Campbell, G.D. and Oelshlegel, F.J. Jr. 1977. Effects of ascorbic acid on glucose-6-phosphate dehydrogenase deficient erythrocytes: studies in an animal model. Blood. 49(3):471-5

2576) Uehara, Y., Mochizuki, Matsuno, K., Haino, T., and Asai, A. 2009. New high-throughput screening system to identify STAT3-SH2 antagonists. Biochem Biophys Communal Res. 380(3): 627-31

2577) Uemura, M., Manabe, H., Yoshida, N., Fujita, N., Ochiai, J., Matsumoto, N., Takagi, T., Natio, Y. and Yoshikawa, T. 2002. Alpha - Tocopherol prevents vascular endothelial cell apoptosis by a mechanism that goes beyond mere antioxidant activity. Eur J Pharmacol. 456(1-3): 29-37

2578) Ueng , Y.F. , Chen , CC , Yamazaki , H. , Kiyotani , K. , Chang , Y.P. , Lo , W.S. , Li , D.T. and Tsai, P.L. Drugs Metab Pharmacokinet. 28(3): 229-3

2579) Uhlmann, S., Friedrichs, U., Eichler, W., Hoffmann, S. and Wiedemann, P. 2001. Direct measurement of VEGF-induced nitric oxide production by choroidal endothelial cells. Microvasc Res. 62(2):179-89

2580) Uhmann, A., Niemann, H., Lammering, B., Henkel, C., Heβ, I., Rosenberger, A., Dullin, C., Schraepler, A., Schulz-Schaeffer, W., and Hahn , H. 2012. Calcitriol inhibits hedgehog signaling and induces vitamin D receptor signaling and differentiation in the patchy mouse model of embryonal rhabdomyosarcoma. Sarcoma. Vol. 2012, Article ID: 357040, 7 pages

2581) Ujiki , B.M. , Ding , X. , Salabat , R.M. , Bentrem , J.D. , Golkar , L. , Milam , B. , Talamonti , S.M. , Bell Jr. , H.R. , Iwamura , T. and Adrian , E.T. 2006. Apigenin inhibits pancreatic cancer cell proliferation by arresting the G2/M cell cycle. molecular cancer. 5:76, doi: 10.1186/1476-4598-5-76, 8 pages

2582) Ulrich-Merzenich, G., Zeeitler, H., Panek, D., Bokemeyer, D., & Vetter, H. 2007. Vitamin C promotes human endothelial cell growth through the ERK signaling pathway. Eur J Nutr. 46(2):87-94

2583) Umikalsom, Y. and Harborne, J. B. 1991. Distribution of flavonoids in asplenioid ferns. pertanika. 14(3): 297-300

2584) Ungvari, Z., Bagi, Z., Feher, A., Recchia, FA, Sunday, W.E., Pearson, K., de Cabo, R., and Csiszar, A. 2010. Resveratrol confers endothelial protection by activating the antioxidant transcription factor Nrf2. I am J Physiol Heart Circ Physiol. 299(1): H18-24

2585) Urs, S., Turner, B., Tang, Y., Rostama, B., Small, D., & Liaw, L. 2012. Effect of soluble Jagged1-mediated inhibition of Notch signaling on proliferation and differentiation of an adipocyte progenitor cell model. adipocytes. 1(1): 46-57

2586) USDA. United States Department of Agriculture. Agricultural Research Service: Nutritional Nutrients Database for Standard Reference Version 28, Software v., National Agricultural Library.

2587) Uslu, R., Sanli, UA, Dikmen, Y., Karabulut, B., Ozsaran, A., Sezgin, C., Muezzinoglu, GG, Omay, SB, & Goker, E. 2005. Predictive value of interleukin serum -8 Values ​​in ovarian cancer patients treated with paclitaxel-containing regimens. Int J Gynecologic cancer. 15(2):240-5

2588) Vadlapatla RK, Vadlapudi AD, Pal D, Mukherji M, and Mitra AK 2014. Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelium cells in vitro. Eye. 28(1): 93-101

2589) Valdameri , G. , Trombetta-Lima , M. , Worfel , R.P. , Pires , AR , Martinez , R.G. , Noleto , R.G. , Chain , C.S.M.S. , Sogayar , C.M. , Winnischofer , B.M.S. , Rocha , M.E. . 2011. Engagement of catalase in the apigenin-induced apoptotic mechanism in human hepatoma HepG2 cells. Chemical-biological interactions. 193(2): 180-189

2590) Valis, K., Prochazka, L., Boura, E., Chladova, J., Obsil, T., Rohlena, J., Truksa, J., Dong, L.F., Ralph, S.J. and Neuzil, J. 2011 Hippo/Mst1 stimulates transcription of the pro-apoptotic mediator NOXA in a FoxO1-dependent manner. Cancer Res 71(3): 946-54

2591) Valkama, E., Salminen, J., Koricheva, J. and Pihlaja, K. 2004. Changes in leaf trichomes and epicuticular flavonoids during leaf development in three birch taxa. Anna Bot.94(2):233-242

2592) Valko, M., Izakovic, M., Mazur, M., Rhodes, C.J. and Telser, J. 2004. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 266(1-2): 37-56

2593) Van Aller GS, Carson JD, Tang W, Peng H, Zhao L, Copeland RA, Tummino PJ and Luo L 2011. Epigallocatechin gallate (EGCG), a major component of green tea, is a phosphoinositide-3-kinase dual/ mTOR inhibitor. Biochem Biophys Nothing Common. 406(2):194-9

2594) van den Berg, J.H., Beijnen, J.H., Balm, A.J.M. and Schellens, J.H.M. 2006. Future ways to prevent cisplatin-induced ototoxicity. Reviews of cancer treatments. 32(5): 390-397

2595) Van den Brandt, P.A., Goldbohm, RA, van't Veer, P., Bode, P., Dorant, E., Hermus, R.J.J. and Sturmans, F. 1993. A prospective cohort study on selenium status and lung cancer risk. Cancer research. 53(20):4860-4865

2596) Van den Brandt, P.A., Zeegers, M.P.A., Bode, P., and Goldbohm, RA. 2003. Selenium levels in toenails and subsequent risk of prostate cancer. A prospective study. Biomarkers and prevention of cancer epidemiology. 12(9):866-871

2597) Van den Donk, M., Visker, M. H. P. W., Harryvan, J. L., Kok, F. J., & Kampman, E. 2007. Dietary intake of B vitamins, thymidylate synthase and serine hydroxymethyltransferase 1 polymorphisms, and risk of colorectal adenoma: a Dutchman Cases and controls study. cancer letters 250(1): 146-153

2598) van der Heijden, J.W., Oerlemans, R., Lems, WF., Scheper, R.J., Dijkmans, BA y Jansen, G. 2009 Células de pacientes con arthritis rheumatoid. Clin Exp Rheumatol. 27(1):92-8

2599) Van Dross, R. T., Hong, X. und Pelling, J. C. 2005. Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in keratinocytes humans. Mol Carcinog. 44(2): 83-91

2600) Van Erp, N.P., Eechoute, K., van der Veldt, A.A., Haanen, J.B., Reyners, A.K.L., Mathijssen, R.H.J., Boven, E., van der Straaten, T., Baak-Pablo, R.F., Wessels, J.A.M., Guchelaar, H. and Gelderblom, H. 2010. Pharmacogenetic pathway analysis to determine sunitinib-induced toxicity. Journal of Clinical Oncology. 27(26): 4406-12

2601) Van Heijst, J.W., Niessen, HW, Hoekman, K. and Schalkwijk, C.G. 2005. Advanced glycation endproducts in human cancer tissues: detection of nepsilon-(carboxymethyl)lysine and argpyrimidine. Ann NY Acad. science 1043(1): 725-33

2602) Van Horssen, R., ten Hagen, T. L. M., & Eggermont, A. M. M. 2006. TNF-α in cancer treatment: molecular insights, antitumor effects, and clinical utility. The oncologist. 11(4):397-408

2603) Van Poppel, G., Verhoeven, D.T., Verhagen, H. & Goldbohm, RA 1999. Brassica Vegetables and Cancer Prevention. Epidemiology and Mechanisms. Adv Exp Med Biol. 472: 159-68, doi: 10.1016/j.nutres.2008.03.007

2604) Van Tine BA, Crowder RJ, and Ellis MJ 2011. ER and PI3K independently modulate endocrine resistance in ER-positive breast cancer. Discovery of cancer. 1(4): 287-8

2605) Van, Hauwenhuyse, F., Fiori, A., & Van Dijck, P. 2014. Ascorbic acid inhibition of Hsp90-mediated Candida albicans morphogenesis occurs via the transcriptional regulator Upc2. eukaryotic cell. 13(10): 1278-89

2606) Vanaja, D.K., Mitchell, S.H., Toft, D.O. and Young, CYF 2002. Effect of geldanamycin on androgen receptor stability and function. cellular stress chaperones. 7(1): 55-64

2607) Vanamala, J., Radhakrishnan, S., Reddivari, L., Bhat, V., & Ptitsyn, A. 2011. Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis by targeting the pathway of FAK signaling from pentose phosphate and talin -A proteomic approach. proteome science. 9:49, doi: 10.1186/1477,5656-9-49, 11 pages

2608) Vander Griend, D.J., Antony, L., Dalrymple, S.L., Xu, Y., Christensen, S.B., Denmeade, S.R. and Isaacs, J.T. 2009 of prostate cancer cells. Mol Cancer Ther. 8(5): 1340-9

2609) Vanderslice, J.T. and Higgs, D. J. 1991. Vitamin C content of foods: sample variability. Bin J Clin Nutr. 54 (6 supplements): 13235-13275

2610) Vasaitis TS, Bruno RD and Njar VC O 2011. CYP17 inhibitors for the therapy of prostate cancer. J Steroid Biochem Mol Biol. 125(1-2): 23-3

2611) Vasamsetti SB, Karnewar S, Kanugula AK, Thatipalli AR, Kumar JM, and Kotamraju S 2015. Metformin inhibits monocyte-to-macrophage differentiation through AMPK-mediated inhibition of STAT3 activation: possible role in atherosclerosis. Diabetes. 64(6):2028-41

2612) Vasilevskaya IA, Selvakumaran M, Hierro LC, Goldstein SR, Winkler JD, and O'Dwyer PJ 2015. JNK inhibition sensitizes hypoxic colon cancer cells to DNA-damaging agents. Cancer Clinic Res. 21(18): 4143-52

2613) Vasilijevic, A., Buzadic, B., Korac, A., Petrovic, V., Jankovic, A., & Korac, B. 2007. Beneficial effects of the L-arginine nitric oxide-producing pathway in rats treated with alloxane . J Physiol. 584(pt3): 921-933

2614) Vattem, D. A., Ghaedian, R., & Shetty, K. 2005. Enhancing the health benefits of berries by fortifying them with phenolic antioxidants: a blueberry focus. Asia Pacific J Clin Nutr. 14(2):120-30

2615) Vazques, A., Bond, E.E., Levine.A. J. and Bond, GL 2008. The genetics of p53 signaling, apoptosis, and cancer therapy. Nat Rev Drug Discovery. 7(12):979-987

2616) Veitch, N. C. & Grayer, R. J. 2008. Flavonoids and their glycosides, including anthocyanins. Natural product reviews. 25(3): 555-611

2617) Venier, A.N., Colquhoun, J.A., Fleshner, E.N., Klotz, HL, & Venkateswaran, V. 2012. Lycopene enhances the antiproliferative and proapoptotic effects of capsaicin in prostate cancer in vitro. Journal of Cancer Therapeutics Research. 1:30, 9 pages

2618) Ventura, J.J., Hubner, A., Zhang, C., Flavell, RA, Shokat, KM, and Davis, R.J. 2006. Chemical-genetic analysis of the time course of signal transduction by JNK. Mole cell. 21(5): 701-10

2619) Verhoeven, DTH, Assen, N., Goldbohm, RA, Dorant, E., van't Veer, P., Sturmans, F., Hermus, R.J.J. and van den Brandt, P.A. 1997. Vitamins C and E, retinol, beta-carotene, and dietary fiber in relation to breast cancer risk: a prospective cohort study. British journal of cancer. 75(1): 149-155

2620) Veronesi, U. and Decensi, A. 2001. Retinoids for the prevention of ovarian cancer: laboratory data form the basis for well-designed clinical trials. J National Cancer Institute 93(7): 486-488

2621) Veronesi, U., De Palo, G., Marubini, E., Costa, A., Formelli, F., Mariani, L., Decensi, A., Camerini, T., Del Turco, M.R., Di Mauro , M.G., Muraca, M.G., Del Vecchio, M., Pinto, C., D'Aiuto, G., Boni, C., Campa, T., Magni, A., Miceli, R., Perloff, M., Malone, WF and Sporn, MP 1999. Randomized trial of fenretinide for the prevention of second breast malignancy in women with early breast cancer. J National Cancer Institute 91(21): 1847-56

2622) Veronesi , U. , Maisonneuve , P. , Rotmensz , N. , Costa , A. , Sacchini , V. , Travaglini , R. , D'Aiuto , G. , Lovison , F. , Gucciardo , G. , Muraca , M. G. , Pizzichetta , M. A. , Conforti , S. , Decency , A. , Robertson , C. , Boyle , P. ; South-Group Italian. J National Cancer Institute. 95(2): 160-5

2623) Verrax, J. and Calderon, Y.B. 2008. The Controversial Place of Vitamin C in Cancer Treatment. Biochemical Pharmacology. 76(12):1644-1652

2624) Villa, B., Calabresi, L., Chiesa, G., Rise, P., Galli, C. and Sirtori, C.R. 2002. Omega-3 fatty acid ethyl esters increase heart rate variability in patients with coronary artery disease. Pharmaceutical Research. 45(6): 475-478.

2625) Villasante, A., Piazzolla, D., Li, H., Gomez-Lopez, G., Djabali, M., and Serrano, M. 2011. Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. cellular cycle. 10(9): 1488-1498

2626) Villeneuve, J.P., Johnson, C.K., Kreiger, N., Mao, Y., and the Canadian Cancer Registries Epidemiology Research Group. Causes and control of cancer. 10(5): 355-367

2627) Vimala K, Sundarraj S, Sujitha MV and Kannan S 2002. Reduction of E2F3 overexpression in breast cancer by siRNA (E2F3)-based gene silencing. Medical Research Archives. 43(6): 415-422

2628) Vin H , Ojeda SS , Ching G , Leung LM , Chitsazzadeh V , Dwyer WD , Adelmann HC , Restrepo M , Richards NK , Stewart RL , Du L . , Ferguson , BS , Chakravarti , D , Ehrenreiter , K , Baccarini , M , Ruggieri , R , Curry , LJ , Kim , BK , Ciurea , MA , Duvic , M , Prieto , GV , Ullrich , ES , Dalby , NK , Flowers , R.E. , and Tsai , Y.K. 2013 BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. human biology and medicine. 2:e00969, doi:10.7554/eLife.00969, 25 pages.

2629) Viña, A. and Murillo, E. 2003. Consumption of essential oils from twelve cultivars of basil (Ocimum spp.) cultivated in Colombia. Magazine of the Brazilian Society of Chemistry. 14(5):744-749

2630) Vineis, P. and Pirastu, R. 1997. Aromatic amines and cancer. Causes and control of cancer. 8(3): 346-355

2631) Virtamo , J. , Valkeila , E. , Alfthan , G. , Punsar , S. , Huttunen , J.K. and Karvonen, M.J. (1999). 1987. Serum selenium and risk of cancer. A nine-year prospective follow-up. Cancer. 60(2):145-148

2632) Vitrac, X., Bornet, A., Vanderlinde, R., Valls, J., Richard, T., Delaunay, J., Merillon, J. and Teissedre, P. 2005. Determination of stilbenes (δ-viniferine , trans-astringin, trans-piceid, cis- and trans-resveratrol, E-viniferin) in Brazilian wines. J Agricultural food chemistry. 53(14): 5664-5669

2633) Vivanco, I. and Sawyers, C. L. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2(7): 489-501

2634) Vleugel MM, Greijer AE, Bos R, van der Wall E and van Diest PJ 2006. Activation of c-Jun is associated with proliferation and angiogenesis in invasive breast cancer. Hum Patol. 37(6): 668-74

2635) Vogelstein, B., Sur, S. & Prives, C. 2010. P53: The most frequently altered gene in human cancers. nature education. 3(9): 6

2636) Vogen, S., Gidalevits, T., Biswas, C., Simen, B. B., Stein, E., Gulmen, F., and Argan, Y. 2002. Radicicol-responsive peptide binding to the N-terminal portion of GRP94 . JBiolChem. 277(43): 40742-50

2637) Vojislav, V., Trudey, N. and Hedley, D. W. 2001. Differential effect of buthionine sulfoximine on hypoxic and non-hypoxic regions of human cervical carcinoma xenografts. radiotherapy and oncology. 60(1):69-73

2638) Volk A, Li J, Xin J, You D, Zhang J, Liu X, Xiao Y, Breslin P, Li Z, Wei W., Schmidt R, Li X, Zhang Z, Kuo CP, Nand S, Zhang J , Chen J and Zhang J 2014. Co-inhibition of NF-kB and JNK is synergistic in TNF-expressing human AML. J Exp. Med. 211(6): 1093-1108

2639) Voloshanenko O, Erdmann G, Dubash D T, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B. , Demir, K, Boehm, C, Leible, S, Ball, RC, Glimm , H, Spang, R, and Boutros, M. 2013. Wnt secretion is required to maintain high levels of Wnt maintenance activity in colon cancer cells. nature communication. 4:2610, doi:10.1038/ncooms3610, 13 pages.

2640) Von Essen, R. M., Kongsbak, M., Schjerling, P., Olgaard, K., Odum, N., & Geisler, C. 2010. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. immunology of nature. 11:344-349, doi:10.1038/ni.1851

2641) Von Hoff, D.D., LoRusso, P.M., Rudin, C.M., Reddy, J.C., Yauch, R.L., Tibes, R., Weiss, G.J., Borad, M.J., Hann, C.L., Brahmer, J.R., Mackey, H.M., Lum, B. L., Darbonne, W. C., Marsters, J. C., de Sauvage, F. J. und Low, J. A. 2009. Inhibition of the Hedgehog pathway in advanced basal cell carcinoma. no english J Med. 361(12): 1164-72

2642) Voorrips, L.E., Goldbohm, RA, Brants, H.A.M., van Poppel, GA F.C., Sturmans, F., Hermus, R.J.J. and van den Brandt, P.A. 2000. A Prospective Cohort Study of Antioxidant and Folic Acid Intake and Lung Cancer Risk in Men Biomarkers of the Cancer Epidemic Prev. 9(4):357-365

2643) Voronkov, A. and Krauss, S. 2012. Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des. 19(4): 634-664

2644) Vrhovsek, U., Guella, G., Gasperotti, M., Pojer, E., Zancato, M. and Mattivi, F. 2012. Clarifying the identity of the main ellagitannins in the fruit of the strawberry, Fragaria vesca and Fragaria ananasca du. J Agricultural food chemistry. 60(10): 2507-2516

2645) Vrieling, A., Hein, R., Abbas, S., Schneeweiss, A., Flesch-Janys, D., & Chang-Claude, J. 2011. Serum 25-hydroxyvitamin D and postmenopausal Breast Cancer Survival: a prospect patient cohort study. breast cancer research. 13(4):R74-R83

2646) Vucenik, I. and Shamsuddin, A.M. 2006. Protection against cancer by dietary IP6 and inositol. Walnut cancer. 55(2):109-25

2647) Wagner, A.E., Ernst, I., Iori, R., Desel, C. & Rimbach, G. 2010. Sulforaphane but not ascorbigen, indoli-3-carbinol and ascorbic acid activate the Nrf2 transcription factor and induce phase 2 and antioxidant enzymes in cultured human keratinocytes. Exp. Dermatol. 19(2):137-44

2648) Wagner, FE and Nebreda, RA 2009. Integration of signaling via JNK and p38 MAPK pathways in cancer development. Nature informs about cancer. 9:537-549. DOI: 10.1038/nrc2694

2649) Wagner, K. R., Hua, Y., de Courten-Myers, G. M., Broderick, J. P., Nishimura, R. N., Lu, S. Y. y Dwyer, B. E. 2000. Tin-mesoporphyrin, a potent heme oxigenase inhibitor for treatment of intracerebral hemorrhage: Estudios in vivo e in vitro. Zelle Mol Biol. 46(3): 597-608

2650) Wagner, M., Bohm-Audorff, U., Hegewald, J., Fishta, A., Schlattmann, P., Schmitt, J., and Seidler, A. 2014. Occupational exposure to polycycloaromatic hydrocarbons and risk of lung cancer. larynx: a systematic review and meta-analysis. Occupy Environment Med. 72(3):226-33

2651) Wahba, Z.Z., Coogan, TP, Rhodes, SW and Waalkes, MP 1993. Prospective effects of selenium on cadmium toxicity in rats: role of altered toxicokinetics and metallothionein. Journal of Toxicology and Environmental Health. 38(2):171-182

2652) Wahlqvist, M.L. 1998. Dietary pathways for coronary artery disease. atherosclerosis 136 (Supplement 1): 528.

2653) Waldecker, M., Kautenburger, T., Daumann, H., Busch, C. & Schrenk, D. 2008. Inhibition of histone deacetylase activity by colonically formed short-chain fatty acids and some polyphenol metabolites . J Nutr Biochem. 19(9):587-93

2654) Waldner, M. J., Foersch, S., & Neurath, M. F. 2012. Interleukin-6: a key regulator of colorectal cancer development. in t. J. Biol. Science 8(9): 1248-1253

2655) Walker, H.E., Pacold, EM, Perisic, O., Stephens, L., Hawkins, TP, Wymann, P.M. and Williams, L.R. 2000. Structural determinants of phosphoinositide-3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. molecular cell. 6(4): 909-919

2656) Walker, T., Mitchell, C., Park, MA, Yacoub, A., Rahmani, M., Haussinger, D., Reinehr, R., Voelkel-Johnson, C., Fisher, PB, Grant, S and Dent, P. 2010. 17AAG and MEK1/2 inhibitors kill GI tumor cells through GRP78/BİP-dependent suppression and induction of ceramide and ROS. Mol Cancer Ther. 9(5): 1378-1395

2657) Wallin, J.J., Edgar, AK, Guan, J., Berry, M., Prior, W.W., Lee, L., Lesnick, D.J., Lewis, C., Nonomiya, J., Pang, J., Salphati, L, Olivero, GA, Sutherlin, PD, O'Brien, C, Spoerke, MJ, Patel, S, Lensun, L, Kasees, R, Ross, L, Lackner, RM, Sampath, D., Belvin, M., and Friedman, S. L. 2011. GDC-0980 is a novel class 1 PI3K/mTOR kinase inhibitor with robust activity in PI3K pathway-driven cancer models. Mol Cancer Ther. 10(12):2426-36

2658) Waltering, K. K., Urbanucci, A. & Visakorpi, T. 2012. Androgen receptor (AR) aberrations in castration-resistant prostate cancer. Mol Cell Endocrinol. 360(1-2): 38-43

2659) Wan, J., Liu, T., Mei, L., Li, J., Gong, K., Yu, C., and Li, W. 2013. The synergistic antitumor activity of sorafenib in combination with tetrandrine is mediated via reactive oxygen species (ROS)/Akt signaling. British journal of cancer. 109:342-350, doi:10.1038/bjc.2013.334

2660) Wang B, Chen L, Ni Z, Dai X, Qin L, Wu Y, Li X, Xu L, Lian J, and He F 2014. Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-) gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells. Exp. cell res. 328(2): 379-87

2661) Wang B, Ni Z, Dai X, Qin L, Li X, Xu L, Lian J and He F 2014. The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells. mole cancer. 13:98, doi: 10.1186/1476-4598-13-98, 11 pages

2662) Wang, CJ, Guo, DK, You, TG, Shen, DW, Wang, C, Tang, L, Wang, J, Xu, RH, and Zhang, H. 2014. Inhibition of hepatocellular carcinoma by fulvestrant, the receptor for α estrogen and Wnt pathways in vitro and in patients. Mol Med Rep. 10(6):3125-31

2663) Wang CT, Chang HH, Hsiao CH, Lee MJ, Ku HC, Hu YJ, and Kao YH 2009. The effects of green tea (-)-epigallocatechin-3-gallate pn-reactive oxygen species on 3T3-L1 preadipocytes and adipocytes are dependent on the 67 kDa glutathione and laminin receptor pathways. Mol Nutr Food Res. 53(3):349-60

2664) Wang G, Wang JJ, Chen LX, Du MS, Li SD, Pei JZ, Lan H and Wu BL 2013. Mitochondrial and JAK2/STAT3 pathways are essential for quercetin nanoliposome-induced C6 glioma cell death. cell death and disease. 4: e746, doi: 10.1038/cddis. 2013.242, 12 pages

2665) Wang, G., Wang, X., Yu, H., Wei, S., Williams, N., Holmes, L.D., Halfmann, R., Naidoo, J., Wang, L., Li, L. , Chen, S., Harran, P., Lei, X., & Wang, X. 2013. Activation of the TRAIL small molecule DR5 receptor in human cancer cells. natural chemical biology. 9:84-89, doi:10.1038/nchembio.1153

2666) Wang, H. and Wang, W. 2013. Relationship between CYP1A1 polymorphisms and breast cancer invasion and metastasis. Asian Pacific Journal of Tropical Medicine. 6(1)): 835-838

2667) Wang, H., Helliwell, K. and You, X. 2000. Isocratic elution system for the determination of catechins, caffeine and gallic acid in green tea using HPLC. Food Chemistry. 68(1): 115-121

2668) Wang H, Jia X, Sui C, Zhao Y, Mei Y, Zheng Y, and Zhang Z 2014. Effects of thapsigargin on human rheumatoid arthritis synovial cell proliferation and survival. The Magazine of the Scientific World. Entry ID 605416, vol. 2014, ppp: 7 pages

2669) Wang, H., Liu, T., Li, L., Wang, Q., Yu, C., Liu, X., & Wenhua, L. 2015. Tetrandrine is a potent agonist of cellular autophagy through of the activated intracellular reactive oxygen Species. Cellular and life sciences. 5:4, doi: 10.1186/2045-3701-5-4, 9 pages

2670) Wang, H., Provan, G. J. and Helliwell, K. 2004. Determination of rosmarinic acid and caffeic acid in aromatic herbs by HPLC. Food Chemistry. 87(2): 307-311

2671) Wang, H., Zhang, Z., Wei, X., and Dai, R. 2015. The small molecule inhibitor of Bcl-2 (TW-37) suppresses growth and ameliorates cisplatin-induced apoptosis in cells of ovarian cancer. Ovarian Research Journal. 8: 3, doi: 10.1186/s13048-015-0130-x, 8 pages

2672) Wang, J. and Yi, J. 2008. Killing of cancer cells by ROS: increase or decrease, that is the question here. Cancer Biol. Ther. 7(12): 1875-84

2673) Wang, J., Yin, Y., Hua, H., Li, M., Luo, T., Xu, L., Wang, R., Liu, D., Zhang, Y., and Jiang, Y. 2009. GRP78 blockade sensitizes breast cancer cells to microtubule disrupting agents that induce the displayed protein response. J Cell Mol Med. 13(9B): 3888-3897

2674) Wang, K., Ma, Q., Ren, Y., He, J., Zhang, Y., Zhang, Y., & Chen, W. 2006. Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt catenin /β signaling in HER2-overexpressing human breast cancer cells. oncology reports. 17(1):89-96

2675) Wang LJ, Han SX, Bai E, Zhou X, Li M, Jing GH, Zhao J, Yang AG, and Zhu Q 2013. Dose-dependent effect of tamoxifen on tamoxifen-resistant breast cancer cells through the stimulation by ERK 1/2 and AKT signaling pathways. Oncol Rep. 29(4):1563-9

2676) Wang L, Lee I, Zhang SM, Blumberg JB, Buring JE, and Sesso HD 2009. Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and cancer risk in middle-aged and elderly women. Bin J Clin Nutr. 89(3):905-12

2677) Wang, M. W., Wei, S., Faccio, R., Takeshita, S., Thebes, P., Powderly, W. G., Teitelbaum, S. L., and Ross, F. P. 2004. HIV protease inhibitor ritonavir blocks osteoclastogenesis and function through RANKL-induced signaling impairment. J Clin Invest. 114(2): 206-13

2678) Wang, M., Simon, J.E., Aviles, I.F., He, K., Zheng, Q.Y. and Tadmor, Y. 2003. Analysis of antioxidant phenolic compounds in artichoke (Cynara scolymus L.). J Agricultural food chemistry. 51(3):601-8

2679) Wang Q, He Y, Shen Y, Zhang Q, Chen D, Zuo C, Qin J, Wang J, and Yu Y 2014. Vitamin D inhibits COX-2 expression and inflammatory response by targeting member 4 of the thioesterase superfamily. J Biol Chem. 289(17):11681-94

2680) Wang S, Avery JE, Hannafon BN, Lind SE, and Ding WQ 2013. Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: involvement of the Wnt signaling pathway /β-catenin. Biochem Pharmacol. 85(11): 1611-8

2681) Wang, S., Liu, L., Wang, L., Hu, Y., Zhang, W., & Liu, R. 2012. Structural characterization and identification of major components in Jitai tablets by high performance liquid chromatography / Diode array detection coupled to electrospray ionization tandem mass spectrometry. molecules. 17: 10470-10493, doi: 10.3390/molecules170910470

2682) Wang, T.T.Y., Hudson, T.S., Wang, T., Remsberg, CM, Davies, N.M., Takahashi, Y., Kim, Y.S., Seifried, H., Vinyard, BT, Perkins, SN & Hursting, SD 2008 Effects differentials of resveratrol in LNCaP-sensitive human prostate cancer cells in vitro and in vivo. carcinogenesis. 29(10): 2001-2010

2683) Wang, T.T.Y., Sathyamoorthy, N. and Phang, J.M. 1995. Molecular effects of genistein on estrogen receptor-mediated pathways. carcinogenesis. 17(2): 271-275

2684) Wang, T., Hsu, S., Feng, H., & Huang, R. S. 2012. Folate deprivation enhances human colon cancer cell invasiveness mediated by activation of hedgehog sonic signaling via promoter hypomethylation and cross-action with the central transcription factor. kappa B -Route. carcinogenesis. 33(6): 1158-1168

2685) Wang, T., Lu, S., Xia, Q., Fang, Z., & Johnson, S. 2015. Separation and purification of amygdalin from diluted boyberry seeds using macroporous adsorption resins. Journal of Chromatography B. 975: 52-58,

2686) Wang, W. and Higuchi, C. M. 1995. Induction of NAD(P)H:chinin reductase by vitamins A, E and C in Colo205-Darmkrebszellen. Krebs Brief. 98(1):63-69

2687) Wang, W.H., Abreu-Delgado, Y., and Young, CY 2003. Effects of vitamin C on androgen receptor-mediated effects in the human prostate adenocarcinoma cell line LAPC-4. Urology. 62(1):167-171

2688) Wang X F, Xie Y, Wang H G, Zhang Y, Duan X C, and Lu Z J 2010. Α-Tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cells via the NF-kB pathway. Acta Pharmacol Sin. 31(12): 1604-10

2689) Wang, X. M., Wu, TX, Lee, Y. S., and Dionne, R. A. 2006. Rofecoxib regulates the expression of genes associated with matrix metalloproteinase signaling in humans: implications for side effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 79(4): 303-15

2690) Wang, X. Y., Wang, Y., & Liu, H. C. 2011. Tamoxifen reduces the MMP-9/TIMP-1 ratio and inhibits the invasiveness of ER-positive non-small cell lung cancer cells. Biomedical Pharmacist. 65(7):525-8

2691) Wang, X., Chai, H., Lin, PH, Yao, Q., and Chen, C. 2009. Functions and mechanisms of the human immunodeficiency virus protease inhibitor Ritonavir and other anti-HIV drugs. Human Immunodeficiency in Porcine Pulmonary Artery Endothelial Dysfunction and Human Pulmonary Artery Endothelial Cells. The American Journal of Pathology. 174(3):771-781

2692) Wang, X., Inzunza, H., Chang, H., Qi, Z., Hu, B., Malone, D., & Cogswell, J. 2013. Mutations in the SMO and PTCH1 genes of the Hedgehog pathway in Human Gastric Tumor. More eins. 8(1): e54415, doi: 10.1371/journal.pone.0054415, 8 Seiten

2693) Wang, X., Ju, W., Renouard, J., Aden, J., Belinsky, S.A. and Lin, Y. 2006. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer-cell death by blocking nuclear factor-kB signaling. Cancer Res 66(2): 1089-1095

2694) Wang, X., Li, G., Wang, A., Zhang, Z., Merchan, J. R., & Halmos, B. 2013. Combined inhibition of histone deacetylase and cyclooxygenase achieves enhanced antiangiogenic effects in lung cancer cells . carcinogenic mole 52(3): 218-228

2695) Wang, X., Mu, H., Chai, H., Liao, D., Yao, Q., and Chen, C. 2007. Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from foam cells derived from human macrophages. I'm J Pathol. 171(1):304-314

2696) Wang, X., Wang, Y., & Gao, W. 2015. Honokiol has potential anti-inflammatory effects on rheumatoid arthritis, and GM-CSF may be a target for its treatment. international J. Clin. Exp. Pathol. 8(7): 7929-7936

2697) Wang, X., Zhang, L., O'Neill, A., Bahamon, B., Alsop, D.C., Mier, J.W., Goldberg, S.N., Signoretti, S., Atkins, M.B., Wood, C.G. and Bhatt , R. S. 2013. Cox-2 inhibition enhances sunitinib activity in human renal cell carcinoma xenografts. Br J Cancer. 108(2):319-26

2698) Wang, Y., Gao, J., Zhang, D., Zhang, J., Ma, J., and Jiang, H. 2010. New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis . J Hepatol. 53(1):132-44

2699) Wang Y, Huang G, Vogel P, Neale G, Reizis B and Chi H 2012. Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in dendritic cell survival promotes dendritic cell survival. immune function and homeostasis. PNAS. 109(6): E343-E352

2700) Wang Y, Jacobs JE, Newton CC, and McCullough LM 2016. Lycopene, tomato products, and prostate cancer-specific mortality in men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II dietary cohort. International Journal of Cancer. 138(12): 2846-2855

2701) Wang, Y., Zhou, Y., & Graves, D. T. 2014. FOXO transcription factors: Their clinical significance and regulation. International BioMed Research. Vol. 2014, article ID 925350, doi: 1555/2014/925350, 13 pages

2702) Wang, Z. and Sun, Y. 2010. Targeting p53 for a new cancer therapy. Translationale Onkologie. 3(1): 1-12

2703) Wang ZM, Gao W, Wang H, Zhao D, Nie ZL, Shi JQ, Zhao S, Lu X, Wang LS and Yang ZJ 2014. Green tea The polyphenol epigallocatechin-3-gallate inhibits TNF-induced monocyte production -α chemoattractant protein-1 in human umbilical vein endothelial cells. cell physiology biochemistry 33(5):1349-58

2704) Wang, Z., Ahmad, A., Li, Y., Azmi, A. S., Miele, L. und Sarkar, F. H. 2011. Notch targeting to kill pancreatic cancer cells for cancer therapy. Krebsforschung. 31(4): 1105-1113

2705) Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang de P, Guan XY, and Chen JP 2012. Dioscin induces cancer cell apoptosis through increased oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biol. Ther. 13(3):138-47

2706) Wang, Z., Jiang, C. und Lü, J. 2002. Induction of caspase-mediated apoptosis and G1 arrest of the cell cycle by the selenium metabolite methyselenol. Mol Carcinog. 34(3): 113-20

2707) Wang, Z., Li, W., Meng, X., & Jia, B. 2012. Resveratrol induces apoptosis of gastric cancer cells via reactive oxygen species but independently of sirtuin 1. Clin Exp Pharmacol Physiol. 39(3):227-32

2708) Ward, Q. W. and Singh, A. 2005. Omega-3/6 fatty acids: alternative sources of production. biochemistry of the process. 40(12):3631.

2709) Wardell, S.E., Burnstein, KL., Defranco, D., Fuller, P.J., Giguere, V., Hochberg, R.B., McKay, L., Renoir, J.M., Weigel, N.L., Wilson, EM., McDonnell, D.P. , and Cidlowski, J.A. 2006. The pharmacology and classification of the nuclear receptor superfamily; Glucocorticoid, mineralocorticoid, progesterone, and estrogen receptors. Pharmacol Rev. 58(4): 782-97

2710) Ware, R. W. Jr. and King, S. B. 2000. P-nitrophosphate compounds: new N-O-heterodienophiles and nitroxyl delivery agents. J.Org. Chem. 65(25): 8725-8729

2711) Waris, G. and Ahsan, H. 2006. Reactive oxygen species: role in the development of cancer4 and various chronic diseases. Journal of Carcinogenesis. 5(1):14

2712) Watabe, M., Machida, K. and Osada, H. 2000. MT-21 is a synthetic apoptosis inducer that directly induces the release of cytochrome c from mitochondria. Cancer research. 60(18): 5214-5222

2713) Waters, J.P., Pober, J.S. and Bradley, J.R. 2013. Tumor necrosis factor and cancer. Pathology Journal. 230 (3rd

2714) Watkins, D. N., Berman, D. M., Burkholder, S. G., Wang, B., Beachy, P. A. & Baylin, S. B. 2003. Hedgehog signaling within airway epithelial progenitors and in small cell lung cancer. Nature 422 (6229): 313-7

2715) Watson, J. L., Greenshields, A., Hill, R., Hilchie, A., Lee, P. W., Giacomantononia, CA, and Hoskin, D. W. 2010. Curcumin-induced apoptosis in ovarian carcinoma cells is independent of p53 e involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and Akt signaling and survival expression. carcinogenic mole 49(1):13-24

2716) Wayne, N., Mishra, P. und Bolon, D. N. 2011. Hsp90 and client protein maturation. Método Mol. Biol. 787: 33-44, doi:

2717) Weber, P. & Raederstorff, D. 2000. Triglyceride-lowering effect of LC omega-3 polyunsaturated fatty acids: a review. Nutrition, metabolism and cardiovascular diseases. 10(1): 28-37.

2718) Weber, T., Lu, M., Andera, L., Lahm, H., Gellert, N., Fariss, M.W., Korinek, V., Sattler, W., Ucker, D.S., Terman, A., Schröder, A., Erl, W., Brunk, UT, Coffey, R.J., Weber, C., & Neuzil, J. 2002. Vitamin E succinate is a novel and potent antineoplastic agent with high selectivity and cooperation with cancer factor. Tumor necrosis ligand inducing apoptosis (Apo2ligand) in vivo. Cancer Clinic Res. 8(3):863-869

2719) Wei, E.K., Giovannucci, E., Selhub, J., Fuchs, C.S., Hankinson, S.E., and Ma, J. 2005. Plasma Vitamin B6 and the risk of colorectal cancer and adenoma in women. Zeitschrift of the National Cancer Institute-JNCI. 97(9):684-692

2720) Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang D, Ghosh G, Stark RG and Lu T 2013. PRMT5 dimethylates R30 p65 subunit to activate NF-kB. PNAS. 110(33): 13516-13521

2721) Wei, H., Wei, W., Bredesen, DE and Perry, DC 1998. Bcl-2 protects against apoptosis in neuronal cell lines caused by thapsigargin-induced depletion of intracellular calcium stores. J Neurochem. 70(6):2305-14

2722) Wei, T., Chen, C., Hou, J., Xin, W., and Mori, A. 2000. Nitric oxide induces oxidative stress and apoptosis in neuronal cells. Biochim Biophys Act. 1498(1):72-9

2723) Wei, W., Abnet, CC Qiao, Y., Dawsey, SM, Dong, Z., Sun, X., Fan, J., Gunter, E.W., Taylor, P.R. and Mark, J.D. 2004. Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke and total death. The American Journal of Clinical Nutrition. 79(1):80-85

2724) Wei, Y. M. and Giovannucci, L. E. 2012. Lycopene, tomato products, and prostate cancer incidence: review and reappraisal in the era of PSA screening. Oncology Journal. Vol. 2012. Entry ID 271063, doi: 10.1155/2012/271063, 7 pages

2725) Wei, Y, Xu, Y, Han, X, Qi, Y, Xu, L, Xu, Y, Yin, L, Sun, H, Liu, K, and Peng, J 2013. Anticancer effects of dioscin in three types of human lung cancer cell lines by inducing DNA damage and activating mitochondrial signaling. Food Chem Toxicol. 59: 118-28, doi: 10.1016/j.fct.2013.05.054

2726) Weihua , Z. , Saji , S. , Makinen , S. , Cheng , G. , Jensen , E. V. , Warner , M. and Gustafsson , J. 2000 uterus . Proc Natl Acad Sci USA. 97(11):5936–5941

2727) Weikl, T., Muschler, P., Richter, K., Veit, T., Reinstein, J., & Buchner, J. 2000. C-terminal regions of Hsp90 are important for nucleotide capture during the cycle ATPase. J. Mol. Biol. 303(4): 583-92

2728) Weinberg, E.D. 1996. The role of iron in cancer. Eur J Cancer Before. 5(1): 19-36

2729) Weinstein JS, Wright EM, Pietinen P, King I, Tan C, Taylor RP, Virtamo J, and Albanes D 2005. Serum α-tocopherol in relation to prostate cancer risk in a prospective study. JNCI. 97(5):396-399

2730) Weinstein, S. J., Albanes, D., Selhub, J., Graubard, B., Lim, U., Taylor, P. R., Virtamo, J. and Stolzenberg-Solomon, R. 2008. Biomarkers and risk of the one- carbon -Metabolism of colon and rectal cancer. Biomarkers of the cancer epidemic Prev. 17(11): 3233-3240

2731) Weiser MA, Cabanillas ME, Konopleva M, Thomas DA, Pierce SA, Escalante CP, Kantarjian HM, O'Brien SM 2004. Relationship between duration of remission and hyperglycemia during induction chemotherapy for acute lymphoblastic leukemia with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen. Cancer. 100(6): 1179-1185

2732) Weitberg, AB and Corvese, D. 1997. Effect of vitamin E and beta-carotene on DNA strand breaks induced by tobacco-specific nitrosamines and stimulated human phagocytes. Journal of Experimental Research and Cancer Clinic. 16(1): 11-14

2733) Weitsman, GE, Ravid, A, Liberman, UA, & Koren, R. 2003. Vitamin D enhances caspase-dependent and independent TNF-induced breast cancer cell death: the role of reactive oxygen species. Ann NY Acad. science 1010:437-40, doi:10.1196/annals.1299.079

2734) Weitsman, GE, Ravid, A, Liberman, UA, & Koren, R. 2003. Vitamin D enhances caspase-dependent and independent TNF-induced breast cancer cell death: the role of reactive oxygen species. Ann NY Acad. science 1010: 437-440

2735) Weitzel, F. and Wendel, A. 1993. Selenoenzymes regulate leukocyte 5-lipoxygenase activity through peroxide tone. The Journal of Biological Chemistry. 268(9):6288-6292

2736) Welcsh, P. L. and King, M. 2001. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hummol Genet. 10(7):705-713

2737) Wen, J., Fu, A.F., Chen, L.J., Xie, X.J., Yang, GL, Chen, X.C., Wang, Y.S., Li, J., Chen, P., Tang, MH, Shao, X.M., Zhao , X. and Wei, Y. Q. 2009. Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in a xenograft tumor model. Int J Cancer. 124(11): 2709-18

2738) Weng J, Tsai C, Kulp SK and Chen C 2008. Indole-3-carbinol as a chemopreventive and anticancer agent. Cancer Lett. 262(2): 153, doi: 10.1016/j.canlet.2008.01.033, 18 pages

2739) Wertz, K., Hunziker, P.B., Seifert, N., Riss, G., Neeb, M., Steiner, G., Hunziker, W. and Goralczyk, R. 2005. Beta-carotene interferes with ultraviolet A light gene expression induced through multiple pathways. Journal of Investigative Dermatology. 124:428–434, doi=10.1111/J.0022-202X.2004.23593.X

2740) Werz, O. and Steinhilber, D. 1996. Selenium-dependent peroxidases suppress 5-lipoygenase activity in β-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. Eur. J. Biochem. 242(1):90-97

2741) West, W.P., Parker, C.L., Ward, R.J. and Sabroe, I. 2008. Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1. Immunology. 125(1): 101-110

2742) Whelan, J. and Rust, C. 2006. Innovative dietary sources of n-3 fatty acids. Annual nutrition review. 26, 75-103.

2743) White, D.A., Fisk, I.D. and Gray, DA 2006. Characterization of oat (Avena sativa L.) oil bodies and intrinsically associated E-vitamers. Cereal science journal. 43(2):244-249

2744) White, J.R., Lee, J.M., Young, P.R., Hertzberg, R.P., Jurewicz, A.J., Chaikin, M.A., Widdowson, K., Foley, J.J., Martin, L.D., Griswold, DE and Sarau, H.M. 1998. Identification of a potent selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. JBiolChem. 273(17):10095-8

2745) Whitehouse, D. B., Pilz, A. J., Porta, G. and Hopkinson, D. A. 1988. Rhodanase isoenzymes in human tissues. Ann Hum Genet. 52 (Part 1): 1-10

2746) Whitesell, L., Mimnaugh, G. E., DeCosta, B., Myers, E. C. und Neckers, M. L. 1994. Inhibition of heteroprotein complex formation of heat shock proteins by benzoquinone ansamycins: essential role of stress proteins in oncogenic transformation. Proc Natl Acad Sci. 91(18): 8324-8328

2747) Wijendran, V. and Hayes, K.C. 2004. Dietary balance of n-6 and n-3 fatty acids and cardiovascular health. Annual nutrition review. 24, 597-615.

2748) Wiktorska, K., Misiewicz-Krzeminska, I., Stypulkowski, R., Lubelska, K., & Kasprzycka-Guttman, T. 2009. Sulforaphane and its analogues inhibit benzo[a]-induced CYP1A1 and CYP1A2 activity pyrene. Journal of Biochemical and Molecular Toxicology. 23(1): 18-28

2749) Wikul, A., Damsud, T., Kataoka, K. and Phuwapraisirisan, P. 2012. (+)-Pynoresinol is a putative hypoglycemic agent in defatted sesame seeds (Sesamum indicum), although it inhibits α-glycosidase. Bioorg Med. Chem. Lett. 22(16):5215-7

2750) Wiley , S.R. , Schooley , K. , Smolak , P.J. , Din , W.S. , Huang , C.P. , Nicholl , J.K. , Sutherland , G.R. , Smith , T.D. , Rauch , C. , Smith , CA and Goodwin , G.R. 1995. Identification and characterization of a novel TNF family member that induces apoptosis. Immunity. 3(6): 673-8

2751) Wilhelm, S. M., Adnane, L., Newell, P., Villanueva, A., Llovet, J. M., and Lynch, M. 2008. Preclinical review of sorafenib, a multikinase inhibitor targeting both Raf and VEGF and the tyrosine receptor PDGF kinase signaling. Molecular Cancer Therapeutics. 7(10): 3129-40

2752) Williams, J.D., Jacobson, E.L., Kim, H., Kim, M., and Jacobson, M.K. 2012. Folate in the prevention of skin cancer. Subcellular Biochemistry 56: 181-197, doi:

2753) Williams-Brown, MY, Salih, SM, Xu, X, Veenstra, TD, Saeed, M, Theiler, SK, Diaz-Arrastia, CR, & Salama, SA 2011. The effect of tamoxifen and raloxifene on metabolism and estrogen risk of endometrial cancer. J Steroid Biochem Mol Biol. 126(3-5): 78-86

2754) Williamson, P. T., Amirahmadi, S., Joshi, G., Kaludov, K. N., Martinov, N. M., Johnson, A. D., and Johnson, A. J. 2012. Discovery of novel and strong inducers of Nrf2 through quantum modeling, virtual detection, and in vitro experiments Validation. Chem Biol Drug Des. 80(6): 810-820

2755) Will, R.BH. and Stuart, D. L. 2000. Effect of handling and storage on alkylamides and cichoric acid in Echinacea purpurea. Journal of Agricultural and Food Sciences. 80(9): 1402-1406

2756) Wilson, TR, Wang, J, Chinchilli, V, Richie, JP, Virtamo, J, Moore, LE, & Albanes, D. 2009. Fish, vitamin D, and flavonoids in relation to renal cell cancer in smokers. Am J Epidemiol. 170(6):717-729

2757) Wina, E., Mützel, S. and Becker, K. 2005. The influence of saponins or saponin-containing plant materials on ruminant production: an overview. J Agricultural food chemistry. 53(21): 8093-8105

2758) Windey, K., De Preter, V. & Verbeke, K. 2012. Relevance of protein fermentation for gut health. Mol Nutr. Res. 56(1):184-96

2759) Winnicka, K., Bielawski, K., Bielawska, A., & Miltyk, W. 2007. Apoptosis-mediated cytotoxicity of ouabain, digoxin, and proscillaridin A in estrogen-independent MDA-MB-231 breast cancer cells. Arch Pharm Res. 30(10): 1216-1224

2760) Winstanley, H. M., Pratt, S. I., Chapman, K., Griffin, J. H., Croager, J. E., Olver, N. I., Sinclair, C. und Slevin, J. T. 2011. Alcohol and cancer: a Cancer Council Australia position statement. Das medizinische Journal von Australien. 194(9): 479-482

2761) Wise, R.D. and Thompson, B.C. 2010. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 35(8): 427-433

2762) Wiseman, H., O'Reilly, J.D., Adlercreutz, H., Mallet, A.I., Bowey, E.A., Rowland, IR, and Sanders, T.AB. 2000. Isoflavone phytoestrogens consumed in soybean decrease F2 isoprostane concentrations and increase low-density lipoprotein resistance to oxidation in humans. Bin J Clin Nutr. 72(2):395-400

2763) Wodinsky, I. and Swiniarski, J. K. 1975. Antitumor activity of amygdalin MF (NSC-15780) as a single agent and with beta-glucosidase (NSC-128056) in a spectrum of transplantable rodent tumors. Cancer Chemother Rep. 59(5): 939-50

2764) Wojenski, C.M., Silver, M.J. and Walker, J. 1991. Eicosapentaenoic acid ethyl ester as an antithrombotic agent: comparison with a fish extract. Biochemistry and Biophysics Act. 1081(1):33-38.

2765) Wolfman, C., Viola, H., Paladini, A., Dajas, F., & Medina, J. H. 1994. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Behavior of Pharmacol Biochem. 47(1):1-4

2766) Wolter, F., Turchanowa, L. and Stein, J. 2003. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. carcinogenesis. 24(3): 469-74

2767) Woltil, H.A., Beusekom, C.M., Okken-Beukens, M., Schaafsma, A., Muskiet, F.A.J. and Okken, A. 1999. The development of low birth weight infants at one month of age is correlated with early intake and status of long-chain polyunsaturated fatty acids. prostaglandins, leukotrienes and essential fatty acids. 61(4): 235-241.

2768) Woltowicz-Praga, S.M., Dickson, R.B. and Hawkins, M.J. 1997. Matrix metalloproteinase inhibitors. Invest in new drugs. 15(1): 61-75

2769) Wondrak G T, Villeneuve N F, Lamore SD, Bause AS, Jiang T and Zhang D D 2010. Cinnamon-derived dietary factor cinnamaldehyde activates the Nrf2-dependent antioxidant response in human colon epithelial cells. molecules. 15(5):3338-55

2770) Wong B C, Wang W P, Cho CH, Fan X M, Lin M C, Kung HF and Lam SK 2001. Inhibition of 12-lipoxygenase induced apoptosis in human gastric cancer cells. carcinogenesis. 22(9):1349-54

2771) Wong, G. Y., Bradlow, L., Sepkovic, D., Mehl, S., Mailman, J. und Osborne, M. P. 1997. Dose-Ranging Study of Indole-3-Carbinol for Breast Cancer Prevention. J Cell Biochem Supl. 28-29: 111-116, doi: 10.1002/(SICI)1097-4644(1997)28/29+<111:AID-JCB12>3.0.CO; 2-K

2772) Wong, P., Cuello, C., Bertouch, J. V., Roberts-Thompson, P. J., Ahern, M. J., Smith, M. D. und Youssef, P. P. 2000. The effects of pulsed methylprednisolone on matrix metalloproteinase and tissue inhibitor of metalloproteinase-1 Ausdruck bei Rheumatoid arthritis. Rheumatology. 39(10):1067-73

2773) Woo, K. J. and Kwon, T. K. 2007. Sulforaphane represses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through modulation of multiple targets in the COX-2 gene promoter. Immunopharmaceutical International. 7(13): 1776-83

2774) Wood, JM 2000. Inhibition of vascular endothelial growth factor (VEGF) as a new approach for cancer therapy. Medicine. 60 (Supplement 11): 41-47

2775) Wood, O.L., Spark, A. & Spark, A. 1996. Guidelines for medical nutrition therapy in the treatment of patients with breast cancer. Journal of the American Dietetic Association. 96 (Appendix 1), A35.

2776) Woodson, K., Albanes, D., Tangrea, A.J., Rautalahti, M., & Virtamo, J. 1999. Association between alcohol and lung cancer in the alpha-tocopherol-beta-cancer prevention study. carotene in Finland. Causes and control of cancer. 10(3): 219-226

2777) Woodson , K. , Tangrea , A. J. , Barrett , J. M. , Virtamo , J. , Taylor , R. P. and Albanes , D. 1999. Serum α-Tocopherol and after risk of lung cancer among male smokers. J National Cancer Institute. 91(20): 1738–1743

2778) Wright, T. M., Wardell, S. E., Jasper, J. S., Stice, J. P., Safi, R., Nelson, E. R. and McDonnell, D. P. 2014. Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in resistant patients Brustkrebs endocrine therapy. Mol Cancer Res. 12: 1829, doi: 10.1158/1541-7786.MCR-14-0195

2779) Wu Chiang Fu Chien Chung Horng Formosanin-C, an immunomodulator with antitumor activity Int J Immunopharmacol. 12:777-86.

2780) Wu, B. Y. and Yu, A. C. 2000. Quercetin inhibits the expression of c-fos, heat shock protein, and glial fibrillary acidic protein in injured astrocytes. J Neurosci Res. 62(5): 730-6

2781) Wu, C., Han, L., Riaz, H., Wang, S., Cai, K., & Yang, L. 2013. The chemopreventive effect of mandarin β-cryptoxanthin on human gastric cells (BGC -823) . Food Chemistry. 136(3-4): 1122-1129

2782) Wu, J. H., Miao, W., Hu, L. G., & Batist, G. 2010. Identification and characterization of novel Nrf2 inducers designed to target Keap intervention 1. Chem Biol Drug Des. 75(5): 475-80

2783) Wu, J. Q., Yang, Y., Vogtmann, E., Wang, J., Han, HL, Li, L. H., & Xiang, B. Y. 2013. Cruciferous vegetable intake and the risk of colorectal cancer: a meta-analysis of observational studies . Ana Oncól. 24(4): 1079-1087

2784) Wu, J., DiPietrantonio, A., & Hsieh, T. 2001. Mechanism of fenretinide (4-HPR)-induced cell death. apoptosis. 6(5): 377-88

2785) Wu, M., Lien, G., Shen, S., Yang, L., and Chen, Y. 2013. HSP90 inhibitors geldanamycin and radicicol ameliorate fisetin-induced cytotoxicity by inducing apoptosis in cells of human colon cancer. Alternative and complementary medicine based on evidence. Vol.2013. Entry ID 987612, doi: 10.1155/2013/987612, 11 pages

2786) Wu , R.T. , Chiang , H.C. , Fu , W.C. , Chien , K.Y. , Chung , Y.M. and Horng , L.Y. 1990. Formosanin-C an immunomodulator with antitumor activity. International Journal of Immunopharmacology. 12(7):777-786

2787) Wu, S.H., Hang, L.W., Yang, J.S., Chen, HY, Lin, HY, Chiang, J.H., Lu, CC, Yang, J.L., Lai, TY, Ko, Y.C. and Chung, J.G. 2010. Curcumin induces apoptosis in NCL-H460 human non-small cell lung cancer cells via ER stress and caspase cascade and mitochondria-dependent signaling pathways. Res. against cancer. 30(6):2125-33

2788) Wu, S. J. and Ng, L. T. 2007. Tetrandrine inhibits the expression of proinflammatory cytokines, INOS and COX-2 in human monocyte cells. BiolPharmBull. 30(1): 59-62

2789) Wu, W. S., Wu, J. R., & Hu, CT 2008. Signaling crosstalk for sustained MAPK activation and cell migration: the potential role of reactive oxygen species. Cancer Metast Rev. 27(2): 303-314

2790) Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T.J., de Leon, GP, Chen, Y., Finkle, D-, Venook, R., Wu, X., Ridgway, J. Schahin-Reed, D. Dow, G.J., Shelton, A., Stawicki, S., Watts, R.J., Zhang, J., Choy, R., Howard, P., Kadyk, L., Yan, M. , Zha, J., Callahan, CA, Hymowitz, S.G., and Siebel, C.W. 2010. Targeting therapeutic antibodies to individual Notch receptors. Nature. 464: 1052-1059, doi: 10.1038/natur08878

2791) Wu, Z.G., Zhu, H., Shimoishi, B., Nakamura, Y. and Murata, Y. 2009. UVA radiation-assisted induction of apoptosis by beta-carotene and dimethyltetrasulfide in HL-60 cells. Biosci Biotechnol Biochem. 73(5):1347–6947

2792) Würstle, M. L., Laussmann, M. A., & Rehm, M. 2012. The central role of the caspase-9 initiator in apoptosis signal transduction and the regulator of its activation and activity in the apoptosome. Experimentelle Zellforschung. 318(11): 1213-1220

2793) Xia J, Duan Q, Ahmad A, Bao B, Banerjee S, Shi Y, Ma J, Geng J, Chen Z, Rahman KM. , Miele, L., Sarkar, F. H., and Wang, Z. 2012. Genistein inhibits cell growth and induces apoptosis by upregulating miR-34a in pancreatic cancer cells. Curr drug targets. 13(14): 1750-6

2794) Xia, Z., Luo, T., Liu, H., Wang, F., Xia, Z., Irwin, M., & Vanhoutte, M. P. 2010. L-arginine increases nitration stress and aggravates the factor of tumor necrosis-α toxicity against human endothelial cells in culture: prevention by propofol. Journal of Cardiovascular Pharmacology. 55(4):358-367

2795) Xiang, X., Liu, J., Qiu, X., Pan, F., Yu, S., & Chen, X. 2015. Piperlongumin induces apoptotic and autophagic death of primary myeloid leukemia cells of the patients by activating ROS -p38/JNK signaling pathways. Acta Pharmacol Sin. 36(3): 362-374

2796) Xiao, D. and Singh, S.V. 2010. P66Shc is essential for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells. cancer res 70(8):3150-8

2797) Xiao, H. and Parkin, K. L. 2006. Induction of phase II enzyme activity by different selenium compounds. Walnut cancer. 55(2):210-23

2798) Xiao, H. B., lu, X. Y., Liu, Z. K., and Luo, Z. F. 2016. Kaempferol inhibits ROS production to modulate the OPN-αvβ3 integrin pathway in HUVEC. J Physiol. biochemistry 72(2):303-13

2799) Xiao, L., Xiangyi, L., and Ruden, M.D. 2006. Efficacy of Hsp90 Inhibitors as Anticancer Drugs. Mini-reviews in medicinal chemistry. 6(10): 1137-1143

2800) Xiao R Z, Chen Y, Wang L L, Ruan X X, He CM, Xiong M J, and Lin D J 2011. Sorafenib induces apoptosis of U937 cells through inhibition of the WNT signaling pathway Zhongqquo Shi Yan Xue Ye Xue Za zhi. 19(2):353-7

2801) Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, and Liu X 2015. Tetrandrine induces G1/S cell cycle inhibition through the ROS/Akt pathway in EOMA cells e inhibits angiogenesis in vivo. international J Oncol. 46(1):360-8

2802) Xiao, X., Shi, D., Liu, L., Wang, J., Xie, X., Kang, T., & Deng, W. 2011. Quercetin suppresses cyclooxygenase-2 expression and angiogenesis by inactivating P300 signaling. Plus one. 6(8): e22934, doi: 10.1371/journal.pone.0022934, 10 pages

2803) Xie , J. , Johnson , R.L. , Zhang , X. , Bare , J.W. , Waldman , F.M. , Cogen , PH , Menon , A.G. , Warren , R.S. , Chen , L. , Scott , MP and Epstein , Jr . E.H. 1997. Patched genetic mutations in several types of sporadic extracutaneous tumors. Cancer res 57(12): 2369-2372

2804) Xu, C., Wensing, T. and Beynen, A. C. 1999. Fat digestion and fecal bile acid excretion in calves fed milk replacer containing coconut fat or tallow. Science and technology of animal nutrition. 81(1-2): 161-166

2805) Xu, D., Hu, J., De Bruyne, E., Menu, E., Schots, R., Vanderlerken, K., & Van Valckenborgh, E. 2012. DII1/Notch activation contributes to bortezomib a through upregulation - Resistance in CYP1A1 in multiple myeloma. Biochem Biophys Common Res. 428(4):518-24

2806) Xu , D. , Lin , T. , Yeh , C. , Cheng , MA , Chen , L. , Chang , C. and Yeh , S. 2014 Growth of ovarian cancer cells . International Biomedical Research. Vol. 2014, Article ID: 713263, 11 pages

2807) Xu, J., Hu, H., Chen, B., Yue, R., Zhou, Z., Liu, Y., Zhang, S., Xu, L., Wang, H., and Zhengping, Y. 2015. Lycopene protects against hypoxia/reoxygenation damage by alleviating ER stress-induced apoptosis in neonatal mouse cardiomyocytes. Plus one. 10(8): E0136443, doi: 10.1371/journal.pone.0136443, 16 pages

2808) Xu, M., Wang, S., Ren, Z., Frank, A.J., Yang, H.X., Zhnag, Z., Ke, Z., Shi, X., & Luo, J. 2015. Chronic exposure to Ethanol increases dying breast cancer aggressiveness: the role of p38ϒ. oncotarget 7(3): 3489-3505

2809) Xu, X. C., Mitchell, M. F., Silva, E., Jetten, A. y Lotan, R. 1999. Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin and cornifin in cervical intraepithelial neoplasia. Clínica de Cáncer Res. 5(6): 1503-1508.

2810) Xu, X., Liu, Y., Wang, L., He, J., Zhang, H., Chen, X., Li, Y., Yang, J., and Tao, J. 2009. Gambogic acid induces apoptosis by regulating Bax and Bcl-2 expression and enhancing caspase-3 activity in A375 human malignant melanoma cells. Int J Dermatol. 48(2):186-92

2811) Xu, X., Xing, B., Han, H., Zhao, W., Hu, M., Xu, Z., Li, J., Xie, Y., Gu, J., Wang, Y. und Zhang, Z. 2010. The properties of tumor-initiating cells of the primary and recurrent tumor of a patient with hepatocellular carcinoma. Karzinogenese. 3(2): 167-174

2812) Xu, Z. & Ji, R. 2011. Resolvins are effective analgesics for arthritic pain. Br J Pharmacol. 164(2): 274-277

2813) Xu, Z., Yuan-mao, J., Fu-tian, P., Nai-bo, H., Yan-ju, L., and Deng-chao, Z. 2007. Changes in flavor components in the sweets of Hongdeng Cherry during the development of the fruit. Agricultural Sciences in China. 6(11): 1376-1382

2814) Xun, P., Bujnowski, D., Liu, K., Morris, J.S., Guo, Z., and He, Ka. 2011. Distribution of selenium levels in toenails in Caucasian and African-American young adults in the United States: the CARDIA-Trace Element Study. environmental research. 111(4):514-519

2815) Yadav, V., Sultana, S., Yadav, J. & Saini, N. 2012. Gatifloxacin induces cell cycle arrest at S and G2 phases in pancreatic cancer cells via p21/p27/ p53. Plus one. 7(10): e47796, doi: 10.1371/journal.pone.0047796

2816) Yahia, A.D., Madani, S., Savelli, L.J., Prost, J., Bouchenak, M., & Belleville, J. 2003. Dietary fish protein lowers blood pressure and alters polyunsaturated fatty acid composition tissues in spontaneously hypertensive rats. Nutrition. 19(4):342-346.

2817) Yamaguchi, H. and Wang, H. G. 2004. CHOP is involved in stress-induced endoplasmic reticulum apoptosis by enhancing DR5 expression in human carcinoma cells. JBiolChem. 279(44): 45495-502

2818) Yamamoto, K., Mizumoto, A., Nishimura, K., Uda, A., Mukai, A., Yamashita, K., Kume, M., Makimoto, H., Bito, T., Nishigori, C. ., Nakagawa, T., Hirano, T., and Hiari, M. 2014. Association of human keratinocyte toxicity of sorafenib and sunitinib with inhibition of signal transduction and activator of transcription 3 (STAT3). Plus one. 9(7): e102110, 7 pages, doi: 10.1371/journal.pone.0102110.g001

2819) Yamamoto, M., Taquchi, Y., Ito-Kureha, T., Semba, K., Yamaquchi, N. e Inoue, J. 2013. Nat Comun. 4: 2299. doi: 10.1038/ncomms3299

2820) Yamamoto, T., Hsu, S., Lewsi, J., Wataha, J., Dickinson, D., Singh, B., Bollag, W.B., Lockwood, P., Ueta, E., Osaki, T. and Schuster, G. 2003. Green tea polyphenol elicits different oxidative environments in tumor cells versus normal epithelial cells. The Journal of Pharmacology and Experimental Therapeutics. 307(1): 230-236

2821) Yan, G., Freeman, T., & Lanza-Jacoby, S. 2013. Abstract 5405: Limiting glucose availability with metformin increased reactive oxygen species, decreased cell survival, and promoted apoptosis in cells of human and mouse pancreatic cancer. cancer res 73:5405, doi:10.1158/1538-7445. AM2013-5405

2822) Yan, L., Zhang, D.J., Wang, B., Lv, J.Y., Jiang, H., Liu, L.G., Qiao, Y., Ren, M. and Guo, FX 2013. Quercetin inhibits ventricular hypertrophy left in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cell hypertrophy by enhancing PPAR-ϒ expression and suppressing AP-1 activity. 8(9): e72548, doi:10.1371/journal.pone.0072548, 19 pages.

2823) Yan, M. 2011. Therapeutic promise and challenges in DLL4/NOTCH1 selection. vascular cell. 3:17, doi:10.1186/2045-824X-3-17, 5 pages

2824) Yan, Y. E., Wang, H., Wang, T., & Zeng, H. G. 2006. Indole-3-carbinol alters levels of placental cytochrome P4501A1 and P-glycoprotein in rats: a potential role in enhancement of delay of fetal intrauterine growth caused by tobacco smoke. Exp. Toxicol Pathol. 58(1): 39-47

2825) Yang, C. M., Yen, Y. T., Huang, C. S. und Hu, M. L. 2011. Growth inhibitory efficacy of lycopene and β-carotene against xenografted androgen-independent prostate tumor cells in nude mice. Mol Nutr Food Res. 55(4): 606-12

2826) Yang, CS, Suh, N & Kong, AT 2012. Does vitamin E prevent or promote cancer? Cancer Previous Res. 5(5):701-705

2827) Yang E, Lee J, Lee S, Kim E, Moon Y, Jung YO, Park S, and Cho M 2014. EGCG attenuates autoimmune arthritis by inhibiting STAT3 and HIF-1α with Th17/Treg control. Plus one. 9(2): e86062, doi: 10.1371/journal.pone.008062, 11 pages

2828) Yang F, Jove V, Buttner R, Xin H, Wu J, Wang Y, Nam S, Xu Y, Ara T, DeClerck YA. , Seeger, R., Yu, H., and Jove, R. 2012. Sorafenib inhibits endogenous and IL-6/S1P-induced JAK2-STAT3 signaling in human neuroblastoma associated with growth suppression and apoptosis. Cancer Biol. Ther. 13(7):534-41

2829) Yang F, Wang J, Yan J, Huang J, Che J, Wang G, Liu M, and Zheng J 2014. Metformin inhibits cell growth by upregulating -26a microRNA in kidney cancer cells. international J. Clin. Exp. Med. 7(10): 3289-3296

2830) Yang, F., Zhuang, S., Zhang, C., Dai, H., & Liu, W. 2013. Sulforaphane inhibits CYP1A1 activity and promotes the induction of 2,3,7,8-tetrachlorodibenzo- p-dioxin. in vitro genotoxicity. Toxicology and applied pharmacology. 269(3): 226-232

2831) Yang Q, Titus MA, Fung KM and Lin HK 2008. 5alpha-androstane-3alpha,17beta-diol supports the survival and proliferation of human prostate cancer cells through androgen receptor-independent signaling pathways: implication of androgen-independent progression of prostate cancer. J Cell Biochem. 104(5):1612-24

2832) Yang, S., Zhou, Q. & Yang, X. 2007. Caspase-3 status is a determinant of differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cells . Biochimica et Biophysica Acta (BBA) - Molecular cell research. 1773(6): 903-911

2833) Yang Z, Di M, Yuan J, Shen W, Zheng D, Chen J, Mao C, and Tang J 2015. The prognostic value of phosphorylated Akt in breast cancer: a systematic review. Scientific reports. 5: 7758, doi: 10.1038/srep07758, 9 pages

2834) Yao C, Yang C, Chuang S, Yan J, Liu C, Chen S, Yan K, Lai T, and Lai G 2011. Targeting of PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in acute promyelocytic leukemia NB4 cells. Alternative and complementary medicine based on evidence. 2011: 98415, doi: 10.1093/ecam/nep165, 11 pages

2835) Yao, J., Ge, C., Duan, D., Zhang, B., Cui, X., Peng, S., Liu, Y., and Fang, J. 2014. Activation of phase II enzymes for neuroprotection by the ginger active substance 6-dehydrogingerdione in PCL2 cells. Journal of agricultural and food chemistry. 62:5507-5518,

2836) Yao, X., Wu, Y., Zhu, M., Qian, H., & Chen, Y. 2015. Cyclic guanosine monophosphate/nitric oxide inducers Sodium nitroproside and L-arginine inhibit the proliferation of gastric cancer cells by activation of cyclic guanosine monophosphate dependent protein kinase type II Oncol Lett. 10(1): 479-484

2837) Yap , T.A. , Walton , M.I. , Grimshaw , K.M. , Te Poele , R.H. , Eve , P.D. , Valenti , M.R. , de Haven , B.A.K. , Martins , V. , Zetterlund , A. , Heaton , S.P. , Heinzmann , K . , Jones , P.S. , Feltell , R.E. , Reule , M. , Woodhead , S.J. , Davies , T.G. , Lyons , J.F. , Raynaud , F.I. , Eccles , S.A. , Workman , P. , Thompson , N.T. and Garrett, M.D. 2012. AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Clinic Res. 18(14): 3912-2

2838) Yap, T. A., Walton, M. I., Hunter, L. J., Valenti, M., de Haven, B. A., Eve, P. D., Ruddle, R., Heaton, S. P., Henley, A., Pickard, L., Vijayaraghavan, G ., Caldwell, J. J., Thompson, N. T., Aherne, W., Raynoud, F. I., Eccles, S. A., Workman, P., Collins, I., and Garrett, M. D. 2011. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the neuartiger, potent Akt-Inhibitor CCT128930. Mol Cancer Ther. 10(2): 360-71

2839) Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X. und Zhang, D. 2004. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Krebs Lett. 211(1): 39-46

2840) Ye, M., Zhang, J., Zhang, J., Miao, Q., Yao, L., and Zhang, J. 2015. Curcumin promotes apoptosis by activating p53-miR-192-5p/215 -XIAP signaling pathway in non-small cell lung cancer. Cancer Lett. 357(1): 196-205

2841) Ye, R., Bodero, A., Zhou, BB, Khanna, KK, Lavin, MF, and Lees-Miller, S.P. 2001. The plant isoflavonoid genistein activates p53 and Chk2 in an ATM-dependent manner. JBiolChem. 276(7): 4828-33

2842) Ye, Y., Miao, S., Wang, Y., Zhou, J., and Lu, R. 2015. 3,3'-Diindoylmethane potentiates ligand-induced apoptosis induced by related tumor necrosis factor with gastric cancer cells. Oncology Letters. 9:2393-2397, doi:10.3892/ol.2015.3008

2843) Yeh, C. and Yen, G. 2005. Effect of sulforaphane on metallothionein expression and apoptosis induction in human hepatoma hepG2 cells. Karzinogenese. 26(12): 2138-2148

2844) Yeh, C., You, S., Chen, C., & Sung, F. 2006. Peanut consumption and reduced risk of colon cancer in women: a prospective study in Taiwan. World J Gastroenterol. 12(2): 222-227.

2845) Yeh, S. and Chang, C. 1996. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc Natl Acad Sci USA. 93(11): 5517-5521

2846) Yeh, W., Shioda, K., Coser, KR, Rivizzigno, D., McSweeney, KR, and Shioda, T. 2013. Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor protein α in MCF- 7 cells require the CSK-c-Src tyrosine kinase. Plus one. 8(4): e608889, doi: 10.1371/journal.pone.0060889

2847) Yehuda, S., Rabinovitz, S. and Mostofsky, D.I. 1999. Essential fatty acids are mediators of brain biochemistry and cognitive function. Neuroscience Research Journal. 56(6): 565-566.

2848) Yehuda, S., Rabinovitz, S. and Mostofsky, D.I. 2005. Essential fatty acid blend reduces test anxiety. Nutritional Neuroscience. 8(4): 265-267.

2849) Yen, W.C., Fischer, M.M., Axelrod, F., Bond, C., Cain, J., Cancilla, B., Henner, W.R., Meisner, R., Sato, A., Shah, J., Tang , T., Wallace, B., Wang, M., Zhang, C., Kapoun, AM, Lewicki, J., Gurney, A., & Hoey, T. 2015. Targeting of Notch signaling with a Notch2 antagonist /Notch3 (tarextumab ) inhibits tumor growth and reduces the frequency of tumor-initiating cells. Cancer Clinic Res. 21(9): 2084-95

2850) Yeum, K.–J. und Russell, R. M. 2002. Bioavailability and bioconversion of carotenoids. Jährliche Rev. Nutr. 22(1): 483-504

2851) Yi, Y.W., Kang, H.J. and Bae, I. 2014. BRCA1 and oxidative stress. Cancer. 6:771-795, doi:10.3390/cancers6020771

2852) Yi, Y. W., Kang, H. J., Kim, H. J., Kong, Y., Brown, M. L. and Bae, I. 2013. Targeting of mutant p53 by a SIRT1 activator YK-3-237 promotes the proliferation of triple-negative breast cancers Zellen . Oncotarget. 4(7): 984-9

2853) Yin, F., Giuliano, AE, Law, R.E. and VanHerle, A.J. 2001. Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and activating ERK-MAP kinase in breast cancer cells. Res. against cancer. 21(1A): 413-20

2854) Yin, Z., Henry, E.C. and Gasiewicz, TA 2009. (-)-Epigallocatechin-3-gallate is a new inhibitor of Hsp90. Biochemistry. 48(2): 336-45

2855) Yodkeeree, S., Sung, B., Limtrakul, P., and Aggarwal, BB 2009. Zerumbone enhances TRAIL-induced apoptosis by inducing death receptors in human colon cancer cells: evidence for an essential role of species oxygen reagents. cancer res 69(16): 6581-9

2856) Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ, Sung MS, Yoo HG and Yoo WH 2013. Kaempferol inhibits IL-1β-induced synovial fibroblast proliferation in rheumatoid arthritis and COX-2 production , PGE2 and MMP. international J. Mol. Med. 32(4): 971-7

2857) Yoon, S. and Seger, R. 2006. The extracellular signal-regulated kinase: multiple substrates regulate different cellular functions. growth factors 24(1): 21-44

2858) Yoon, SJ, Lee,JH, Choi,HS, Chang,E, Lee,YS and Lee,JE 2011. Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts of the Graves' orbitopathy. Plus one. 6(10): e26261, doi: 10.1371/journal.pone.0026261

2859) Yorimitsu, M., Muranaka, S., Sato, E. F., Fujita, H., Abe, K., Yasuda, T., Inoue, M., and Utsumi, K. 2004 the mitochondrial permeability assay. physiol. physical chemistry Medicine. NMR 36(2): 95-107

2860) You, X. Y., Chen, J. G. and Hu, Y. N. 1990. Studies on the relationship between bladder cancer and benzidine or its derivative dyes in Shanghai. Br J Int. Med. 47(8):544-552

2861) Youn, C.K., Park, S.J., Li, M.H., Lee, M.Y., Lee, K.Y., Cha, M.J., Kim, O.H., You, H.J., Chang, I.Y., Yoon, S.P. and Jeon, Y.J. 2013. Radicicol Inhibits iNOS Expression in Cytokine-stimulated Pancreatic Beta Cells. Korean J Physiol Pharmacol. 17(4):315-20

2862) Youn, SG, Kwon, D, Ju, MS, Rhim, H, Bae, SY, Choi, YS, & Park, J. 2014. Celastrol attenuates HIV-1 Tat-induced inflammatory responses by induction in astrocytes. Toxicology and applied pharmacology. 280(1): 42-52

2863) Young, E.A., Altemus, M., Parkison, V., & Shastry, S. 2001. Effects of estrogen antagonists and agonists on the ACTH response to obsessive-compulsive stress in female rats. Neuropsychopharmacology. 25(6):881-91

2864) Young, J. C., Moarefi, I. und Hartl, F. U. 2001. Review Hsp90: a specialized but essential protein folding tool. J Cell Biol. 154(2): 267-73

2865) Yu, D., Macdonald, J., Liu, G., Lee, AS, Ly, M., Davis, T., Ke, N., Zhou, D., Wong-Staal, F., and Li, Q. 2008. Pyrvinium targets the unfolded protein response to hypoglycemia, and combination therapy enhances antitumor activity. Plus one. 3(12): e3951, doi: 10.1371/journal.pone.0003951

2866) Yu, D., Shin, H., Lee, Y. S., Lee, D., Kim, S., & Lee, Y. C. 2014. Genistein attenuates cancer stem cell properties in gastric cancer by downregulating Gli1. oncology reports. 31(2): 673-8

2867) Yu, J. A., Mauchley, D., Li, H., Meng, X., Nemenoff, R. A., Fullerton, D. A., & Weyant, M. J. 2012. Elimination of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg. 144(5): 1185-91

2868) Yu, J., Zhang, L., Hwang, M.P., Kinzler, W.K. and Vogelstein, B. 2001. PUMA induces rapid apoptosis of colon cancer cells. molecular cell. 7(3): 673-682

2869) Yu, J., Zhou, X., He, X., Sai, M. & Zhang, Q. 2011. Curcumin induces Bax/bcl-2 apoptosis in SMMC-7721 human hepatoma cells. Asia Pacific J Cancer Before. 12(8): 1925-9

2870) Yu, KM, Samlowski, EW, Baichwal, V, Brown, B, Evans, AB, Woodland, D, Mather, G, Patnaik, A, Tolcher, WA, and Papadopoulos, K. 2010 MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients. J Clin Oncol (Meeting abstracts). Vol. 28, No (Supplement May 20, 2010: e13112

2871) Yu P, Laird D, Du X, Wu J, Won K, Yamaguchi K, Hsu P P, Qian F, Jaeger CT, Zhang W, Buhr CA, Shen P, Abulafia W, Chen J, Young J, Plonowski A, Yakes FM, Chu F, Lee M, Bentzien F, Lam, S. T., Dale, S., Matthews, D. J., Lamb, P., and Foster, P. 2014. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with various genetic alterations that affect the PI3K signaling pathway. Mol Cancer Ther. 13(5): OF1-OF14, doi: 10.1158/1135-7163. MCT-13-0709

2872) Yu, Q., Geng, Y., & Sicinski, P. 2001. Specific protection against breast cancer by cyclin D1 ablation. Nature. 411 (6841): 1017-1021

2873) Yu, S., Shen, G., Khor, OT, Kim, J., & Kong, A. 2008. Curcumin inhibits Akt/mTOR signaling through a protein phosphate-dependent mechanism. Mol Cancer Ther. 7(9): 2609-20

2874) Yu, X., Vazquez, A., Levine, J. A., & Carpizo, R. D. 2012. Allele-specific p53 mutant reactivation. Krebszelle. 21(5): 614-625

2875) Yuan, Z., Goetz, J. A., Singh, S., Ogden, S. K., Petty, W. J., Black, C. C., Memoli, V. A., Dmitrovsky, E., and Robbins, D. J. 2007. Frequent requirement for hedgehog signaling in non- - kleinzelliges Lungenkarzinom. Onkogen. 26(7): 1046-1055

2876) Yuan-Qing J., B and D. 2015. Effect of individual omega-3 fatty acids on prostate cancer risk: a systematic review and dose-response meta-analysis of prospective cohort studies. J 25(4): 261-274.

2877) Yung, H., Korolchuk, S., Tolkovsky, AM, Charnock-Jones, DS and Burton, GJ 2007. Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis by attenuating Akt protein synthesis in cells of human choriocarcinoma. The FASEB Journal. 21(3):872-884

2878) Zacharski, LR and Sukhatme, VP 2005. Coley's toxin revisited: immunotherapy or plasminogen activator therapy of cancer. Journal of Thrombosis and Hemostasis. 3(3): 424-427

2879) Zache, N., Lambert, J. M., Rokaeus, N., Shen, J., Hainaut, P., Bergman, J., Wiman, K. G. y Bykov, V. J. 2008. Mutant p53 targeting by the low Molecular Weight Compound STIMA -1. Mol Oncol. 2(1): 70-80

2880) Zaharevitz, W.D., Gussio, R., Leost, M., Senderowicz, MA, Lahusen, T., Kunick, C., Meijer, L. and Sausville, AE 1999. Discovery and initial characterization of the papulones, a New class of small molecule inhibitors of cyclin-dependent kinases. Cancer research. 59(11):2566-9

2881) Zaineddin AK, Buck K, Vrieling A, Heinz J, Flesch-Janys D, Linseisen J, and Chang-Claude J 2012. The association between dietary lignans, phytoestrogen-rich diet, and dietary fiber intake and risk of Postmenopausal breast cancer: a German case-control study. Walnut cancer. 64(5): 652-65

2882) Zakikhani, M., Blouin, M.J., Piura, E., & Pollak, MN 2010. Metformin and rapamycin have differential effects on Akt signaling and proliferation in breast cancer cells. breast cancer treatment. 123(1):271-9

2883) Zanotto-Filho, A., Braganhol, E., Battastini, AM and Moreira, J.C. 2012. The MG132 proteasome inhibitor induces selective apoptosis in glioblastoma cells by inhibiting the PI3K/Akt and NFkappaB signaling pathways. Mitochondrial dysfunction and activation of p38 JNK1/2 signaling. Invest in new drugs. 30(6):2252-62

2884) Zeegers, MPA, Goldbohm, R.A., and van den Brandt, P.A. 2001. Are taking retinol, vitamin C, vitamin E, folic acid, and carotenoids associated with bladder cancer risk? Results of the Dutch cohort study. British journal of cancer. 85(7):977-983

2885) Zeng, H., Botnen, J. H., and Briske-Anderson, M. 2009. Deoxycholic acid and the selenium metabolite methylselenol exert common and distinct effects on the cell cycle, apoptosis, and MAP kinase pathway in cells of HCT116 human colon cancer. 62(1): 85-92

2886) Zeng, L, Wu, G, Goh, JK, Lee, MY, Ng, CC, You, BA, Wang, J, Jia, D, Hao, A, Yu, Q and Li, B. 2008. Saturated Los Fatty acids modulate the cellular response to DNA damage: implication of their role in tumorigenesis. Plus one. 3(6): e2329, doi: 10.1371/journal.pone. 0002329, 9 pages

2887) Zeng Y, Yokohira M, Saoo K, Takeuchi H, Chen Y, Yamakawa K, Matsuda Y, Kakehi Y and Imaida K 2005. Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an anti-estrogen with antiandrogenic activity, but not nimesulide, a selective inhibitor of cyclooxygenase-2. carcinogenesis. 26(6): 1109-1116

2888) Zengerlin F, Streicher W, Schrader AJ, Schrader M, Nitzsche B, Cronauer MV and Hopfner M 2012. Effects of sorafenib on C-terminal truncated androgen receptor variants in human prostate cancer cells. international J.Mol.Sci. 13(9): 11530-11542

2889) Zenmyo M, Komiya S, Hamada T, Hiraoka K, Kato S, Fujii T, Yano H, Irie K and Nagata K 2001. Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to the differentiation of p53-deficient MG-63 osteosarcoma cells. Hum Patol. 32(4): 410-6

2890) Zerbini, L.F. and Libermann, T.A. 2005. Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaβ-mediated escape from programmed cell death. cellular cycle. 4(1):18-20

2891) Zerp , F.S. , Stoter , R. , Kuipers , G. , Yang , D. , Lippman , EM. , van Blitterswijk , J.W. , Bartelink , H. , Rooswinkel , R. , Lafleur , V. and Verheij , M. . 2009 AT-101, a small-molecule inhibitor of antiapoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. Radiotherapeutic Oncology. 4:47, doi:10.1186/1748-717X-4-47, 10 pages

2892) Zhai Y, Lu Q, Liu Y, Cheng Q, Wei Y, Zhang F, Li C and Yin X 2013. Overproduction of nitric oxide by oxidative stress-induced activation of the TGF-β1/PI3K/Akt pathway in mesangial cells grown in high glucose. Pharmacol Act. 34(4):507-514

2893) Zhan, C. D. and Pan, J. Y. 2000. Nitric oxide inhibits angiotensin II and endothelin-1 induced expression of the c-fos proto-oncogene in cardiomyocytes. Sheng Li Xue Bao. 52(6):450-4

2894) Zhan, Q., Bae, I., Kastan, M.B. and Fornace, Jr., A.J. 1994. The p53-dependent ϒ-ray response of GADD45. Cancer research. 54(10): 2755-2760

2895) Zhang, D., Li, J., Song, L., Ouyang, W., Gao, J., and Huang, C. 2008. JNK1/AP-1-dependent Cox-2 induction is involved in 12 - O-tetradecanoylphorbol-13-acetate-induced cell transformation by regulating cell cycle progression. Mol Cancer Res. 6(1):165-174

2896) Zhang, G., Wu, H., Zhu, B., Shimoishi, Y., Nakamura, Y. and Murata, Y. 2009. Induction of apoptosis by beta-carotene and dimethyl tetrasulfide assisted by UVA radiation in HL- 60 Zellen. Biosci. Biotechnology. Biochemistry 73(5):1014-1020

2897) Zhang, H. P., Zheng, F. L., Zhao, J. H., Guo, D. X., & Chen, X. L. 2013. Genistein inhibits HUVEC expression induced by ox-LDL, ICAM-1 and McP-1 of HUVEC by heme oxygenase -1 . Arch Med. Res. 44(1): 13-20

2898) Zhang, J., Espinoza, L. A., Kinders, R. J., Lawrence, S. M., Pfister, T. D., Zhou, M., Veenstra, T. D., Thorgeirsson, S. S. und Jessup, J. M. 2013. Nanog modulates rigidity in human colorectal cancer . Onkogen. 32(37): 4397-405

2899) Zhang L, Ii L, Jiao M, Wu D, Wu K, Li X, Zhu G, Yang L, Wang X, Hsieh JT and He, D. 2012. Genistein inhibits stem cell properties of cells of prostate cancer by targeting the hedgehog Gli1 signaling pathway. Cancer Lett. 323(1): 48-57

2900) Zhang L, Xu X, Yang R, Chen J, Wang S, Yang J, Xiang X, He Z, Zhao Y, Dong Z, and Zhang, D. 2015. Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signing. Drugs Des Devel Ther. 9:2139-48, doi:10.2147/DDDT-S81390

2901) Zhang M, Wang S, Mao L, Leak RK, Shi Y, Zhang W, Hu X, Sun B, Cao G, Gao Y, Xu, Y., Chen, J. and Zhang, F. 2014. Omega- 3 fatty acids protect the brain from ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. The Journal of Neuroscience. 34(5): 1903-1915

2902) Zhang, M., Xie, X., Lee, H.A. and Binns, WC 2004. Soy and isoflavone intake is associated with a reduced risk of ovarian cancer in southeast China. Diet and cancer. 49(2): 125-130

2903) Zhang, M., Zhou, X., and Zhou, K. 2013. Resveratrol inhibits the growth of human nasopharyngeal carcinoma cells by blocking the pAkt/p70S6K signaling pathways. international J. Mol. Med. 31(3): 621-7

2904) Zhang P, Li H, Yang B, Yang F, Zhang L L, Kong Q Y, Chen X Y, Wu M L, and Liu J 2014. Biological significance and therapeutic implications of resveratrol-inhibited Wnt, Notch, and STAT3 signaling in cancer cells of cervix. cancer genes 5(5-6): 154-64

[ PMC free article ] [ PubMed ] 2905) Zhang P, Suidasari S, Hasegawa T, Yanaka N and Kato N 2013. High concentrations of pyridoxal stimulate IGFBP1 expression in HepG2 cells through positive regulation of the ERK/1 signaling pathway. c-Jun. . . . . . . . . . . . . Molecular Medicine Reports. 8(4):973-978

2906) Zhang, Q. and Ye, M. 2009. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). Journal of Chromatography A. 1216: 1954-1969.

2907) Zhang, R., Xu, Y., Ekman, N., Wu, Z., Wu, J., Alitalo, K., and Min, W. 2003. Etk/Bmx transactivates vascular endothelial growth factor-2 and recruits Phosphatidylinositol-3-kinase to mediate the angiogenic pathway induced by tumor necrosis factor. Journal of Biological Chemistry. 278(51): 51267-51276

2908) Zhang, SM, Willett, WC, Selhub, J, Hunter, DJ, Giovannucci, EL, Holmes, MD, Colditz, GA and Hankinson, SE 2003. Plasma folate, vitamin B6, vitamin B12, homocystone and maternal risk Cancer. Zeitschrift of the National Cancer Institute. 95(5):373-380

2909) Zhang, S., Hunter, D.J., Hankinson, SE, Giovannucci, EL, Rosner, BA, Colditz, GA, Speizer, FE, and Willett, W.C. 1999. A prospective study on folate intake and breast cancer risk. NEVER. 281(17):1632-1637

2910) Zhang, T., Inesta-Vaguera, F., Niepel, M., Zhang, J., Ficarro, S.B., Machleidt, T., Xie, T., Marto, J.A., Kim, N., Sim, T. ., Laughlin, J. D., Park, H., LoGrasso, P. V., Patricelli, M., Nomandbhoy, T. K., Sorger, P. K., Alessi, D. R., and Gray, N. S. 2012. Discovery of potent and selected covalent inhibitors of JNK. Chemistry Biol. 19(1): 140-54

2911) Zhang, T., Li, Y., Zhu, Z., Gu, M., Newman, B., & Sun, D. 2010. MEK inhibition potentiates the activity of the Hsp90 inhibitor 17-AAG against cells of pancreatic cancer. Mol Pharm. 7(5):1576-1584

2912) Zhang W, Shu X, Li H, Yang G, Cai H, Ji B, Gao J, Gao Y, Zheng W, and Xiang Y 2012. Vitamin intake and risk of liver cancer: a report of two cohort studies in China. JNCL-J National Cancer Institute 104(15):1174-1182

2913) Zhang, W., Wang, X., & Chen, T. 2011. Resveratrol induces mitochondria-mediated AIF and, to a lesser extent, caspase-9-dependent apoptosis in ASTC-a-1 human lung adenocarcinoma cells. Mol Cell Biochem. 354(1-2): 29-37

2914) Zhang, X. and Zanello, L. P. 2008. Vitamin D receptor-dependent 1-alpha, 25(OH)2-vitamin D3-dependent PI3K/AKT-induced antiapoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res. 23(8): 1238-48

2915) Zhang, X. F., Hung, T. M., Phuong, P. T., Ngoc, T. M., Min, B., Song, K., Seong, Y. H. und Bae, K. 2006. Anti-inflammatory activity of flavonoids from Populus davidiana. Archive der Pharmakolforschung. 29(12): 1102-1108

2916) Zhang, X, Lee, JE, Ma, J, Je, Y, Wu, K, Willet, WC, Fuchs, CS & Giovannucci, EL 2012. Prospective cohort studies on vitamin B6 intake and cancer incidence colorectal: change after time?. Biomarkers of the cancer epidemic Prev. 21(3):560

2917) Zhang, X., Wang, G., Gurley, EC, & Zhou, H. 2014. The flavonoid apigenin inhibits the lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages. Plus one. 9(9): e107072, doi: 10.1371/journal.pone.0107072

2918) Zhang, Y. and Xiong, Y. 2001. Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Different cell growth. 12(4): 175-186

2919) Zhang, YM, Deng, YH, Luther, T, Muller, M, Ziegler, R, Waldherr, R, Stern, DM & Nawroth, PP 1994. Tissue factor controls the balance of angiogenic and antiangiogenic properties of cells tumors in mice. Clinical Research Journal. 94(3):1320-1327

2920) Zhang Y Y, Long J R, Liu P Y, Liu Y J, Shen H, Zhao L J, and Deng H W 2003. Vitamin D and estrogen receptor alpha gene polymorphisms and bone mineral density: association study of healthy subjects Chinese women before and after menopause. Biochem Biophys Communal Res. 308(4):777-83

2921) Zhang Y, Chen AY, Li M, Chen C and Yao Q 2008. Gingko biloba extract Kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. Surgical Research Journal. 148(1):17-23

2922) Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, and Goleva E 2012. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK-phosphate-1 targets. J Immunol. 188(5):2127-35

2923) Zhang, Y., Tao, S., Shen, H., and Ma, J. 2009. Inhalation exposure to atmospheric polycyclic aromatic hydrocarbons and lung cancer risk of the Chinese population. PNAS. 106(50): 21063-21067

2924) Zhang Z, Wang C, Du G, Qi L, Calway T, He T, Du W and Yuan C 2013. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/dependent signaling p53 in human colon cancer cells. international J Oncol. 43(1): 289-296

2925) Zhao, B., Fei, Y., Chen, Y., Ying, Y., Song, X., Wang, L., Chen, E., & Mao, E. 2014. Pharmacological vitamin C preconditioning attenuates Injury by induction of heme oxygenase-1 after hemorrhagic shock in rats. Plus one. 9(6):e99134, 12 pages, doi=10.371/journal.pone.0099134

2926) Zhao, F., Edwards, R., Dizon, D., Mastroianni, J. R., Geyfman, M., Ouellette, A. J., Andersen, B., and Lipkin, S. M. 2010. Disruption of Paneth and cell homeostasis foveolar stress and increased endoplasmic reticulum stress homeostasis in Agr2-/-mice. Dev Biol. 338(2): 270-279

2927) Zhao, J., Dasmahapatra, AK, Khan, SI & Khan, IA 2008. Anti-aromatase activity of Damiana (Turnera diffusa) components. Journal of Ethnopharmacology. 120(3):387-393

2928) Zhao M, Ma J, Zhu H Y, Zhang X H, Du Z Y, Xu Y J, and Yu X D 2011. Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells by targeting the CK2 targeting trinity , Cdc37 and Hsp90. mole cancer. 10:104, doi: 10.1186/1476-4598-10-104, 14 pages

2929) Zhao, R., Leung, E., Grüner, S., Schapira, M., and Houry, W.A. 2010. Tamoxifen potentiates the molecular ATPase activity of the Hsp90 chaperone. Plus one. 5(4): e9934, doi: 10.1371/journal.pone.0009934, 8 pages

2930) Zhao, S., Huang, Z. and Gao, J. 2011. Lupan-like triterpenoids from the leaves of Heteropanax fragrans. Bull Korean Chem Soc. 32(4): 1368-1370

2931) Zhao Y, Zhang C, Zhou W, Chen J, Luo N, Gong L, Du L and Zhou J 2014. Is there a role for TNFR1 in cases of acute lung injury associated with extracorporeal circulation?. J Zhejiang Univ Sci B. 15(3): 281-288

2932) Zhao, Y., Zhou, S. and Heng, C. K. 2009. Celecoxib inhibits serum amyloid-a-induced matrix metalloproteinase 10 expression in human endothelial cells. J Vasc Res. 46(1): 64-72

2933) Zhao Z, Cheng X, Wang Y, Han R, Li L, Xiang T, He L, Long H, Zhu B and He Y 2014. Metformin inhibits IL-6-induced epithelial-mesenchymal transition and growth and Lung adenocarcinoma metastasis. Plus one. 9(4): e95884, doi: 10.1371/journal.pone.0095884, 12 pages

2934) Zhao, Z., Egashira, Y. and Sanada, H. 2005. Phenolic antioxidants, abundant in corn bran, are readily bioavailable in rats. Journal of agricultural and food chemistry. 53(12): 5030-5035

2935) Zheng, A., Kallio, A., and Harkonen, P. 2007. Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated through extracellular signal-regulated kinase signaling and may be abolished by estrogen. Endocrinology. 148(6): 2764-2777

2936) Zheng, M., Ekmekcioğlu, S., Walch, ET, Tang, CH & Grimm, EA 2004. Inhibition of nuclear factor kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. melanomares. 14(3):165-71

2937) Zheng, M., Yang, J., Xu, X., Sebolt, J. T., Wang, S., & Sun, Y. 2010. Efficacy of the Mdm2 inhibitor MI-219 against lung cancer cells alone or in combination with Mdm2 knockdown B. a XIAP inhibitor or etoposide. Res. against cancer. 30(9):3321-31

2938) Zheng, S., Lamhamedi-Cherradi, S., Wang, P., Xu, L., & Chen, H. Y. 2005. The tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. diabetes mellitus 54(5): 1423-1428

2939) Zheng W, Anderson KE, Kushi L, Sellers TA, Greenstein J, Hong C, Cerhan JR, Bostick RM and Folsom AR 1998. A prospective cohort study on the intake of calcium, vitamin D and other micronutrients in relation to incidence of rectal cancer in postmenopausal women. Epidemiology, biomarkers and cancer prevention. 7(3): 221-225

2940) Zheng, W., Sellers, TA, Doyle, TJ, Kushi, LH, Potter, JD, & Folsom, AR 1995. Retinol, antioxidant vitamins, and upper digestive tract cancers in a prospective cohort study of postmenopausal women. American Journal of Epidemiology. 142(9):955-960

2941) Zhiyu W, Yue C, Neng W, Mei WD, Wei LY, Feng H, Gang SJ, Po YD, Yuan GX, and Jian-Ping C 2012. Dioscin induces cancer cell apoptosis through increased stress oxidative mediated downregulation of peroxiredoxins. Cancer Biology and Therapy. 13(3):138-147

2942) Zhong HM, Ding QH, Chen WP, and Luo RB 2013. Vorinostat, an HDAC inhibitor, showed anti-OA activities by inhibiting iNOS and MMP expression, p38 and ERK phosphorylation, and blocking NF-kB nuclear translocation. Immunopharmaceutical International. 17(2):329-35

2943) Zhong, W., Gu, B., Gu, Y., Groome, L. J., Sun, J., & Wang, Y. 2014. Vitamin D receptor activation promotes VEGF and CuZn-SOD expression in cells endothelial J Seroid Biochem Mol Biol. 140:56-62, doi:10.16/j.jsbmb. 2013.11.017

2944) Zhou Y, García-Prieto C, Carney DA, Xu R, Pelicano H, Kang Y, Yu W, Lou, Kondo S, Liu J, D , M. Harris., Estrov, Z., Keating, M.J., Zhin , J. and Huang, P. 2005. OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action. J National Cancer Institute 97:1781-5

2945) Zhou C, Li C, Li D, Wang Y, Shao W, You Y, Peng J, Zhang X, Lu L and Shen X 2013. BIG1, a guanine nucleotide exchange protein inhibited by brefeldin A, regulates the neurite development through PI3K -AKT and ERK signaling pathways. neuroscience 254:361-8, doi:10.1016/j.neuroscience.2013.09.045

2946) Zhou C, Li C, Li D, Wang Y, Shao W, You Y, Peng J, Zhang X, Lu L and Shen X 2013. BIG1, a guanine nucleotide exchange protein inhibited by brefeldin A, regulates the neurite development through PI3K -AKT and ERK signaling pathways. neuroscience 254:361-8, doi:10.1016/j.neuroscience.2013.09.045

2947) Zhou, C., Tabb, MM, Sadatrafiei, A., Grün, F., Blumberg, B. 2004. Tocotrienols activate the steroid and xenobiotic receptor SXR and selectively regulate the expression of its target genes. Elimination of drug metab. 32(10):1075-82

2948) Zhou, J., Joplin, D.G., Cross, J.V. and Templeton, D.J. 2012. Sulforaphane inhibits prostaglandin E2 synthesis by repressing microsomal prostaglandin E synthase 1. PLoS One. 7(11):e49744, doi:10.1371/Journal.pone.0049744. epub2012Nov16

2949) Zhou, X., Li, W., Jiang, L., Bao, J., Tao, L., Li, J., & Wu, L. 2013. Tatrandrine inhibits and alleviates osteoarthritis signaling pathway of Wnt/β-catenin: An in vitro and in vivo study. Alternative and complementary medicine based on evidence. Item ID 809579, 8 pages

2950) Zhou, Y. and Lee, A.S. 1998. Mechanism of suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soybean. J National Cancer Institute 90(5): 381-388

2951) Zhou Y, Zhao W, Xie G, Huang M, Hu M, Jiang X, Zeng D, Liu J, Zhou H, Chen H., Wang, G. H., and Zhang, X. K. 2014. Induction of the Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK. carcinogenesis. 35(12):2660-9

2952) Zhu, G., Conner, S.E., Zhou, X., Shih, C., Li, T., Anderson, B.D., Brooks, H.B., Campbell, R.M., Considine, E., Dempsey, J.A., Faul, M.M. , Ogg, C., Patel, B., Schultz, R. M., Spencer, CD., Teicher, B., and Watkins, S. A. 2003. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent inhibitors of cyclin D1-CDK4 . J MedChem. 46(11): 2027-30

2953) Zhu T, Gu J, Yu K, Lucas J, Cai P, Tsao R, Gong Y, Li F, Chaudhary I, Desai P ., Ruppen, M., Fawzi, M., Gibbons, J., Ayral- Kaloustian, S., Skotnicki, J., Mansour, T. y Zask, A. 2006. Pegylated Wortmannin and 17-Hydroxywortmannin Conjugates as Phosphoinositides 3 -kinase inhibitors active in human tumor xenograft models. J MedChem. 44(4): 1373-1378

2954) Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y and Chen L 2011. 5- Formylhonokiol exerts anti-angiogenesis activity by inactivating the ERK signaling pathway. Exp Mol Med. 43(3):146-52

2955) Zhu W, Xu J, Ge Y, CaO H, Ge X, Luo J, Xue J, Yang H, Zhang S, and Cao J 2014. Epigallocatechin-3-gallate (EGCG) protects skin cells from Ionizing radiation through hemo-overexpression of oxygenase-1 (HO-1). J Radiation Res. 55(6): 1056-1065

2956) Zhu, W., Zhang, JS and Young, CY 2001. Silymarin inhibits androgen receptor function by reducing the nuclear localization of the receptor in the human prostate cancer cell line LNCaP. carcinogenesis. 22(9):1399-403

2957) Zhu, Y. and Sun, G. 2005. 5α-reductase isoenzymes in the pristate. J.Med. science 25(1):1-12

2958) Zimmerman, J. 1997. Optimal Nutrition for HIV/AIDS Wellness. Journal of the American Dietetic Association, 97 (Supplement 1), A18.

2959) Zingg, J. M., Azzi, A. Meydani, M. 2015. Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via lipid exchange mediated by PI3Kϒ/PKB and hTAP1/SEC14L2. J Cell Biochem. 116(3): 398-407

2960) Zou, J., Feng, D., Ling, W. H., and Duan, R. D. 2013. Lycopene suppresses the proinflammatory response in lipopolysaccharide-stimulated macrophages by inhibiting ROS-induced TLR4 transport to lipid raft-like domains. J Nutr Biochem. 24(6):1117-22

2961) Zou W, Yue P, Lin N, He M, Zhou Z, Lonial S, Khuri F R, Wang B and Sun S 2006. Vitamin C inactivates proteasome inhibitor PS-341 in human cancer cells. chin cancer res. 12(1):273-280

2962) Zucchetti , M. , Bonezzi , K. , Frapolli , R. , Sala , F. , Borsotti , P. , Zangarini , M. , Cvitkovic , E. , Noel , K. , Ubezio , P. , Giavazzi , R . ., D'Incalci, M. and Taraboletti, G. 2013. Pharmacokinetics and antineoplastic activity of galectin-1 targeting OTX008 in combination with sunitinib. Cancer Chemother Pharmacol. 72(4):879-87

2963) Zunino, S.J. and Storms, D.H. 2006. Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulating the mitochondrial permeability transition pore. cancer letters 240(1): 123-134

(Video) A Closer Look at…Cancer Prevention

2964) Ziriax, BC and Windler, E. 2000. Dietary fat in the prevention of cardiovascular disease: a review. European journal of lipid science and technology. 102(5): 355-365.


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